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Protein

Protein S100-A5

Gene

S100A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityAdd
BLAST
Calcium bindingi60 – 71122; high affinityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. zinc ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100A5
Synonyms:S100D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10495. S100A5.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Protein S100-A5PRO_0000143980Add
BLAST

Proteomic databases

PaxDbiP33763.
PRIDEiP33763.

PTM databases

PhosphoSiteiP33763.

Expressioni

Gene expression databases

BgeeiP33763.
CleanExiHS_S100A5.
GenevestigatoriP33763.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP33763. 1 interaction.
MINTiMINT-7256702.
STRINGi9606.ENSP00000352148.

Structurei

Secondary structure

1
92
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2017Combined sources
Beta strandi22 – 243Combined sources
Beta strandi26 – 305Combined sources
Helixi31 – 399Combined sources
Turni45 – 473Combined sources
Helixi52 – 598Combined sources
Turni60 – 623Combined sources
Beta strandi63 – 686Combined sources
Helixi69 – 8517Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KAXNMR-A/B1-92[»]
2KAYNMR-A/B1-92[»]
4DIRX-ray2.60A/B1-92[»]
SMRiP33763. Positions 1-92.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33763.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini47 – 8236EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG46820.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP33763.
OMAiELCLGEM.
OrthoDBiEOG7R833W.
PhylomeDBiP33763.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P33763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES
60 70 80 90
SIDDLMKSLD KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK
Length:92
Mass (Da):10,744
Last modified:April 15, 2002 - v2
Checksum:i49C2B1DAEC481561
GO
Isoform 2 (identifier: P33763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPAAWILWAHSHSELHTVM

Note: No experimental confirmation available.

Show »
Length:110
Mass (Da):12,813
Checksum:iF117933AD2DAA71B
GO

Sequence cautioni

The sequence CAA79472.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA79475.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA79479.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541D → G.
VAR_001305

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPAAWILWAHSHSELHTVM in isoform 2. 1 PublicationVSP_055506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18954 mRNA. Translation: CAA79479.1. Different initiation.
Z18949 Genomic DNA. Translation: CAA79472.1. Different initiation.
Z18950 Genomic DNA. Translation: CAA79475.1. Different initiation.
BX470102 Genomic DNA. Translation: CAI14753.1.
CH471121 Genomic DNA. Translation: EAW53317.1.
BC093955 mRNA. Translation: AAH93955.1.
BC093957 mRNA. Translation: AAH93957.1.
CCDSiCCDS1041.2. [P33763-1]
RefSeqiNP_002953.2. NM_002962.1. [P33763-1]
XP_005245487.1. XM_005245430.1. [P33763-2]
UniGeneiHs.2960.

Genome annotation databases

EnsembliENST00000368717; ENSP00000357706; ENSG00000196420. [P33763-1]
ENST00000368718; ENSP00000357707; ENSG00000196420. [P33763-1]
GeneIDi6276.
KEGGihsa:6276.
UCSCiuc001fbx.3. human. [P33763-1]

Polymorphism databases

DMDMi20178321.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18954 mRNA. Translation: CAA79479.1. Different initiation.
Z18949 Genomic DNA. Translation: CAA79472.1. Different initiation.
Z18950 Genomic DNA. Translation: CAA79475.1. Different initiation.
BX470102 Genomic DNA. Translation: CAI14753.1.
CH471121 Genomic DNA. Translation: EAW53317.1.
BC093955 mRNA. Translation: AAH93955.1.
BC093957 mRNA. Translation: AAH93957.1.
CCDSiCCDS1041.2. [P33763-1]
RefSeqiNP_002953.2. NM_002962.1. [P33763-1]
XP_005245487.1. XM_005245430.1. [P33763-2]
UniGeneiHs.2960.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KAXNMR-A/B1-92[»]
2KAYNMR-A/B1-92[»]
4DIRX-ray2.60A/B1-92[»]
SMRiP33763. Positions 1-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP33763. 1 interaction.
MINTiMINT-7256702.
STRINGi9606.ENSP00000352148.

PTM databases

PhosphoSiteiP33763.

Polymorphism databases

DMDMi20178321.

Proteomic databases

PaxDbiP33763.
PRIDEiP33763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368717; ENSP00000357706; ENSG00000196420. [P33763-1]
ENST00000368718; ENSP00000357707; ENSG00000196420. [P33763-1]
GeneIDi6276.
KEGGihsa:6276.
UCSCiuc001fbx.3. human. [P33763-1]

Organism-specific databases

CTDi6276.
GeneCardsiGC01M153509.
HGNCiHGNC:10495. S100A5.
MIMi176991. gene.
neXtProtiNX_P33763.
PharmGKBiPA34907.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46820.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP33763.
OMAiELCLGEM.
OrthoDBiEOG7R833W.
PhylomeDBiP33763.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP33763.
GeneWikiiS100A5.
GenomeRNAii6276.
NextBioi13616844.
PROiP33763.
SOURCEiSearch...

Gene expression databases

BgeeiP33763.
CleanExiHS_S100A5.
GenevestigatoriP33763.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E."
    Engelkamp D., Schaefer B.W., Mattei M.-G., Erne P., Heizmann C.W.
    Proc. Natl. Acad. Sci. U.S.A. 90:6547-6551(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
    Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
    J. Biol. Chem. 275:30623-30630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states."
    Bertini I., Das Gupta S., Hu X., Karavelas T., Luchinat C., Parigi G., Yuan J.
    J. Biol. Inorg. Chem. 14:1097-1107(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH CALCIUM IONS, SUBUNIT.

Entry informationi

Entry nameiS10A5_HUMAN
AccessioniPrimary (citable) accession number: P33763
Secondary accession number(s): Q52LE7, Q5RHS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: April 15, 2002
Last modified: March 31, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.