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P33763 (S10A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene names
Name:S100A5
Synonyms:S100D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Ref.3

Subunit structure

Homodimer. Ref.4

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Sequence caution

The sequence CAA79472.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA79475.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA79479.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Protein S100-A5
PRO_0000143980

Regions

Domain12 – 4736EF-hand 1
Domain47 – 8236EF-hand 2
Calcium binding20 – 33141; low affinity
Calcium binding60 – 71122; high affinity

Natural variations

Natural variant541D → G.
VAR_001305

Secondary structure

............... 92
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P33763 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: 49C2B1DAEC481561

FASTA9210,744
        10         20         30         40         50         60 
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD 

        70         80         90 
KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK 

« Hide

References

« Hide 'large scale' references
[1]"Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E."
Engelkamp D., Schaefer B.W., Mattei M.-G., Erne P., Heizmann C.W.
Proc. Natl. Acad. Sci. U.S.A. 90:6547-6551(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Kidney.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states."
Bertini I., Das Gupta S., Hu X., Karavelas T., Luchinat C., Parigi G., Yuan J.
J. Biol. Inorg. Chem. 14:1097-1107(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR IN COMPLEX WITH CALCIUM IONS, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z18954 mRNA. Translation: CAA79479.1. Different initiation.
Z18949 Genomic DNA. Translation: CAA79472.1. Different initiation.
Z18950 Genomic DNA. Translation: CAA79475.1. Different initiation.
BX470102 Genomic DNA. Translation: CAI14753.1.
RefSeqNP_002953.2. NM_002962.1.
XP_005245487.1. XM_005245430.1.
UniGeneHs.2960.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2KAXNMR-A/B1-92[»]
2KAYNMR-A/B1-92[»]
4DIRX-ray2.60A/B1-92[»]
ProteinModelPortalP33763.
SMRP33763. Positions 1-92.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP33763. 1 interaction.
MINTMINT-7256702.
STRING9606.ENSP00000352148.

PTM databases

PhosphoSiteP33763.

Polymorphism databases

DMDM20178321.

Proteomic databases

PaxDbP33763.
PRIDEP33763.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368717; ENSP00000357706; ENSG00000196420.
ENST00000368718; ENSP00000357707; ENSG00000196420.
GeneID6276.
KEGGhsa:6276.
UCSCuc001fbx.3. human.

Organism-specific databases

CTD6276.
GeneCardsGC01M153509.
HGNCHGNC:10495. S100A5.
MIM176991. gene.
neXtProtNX_P33763.
PharmGKBPA34907.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46820.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP33763.
OrthoDBEOG7R833W.
PhylomeDBP33763.
TreeFamTF332727.

Gene expression databases

ArrayExpressP33763.
BgeeP33763.
CleanExHS_S100A5.
GenevestigatorP33763.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5/S100-A6.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF14. PTHR11639:SF14. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP33763.
GeneWikiS100A5.
GenomeRNAi6276.
NextBio24361.
PROP33763.
SOURCESearch...

Entry information

Entry nameS10A5_HUMAN
AccessionPrimary (citable) accession number: P33763
Secondary accession number(s): Q5RHS3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 16, 2002
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM