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P33763

- S10A5_HUMAN

UniProt

P33763 - S10A5_HUMAN

Protein

Protein S100-A5

Gene

S100A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinityAdd
    BLAST
    Calcium bindingi60 – 71122; high affinityAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB
    4. zinc ion binding Source: UniProtKB

    Keywords - Ligandi

    Calcium, Copper, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A5
    Alternative name(s):
    Protein S-100D
    S100 calcium-binding protein A5
    Gene namesi
    Name:S100A5
    Synonyms:S100D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10495. S100A5.

    Subcellular locationi

    GO - Cellular componenti

    1. neuronal cell body Source: Ensembl
    2. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Protein S100-A5PRO_0000143980Add
    BLAST

    Proteomic databases

    PaxDbiP33763.
    PRIDEiP33763.

    PTM databases

    PhosphoSiteiP33763.

    Expressioni

    Gene expression databases

    ArrayExpressiP33763.
    BgeeiP33763.
    CleanExiHS_S100A5.
    GenevestigatoriP33763.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    IntActiP33763. 1 interaction.
    MINTiMINT-7256702.
    STRINGi9606.ENSP00000352148.

    Structurei

    Secondary structure

    1
    92
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 2017
    Beta strandi22 – 243
    Beta strandi26 – 305
    Helixi31 – 399
    Turni45 – 473
    Helixi52 – 598
    Turni60 – 623
    Beta strandi63 – 686
    Helixi69 – 8517

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KAXNMR-A/B1-92[»]
    2KAYNMR-A/B1-92[»]
    4DIRX-ray2.60A/B1-92[»]
    ProteinModelPortaliP33763.
    SMRiP33763. Positions 1-92.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP33763.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini47 – 8236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG46820.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP33763.
    OrthoDBiEOG7R833W.
    PhylomeDBiP33763.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028497. S100-A5.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P33763-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES   50
    SIDDLMKSLD KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK 92
    Length:92
    Mass (Da):10,744
    Last modified:April 16, 2002 - v2
    Checksum:i49C2B1DAEC481561
    GO
    Isoform 2 (identifier: P33763-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MPAAWILWAHSHSELHTVM

    Note: No experimental confirmation available.

    Show »
    Length:110
    Mass (Da):12,813
    Checksum:iF117933AD2DAA71B
    GO

    Sequence cautioni

    The sequence CAA79472.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA79475.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA79479.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541D → G.
    VAR_001305

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MPAAWILWAHSHSELHTVM in isoform 2. 1 PublicationVSP_055506

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18954 mRNA. Translation: CAA79479.1. Different initiation.
    Z18949 Genomic DNA. Translation: CAA79472.1. Different initiation.
    Z18950 Genomic DNA. Translation: CAA79475.1. Different initiation.
    BX470102 Genomic DNA. Translation: CAI14753.1.
    CH471121 Genomic DNA. Translation: EAW53317.1.
    BC093955 mRNA. Translation: AAH93955.1.
    BC093957 mRNA. Translation: AAH93957.1.
    CCDSiCCDS1041.2.
    RefSeqiNP_002953.2. NM_002962.1.
    XP_005245487.1. XM_005245430.1.
    UniGeneiHs.2960.

    Genome annotation databases

    EnsembliENST00000368717; ENSP00000357706; ENSG00000196420. [P33763-1]
    ENST00000368718; ENSP00000357707; ENSG00000196420. [P33763-1]
    GeneIDi6276.
    KEGGihsa:6276.
    UCSCiuc001fbx.3. human.

    Polymorphism databases

    DMDMi20178321.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z18954 mRNA. Translation: CAA79479.1 . Different initiation.
    Z18949 Genomic DNA. Translation: CAA79472.1 . Different initiation.
    Z18950 Genomic DNA. Translation: CAA79475.1 . Different initiation.
    BX470102 Genomic DNA. Translation: CAI14753.1 .
    CH471121 Genomic DNA. Translation: EAW53317.1 .
    BC093955 mRNA. Translation: AAH93955.1 .
    BC093957 mRNA. Translation: AAH93957.1 .
    CCDSi CCDS1041.2.
    RefSeqi NP_002953.2. NM_002962.1.
    XP_005245487.1. XM_005245430.1.
    UniGenei Hs.2960.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KAX NMR - A/B 1-92 [» ]
    2KAY NMR - A/B 1-92 [» ]
    4DIR X-ray 2.60 A/B 1-92 [» ]
    ProteinModelPortali P33763.
    SMRi P33763. Positions 1-92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P33763. 1 interaction.
    MINTi MINT-7256702.
    STRINGi 9606.ENSP00000352148.

    PTM databases

    PhosphoSitei P33763.

    Polymorphism databases

    DMDMi 20178321.

    Proteomic databases

    PaxDbi P33763.
    PRIDEi P33763.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368717 ; ENSP00000357706 ; ENSG00000196420 . [P33763-1 ]
    ENST00000368718 ; ENSP00000357707 ; ENSG00000196420 . [P33763-1 ]
    GeneIDi 6276.
    KEGGi hsa:6276.
    UCSCi uc001fbx.3. human.

    Organism-specific databases

    CTDi 6276.
    GeneCardsi GC01M153509.
    HGNCi HGNC:10495. S100A5.
    MIMi 176991. gene.
    neXtProti NX_P33763.
    PharmGKBi PA34907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46820.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P33763.
    OrthoDBi EOG7R833W.
    PhylomeDBi P33763.
    TreeFami TF332727.

    Miscellaneous databases

    EvolutionaryTracei P33763.
    GeneWikii S100A5.
    GenomeRNAii 6276.
    NextBioi 24361.
    PROi P33763.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P33763.
    Bgeei P33763.
    CleanExi HS_S100A5.
    Genevestigatori P33763.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028497. S100-A5.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF65. PTHR11639:SF65. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E."
      Engelkamp D., Schaefer B.W., Mattei M.-G., Erne P., Heizmann C.W.
      Proc. Natl. Acad. Sci. U.S.A. 90:6547-6551(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
      Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
      J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states."
      Bertini I., Das Gupta S., Hu X., Karavelas T., Luchinat C., Parigi G., Yuan J.
      J. Biol. Inorg. Chem. 14:1097-1107(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR IN COMPLEX WITH CALCIUM IONS, SUBUNIT.

    Entry informationi

    Entry nameiS10A5_HUMAN
    AccessioniPrimary (citable) accession number: P33763
    Secondary accession number(s): Q52LE7, Q5RHS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3