P33759 (RT05_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
37S ribosomal protein S5, mitochondrial

Gene names

Name:	MRPS5
Ordered Locus Names:	YBR251W
ORF Names:	YBR1704

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial small ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.4 Ref.5
Subcellular location	Mitochondrion Ref.6 Ref.8.
Miscellaneous	Present with 6680 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ribosomal protein S5P family. Contains 1 S5 DRBM domain.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial translation Inferred by curator Ref.4. Source: SGD
Cellular_component	mitochondrial small ribosomal subunit Inferred from physical interaction Ref.4. Source: SGD
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from physical interaction Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 13	13	Mitochondrion Potential
	Chain	14 – 307	294	37S ribosomal protein S5, mitochondrial		PRO_0000131688
Regions
	Domain	144 – 208	65	S5 DRBM

Sequences

	Sequence		Length	Mass (Da)
	P33759 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 7A7BC49A4D414FC1	FASTA	307	34,883
	10 20 30 40 50 60 MFKRQLSTSV RYLQHYDESL LSRYYPESLL KSIKLAQQTI PEDTKFRVSR NVEFAPPYLD 70 80 90 100 110 120 DFTKIHPFWD YKPGMPHLHA QEENNNFSIF RWDQVQQPLP GEGNILPPGV SLPNDGGRKS 130 140 150 160 170 180 KSADVAAGLH KQTGVDPDYI TRKLTMKPLV MKRVSNQTGK GKIASFYALV VVGDKNGMVG 190 200 210 220 230 240 LGEGKSREEM SKAIFKAHWD AVRNLKEIPR YENRTIYGDI DFRYHGVKLH LRSAKPGFGL 250 260 270 280 290 300 RVNHVIFEIC ECAGIKDLSG KVYKSRNDMN IAKGTIEAFT KAQKTLDEVA LGRGKKLVDV RKVYYSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequence of a 6794 bp segment located on the right arm of chromosome II of Saccharomyces cerevisiae. Finding of a putative dUTPase in a yeast." Doignon F., Biteau N., Aigle M., Crouzet M. Yeast 9:1131-1137(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues." Saveanu C., Fromont-Racine M., Harington A., Ricard F., Namane A., Jacquier A. J. Biol. Chem. 276:15861-15867(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL SMALL COMPLEX, MASS SPECTROMETRY.
[5]	"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K. Eur. J. Biochem. 269:5203-5214(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL SMALL COMPLEX, MASS SPECTROMETRY.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L20296 Genomic DNA. Translation: AAA65610.1. Z36120 Genomic DNA. Translation: CAA85214.1. BK006936 Genomic DNA. Translation: DAA07367.1.
PIR	S38374.
RefSeq	NP_009810.3. NM_001178599.3.
3D structure databases
ProteinModelPortal	P33759.
SMR	P33759. Positions 147-294.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2869N.
IntAct	P33759. 44 interactions.
MINT	MINT-615779.
STRING	4932.YBR251W.
Proteomic databases
PaxDb	P33759.
PeptideAtlas	P33759.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR251W; YBR251W; YBR251W.
GeneID	852553.
KEGG	sce:YBR251W.
Organism-specific databases
CYGD	YBR251w.
SGD	S000000455. MRPS5.
Phylogenomic databases
eggNOG	COG0098.
GeneTree	ENSGT00390000001878.
HOGENOM	HOG000247984.
KO	K02988.
OMA	ICECAGI.
OrthoDB	EOG451J17.
Enzyme and pathway databases
BioCyc	YEAST:G3O-29177-MONOMER.
Gene expression databases
Genevestigator	P33759.
GermOnline	YBR251W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.30.160.20. 1 hit. 3.30.230.10. 1 hit.
InterPro	IPR014720. dsRNA-bd-like_dom. IPR000851. Ribosomal_S5. IPR005324. Ribosomal_S5_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR013810. Ribosomal_S5_N. IPR018192. Ribosomal_S5_N_CS. [Graphical view]
PANTHER	PTHR13718. PTHR13718. 1 hit.
Pfam	PF00333. Ribosomal_S5. 1 hit. PF03719. Ribosomal_S5_C. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00585. RIBOSOMAL_S5. 1 hit. PS50881. S5_DSRBD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971646.

Entry information

Entry name

RT05_YEAST

Accession

Primary (citable) accession number: P33759
Secondary accession number(s): D6VQP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program