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Protein

37S ribosomal protein S5, mitochondrial

Gene

MRPS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 6680 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S5, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS5m1 Publication
Gene namesi
Name:MRPS5
Ordered Locus Names:YBR251W
ORF Names:YBR1704
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR251W.
SGDiS000000455. MRPS5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionSequence analysisAdd BLAST13
ChainiPRO_000013168814 – 30737S ribosomal protein S5, mitochondrialAdd BLAST294

Proteomic databases

MaxQBiP33759.
PRIDEiP33759.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.3 Publications

Protein-protein interaction databases

BioGridi32946. 117 interactors.
DIPiDIP-2869N.
IntActiP33759. 44 interactors.
MINTiMINT-615779.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25EE14-306[»]
5MREelectron microscopy3.75EE14-306[»]
5MRFelectron microscopy4.97EE14-306[»]
ProteinModelPortaliP33759.
SMRiP33759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 208S5 DRBMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000001878.
HOGENOMiHOG000247984.
InParanoidiP33759.
KOiK02988.
OMAiICECAGI.
OrthoDBiEOG092C36LI.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiView protein in Pfam
PF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiView protein in PROSITE
PS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRQLSTSV RYLQHYDESL LSRYYPESLL KSIKLAQQTI PEDTKFRVSR
60 70 80 90 100
NVEFAPPYLD DFTKIHPFWD YKPGMPHLHA QEENNNFSIF RWDQVQQPLP
110 120 130 140 150
GEGNILPPGV SLPNDGGRKS KSADVAAGLH KQTGVDPDYI TRKLTMKPLV
160 170 180 190 200
MKRVSNQTGK GKIASFYALV VVGDKNGMVG LGEGKSREEM SKAIFKAHWD
210 220 230 240 250
AVRNLKEIPR YENRTIYGDI DFRYHGVKLH LRSAKPGFGL RVNHVIFEIC
260 270 280 290 300
ECAGIKDLSG KVYKSRNDMN IAKGTIEAFT KAQKTLDEVA LGRGKKLVDV

RKVYYSS
Length:307
Mass (Da):34,883
Last modified:February 1, 1994 - v1
Checksum:i7A7BC49A4D414FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20296 Genomic DNA. Translation: AAA65610.1.
Z36120 Genomic DNA. Translation: CAA85214.1.
BK006936 Genomic DNA. Translation: DAA07367.1.
PIRiS38374.
RefSeqiNP_009810.3. NM_001178599.3.

Genome annotation databases

EnsemblFungiiYBR251W; YBR251W; YBR251W.
GeneIDi852553.
KEGGisce:YBR251W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20296 Genomic DNA. Translation: AAA65610.1.
Z36120 Genomic DNA. Translation: CAA85214.1.
BK006936 Genomic DNA. Translation: DAA07367.1.
PIRiS38374.
RefSeqiNP_009810.3. NM_001178599.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25EE14-306[»]
5MREelectron microscopy3.75EE14-306[»]
5MRFelectron microscopy4.97EE14-306[»]
ProteinModelPortaliP33759.
SMRiP33759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32946. 117 interactors.
DIPiDIP-2869N.
IntActiP33759. 44 interactors.
MINTiMINT-615779.

Proteomic databases

MaxQBiP33759.
PRIDEiP33759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR251W; YBR251W; YBR251W.
GeneIDi852553.
KEGGisce:YBR251W.

Organism-specific databases

EuPathDBiFungiDB:YBR251W.
SGDiS000000455. MRPS5.

Phylogenomic databases

GeneTreeiENSGT00390000001878.
HOGENOMiHOG000247984.
InParanoidiP33759.
KOiK02988.
OMAiICECAGI.
OrthoDBiEOG092C36LI.

Enzyme and pathway databases

BioCyciYEAST:G3O-29177-MONOMER.

Miscellaneous databases

PROiPR:P33759.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiView protein in Pfam
PF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiView protein in PROSITE
PS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT05_YEAST
AccessioniPrimary (citable) accession number: P33759
Secondary accession number(s): D6VQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 12, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.