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Protein

37S ribosomal protein S5, mitochondrial

Gene

MRPS5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 6680 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • RNA binding Source: InterPro
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29177-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S5, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS5m1 Publication
Gene namesi
Name:MRPS5
Ordered Locus Names:YBR251W
ORF Names:YBR1704
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR251W
SGDiS000000455 MRPS5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionSequence analysisAdd BLAST13
ChainiPRO_000013168814 – 30737S ribosomal protein S5, mitochondrialAdd BLAST294

Proteomic databases

MaxQBiP33759
PaxDbiP33759
PRIDEiP33759

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32946, 120 interactors
DIPiDIP-2869N
IntActiP33759, 66 interactors
MINTiP33759
STRINGi4932.YBR251W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25EE14-306[»]
5MREelectron microscopy3.75EE14-306[»]
5MRFelectron microscopy4.97EE14-306[»]
ProteinModelPortaliP33759
SMRiP33759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 208S5 DRBMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000001878
HOGENOMiHOG000247984
InParanoidiP33759
KOiK02988
OMAiLRVNHVI
OrthoDBiEOG092C36LI

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRQLSTSV RYLQHYDESL LSRYYPESLL KSIKLAQQTI PEDTKFRVSR
60 70 80 90 100
NVEFAPPYLD DFTKIHPFWD YKPGMPHLHA QEENNNFSIF RWDQVQQPLP
110 120 130 140 150
GEGNILPPGV SLPNDGGRKS KSADVAAGLH KQTGVDPDYI TRKLTMKPLV
160 170 180 190 200
MKRVSNQTGK GKIASFYALV VVGDKNGMVG LGEGKSREEM SKAIFKAHWD
210 220 230 240 250
AVRNLKEIPR YENRTIYGDI DFRYHGVKLH LRSAKPGFGL RVNHVIFEIC
260 270 280 290 300
ECAGIKDLSG KVYKSRNDMN IAKGTIEAFT KAQKTLDEVA LGRGKKLVDV

RKVYYSS
Length:307
Mass (Da):34,883
Last modified:February 1, 1994 - v1
Checksum:i7A7BC49A4D414FC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20296 Genomic DNA Translation: AAA65610.1
Z36120 Genomic DNA Translation: CAA85214.1
BK006936 Genomic DNA Translation: DAA07367.1
PIRiS38374
RefSeqiNP_009810.3, NM_001178599.3

Genome annotation databases

EnsemblFungiiYBR251W; YBR251W; YBR251W
GeneIDi852553
KEGGisce:YBR251W

Similar proteinsi

Entry informationi

Entry nameiRT05_YEAST
AccessioniPrimary (citable) accession number: P33759
Secondary accession number(s): D6VQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health