Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Butyrate--acetoacetate CoA-transferase subunit A

Gene

ctfA

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation.

Catalytic activityi

Butanoyl-CoA + acetoacetate = butanoate + acetoacetyl-CoA.

GO - Molecular functioni

  • butyrate-acetoacetate CoA-transferase activity Source: UniProtKB-EC
  • CoA-transferase activity Source: MENGO

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:COATACLOS-MONOMER
SABIO-RKiP33752

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrate--acetoacetate CoA-transferase subunit A (EC:2.8.3.9)
Short name:
Coat A
Alternative name(s):
Acetoacetyl-CoA:acetate/butyrate:CoA transferase subunit A
Gene namesi
Name:ctfA
Ordered Locus Names:CA_P0163
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579141 – 218Butyrate--acetoacetate CoA-transferase subunit AAdd BLAST218

Proteomic databases

PRIDEiP33752

Expressioni

Inductioni

Induced during switch to solvent production.

Interactioni

Subunit structurei

Heterodimer.

Structurei

3D structure databases

ProteinModelPortaliP33752
SMRiP33752
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 30CoA-bindingSequence analysis7

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000221244
KOiK01034
OMAiKGTARNF

Family and domain databases

InterProiView protein in InterPro
IPR012792 3-oxoacid_CoA-transf_A
IPR004165 CoA_trans_fam_I
IPR004163 CoA_transf_BS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR13707 PTHR13707, 1 hit
PfamiView protein in Pfam
PF01144 CoA_trans, 1 hit
SMARTiView protein in SMART
SM00882 CoA_trans, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR02429 pcaI_scoA_fam, 1 hit
PROSITEiView protein in PROSITE
PS01273 COA_TRANSF_1, 1 hit

Sequencei

Sequence statusi: Complete.

P33752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKIIRFEN LRSFFKDGMT IMIGGFLNCG TPTKLIDFLV NLNIKNLTII
60 70 80 90 100
SNDTCYPNTG IGKLISNNQV KKLIASYIGS NPDTGKKLFN NELEVELSPQ
110 120 130 140 150
GTLVERIRAG GSGLGGVLTK TGLGTLIEKG KKKISINGTE YLLELPLTAD
160 170 180 190 200
VALIKGSIVD EAGNTFYKGT TKNFNPYMAM AAKTVIVEAE NLVSCEKLEK
210
EKAMTPGVLI NYIVKEPA
Length:218
Mass (Da):23,641
Last modified:February 1, 1994 - v1
Checksum:i4E83A17413D19CE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151V → I in AAB53234 (PubMed:8423010).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72831 Genomic DNA Translation: CAA51345.1
M93363 Genomic DNA Translation: AAB53234.1
AE001438 Genomic DNA Translation: AAK76908.1
L14817 Genomic DNA No translation available.
PIRiB49346
RefSeqiNP_149326.1, NC_001988.2
WP_010890847.1, NC_001988.2

Genome annotation databases

EnsemblBacteriaiAAK76908; AAK76908; CA_P0163
GeneIDi1116168
KEGGicac:CA_P0163
PATRICifig|272562.8.peg.164

Similar proteinsi

Entry informationi

Entry nameiCTFA_CLOAB
AccessioniPrimary (citable) accession number: P33752
Secondary accession number(s): O06494
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health