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P33750

- DCA13_YEAST

UniProt

P33750 - DCA13_YEAST

Protein

Protein SOF1

Gene

SOF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Required for ribosomal RNA processing.1 Publication

    GO - Biological processi

    1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32116-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein SOF1
    Alternative name(s):
    U3 small nucleolar RNA-associated protein SOF1
    Short name:
    U3 snoRNA-associated protein SOF1
    Gene namesi
    Name:SOF1
    Ordered Locus Names:YLL011W
    ORF Names:L1339
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLL011w.
    SGDiS000003934. SOF1.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489Protein SOF1PRO_0000051222Add
    BLAST

    Proteomic databases

    MaxQBiP33750.
    PaxDbiP33750.
    PeptideAtlasiP33750.

    Expressioni

    Gene expression databases

    GenevestigatoriP33750.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with NOP1 and MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

    Protein-protein interaction databases

    BioGridi31240. 57 interactions.
    DIPiDIP-746N.
    IntActiP33750. 12 interactions.
    MINTiMINT-635582.
    STRINGi4932.YLL011W.

    Structurei

    3D structure databases

    ProteinModelPortaliP33750.
    SMRiP33750. Positions 65-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati65 – 10541WD 1Add
    BLAST
    Repeati113 – 15846WD 2Add
    BLAST
    Repeati177 – 21438WD 3Add
    BLAST
    Repeati217 – 25741WD 4Add
    BLAST
    Repeati259 – 29941WD 5Add
    BLAST
    Repeati303 – 34240WD 6Add
    BLAST
    Repeati346 – 38540WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat DCAF13/WDSOF1 family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00390000005711.
    HOGENOMiHOG000210082.
    KOiK11806.
    OMAiKHPKSLA.
    OrthoDBiEOG7QRR44.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR007287. Sof1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF04158. Sof1. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33750-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL    50
    ERMFAKPFVG QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR 100
    EEFVSFKAHY GLVTGLCVTQ PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI 150
    NVDDYSNKNS SDNDSVTNEE GLIRTFDGES AFQGIDSHRE NSTFATGGAK 200
    IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS DNSIVLYDLR 250
    TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV 300
    FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH 350
    VFQVKYSMDS KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL 400
    KERFRHMPEI KRISRHRHVP QVIKKAQEIK NIELSSIKRR EANERRTRKD 450
    MPYISERKKQ IVGTVHKYED SGRDRKRRKE DDKRDTQEK 489
    Length:489
    Mass (Da):56,789
    Last modified:February 1, 1994 - v1
    Checksum:i4B28371CC61DE7E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70052 Genomic DNA. Translation: CAA49658.1.
    X91488 Genomic DNA. Translation: CAA62781.1.
    Z73116 Genomic DNA. Translation: CAA97455.1.
    BK006945 Genomic DNA. Translation: DAA09307.1.
    PIRiS35323.
    RefSeqiNP_013090.1. NM_001181831.1.

    Genome annotation databases

    EnsemblFungiiYLL011W; YLL011W; YLL011W.
    GeneIDi850649.
    KEGGisce:YLL011W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70052 Genomic DNA. Translation: CAA49658.1 .
    X91488 Genomic DNA. Translation: CAA62781.1 .
    Z73116 Genomic DNA. Translation: CAA97455.1 .
    BK006945 Genomic DNA. Translation: DAA09307.1 .
    PIRi S35323.
    RefSeqi NP_013090.1. NM_001181831.1.

    3D structure databases

    ProteinModelPortali P33750.
    SMRi P33750. Positions 65-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31240. 57 interactions.
    DIPi DIP-746N.
    IntActi P33750. 12 interactions.
    MINTi MINT-635582.
    STRINGi 4932.YLL011W.

    Proteomic databases

    MaxQBi P33750.
    PaxDbi P33750.
    PeptideAtlasi P33750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLL011W ; YLL011W ; YLL011W .
    GeneIDi 850649.
    KEGGi sce:YLL011W.

    Organism-specific databases

    CYGDi YLL011w.
    SGDi S000003934. SOF1.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00390000005711.
    HOGENOMi HOG000210082.
    KOi K11806.
    OMAi KHPKSLA.
    OrthoDBi EOG7QRR44.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32116-MONOMER.

    Miscellaneous databases

    NextBioi 966596.
    PROi P33750.

    Gene expression databases

    Genevestigatori P33750.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR007287. Sof1.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF04158. Sof1. 1 hit.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing."
      Jansen R., Tollervey D., Hurt E.C.
      EMBO J. 12:2549-2558(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH NOP1 AND SNORNA U3, SUBCELLULAR LOCATION.
    2. "Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR."
      Miosga T., Zimmermann F.K.
      Yeast 12:693-708(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 90840 / EAY235 / FY23.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDCA13_YEAST
    AccessioniPrimary (citable) accession number: P33750
    Secondary accession number(s): D6VXZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6620 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3