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Protein

Protein SOF1

Gene

SOF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for ribosomal RNA processing.1 Publication

GO - Biological processi

  1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32116-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SOF1
Alternative name(s):
U3 small nucleolar RNA-associated protein SOF1
Short name:
U3 snoRNA-associated protein SOF1
Gene namesi
Name:SOF1
Ordered Locus Names:YLL011W
ORF Names:L1339
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLL011w.
SGDiS000003934. SOF1.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489Protein SOF1PRO_0000051222Add
BLAST

Proteomic databases

MaxQBiP33750.
PaxDbiP33750.
PeptideAtlasiP33750.

Expressioni

Gene expression databases

GenevestigatoriP33750.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with NOP1 and MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

Protein-protein interaction databases

BioGridi31240. 58 interactions.
DIPiDIP-746N.
IntActiP33750. 12 interactions.
MINTiMINT-635582.
STRINGi4932.YLL011W.

Structurei

3D structure databases

ProteinModelPortaliP33750.
SMRiP33750. Positions 40-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati65 – 10541WD 1Add
BLAST
Repeati113 – 15846WD 2Add
BLAST
Repeati177 – 21438WD 3Add
BLAST
Repeati217 – 25741WD 4Add
BLAST
Repeati259 – 29941WD 5Add
BLAST
Repeati303 – 34240WD 6Add
BLAST
Repeati346 – 38540WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
InParanoidiP33750.
KOiK11806.
OMAiKHPKSLA.
OrthoDBiEOG7QRR44.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33750-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL
60 70 80 90 100
ERMFAKPFVG QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR
110 120 130 140 150
EEFVSFKAHY GLVTGLCVTQ PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI
160 170 180 190 200
NVDDYSNKNS SDNDSVTNEE GLIRTFDGES AFQGIDSHRE NSTFATGGAK
210 220 230 240 250
IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS DNSIVLYDLR
260 270 280 290 300
TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV
310 320 330 340 350
FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH
360 370 380 390 400
VFQVKYSMDS KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL
410 420 430 440 450
KERFRHMPEI KRISRHRHVP QVIKKAQEIK NIELSSIKRR EANERRTRKD
460 470 480
MPYISERKKQ IVGTVHKYED SGRDRKRRKE DDKRDTQEK
Length:489
Mass (Da):56,789
Last modified:February 1, 1994 - v1
Checksum:i4B28371CC61DE7E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70052 Genomic DNA. Translation: CAA49658.1.
X91488 Genomic DNA. Translation: CAA62781.1.
Z73116 Genomic DNA. Translation: CAA97455.1.
BK006945 Genomic DNA. Translation: DAA09307.1.
PIRiS35323.
RefSeqiNP_013090.1. NM_001181831.1.

Genome annotation databases

EnsemblFungiiYLL011W; YLL011W; YLL011W.
GeneIDi850649.
KEGGisce:YLL011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70052 Genomic DNA. Translation: CAA49658.1.
X91488 Genomic DNA. Translation: CAA62781.1.
Z73116 Genomic DNA. Translation: CAA97455.1.
BK006945 Genomic DNA. Translation: DAA09307.1.
PIRiS35323.
RefSeqiNP_013090.1. NM_001181831.1.

3D structure databases

ProteinModelPortaliP33750.
SMRiP33750. Positions 40-378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31240. 58 interactions.
DIPiDIP-746N.
IntActiP33750. 12 interactions.
MINTiMINT-635582.
STRINGi4932.YLL011W.

Proteomic databases

MaxQBiP33750.
PaxDbiP33750.
PeptideAtlasiP33750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL011W; YLL011W; YLL011W.
GeneIDi850649.
KEGGisce:YLL011W.

Organism-specific databases

CYGDiYLL011w.
SGDiS000003934. SOF1.

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
InParanoidiP33750.
KOiK11806.
OMAiKHPKSLA.
OrthoDBiEOG7QRR44.

Enzyme and pathway databases

BioCyciYEAST:G3O-32116-MONOMER.

Miscellaneous databases

NextBioi966596.
PROiP33750.

Gene expression databases

GenevestigatoriP33750.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04158. Sof1. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing."
    Jansen R., Tollervey D., Hurt E.C.
    EMBO J. 12:2549-2558(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH NOP1 AND SNORNA U3, SUBCELLULAR LOCATION.
  2. "Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR."
    Miosga T., Zimmermann F.K.
    Yeast 12:693-708(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 90840 / EAY235 / FY23.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCA13_YEAST
AccessioniPrimary (citable) accession number: P33750
Secondary accession number(s): D6VXZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 4, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6620 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.