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P33750 (DCA13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SOF1
Alternative name(s):
U3 small nucleolar RNA-associated protein SOF1
Short name=U3 snoRNA-associated protein SOF1
Gene names
Name:SOF1
Ordered Locus Names:YLL011W
ORF Names:L1339
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for ribosomal RNA processing. Ref.1

Subunit structure

Interacts with snoRNA U3. Interacts with NOP1 and MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Ref.1 Ref.5

Subcellular location

Nucleusnucleolus Ref.1.

Miscellaneous

Present with 6620 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the WD repeat DCAF13/WDSOF1 family.

Contains 7 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Protein SOF1
PRO_0000051222

Regions

Repeat65 – 10541WD 1
Repeat113 – 15846WD 2
Repeat177 – 21438WD 3
Repeat217 – 25741WD 4
Repeat259 – 29941WD 5
Repeat303 – 34240WD 6
Repeat346 – 38540WD 7

Sequences

Sequence LengthMass (Da)Tools
P33750 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 4B28371CC61DE7E4

FASTA48956,789
        10         20         30         40         50         60 
MKIKTIKRSA DDYVPVKSTQ ESQMPRNLNP ELHPFERARE YTKALNATKL ERMFAKPFVG 

        70         80         90        100        110        120 
QLGYGHRDGV YAIAKNYGSL NKLATGSADG VIKYWNMSTR EEFVSFKAHY GLVTGLCVTQ 

       130        140        150        160        170        180 
PRFHDKKPDL KSQNFMLSCS DDKTVKLWSI NVDDYSNKNS SDNDSVTNEE GLIRTFDGES 

       190        200        210        220        230        240 
AFQGIDSHRE NSTFATGGAK IHLWDVNRLK PVSDLSWGAD NITSLKFNQN ETDILASTGS 

       250        260        270        280        290        300 
DNSIVLYDLR TNSPTQKIVQ TMRTNAICWN PMEAFNFVTA NEDHNAYYYD MRNLSRSLNV 

       310        320        330        340        350        360 
FKDHVSAVMD VDFSPTGDEI VTGSYDKSIR IYKTNHGHSR EIYHTKRMQH VFQVKYSMDS 

       370        380        390        400        410        420 
KYIISGSDDG NVRLWRSKAW ERSNVKTTRE KNKLEYDEKL KERFRHMPEI KRISRHRHVP 

       430        440        450        460        470        480 
QVIKKAQEIK NIELSSIKRR EANERRTRKD MPYISERKKQ IVGTVHKYED SGRDRKRRKE 


DDKRDTQEK 

« Hide

References

« Hide 'large scale' references
[1]"A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing."
Jansen R., Tollervey D., Hurt E.C.
EMBO J. 12:2549-2558(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH NOP1 AND SNORNA U3, SUBCELLULAR LOCATION.
[2]"Sequence analysis of the CEN12 region of Saccharomyces cerevisiae on a 43.7 kb fragment of chromosome XII including an open reading frame homologous to the human cystic fibrosis transmembrane conductance regulator protein CFTR."
Miosga T., Zimmermann F.K.
Yeast 12:693-708(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 90840 / EAY235 / FY23.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70052 Genomic DNA. Translation: CAA49658.1.
X91488 Genomic DNA. Translation: CAA62781.1.
Z73116 Genomic DNA. Translation: CAA97455.1.
BK006945 Genomic DNA. Translation: DAA09307.1.
PIRS35323.
RefSeqNP_013090.1. NM_001181831.1.

3D structure databases

ProteinModelPortalP33750.
SMRP33750. Positions 65-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31240. 57 interactions.
DIPDIP-746N.
IntActP33750. 12 interactions.
MINTMINT-635582.
STRING4932.YLL011W.

Proteomic databases

MaxQBP33750.
PaxDbP33750.
PeptideAtlasP33750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLL011W; YLL011W; YLL011W.
GeneID850649.
KEGGsce:YLL011W.

Organism-specific databases

CYGDYLL011w.
SGDS000003934. SOF1.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00390000005711.
HOGENOMHOG000210082.
KOK11806.
OMAKHPKSLA.
OrthoDBEOG7QRR44.

Enzyme and pathway databases

BioCycYEAST:G3O-32116-MONOMER.

Gene expression databases

GenevestigatorP33750.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR020472. G-protein_beta_WD-40_rep.
IPR007287. Sof1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF04158. Sof1. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966596.
PROP33750.

Entry information

Entry nameDCA13_YEAST
AccessionPrimary (citable) accession number: P33750
Secondary accession number(s): D6VXZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families