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Protein

Zinc finger protein MSN4

Gene

MSN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri573 – 596C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri602 – 624C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • age-dependent response to oxidative stress involved in chronological cell aging Source: SGD
  • cellular response to acidic pH Source: SGD
  • chromatin remodeling Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to cold Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to ethanol Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to freezing Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to heat stress Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to increased salt Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation Source: SGD
  • regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction Source: SGD
  • replicative cell aging Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31860-MONOMER.
ReactomeiR-SCE-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein MSN4
Alternative name(s):
Multicopy suppressor of SNF1 protein 4
Gene namesi
Name:MSN4
Ordered Locus Names:YKL062W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL062W.
SGDiS000001545. MSN4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468111 – 630Zinc finger protein MSN4Add BLAST630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei479PhosphothreonineCombined sources1
Modified residuei558PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP33749.
PRIDEiP33749.

PTM databases

iPTMnetiP33749.

Interactioni

Protein-protein interaction databases

BioGridi34071. 96 interactors.
DIPiDIP-6574N.
IntActiP33749. 57 interactors.
MINTiMINT-8285305.

Structurei

3D structure databases

ProteinModelPortaliP33749.
SMRiP33749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri573 – 596C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri602 – 624C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00530000063676.
InParanoidiP33749.
KOiK09468.
OMAiFACMFCE.
OrthoDBiEOG092C5XWP.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33749-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVFGPNSSF VRHANKKQED SSIMNEPNGL MDPVLSTTNV SATSSNDNSA
60 70 80 90 100
NNSISSPEYT FGQFSMDSPH RTDATNTPIL TATTNTTANN SLMNLKDTAS
110 120 130 140 150
LATNWKWKNS NNAQFVNDGE KQSSNANGKK NGGDKIYSSV ATPQALNDEL
160 170 180 190 200
KNLEQLEKVF SPMNPINDSH FNENIELSPH QHATSPKTNL LEAEPSIYSN
210 220 230 240 250
LFLDARLPNN ANSTTGLNDN DYNLDDTNND NTNSMQSILE DFVSSEEALK
260 270 280 290 300
FMPDAGRDAR RYSEVVTSSF PSMTDSRNSI SHSIEFWNLN HKNSSNSKPT
310 320 330 340 350
QQIIPEGTAT TERRGSTISP TTTINNSNPN FKLLDHDVSQ ALSGYSMDFS
360 370 380 390 400
KDSGITKPKS ISSSLNRISH SSSTTRQQRA SLPLIHDIES FANDSVMANP
410 420 430 440 450
LSDSASFLSE ENEDDAFGAL NYNSLDATTM SAFDNNVDPF NILKSSPAQD
460 470 480 490 500
QQFIKPSMML SDNASAAAKL ATSGVDNITP TPAFQRRSYD ISMNSSFKIL
510 520 530 540 550
PTSQAHHAAQ HHQQQPTKQA TVSPNTRRRK SSSVTLSPTI SHNNNNGKVP
560 570 580 590 600
VQPRKRKSIT TIDPNNYDKN KPFKCKDCEK AFRRSEHLKR HIRSVHSTER
610 620 630
PFACMFCEKK FSRSDNLSQH LKTHKKHGDF
Length:630
Mass (Da):69,723
Last modified:February 1, 1994 - v1
Checksum:i3A264FB37C82C385
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08839 Genomic DNA. Translation: AAA34807.1.
X75781 Genomic DNA. Translation: CAA53421.1.
Z28062 Genomic DNA. Translation: CAA81899.1.
BK006944 Genomic DNA. Translation: DAA09095.1.
PIRiS37884.
RefSeqiNP_012861.1. NM_001179628.1.

Genome annotation databases

EnsemblFungiiYKL062W; YKL062W; YKL062W.
GeneIDi853803.
KEGGisce:YKL062W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08839 Genomic DNA. Translation: AAA34807.1.
X75781 Genomic DNA. Translation: CAA53421.1.
Z28062 Genomic DNA. Translation: CAA81899.1.
BK006944 Genomic DNA. Translation: DAA09095.1.
PIRiS37884.
RefSeqiNP_012861.1. NM_001179628.1.

3D structure databases

ProteinModelPortaliP33749.
SMRiP33749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34071. 96 interactors.
DIPiDIP-6574N.
IntActiP33749. 57 interactors.
MINTiMINT-8285305.

PTM databases

iPTMnetiP33749.

Proteomic databases

MaxQBiP33749.
PRIDEiP33749.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL062W; YKL062W; YKL062W.
GeneIDi853803.
KEGGisce:YKL062W.

Organism-specific databases

EuPathDBiFungiDB:YKL062W.
SGDiS000001545. MSN4.

Phylogenomic databases

GeneTreeiENSGT00530000063676.
InParanoidiP33749.
KOiK09468.
OMAiFACMFCE.
OrthoDBiEOG092C5XWP.

Enzyme and pathway databases

BioCyciYEAST:G3O-31860-MONOMER.
ReactomeiR-SCE-3214841. PKMTs methylate histone lysines.

Miscellaneous databases

PROiP33749.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSN4_YEAST
AccessioniPrimary (citable) accession number: P33749
Secondary accession number(s): D6VXM5, P35726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.