Reviewed,
UniProtKB/Swiss-Prot P33744 (ADHE_CLOAB)
Last modified
June 16, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde-alcohol dehydrogenase Including the following 2 domains: 1- Recommended name: Alcohol dehydrogenase Short name=ADH EC=1.1.1.1 2- Recommended name: Acetaldehyde dehydrogenase [acetylating] Short name=ACDH EC=1.2.1.10 | ||||||
| Gene names |
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| Encoded on | Plasmid pSOL1 | ||||||
| Organism | Clostridium acetobutylicum [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1488 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium |
Protein attributes
| Sequence length | 862 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This enzyme has probably two activities: ADH, and ACDH. |
| Catalytic activity | An alcohol + NAD+ = an aldehyde or ketone + NADH. Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. |
| Induction | Induced during switch to solvent production. |
| Sequence similarities | In the N-terminal section; belongs to the aldehyde dehydrogenase family. In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Multifunctional enzyme Plasmid |
| Gene Ontology (GO) | |
| Biological process | carbon utilization Inferred from electronic annotation. Source: InterPro cellular alcohol metabolic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC alcohol dehydrogenase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis." Fischer R.J., Helms J., Duerre P. J. Bacteriol. 175:6959-6969(1993) [PubMed: 8226639] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787. |
| [2] | "Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824." Nair R.V., Bennett G.N., Papoutsakis E.T. J. Bacteriol. 176:871-885(1994) [PubMed: 8300540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787. |
| [3] | "Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787. |
Cross-references
Sequence databases | |
|---|---|
| X72831 Genomic DNA. Translation: CAA51344.1. L14817 Genomic DNA. Translation: AAD04638.1. AE001438 Genomic DNA. Translation: AAK76907.1. | |
| PIR | A49346. |
| RefSeq | NP_149325.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1116167. |
| GenomeReviews | Gene locus CA_P0162 in contig AE001438_GR. |
| KEGG | cac:CA_P0162. |
| NMPDR | fig|272562.1.peg.160. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P33744. |
| OMA | P33744. MASANAF. |
Enzyme and pathway databases | |
| BioCyc | CACE272562:CAP0162-MON. |
| BRENDA | 1.1.1.1. 2866. 1.2.1.10. 2866. |
Family and domain databases | |
| InterPro | IPR001670. ADH_Fe. IPR018211. ADH_Fe_CS. IPR016162. Ald_DH_N. IPR012079. Bifunc_Ald/AlcDH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| Pfam | PF00465. Fe-ADH. 1 hit. [Graphical view] |
| PIRSF | PIRSF000111. ALDH_ADH. 1 hit. |
| PROSITE | PS00913. ADH_IRON_1. 1 hit. PS00060. ADH_IRON_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADHE_CLOAB | ||||||||
| Accession | Primary (citable) accession number: P33744 Secondary accession number(s): Q45808, Q45809 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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