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P33744

- ADHE_CLOAB

UniProt

P33744 - ADHE_CLOAB

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Protein

Aldehyde-alcohol dehydrogenase

Gene
adhE, aad, CA_P0162
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme has probably two activities: ADH, and ACDH.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.
Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei244 – 2441 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi420 – 4256NAD Reviewed prediction

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-EC
  2. alcohol dehydrogenase (NAD) activity Source: CACAO
  3. metal ion binding Source: InterPro

GO - Biological processi

  1. alcohol metabolic process Source: InterPro
  2. carbon utilization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCACE272562:GJIH-4007-MONOMER.
MetaCyc:AADCLOS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde-alcohol dehydrogenase
Including the following 2 domains:
Alcohol dehydrogenase (EC:1.1.1.1)
Short name:
ADH
Acetaldehyde dehydrogenase [acetylating] (EC:1.2.1.10)
Short name:
ACDH
Gene namesi
Name:adhE
Synonyms:aad
Ordered Locus Names:CA_P0162
Encoded oniPlasmid pSOL10 Publication
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Plasmid pSOL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Aldehyde-alcohol dehydrogenasePRO_0000087839Add
BLAST

Expressioni

Inductioni

Induced during switch to solvent production.

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_P0162.

Structurei

3D structure databases

ProteinModelPortaliP33744.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000025256.
KOiK04072.
OMAiTHICNEG.
OrthoDBiEOG6TFCQS.

Family and domain databases

Gene3Di3.40.309.10. 2 hits.
3.40.605.10. 1 hit.
InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012079. Bifunc_Ald-ADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
PF00465. Fe-ADH. 1 hit.
[Graphical view]
PIRSFiPIRSF000111. ALDH_ADH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00913. ADH_IRON_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33744-1 [UniParc]FASTAAdd to Basket

« Hide

MKVTTVKELD EKLKVIKEAQ KKFSCYSQEM VDEIFRNAAM AAIDARIELA    50
KAAVLETGMG LVEDKVIKNH FAGEYIYNKY KDEKTCGIIE RNEPYGITKI 100
AEPIGVVAAI IPVTNPTSTT IFKSLISLKT RNGIFFSPHP RAKKSTILAA 150
KTILDAAVKS GAPENIIGWI DEPSIELTQY LMQKADITLA TGGPSLVKSA 200
YSSGKPAIGV GPGNTPVIID ESAHIKMAVS SIILSKTYDN GVICASEQSV 250
IVLKSIYNKV KDEFQERGAY IIKKNELDKV REVIFKDGSV NPKIVGQSAY 300
TIAAMAGIKV PKTTRILIGE VTSLGEEEPF AHEKLSPVLA MYEADNFDDA 350
LKKAVTLINL GGLGHTSGIY ADEIKARDKI DRFSSAMKTV RTFVNIPTSQ 400
GASGDLYNFR IPPSFTLGCG FWGGNSVSEN VGPKHLLNIK TVAERRENML 450
WFRVPHKVYF KFGCLQFALK DLKDLKKKRA FIVTDSDPYN LNYVDSIIKI 500
LEHLDIDFKV FNKVGREADL KTIKKATEEM SSFMPDTIIA LGGTPEMSSA 550
KLMWVLYEHP EVKFEDLAIK FMDIRKRIYT FPKLGKKAML VAITTSAGSG 600
SEVTPFALVT DNNTGNKYML ADYEMTPNMA IVDAELMMKM PKGLTAYSGI 650
DALVNSIEAY TSVYASEYTN GLALEAIRLI FKYLPEAYKN GRTNEKAREK 700
MAHASTMAGM ASANAFLGLC HSMAIKLSSE HNIPSGIANA LLIEEVIKFN 750
AVDNPVKQAP CPQYKYPNTI FRYARIADYI KLGGNTDEEK VDLLINKIHE 800
LKKALNIPTS IKDAGVLEEN FYSSLDRISE LALDDQCTGA NPRFPLTSEI 850
KEMYINCFKK QP 862
Length:862
Mass (Da):95,321
Last modified:August 29, 2001 - v3
Checksum:iBE09E32B28DD08B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72831 Genomic DNA. Translation: CAA51344.1.
L14817 Genomic DNA. Translation: AAD04638.1.
AE001438 Genomic DNA. Translation: AAK76907.1.
PIRiA49346.
RefSeqiNP_149325.1. NC_001988.2.
WP_010890846.1. NC_001988.2.

Genome annotation databases

EnsemblBacteriaiAAK76907; AAK76907; CA_P0162.
GeneIDi1116167.
KEGGicac:CA_P0162.
PATRICi32034210. VBICloAce74127_0163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X72831 Genomic DNA. Translation: CAA51344.1 .
L14817 Genomic DNA. Translation: AAD04638.1 .
AE001438 Genomic DNA. Translation: AAK76907.1 .
PIRi A49346.
RefSeqi NP_149325.1. NC_001988.2.
WP_010890846.1. NC_001988.2.

3D structure databases

ProteinModelPortali P33744.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_P0162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK76907 ; AAK76907 ; CA_P0162 .
GeneIDi 1116167.
KEGGi cac:CA_P0162.
PATRICi 32034210. VBICloAce74127_0163.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000025256.
KOi K04072.
OMAi THICNEG.
OrthoDBi EOG6TFCQS.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-4007-MONOMER.
MetaCyc:AADCLOS-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 2 hits.
3.40.605.10. 1 hit.
InterProi IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012079. Bifunc_Ald-ADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
PF00465. Fe-ADH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000111. ALDH_ADH. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00913. ADH_IRON_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis."
    Fischer R.J., Helms J., Duerre P.
    J. Bacteriol. 175:6959-6969(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. "Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824."
    Nair R.V., Bennett G.N., Papoutsakis E.T.
    J. Bacteriol. 176:871-885(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiADHE_CLOAB
AccessioniPrimary (citable) accession number: P33744
Secondary accession number(s): Q45808, Q45809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 29, 2001
Last modified: September 3, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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