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P33741 (HTR1_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sensory rhodopsin I transducer
Alternative name(s):
HTR-I
Methyl-accepting phototaxis protein I
Short name=MPP-I
Gene names
Name:htr1
Synonyms:htr, htrI
Ordered Locus Names:VNG_1659G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transduces signals from the phototaxis receptor sensory rhodopsin I (SR-I) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 2 HAMP domains.

Contains 1 methyl-accepting transducer domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 536535Sensory rhodopsin I transducer
PRO_0000110548

Regions

Topological domain2 – 1413Cytoplasmic Potential
Transmembrane15 – 2915Helical; Potential
Topological domain30 – 3910Extracellular Potential
Transmembrane40 – 5516Helical; Potential
Topological domain56 – 536481Cytoplasmic Potential
Domain55 – 10753HAMP 1
Domain149 – 20254HAMP 2
Domain221 – 459239Methyl-accepting transducer

Amino acid modifications

Modified residue2661Glutamate methyl ester (Glu)
Modified residue4731Glutamate methyl ester (Glu)

Experimental info

Sequence conflict341D → E in CAA48578. Ref.2
Sequence conflict551A → G in CAA48578. Ref.2
Sequence conflict59 – 602AS → GR in CAA48578. Ref.2
Sequence conflict651A → G in CAA48578. Ref.2
Sequence conflict1141A → S in CAA48578. Ref.2
Sequence conflict121 – 1266AEAETA → TESETT in CAA48578. Ref.2
Sequence conflict1301A → S in CAA48578. Ref.2
Sequence conflict1391A → S in CAA48578. Ref.2
Sequence conflict154 – 1585TAKRY → SSNRD in CAA48578. Ref.2
Sequence conflict164 – 1652AA → SS in CAA48578. Ref.2
Sequence conflict1701L → F in CAA48578. Ref.2
Sequence conflict1801H → P in CAA48578. Ref.2
Sequence conflict1861V → F in CAA48578. Ref.2
Sequence conflict2431A → P in CAA48578. Ref.2
Sequence conflict3091A → P in CAA48578. Ref.2
Sequence conflict3151Q → H in CAA48578. Ref.2
Sequence conflict4011Q → H in CAA48578. Ref.2
Sequence conflict418 – 4192RD → LH in CAA48578. Ref.2
Sequence conflict4281A → S in CAA48578. Ref.2
Sequence conflict4751A → P in CAA48578. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P33741 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 24B6413266A9D085

FASTA53656,675
        10         20         30         40         50         60 
MTIAWARRRY GVKLGLGYIA TAGLLVGVGV TTNDVPSTIV AGIAGLLTLG SINAAETVAS 

        70         80         90        100        110        120 
IKEIAAQTER VANGNLEQEV TSTRTDEFGS LADSIEQMRQ SLRGRLNEME RTRADLEETQ 

       130        140        150        160        170        180 
AEAETAREEA EQAKQEAQAA EREARELAAT YQDTAKRYGE TMEAAATGDL TQRVDVDTDH 

       190        200        210        220        230        240 
EAMETVGTAF NQMMDDLQAT VRTVTTVADE IEAKTERMSE TSADIEASAG DTVEAVSKIE 

       250        260        270        280        290        300 
SQANDQRTEL DSAADDVQQV SASAEEIAAT IDDLASRSED VATASDAARD SSKSALDEMS 

       310        320        330        340        350        360 
SIETEVDDAV GQVEQLRDQV AEITDIVDVI TDIGEQTNML ALNASIEAAR AGGNADGDGF 

       370        380        390        400        410        420 
SVVADEVKDL AEETQDRANE IAAVVEKVTA QTEDVTASIQ QTRTRVESGS ETVESTLRDI 

       430        440        450        460        470        480 
RTIADSIAEV SNSIDEIQRT TSEQAETVQS TATSVERVAG LSDDTTALAS DAESAVIGQR 

       490        500        510        520        530 
ESAEEIAASL EQFQNTAVEQ LQSRVASFTV ATEDSETAGG SVEQPVMRAG ADGGGA 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of an archaebacterial transducer, a methyl-accepting protein associated with sensory rhodopsin I."
Yao V.J., Spudich J.L.
Proc. Natl. Acad. Sci. U.S.A. 89:11915-11919(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-11; 351-378 AND 458-477.
Strain: Flx5R.
[2]"The methyl-accepting transducer protein HtrI is functionally associated with the photoreceptor sensory rhodopsin I in the archaeon Halobacterium salinarium."
Ferrando-May E., Krah M., Marwan W., Oesterhelt D.
EMBO J. 12:2999-3005(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: L33.
[3]"Genome sequence of Halobacterium species NRC-1."
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. expand/collapse author list , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700922 / JCM 11081 / NRC-1.
[4]"Phototaxis of Halobacterium salinarium requires a signalling complex of sensory rhodopsin I and its methyl-accepting transducer HtrI."
Krah M., Marwan W., Vermeglio A., Oesterhelt D.
EMBO J. 13:2150-2155(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05603 Genomic DNA. Translation: AAA72315.1.
X68591 Genomic DNA. Translation: CAA48578.1.
AE004437 Genomic DNA. Translation: AAG19913.1.
PIRA47190.
E84318.
RefSeqNP_280433.1. NC_002607.1.

3D structure databases

ProteinModelPortalP33741.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG1659G.

Proteomic databases

PaxDbP33741.
PRIDEP33741.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19913; AAG19913; VNG_1659G.
GeneID1448213.
KEGGhal:VNG1659G.

Phylogenomic databases

eggNOGCOG0840.
OMAPRVMISH.
PhylomeDBP33741.
ProtClustDBCLSK242623.

Family and domain databases

InterProIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSPR00260. CHEMTRNSDUCR.
SMARTSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTR1_HALSA
AccessionPrimary (citable) accession number: P33741
Secondary accession number(s): P33955, Q9HPF6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families