Reviewed, UniProtKB/Swiss-Prot P33736 (MS2A_DROSE)

Names and origin

Protein names

Recommended name:
    Accessory gland-specific peptide 26Aa
Alternative name(s):
    Male accessory gland secretory protein 355A

Gene names

Name:	Acp26Aa
Synonyms:	Mst26Aa, mst355a
ORF Names:	GM17990

Organism

Drosophila sechellia (Fruit fly)

Taxonomic identifier

7238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is transferred from male to female's hemolymph during mating, affecting egglaying and behavior after mating.
Subcellular location	Secreted › extracellular space.
Tissue specificity	Main cells of the accessory glands of males.
Post-translational modification	It undergoes several cleavages as it is secreted and it is further processed in the recipient female.

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	behavior Inferred from electronic annotation. Source: UniProtKB-KW mating Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 255	237	Accessory gland-specific peptide 26Aa		PRO_0000021756
Amino acid modifications
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	95	1	N-linked (GlcNAc...) Potential
	Glycosylation	136	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	25	1	Q → L in strain: 35. Ref.3
	Natural variant	33	1	K → R in strain: 7. Ref.3
	Natural variant	36	1	S → F in strain: 77 25 and Praslin. Ref.3
	Natural variant	37	1	T → M in strain: 7. Ref.3
	Natural variant	38	1	K → N in strain: 7. Ref.3
	Natural variant	39	1	S → I in strain: 7. Ref.3
	Natural variant	117	1	L → F in strain: 7. Ref.3
	Natural variant	207	1	I → V in strain: 7. Ref.3
	Natural variant	244	1	G → W in strain: 11. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P33736-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 960B3BFB4A984005	FASTA	255	28,345
	10 20 30 40 50 60 MNLILLCSQI LLLLFTVANC DGEHQLDSSM DLKSDSTKSA VLKNVAPKND ATQAEIAKDD 70 80 90 100 110 120 VALKSGKKGD YVMEIDVSDI PLDDYPINNS KSRKNSSTLP SQILTDKPNQ GSNQIALKAL 130 140 150 160 170 180 KHRLLMEQNN NLFLRNHSVS LMNEIEARKT DIIQARQLNI DLELELEALK RELSEMNAQN 190 200 210 220 230 240 ARKSTKSCKK RPSKDIASPV NQLQEVIVKN TYRNKYLTLL TQLAQKINYE IANVNNPATD 250 VPTGKSPSEG NPSTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polymorphism and divergence in the Mst26A male accessory gland gene region in Drosophila." Aguade M., Miyashita N., Langley C.H. Genetics 132:755-770(1992) [PubMed: 1361475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rob3c / Tucson 14021-0248.25.
[3]	"Molecular population genetics of male accessory gland proteins in the Drosophila simulans complex." Kern A.D., Jones C.D., Begun D.J. Genetics 167:725-735(2004) [PubMed: 15238524] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-255, VARIANTS LEU-25; ARG-33; PHE-36; MET-37; ASN-38; ILE-39; PHE-117; VAL-207 AND TRP-244. Strain: 01, 11, 33, 34, 35, 7, 77 25, 81, Praslin and Robertson.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X72630 Genomic DNA. Translation: CAA51206.1. CH480820 Genomic DNA. Translation: EDW54422.1. AY505178 Genomic DNA. Translation: AAS99356.1. AY505179 Genomic DNA. Translation: AAS99357.1. AY505180 Genomic DNA. Translation: AAS99358.1. AY505181 Genomic DNA. Translation: AAS99359.1. AY505182 Genomic DNA. Translation: AAS99360.1. AY505183 Genomic DNA. Translation: AAS99361.1. AY505184 Genomic DNA. Translation: AAS99362.1. AY505185 Genomic DNA. Translation: AAS99363.1. AY505186 Genomic DNA. Translation: AAS99364.1. AY505187 Genomic DNA. Translation: AAS99365.1.
RefSeq	XP_002038004.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6613536.
KEGG	dse:Dsec_GM17990.
Organism-specific databases
FlyBase	FBgn0260790. Dsec\Acp26Aa.
Phylogenomic databases
OrthoDB	EOG9STSCN
Family and domain databases
InterPro	IPR004315. Male_ac_gland_sc. [Graphical view]
Pfam	PF03082. MAGSP. 1 hit. [Graphical view]
ProDom	PD017367. Male_ac_gland_sc. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MS2A_DROSE

Accession

Primary (citable) accession number: P33736
Secondary accession number(s): B4I1L5 , Q6RCC1, Q6RCC2, Q6RCC3, Q6RCC4, Q6RCC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 24, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project