Skip Header

Contribute Send feedback
Read comments (?) or add your own

P33730 (LYAM2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name=ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name=LECAM2
CD_antigen=CD62E
Gene names
Name:SELE
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›

Protein attributes

Sequence length611 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Subunit structure

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the selectin/LECAM family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 6 Sushi (CCP/SCR) domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Sushi
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 611589E-selectin
PRO_0000017490

Regions

Topological domain23 – 557535Extracellular Potential
Transmembrane558 – 57922Helical; Potential
Topological domain580 – 61132Cytoplasmic Potential
Domain23 – 140118C-type lectin
Domain141 – 17636EGF-like
Domain179 – 24062Sushi 1
Domain241 – 30262Sushi 2
Domain316 – 36550Sushi 3
Domain367 – 42862Sushi 4
Domain430 – 49162Sushi 5
Domain492 – 55059Sushi 6

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 139 By similarity
Disulfide bond112 ↔ 131 By similarity
Disulfide bond144 ↔ 155 By similarity
Disulfide bond149 ↔ 164 By similarity
Disulfide bond166 ↔ 175 By similarity
Disulfide bond181 ↔ 225 By similarity
Disulfide bond211 ↔ 238 By similarity
Disulfide bond243 ↔ 287 By similarity
Disulfide bond273 ↔ 300 By similarity
Disulfide bond305 ↔ 350 By similarity
Disulfide bond336 ↔ 363 By similarity
Disulfide bond368 ↔ 413 By similarity
Disulfide bond399 ↔ 426 By similarity
Disulfide bond431 ↔ 476 By similarity
Disulfide bond462 ↔ 489 By similarity
Disulfide bond494 ↔ 535 By similarity
Disulfide bond521 ↔ 548 By similarity

Sequences

Sequence LengthMass (Da)Tools
P33730 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 35DA9E3DF225E4F6

FASTA61166,315
        10         20         30         40         50         60 
MITSQLLPAL TLVLLLFKEG GAWSYNASTE AMTFDEASTY CQQRYTHLVA IQNQEEIKYL 

        70         80         90        100        110        120 
NSMFTYTPTY YWIGIRKVNK KWTWIGTQKL LTEEAKNWAP GEPNNKQNDE DCVEIYIKRD 

       130        140        150        160        170        180 
KDSGKWNDER CDKKKLALCY TAACTPTSCS GHGECVETVN NYTCKCHPGF RGLRCEQVVT 

       190        200        210        220        230        240 
CQAQEAPEHG SLVCTHPLGT FSYNSSCFVS CDKGYLPSST EATQCTSTGE WSASPPACNV 

       250        260        270        280        290        300 
VECSALTNPC HGVMDCLQSS GNFPWNMTCT FECEEGFELM GPKRLQCTSS GNWDNRKPTC 

       310        320        330        340        350        360 
KAVTCGAIGH PQNGSVSCSH SPAGEFSVRS SCNFTCNEGF LMQGPAQIEC TAQGQWSQQV 

       370        380        390        400        410        420 
PVCKASQCKA LSSPERGYMS CLPGASGSFQ SGSSCEFFCE KGFVLKGSKT LQCGLTGKWD 

       430        440        450        460        470        480 
SEEPTCEAVK CDAVQQPQDG LVRCAHSSTG EFTYKSSCAF SCEEGFELHG SAQLECTSQG 

       490        500        510        520        530        540 
QGVTGGPSCQ VVQCFKSGSF RKDEHKLQGE PVFGAVCAFA CPEGWTLNGS AALMCDATGH 

       550        560        570        580        590        600 
WSGMLPTCEA PTESSIPLAV GLTAGGTSLL TVASFLLWLL KRLRKRAKKF VPASSCQSLQ 

       610 
SDGSYHMPCS I

« Hide

References

[1]"Molecular cloning of canine E-selectin and regulation of expression."
Manning A.M., Lane C.L., Auchampach J.A., Kukielka G.L., Rosenbloom C.L., Anderson D.C.
Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Jugular vein.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L23087 mRNA. Translation: AAA30843.1.
RefSeqNP_001003310.1. NM_001003310.1.
UniGeneCfa.3868.

3D structure databases

ProteinModelPortalP33730.
SMRP33730. Positions 23-179.
ModBaseSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000022350.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403999.
KEGGcfa:403999.

Organism-specific databases

CTD6401.

Phylogenomic databases

eggNOGNOG242963.
HOGENOMHOG000236254.
HOVERGENHBG052375.
InParanoidP33730.
KOK06494.
OrthoDBEOG4JT04Z.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSPR00343. SELECTIN.
SMARTSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
[Graphical view]
SUPFAMSSF56436. C-type_lectin_fold. 1 hit.
SSF57535. Complement_control_module. 6 hits.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817486.

Entry information

Entry nameLYAM2_CANFA
AccessionPrimary (citable) accession number: P33730
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents