Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P33727

- ARSB_FELCA

UniProt

P33727 - ARSB_FELCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Arylsulfatase B

Gene

ARSB

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551CalciumBy similarity
Metal bindingi56 – 561CalciumBy similarity
Metal bindingi93 – 931Calcium; via 3-oxoalanineBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Active sitei149 – 1491By similarity
Binding sitei244 – 2441SubstrateBy similarity
Metal bindingi302 – 3021CalciumBy similarity
Metal bindingi303 – 3031CalciumBy similarity
Binding sitei320 – 3201SubstrateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. N-acetylgalactosamine-4-sulfatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase B (EC:3.1.6.12)
Short name:
ASB
Alternative name(s):
N-acetylgalactosamine-4-sulfatase
Short name:
G4S
Gene namesi
Name:ARSB
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Defects in ARSB are the cause of mucopolysaccharidosis type VI (MPS-VI). MPS-VI has been described in Siamese cats.

Keywords - Diseasei

Mucopolysaccharidosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence AnalysisAdd
BLAST
Chaini42 – 535494Arylsulfatase BPRO_0000033422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 9313-oxoalanine (Cys)By similarity
Disulfide bondi119 ↔ 523By similarity
Disulfide bondi123 ↔ 157By similarity
Disulfide bondi183 ↔ 194By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi407 ↔ 449By similarity
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011021.

Structurei

3D structure databases

ProteinModelPortaliP33727.
SMRiP33727. Positions 45-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3119.
HOVERGENiHBG004282.
InParanoidiP33727.
KOiK01135.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33727-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRRGAASLP RGPSPRRPLL PGVLPLLLRL LLLPSRPGAG AGADRPPHLV
60 70 80 90 100
FVLADDLGWN DVSFHGSNIR TPHLDELAAG GVLLDNYYTQ PLCTPSRSQL
110 120 130 140 150
LTGRYQIHTG LQHQIIWPCQ PSCVPLDEKL LPQLLKEAGY TTHMVGKWHL
160 170 180 190 200
GMYRKECLPT RRGFDTYFGY LLGSEDYYSH ERCALIDSLN VTRCALDFRD
210 220 230 240 250
GEQVATGYKN MYSTNIFTER ATALITSHPP EKPLFLYLAL QSVHEPLQVP
260 270 280 290 300
EEYLKPYDFI QDKNRHYYAG MVSLMDEAVG NVTAALKSHG LWNNTVFIFS
310 320 330 340 350
TDNGGQTLAG GNNWPLRGRK WSLWEGGIRG VGFVASPLLK QKGVKNRELI
360 370 380 390 400
HISDWLPTLV KLARGSTKGT KPLDGFDVWK TISEGSPSPR KELLHNIDPN
410 420 430 440 450
FVDISPCPGK SLAPAKDDSS HPAYLAFNTS LHAAIRHGNW KLLTGYPGCG
460 470 480 490 500
CWFPPPSPYN DSAIPSSDPP TKTLWPFDID QDPEERHDLS RDYPHIVEQL
510 520 530
LSRLQFYHKH SVPVHFPAQD PRCDPKGTGA WGPWV
Length:535
Mass (Da):59,753
Last modified:February 1, 1994 - v1
Checksum:i43A527886A9983C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48472 mRNA. Translation: AAB23941.1.
PIRiA44475.
RefSeqiNP_001135731.1. NM_001142259.1.

Genome annotation databases

GeneIDi100216331.
KEGGifca:100216331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48472 mRNA. Translation: AAB23941.1 .
PIRi A44475.
RefSeqi NP_001135731.1. NM_001142259.1.

3D structure databases

ProteinModelPortali P33727.
SMRi P33727. Positions 45-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000011021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100216331.
KEGGi fca:100216331.

Organism-specific databases

CTDi 411.

Phylogenomic databases

eggNOGi COG3119.
HOVERGENi HBG004282.
InParanoidi P33727.
KOi K01135.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view ]
Pfami PF00884. Sulfatase. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
PROSITEi PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline arylsulfatase B (ARSB): isolation and expression of the cDNA, comparison with human ARSB, and gene localization to feline chromosome A1."
    Jackson C.E., Yuhki N., Desnick R.J., Haskins M.E., O'Brien S.J., Schuchman E.H.
    Genomics 14:403-411(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiARSB_FELCA
AccessioniPrimary (citable) accession number: P33727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3