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P33727

- ARSB_FELCA

UniProt

P33727 - ARSB_FELCA

Protein

Arylsulfatase B

Gene

ARSB

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi55 – 551CalciumBy similarity
    Metal bindingi56 – 561CalciumBy similarity
    Metal bindingi93 – 931Calcium; via 3-oxoalanineBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Active sitei149 – 1491By similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Metal bindingi302 – 3021CalciumBy similarity
    Metal bindingi303 – 3031CalciumBy similarity
    Binding sitei320 – 3201SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. N-acetylgalactosamine-4-sulfatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylsulfatase B (EC:3.1.6.12)
    Short name:
    ASB
    Alternative name(s):
    N-acetylgalactosamine-4-sulfatase
    Short name:
    G4S
    Gene namesi
    Name:ARSB
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    Pathology & Biotechi

    Involvement in diseasei

    Defects in ARSB are the cause of mucopolysaccharidosis type VI (MPS-VI). MPS-VI has been described in Siamese cats.

    Keywords - Diseasei

    Mucopolysaccharidosis

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 535494Arylsulfatase BPRO_0000033422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 9313-oxoalanine (Cys)By similarity
    Disulfide bondi119 ↔ 523By similarity
    Disulfide bondi123 ↔ 157By similarity
    Disulfide bondi183 ↔ 194By similarity
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi407 ↔ 449By similarity
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi460 – 4601N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000011021.

    Structurei

    3D structure databases

    ProteinModelPortaliP33727.
    SMRiP33727. Positions 45-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sulfatase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3119.
    HOVERGENiHBG004282.
    KOiK01135.

    Family and domain databases

    Gene3Di3.40.720.10. 1 hit.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view]
    PfamiPF00884. Sulfatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53649. SSF53649. 1 hit.
    PROSITEiPS00523. SULFATASE_1. 1 hit.
    PS00149. SULFATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33727-1 [UniParc]FASTAAdd to Basket

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    MGRRGAASLP RGPSPRRPLL PGVLPLLLRL LLLPSRPGAG AGADRPPHLV    50
    FVLADDLGWN DVSFHGSNIR TPHLDELAAG GVLLDNYYTQ PLCTPSRSQL 100
    LTGRYQIHTG LQHQIIWPCQ PSCVPLDEKL LPQLLKEAGY TTHMVGKWHL 150
    GMYRKECLPT RRGFDTYFGY LLGSEDYYSH ERCALIDSLN VTRCALDFRD 200
    GEQVATGYKN MYSTNIFTER ATALITSHPP EKPLFLYLAL QSVHEPLQVP 250
    EEYLKPYDFI QDKNRHYYAG MVSLMDEAVG NVTAALKSHG LWNNTVFIFS 300
    TDNGGQTLAG GNNWPLRGRK WSLWEGGIRG VGFVASPLLK QKGVKNRELI 350
    HISDWLPTLV KLARGSTKGT KPLDGFDVWK TISEGSPSPR KELLHNIDPN 400
    FVDISPCPGK SLAPAKDDSS HPAYLAFNTS LHAAIRHGNW KLLTGYPGCG 450
    CWFPPPSPYN DSAIPSSDPP TKTLWPFDID QDPEERHDLS RDYPHIVEQL 500
    LSRLQFYHKH SVPVHFPAQD PRCDPKGTGA WGPWV 535
    Length:535
    Mass (Da):59,753
    Last modified:February 1, 1994 - v1
    Checksum:i43A527886A9983C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48472 mRNA. Translation: AAB23941.1.
    PIRiA44475.
    RefSeqiNP_001135731.1. NM_001142259.1.

    Genome annotation databases

    GeneIDi100216331.
    KEGGifca:100216331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48472 mRNA. Translation: AAB23941.1 .
    PIRi A44475.
    RefSeqi NP_001135731.1. NM_001142259.1.

    3D structure databases

    ProteinModelPortali P33727.
    SMRi P33727. Positions 45-535.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000011021.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100216331.
    KEGGi fca:100216331.

    Organism-specific databases

    CTDi 411.

    Phylogenomic databases

    eggNOGi COG3119.
    HOVERGENi HBG004282.
    KOi K01135.

    Family and domain databases

    Gene3Di 3.40.720.10. 1 hit.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view ]
    Pfami PF00884. Sulfatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53649. SSF53649. 1 hit.
    PROSITEi PS00523. SULFATASE_1. 1 hit.
    PS00149. SULFATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feline arylsulfatase B (ARSB): isolation and expression of the cDNA, comparison with human ARSB, and gene localization to feline chromosome A1."
      Jackson C.E., Yuhki N., Desnick R.J., Haskins M.E., O'Brien S.J., Schuchman E.H.
      Genomics 14:403-411(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiARSB_FELCA
    AccessioniPrimary (citable) accession number: P33727
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3