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P33727

- ARSB_FELCA

UniProt

P33727 - ARSB_FELCA

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Protein

Arylsulfatase B

Gene
ARSB
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi55 – 551Calcium By similarity
Metal bindingi56 – 561Calcium By similarity
Metal bindingi93 – 931Calcium; via 3-oxoalanine By similarity
Binding sitei147 – 1471Substrate By similarity
Active sitei149 – 1491 By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi302 – 3021Calcium By similarity
Metal bindingi303 – 3031Calcium By similarity
Binding sitei320 – 3201Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. N-acetylgalactosamine-4-sulfatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase B (EC:3.1.6.12)
Short name:
ASB
Alternative name(s):
N-acetylgalactosamine-4-sulfatase
Short name:
G4S
Gene namesi
Name:ARSB
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Defects in ARSB are the cause of mucopolysaccharidosis type VI (MPS-VI). MPS-VI has been described in Siamese cats.

Keywords - Diseasei

Mucopolysaccharidosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141 Reviewed predictionAdd
BLAST
Chaini42 – 535494Arylsulfatase BPRO_0000033422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 9313-oxoalanine (Cys) By similarity
Disulfide bondi119 ↔ 523 By similarity
Disulfide bondi123 ↔ 157 By similarity
Disulfide bondi183 ↔ 194 By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi407 ↔ 449 By similarity
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi460 – 4601N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011021.

Structurei

3D structure databases

ProteinModelPortaliP33727.
SMRiP33727. Positions 45-535.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3119.
HOVERGENiHBG004282.
KOiK01135.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33727-1 [UniParc]FASTAAdd to Basket

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MGRRGAASLP RGPSPRRPLL PGVLPLLLRL LLLPSRPGAG AGADRPPHLV    50
FVLADDLGWN DVSFHGSNIR TPHLDELAAG GVLLDNYYTQ PLCTPSRSQL 100
LTGRYQIHTG LQHQIIWPCQ PSCVPLDEKL LPQLLKEAGY TTHMVGKWHL 150
GMYRKECLPT RRGFDTYFGY LLGSEDYYSH ERCALIDSLN VTRCALDFRD 200
GEQVATGYKN MYSTNIFTER ATALITSHPP EKPLFLYLAL QSVHEPLQVP 250
EEYLKPYDFI QDKNRHYYAG MVSLMDEAVG NVTAALKSHG LWNNTVFIFS 300
TDNGGQTLAG GNNWPLRGRK WSLWEGGIRG VGFVASPLLK QKGVKNRELI 350
HISDWLPTLV KLARGSTKGT KPLDGFDVWK TISEGSPSPR KELLHNIDPN 400
FVDISPCPGK SLAPAKDDSS HPAYLAFNTS LHAAIRHGNW KLLTGYPGCG 450
CWFPPPSPYN DSAIPSSDPP TKTLWPFDID QDPEERHDLS RDYPHIVEQL 500
LSRLQFYHKH SVPVHFPAQD PRCDPKGTGA WGPWV 535
Length:535
Mass (Da):59,753
Last modified:February 1, 1994 - v1
Checksum:i43A527886A9983C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48472 mRNA. Translation: AAB23941.1.
PIRiA44475.
RefSeqiNP_001135731.1. NM_001142259.1.

Genome annotation databases

GeneIDi100216331.
KEGGifca:100216331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S48472 mRNA. Translation: AAB23941.1 .
PIRi A44475.
RefSeqi NP_001135731.1. NM_001142259.1.

3D structure databases

ProteinModelPortali P33727.
SMRi P33727. Positions 45-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000011021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100216331.
KEGGi fca:100216331.

Organism-specific databases

CTDi 411.

Phylogenomic databases

eggNOGi COG3119.
HOVERGENi HBG004282.
KOi K01135.

Family and domain databases

Gene3Di 3.40.720.10. 1 hit.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view ]
Pfami PF00884. Sulfatase. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
PROSITEi PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline arylsulfatase B (ARSB): isolation and expression of the cDNA, comparison with human ARSB, and gene localization to feline chromosome A1."
    Jackson C.E., Yuhki N., Desnick R.J., Haskins M.E., O'Brien S.J., Schuchman E.H.
    Genomics 14:403-411(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiARSB_FELCA
AccessioniPrimary (citable) accession number: P33727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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