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Protein

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Gene

PDE6B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei557Proton donorBy similarity1
Metal bindingi561Divalent metal cation 1By similarity1
Metal bindingi597Divalent metal cation 1By similarity1
Metal bindingi598Divalent metal cation 1By similarity1
Metal bindingi598Divalent metal cation 2By similarity1
Metal bindingi718Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CFA-2485179 Activation of the phototransduction cascade
R-CFA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-CFA-4086398 Ca2+ pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (EC:3.1.4.35)
Short name:
GMP-PDE beta
Gene namesi
Name:PDE6B
Synonyms:PDBS, PDEB
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:44358 PDE6B

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Irish setter dogs affected with rod/cone dysplasia (RCD1) contain a nonsense mutation in the gene that gives rise to a protein of 807 AA lacking 49 AA in the C-terminal.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000233462 – 853Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaAdd BLAST852
PropeptideiPRO_0000023347854 – 856Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Lipidationi853S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

PaxDbiP33726

Expressioni

Gene expression databases

BgeeiENSCAFG00000016782

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000024683

Structurei

3D structure databases

ProteinModelPortaliP33726
SMRiP33726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 220GAF 1Add BLAST150
Domaini252 – 429GAF 2Add BLAST178
Domaini481 – 814PDEasePROSITE-ProRule annotationAdd BLAST334

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000119066
HOGENOMiHOG000007069
HOVERGENiHBG053539
InParanoidiP33726
KOiK13756
OMAiSWVEYLS
OrthoDBiEOG091G01RK
TreeFamiTF316499

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.450.40, 2 hits
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSEEQVQH FLDQNPDFTD QYFGKTLSPE HVAGACGDGQ PTDCASFREL
60 70 80 90 100
CQVEESAALF ELVQDMQESV NMERVVFKIL RRLCTILRAD RCSLFMYRQR
110 120 130 140 150
NGVAELATRL FSVQPGSALE DCLVPPDSEI VFPLDIGVVG HVAQTKKMVN
160 170 180 190 200
VQDVTECPHF SPFADELTGY ETRNILATPI MNGKDVVAVI MALNKLDGPC
210 220 230 240 250
FTSEDEDVFL KYLNFGTLNL KIYHLSYLHN CETRRGQVLL WSANKVFEEL
260 270 280 290 300
TDIERQFHKA FYTVRAYLNC DRYSVGLLDM TKEKEFFDVW PVLMGEAQPY
310 320 330 340 350
SGPRTPDGRE IVFYKVIDYI LHGKEDIKVI PSPPADHWAL ASGLPTYVAE
360 370 380 390 400
SGFICNIMNT AADEMFTFQE GPLDDSGWVI KNVLSMPIVN KKEEIVGVAT
410 420 430 440 450
FYNRKDGKPF DEQDEVLMES LTQFLGWSVL NTDTYDKMNK LENRKDIAQD
460 470 480 490 500
MVLYHVRCDK DEIQLILPTR ERLGKEPADC EEDELGILLK EVLPGPSKFD
510 520 530 540 550
IYEFHFSDLE CTELELVKCG IQMYYELGVV RKFQIPQEVL VRFLFSVSKG
560 570 580 590 600
YRRITYHNWR HGFNVAQTMF TLLTTGKLKS YYTDLEAFAM VTAGLCHDID
610 620 630 640 650
HRGTNNLYQM KSQNPLAKLH GSSILERHHL EFGKFLLSEE TLNIYQNLNR
660 670 680 690 700
RQHEHVIHLM DIAIIATDLA LYFKKRTMFQ KIVDESKNYE DRKSWVEYLS
710 720 730 740 750
LETTRKEIVM AMMMTACDLS AITKPWEVQS KVALLVAAEF WEQGDLERTV
760 770 780 790 800
LDQQPIPMMD RNKAAELPKL QVGFIDFVCT FVYKEFSRFH EEILPMFDRL
810 820 830 840 850
QNNRKEWKAL ADEYEAKLKA LEEEKQQQED RTTAKKAGTE ICNGGPAPKS

STCCIL
Length:856
Mass (Da):98,462
Last modified:February 1, 1994 - v1
Checksum:iAC9D03F64D1BA132
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23014 mRNA Translation: CAA80557.1
L13262 mRNA Translation: AAA30882.1 Sequence problems.
PIRiA47451
RefSeqiNP_001002934.1, NM_001002934.1
UniGeneiCfa.3793

Genome annotation databases

EnsembliENSCAFT00000026577; ENSCAFP00000024683; ENSCAFG00000016782
GeneIDi399653
KEGGicfa:399653

Similar proteinsi

Entry informationi

Entry nameiPDE6B_CANLF
AccessioniPrimary (citable) accession number: P33726
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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