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P33724

- CAV1_CANFA

UniProt

P33724 - CAV1_CANFA

Protein

Caveolin-1

Gene

CAV1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

    GO - Molecular functioni

    1. peptidase activator activity Source: Ensembl
    2. protein binding Source: IntAct
    3. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. apoptotic signaling pathway Source: Ensembl
    3. calcium ion transport Source: Ensembl
    4. caveola assembly Source: Ensembl
    5. caveolin-mediated endocytosis Source: Ensembl
    6. cellular response to hyperoxia Source: Ensembl
    7. cellular response to starvation Source: Ensembl
    8. cholesterol homeostasis Source: Ensembl
    9. cytosolic calcium ion homeostasis Source: Ensembl
    10. inactivation of MAPK activity Source: Ensembl
    11. lactation Source: Ensembl
    12. lipid storage Source: Ensembl
    13. mammary gland involution Source: Ensembl
    14. MAPK cascade Source: Ensembl
    15. membrane depolarization Source: Ensembl
    16. negative regulation of anoikis Source: Ensembl
    17. negative regulation of BMP signaling pathway Source: Ensembl
    18. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    19. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
    20. negative regulation of endothelial cell proliferation Source: Ensembl
    21. negative regulation of epithelial cell differentiation Source: Ensembl
    22. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    23. negative regulation of nitric-oxide synthase activity Source: Ensembl
    24. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
    25. negative regulation of protein binding Source: Ensembl
    26. negative regulation of protein ubiquitination Source: Ensembl
    27. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    28. negative regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    29. nitric oxide homeostasis Source: Ensembl
    30. positive regulation of calcium ion transport into cytosol Source: Ensembl
    31. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    32. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    33. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    34. positive regulation of metalloenzyme activity Source: Ensembl
    35. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    36. positive regulation of vasoconstriction Source: Ensembl
    37. protein homooligomerization Source: Ensembl
    38. protein localization Source: Ensembl
    39. receptor internalization involved in canonical Wnt signaling pathway Source: Ensembl
    40. regulation of blood coagulation Source: Ensembl
    41. regulation of fatty acid metabolic process Source: Ensembl
    42. regulation of smooth muscle contraction Source: Ensembl
    43. regulation of the force of heart contraction by chemical signal Source: Ensembl
    44. response to calcium ion Source: Ensembl
    45. response to estrogen Source: Ensembl
    46. response to hypoxia Source: Ensembl
    47. response to ischemia Source: Ensembl
    48. response to progesterone Source: Ensembl
    49. skeletal muscle tissue development Source: Ensembl
    50. T cell costimulation Source: UniProtKB
    51. triglyceride metabolic process Source: Ensembl
    52. vasculogenesis Source: Ensembl
    53. vasoconstriction Source: Ensembl
    54. vesicle organization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caveolin-1
    Alternative name(s):
    Vesicular integral-membrane protein VIP21
    Gene namesi
    Name:CAV1
    Synonyms:CAV
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 14

    Subcellular locationi

    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membranecaveola; Peripheral membrane protein. Membrane raft By similarity
    Note: Colocalized with DPP4 in membrane rafts By similarity. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.By similarity

    GO - Cellular componenti

    1. acrosomal membrane Source: Ensembl
    2. apical plasma membrane Source: Ensembl
    3. basolateral plasma membrane Source: Ensembl
    4. caveola Source: UniProtKB
    5. cell cortex Source: Ensembl
    6. cilium Source: Ensembl
    7. endoplasmic reticulum Source: Ensembl
    8. endosome Source: UniProtKB
    9. Golgi membrane Source: UniProtKB-SubCell
    10. integral component of plasma membrane Source: Ensembl
    11. perinuclear region of cytoplasm Source: Ensembl
    12. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 178177Caveolin-1PRO_0000004762Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei5 – 51N6-acetyllysineBy similarity
    Modified residuei6 – 61PhosphotyrosineBy similarity
    Modified residuei14 – 141Phosphotyrosine; by ABL1By similarity
    Modified residuei25 – 251PhosphotyrosineBy similarity
    Modified residuei37 – 371PhosphoserineBy similarity
    Modified residuei42 – 421PhosphotyrosineBy similarity
    Lipidationi133 – 1331S-palmitoyl cysteine1 Publication
    Lipidationi143 – 1431S-palmitoyl cysteine1 Publication
    Lipidationi156 – 1561S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    Phosphorylation of isoform Beta on serine residues is constitutive. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress By similarity.By similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP33724.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with BMX, BTK, GLIPR2, NOSTRIN, SNAP25 and STX1A. Interacts with PACSIN2 By similarity. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with SLC7A9 By similarity. Interacts with CTNNB1, CDH1 and JUP.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352225EBI-79998,EBI-491549From a different organism.

    Protein-protein interaction databases

    BioGridi139896. 1 interaction.
    IntActiP33724. 5 interactions.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 104103CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 17853CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the caveolin family.Curated

    Phylogenomic databases

    eggNOGiNOG86001.
    GeneTreeiENSGT00390000014924.
    HOGENOMiHOG000036550.
    HOVERGENiHBG003422.
    InParanoidiP33724.
    KOiK06278.
    OMAiRINMQKE.
    OrthoDBiEOG7V1FSD.
    TreeFamiTF315736.

    Family and domain databases

    InterProiIPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view]
    PANTHERiPTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    PfamiPF01146. Caveolin. 1 hit.
    [Graphical view]
    PROSITEiPS01210. CAVEOLIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform Alpha (identifier: P33724-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMSEKQ VYDAHTKEID    50
    LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY 100
    RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI 150
    YVHTFCDPFF EAVGKIFSNI RINMQKET 178
    Length:178
    Mass (Da):20,606
    Last modified:February 1, 1994 - v1
    Checksum:iDD77CE4D436E508D
    GO
    Isoform Beta (identifier: P33724-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-31: Missing.

    Show »
    Length:148
    Mass (Da):17,288
    Checksum:iE367441F6A2FEA2F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 3130Missing in isoform Beta. CuratedVSP_018691Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12161 Genomic DNA. Translation: CAA78151.1.
    U47060 mRNA. Translation: AAA87050.1.
    DP000236 Genomic DNA. Translation: AAR16266.1.
    PIRiA43419.
    RefSeqiNP_001003296.1. NM_001003296.1. [P33724-1]
    UniGeneiCfa.3850.

    Genome annotation databases

    EnsembliENSCAFT00000005462; ENSCAFP00000005060; ENSCAFG00000003404. [P33724-1]
    GeneIDi403980.
    KEGGicfa:403980.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12161 Genomic DNA. Translation: CAA78151.1 .
    U47060 mRNA. Translation: AAA87050.1 .
    DP000236 Genomic DNA. Translation: AAR16266.1 .
    PIRi A43419.
    RefSeqi NP_001003296.1. NM_001003296.1. [P33724-1 ]
    UniGenei Cfa.3850.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 139896. 1 interaction.
    IntActi P33724. 5 interactions.

    Proteomic databases

    PaxDbi P33724.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000005462 ; ENSCAFP00000005060 ; ENSCAFG00000003404 . [P33724-1 ]
    GeneIDi 403980.
    KEGGi cfa:403980.

    Organism-specific databases

    CTDi 857.

    Phylogenomic databases

    eggNOGi NOG86001.
    GeneTreei ENSGT00390000014924.
    HOGENOMi HOG000036550.
    HOVERGENi HBG003422.
    InParanoidi P33724.
    KOi K06278.
    OMAi RINMQKE.
    OrthoDBi EOG7V1FSD.
    TreeFami TF315736.

    Miscellaneous databases

    NextBioi 20817470.

    Family and domain databases

    InterProi IPR001612. Caveolin.
    IPR015504. Caveolin_1.
    IPR018361. Caveolin_CS.
    [Graphical view ]
    PANTHERi PTHR10844. PTHR10844. 1 hit.
    PTHR10844:SF5. PTHR10844:SF5. 1 hit.
    Pfami PF01146. Caveolin. 1 hit.
    [Graphical view ]
    PROSITEi PS01210. CAVEOLIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles."
      Kurzchalia T.V., Dupree P., Parton R.G., Kellner R., Virta H., Lehnert M., Simons K.
      J. Cell Biol. 118:1003-1014(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 48-74 AND 166-176.
      Tissue: Epithelium.
    2. "Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells."
      Sargiacomo M., Sudol M., Tang Z., Lisanti M.P.
      J. Cell Biol. 122:789-807(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Cocker spaniel.
      Tissue: Kidney.
    3. "Comparative analyses of multi-species sequences from targeted genomic regions."
      Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
      , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
      Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Caveolae and sorting in the trans-Golgi network of epithelial cells."
      Dupree P., Parton R.G., Raposo G., Kurzchalia T.V., Simons K.
      EMBO J. 12:1597-1605(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. "Oligomeric structure of caveolin: implications for caveolae membrane organization."
      Sargiacomo M., Scherer P.E., Tang Z., Kubler E., Song K.S., Sanders M.C., Lisanti M.P.
      Proc. Natl. Acad. Sci. U.S.A. 92:9407-9411(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    6. "Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae."
      Dietzen D.J., Hastings W.R., Lublin D.M.
      J. Biol. Chem. 270:6838-6842(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-133; CYS-143 AND CYS-156.
    7. "Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe."
      Scherer P.E., Tang Z., Chun M., Sargiacomo M., Lodish H.F., Lisanti M.P.
      J. Biol. Chem. 270:16395-16401(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE INITIATION.
    8. "Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains."
      Galbiati F., Volonte D., Brown A.M., Weinstein D.E., Ben-Ze'ev A., Pestell R.G., Lisanti M.P.
      J. Biol. Chem. 275:23368-23377(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNB1; CDH1 AND JUP, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCAV1_CANFA
    AccessioniPrimary (citable) accession number: P33724
    Secondary accession number(s): A0M8U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3