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P33717 (IGF2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor II

Short name=IGF-II
Gene names
Name:IGF2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The insulin-like growth factors possess growth-promoting activity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the insulin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
Mitogen
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processexocrine pancreas development

Inferred from electronic annotation. Source: Ensembl

insulin receptor signaling pathway via phosphatidylinositol 3-kinase

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of activated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of glycogen (starch) synthase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of glycogen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

striated muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionprotein serine/threonine kinase activator activity

Inferred from electronic annotation. Source: Ensembl

receptor activator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9168Insulin-like growth factor II
PRO_0000221092
Propeptide92 – 18796E peptide
PRO_0000370382

Regions

Region25 – 5127B
Region52 – 6413C
Region64 – 8522A
Region86 – 916D

Amino acid modifications

Disulfide bond32 ↔ 71 By similarity
Disulfide bond44 ↔ 84 By similarity
Disulfide bond70 ↔ 75 By similarity

Experimental info

Sequence conflict641Missing AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
P33717 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: B301581CD4878EEC

FASTA18720,837
        10         20         30         40         50         60 
MCAARQILLL LLAFLAYALD SAAAYGTAET LCGGELVDTL QFVCGDRGFY FSRPVGRNNR 

        70         80         90        100        110        120 
RINRGIVEEC CFRSCDLALL ETYCAKSVKS ERDLSATSLA GLPALNKESF QKPSHAKYSK 

       130        140        150        160        170        180 
YNVWQKKSSQ RLQREVPGIL RARRYRWQAE GLQAAEEARA MHRPLISLPS QRPPAPRASP 


EATGPQE 

« Hide

References

[1]"Nucleotide sequence and genomic structure of the chicken insulin-like growth factor-II (IGF-II) coding region."
Darling D.C., Brickell P.M.
Gen. Comp. Endocrinol. 102:283-287(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits."
Amills M., Jimenez N., Villalba D., Tor M., Molina E., Cubilo D., Marcos C., Francesch A., Sanchez A., Estany J.
Poult. Sci. 82:1485-1493(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Chemical and biological characterization of chicken insulin-like growth factor-II."
Kallincos N.C., Wallace J.C., Francis G.L., Ballard F.J.
J. Endocrinol. 124:89-97(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-91.
[4]"Purification, partial sequences and properties of chicken insulin-like growth factors."
Dawe S.R., Francis G.L., McNamara P.J., Wallace J.C., Ballard F.J.
J. Endocrinol. 117:173-181(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-60.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S82962, S82960 Genomic DNA. Translation: AAB46818.1.
AY267181 mRNA. Translation: AAP22173.1.
PIRA60740.
T10897.
RefSeqNP_001025513.1. NM_001030342.1.
UniGeneGga.8511.

3D structure databases

ProteinModelPortalP33717.
SMRP33717. Positions 24-91.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP33717.
PRIDEP33717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID395097.
KEGGgga:395097.

Organism-specific databases

CTD3481.

Phylogenomic databases

eggNOGNOG44017.
HOGENOMHOG000233362.
HOVERGENHBG006137.
InParanoidP79890.
KOK13769.
OMARYRWQAE.
OrthoDBEOG7TF7CG.
PhylomeDBP33717.
TreeFamTF332820.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815190.
PROP33717.

Entry information

Entry nameIGF2_CHICK
AccessionPrimary (citable) accession number: P33717
Secondary accession number(s): P79890, Q7ZZT6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families