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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47Important for interaction with integrinBy similarity1
Sitei57Important for interaction with integrinBy similarity1
Sitei60Important for interaction with integrinBy similarity1
Sitei61Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-GGA-114608 Platelet degranulation
R-GGA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-GGA-2428928 IRS-related events triggered by IGF1R
R-GGA-2428933 SHC-related events triggered by IGF1R
R-GGA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Gene namesi
Name:IGF2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000022109224 – 91Insulin-like growth factor IIAdd BLAST68
PropeptideiPRO_000037038292 – 187E peptideAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 71By similarity
Disulfide bondi44 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33717
PRIDEiP33717

Expressioni

Gene expression databases

BgeeiENSGALG00000006555

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010570

Structurei

3D structure databases

ProteinModelPortaliP33717
SMRiP33717
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 51BAdd BLAST27
Regioni52 – 64CAdd BLAST13
Regioni64 – 85AAdd BLAST22
Regioni86 – 91D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY3P Eukaryota
ENOG4111KP2 LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
InParanoidiP33717
KOiK13769
OrthoDBiEOG091G0H56
PhylomeDBiP33717
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAARQILLL LLAFLAYALD SAAAYGTAET LCGGELVDTL QFVCGDRGFY
60 70 80 90 100
FSRPVGRNNR RINRGIVEEC CFRSCDLALL ETYCAKSVKS ERDLSATSLA
110 120 130 140 150
GLPALNKESF QKPSHAKYSK YNVWQKKSSQ RLQREVPGIL RARRYRWQAE
160 170 180
GLQAAEEARA MHRPLISLPS QRPPAPRASP EATGPQE
Length:187
Mass (Da):20,837
Last modified:April 14, 2009 - v2
Checksum:iB301581CD4878EEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Missing AA sequence (PubMed:1688912).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82962, S82960 Genomic DNA Translation: AAB46818.1
AY267181 mRNA Translation: AAP22173.1
PIRiA60740
T10897
RefSeqiNP_001025513.1, NM_001030342.2
UniGeneiGga.8511

Genome annotation databases

EnsembliENSGALT00000053800; ENSGALP00000048743; ENSGALG00000035282
GeneIDi395097
KEGGigga:395097

Similar proteinsi

Entry informationi

Entry nameiIGF2_CHICK
AccessioniPrimary (citable) accession number: P33717
Secondary accession number(s): P79890, Q7ZZT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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