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P33717

- IGF2_CHICK

UniProt

P33717 - IGF2_CHICK

Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors possess growth-promoting activity.

    GO - Molecular functioni

    1. protein serine/threonine kinase activator activity Source: Ensembl
    2. receptor activator activity Source: Ensembl

    GO - Biological processi

    1. exocrine pancreas development Source: Ensembl
    2. insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
    3. organ morphogenesis Source: Ensembl
    4. osteoblast differentiation Source: Ensembl
    5. positive regulation of activated T cell proliferation Source: Ensembl
    6. positive regulation of cell division Source: UniProtKB-KW
    7. positive regulation of glycogen (starch) synthase activity Source: Ensembl
    8. positive regulation of glycogen biosynthetic process Source: Ensembl
    9. positive regulation of insulin receptor signaling pathway Source: Ensembl
    10. positive regulation of MAPK cascade Source: Ensembl
    11. positive regulation of mitosis Source: Ensembl
    12. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    13. positive regulation of protein kinase B signaling Source: Ensembl
    14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    15. striated muscle cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_189769. SHC-related events triggered by IGF1R.
    REACT_189775. IRS-related events triggered by IGF1R.
    REACT_189777. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Gene namesi
    Name:IGF2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9168Insulin-like growth factor IIPRO_0000221092Add
    BLAST
    Propeptidei92 – 18796E peptidePRO_0000370382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 71By similarity
    Disulfide bondi44 ↔ 84By similarity
    Disulfide bondi70 ↔ 75By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP33717.
    PRIDEiP33717.

    Structurei

    3D structure databases

    ProteinModelPortaliP33717.
    SMRiP33717. Positions 24-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 5127BAdd
    BLAST
    Regioni52 – 6413CAdd
    BLAST
    Regioni64 – 8522AAdd
    BLAST
    Regioni86 – 916D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44017.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    InParanoidiP79890.
    KOiK13769.
    OMAiRYRWQAE.
    OrthoDBiEOG7TF7CG.
    PhylomeDBiP33717.
    TreeFamiTF332820.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33717-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCAARQILLL LLAFLAYALD SAAAYGTAET LCGGELVDTL QFVCGDRGFY    50
    FSRPVGRNNR RINRGIVEEC CFRSCDLALL ETYCAKSVKS ERDLSATSLA 100
    GLPALNKESF QKPSHAKYSK YNVWQKKSSQ RLQREVPGIL RARRYRWQAE 150
    GLQAAEEARA MHRPLISLPS QRPPAPRASP EATGPQE 187
    Length:187
    Mass (Da):20,837
    Last modified:April 14, 2009 - v2
    Checksum:iB301581CD4878EEC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti64 – 641Missing AA sequence (PubMed:1688912)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82962, S82960 Genomic DNA. Translation: AAB46818.1.
    AY267181 mRNA. Translation: AAP22173.1.
    PIRiA60740.
    T10897.
    RefSeqiNP_001025513.1. NM_001030342.1.
    UniGeneiGga.8511.

    Genome annotation databases

    GeneIDi395097.
    KEGGigga:395097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S82962 , S82960 Genomic DNA. Translation: AAB46818.1 .
    AY267181 mRNA. Translation: AAP22173.1 .
    PIRi A60740.
    T10897.
    RefSeqi NP_001025513.1. NM_001030342.1.
    UniGenei Gga.8511.

    3D structure databases

    ProteinModelPortali P33717.
    SMRi P33717. Positions 24-91.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P33717.
    PRIDEi P33717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395097.
    KEGGi gga:395097.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    eggNOGi NOG44017.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    InParanoidi P79890.
    KOi K13769.
    OMAi RYRWQAE.
    OrthoDBi EOG7TF7CG.
    PhylomeDBi P33717.
    TreeFami TF332820.

    Enzyme and pathway databases

    Reactomei REACT_189769. SHC-related events triggered by IGF1R.
    REACT_189775. IRS-related events triggered by IGF1R.
    REACT_189777. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

    Miscellaneous databases

    NextBioi 20815190.
    PROi P33717.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 2 hits.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and genomic structure of the chicken insulin-like growth factor-II (IGF-II) coding region."
      Darling D.C., Brickell P.M.
      Gen. Comp. Endocrinol. 102:283-287(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits."
      Amills M., Jimenez N., Villalba D., Tor M., Molina E., Cubilo D., Marcos C., Francesch A., Sanchez A., Estany J.
      Poult. Sci. 82:1485-1493(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Chemical and biological characterization of chicken insulin-like growth factor-II."
      Kallincos N.C., Wallace J.C., Francis G.L., Ballard F.J.
      J. Endocrinol. 124:89-97(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-91.
    4. "Purification, partial sequences and properties of chicken insulin-like growth factors."
      Dawe S.R., Francis G.L., McNamara P.J., Wallace J.C., Ballard F.J.
      J. Endocrinol. 117:173-181(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-60.

    Entry informationi

    Entry nameiIGF2_CHICK
    AccessioniPrimary (citable) accession number: P33717
    Secondary accession number(s): P79890, Q7ZZT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3