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P33717

- IGF2_CHICK

UniProt

P33717 - IGF2_CHICK

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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity.

GO - Molecular functioni

  1. protein serine/threonine kinase activator activity Source: Ensembl
  2. receptor activator activity Source: Ensembl

GO - Biological processi

  1. exocrine pancreas development Source: Ensembl
  2. insulin receptor signaling pathway via phosphatidylinositol 3-kinase Source: Ensembl
  3. organ morphogenesis Source: Ensembl
  4. osteoblast differentiation Source: Ensembl
  5. positive regulation of activated T cell proliferation Source: Ensembl
  6. positive regulation of cell division Source: UniProtKB-KW
  7. positive regulation of glycogen (starch) synthase activity Source: Ensembl
  8. positive regulation of glycogen biosynthetic process Source: Ensembl
  9. positive regulation of insulin receptor signaling pathway Source: Ensembl
  10. positive regulation of MAPK cascade Source: Ensembl
  11. positive regulation of mitosis Source: Ensembl
  12. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  13. positive regulation of protein kinase B signaling Source: Ensembl
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. striated muscle cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiREACT_189769. SHC-related events triggered by IGF1R.
REACT_189775. IRS-related events triggered by IGF1R.
REACT_189777. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Gene namesi
Name:IGF2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9168Insulin-like growth factor IIPRO_0000221092Add
BLAST
Propeptidei92 – 18796E peptidePRO_0000370382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 71By similarity
Disulfide bondi44 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33717.
PRIDEiP33717.

Expressioni

Gene expression databases

ExpressionAtlasiP33717. baseline.

Structurei

3D structure databases

ProteinModelPortaliP33717.
SMRiP33717. Positions 24-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 5127BAdd
BLAST
Regioni52 – 6413CAdd
BLAST
Regioni64 – 8522AAdd
BLAST
Regioni86 – 916D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44017.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP33717.
KOiK13769.
OMAiRYRWQAE.
OrthoDBiEOG7TF7CG.
PhylomeDBiP33717.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33717-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAARQILLL LLAFLAYALD SAAAYGTAET LCGGELVDTL QFVCGDRGFY
60 70 80 90 100
FSRPVGRNNR RINRGIVEEC CFRSCDLALL ETYCAKSVKS ERDLSATSLA
110 120 130 140 150
GLPALNKESF QKPSHAKYSK YNVWQKKSSQ RLQREVPGIL RARRYRWQAE
160 170 180
GLQAAEEARA MHRPLISLPS QRPPAPRASP EATGPQE
Length:187
Mass (Da):20,837
Last modified:April 14, 2009 - v2
Checksum:iB301581CD4878EEC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641Missing AA sequence (PubMed:1688912)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82962, S82960 Genomic DNA. Translation: AAB46818.1.
AY267181 mRNA. Translation: AAP22173.1.
PIRiA60740.
T10897.
RefSeqiNP_001025513.1. NM_001030342.1.
UniGeneiGga.8511.

Genome annotation databases

GeneIDi395097.
KEGGigga:395097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S82962 , S82960 Genomic DNA. Translation: AAB46818.1 .
AY267181 mRNA. Translation: AAP22173.1 .
PIRi A60740.
T10897.
RefSeqi NP_001025513.1. NM_001030342.1.
UniGenei Gga.8511.

3D structure databases

ProteinModelPortali P33717.
SMRi P33717. Positions 24-91.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P33717.
PRIDEi P33717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395097.
KEGGi gga:395097.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

eggNOGi NOG44017.
HOGENOMi HOG000233362.
HOVERGENi HBG006137.
InParanoidi P33717.
KOi K13769.
OMAi RYRWQAE.
OrthoDBi EOG7TF7CG.
PhylomeDBi P33717.
TreeFami TF332820.

Enzyme and pathway databases

Reactomei REACT_189769. SHC-related events triggered by IGF1R.
REACT_189775. IRS-related events triggered by IGF1R.
REACT_189777. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

Miscellaneous databases

NextBioi 20815190.
PROi P33717.

Gene expression databases

ExpressionAtlasi P33717. baseline.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 2 hits.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and genomic structure of the chicken insulin-like growth factor-II (IGF-II) coding region."
    Darling D.C., Brickell P.M.
    Gen. Comp. Endocrinol. 102:283-287(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of three single nucleotide polymorphisms in the chicken insulin-like growth factor 1 and 2 genes and their associations with growth and feeding traits."
    Amills M., Jimenez N., Villalba D., Tor M., Molina E., Cubilo D., Marcos C., Francesch A., Sanchez A., Estany J.
    Poult. Sci. 82:1485-1493(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Chemical and biological characterization of chicken insulin-like growth factor-II."
    Kallincos N.C., Wallace J.C., Francis G.L., Ballard F.J.
    J. Endocrinol. 124:89-97(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-91.
  4. "Purification, partial sequences and properties of chicken insulin-like growth factors."
    Dawe S.R., Francis G.L., McNamara P.J., Wallace J.C., Ballard F.J.
    J. Endocrinol. 117:173-181(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-60.

Entry informationi

Entry nameiIGF2_CHICK
AccessioniPrimary (citable) accession number: P33717
Secondary accession number(s): P79890, Q7ZZT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3