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P33712

- IGF1_CANFA

UniProt

P33712 - IGF1_CANFA

Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation By similarity.By similarity

    GO - Biological processi

    1. negative regulation of apoptotic process Source: UniProtKB
    2. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
    3. positive regulation of glucose import Source: UniProtKB
    4. positive regulation of glycogen biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_174260. SHC-related events triggered by IGF1R.
    REACT_174261. IRS-related events triggered by IGF1R.
    REACT_174262. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor I
    Short name:
    IGF-I
    Alternative name(s):
    Somatomedin
    Gene namesi
    Name:IGF1
    Synonyms:IGFIA
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 15

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 48By similarityPRO_0000330685
    Signal peptidei1 – ?Sequence Analysis
    Chaini49 – 11870Insulin-like growth factor IPRO_0000015650Add
    BLAST
    Propeptidei119 – 15335E peptidePRO_0000015651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 96By similarity
    Disulfide bondi66 ↔ 109By similarity
    Disulfide bondi95 ↔ 100By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP33712.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000010834.

    Structurei

    3D structure databases

    ProteinModelPortaliP33712.
    SMRiP33712. Positions 49-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni49 – 7729BAdd
    BLAST
    Regioni78 – 8912CAdd
    BLAST
    Regioni90 – 11021AAdd
    BLAST
    Regioni111 – 1188D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39886.
    GeneTreeiENSGT00530000063856.
    HOGENOMiHOG000233362.
    HOVERGENiHBG006137.
    KOiK05459.
    OMAiHTVSYIH.
    OrthoDBiEOG7TF7CG.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33712-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP    50
    ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC 100
    DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN 150
    YRM 153
    Length:153
    Mass (Da):16,970
    Last modified:April 29, 2008 - v2
    Checksum:i19D16DBF9151C0EF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1534NYRM → TY in L08254. (PubMed:8359700)Curated

    Polymorphismi

    The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DN380306 mRNA. No translation available.
    L08254 mRNA. No translation available.
    PIRiPN0622.
    RefSeqiXP_853117.1. XM_848024.3.
    UniGeneiCfa.3888.

    Genome annotation databases

    EnsembliENSCAFT00000011690; ENSCAFP00000010833; ENSCAFG00000007304.
    GeneIDi610255.
    KEGGicfa:610255.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A dog's life - Issue 92 of March 2008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DN380306 mRNA. No translation available.
    L08254 mRNA. No translation available.
    PIRi PN0622.
    RefSeqi XP_853117.1. XM_848024.3.
    UniGenei Cfa.3888.

    3D structure databases

    ProteinModelPortali P33712.
    SMRi P33712. Positions 49-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000010834.

    Proteomic databases

    PaxDbi P33712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000011690 ; ENSCAFP00000010833 ; ENSCAFG00000007304 .
    GeneIDi 610255.
    KEGGi cfa:610255.

    Organism-specific databases

    CTDi 3479.

    Phylogenomic databases

    eggNOGi NOG39886.
    GeneTreei ENSGT00530000063856.
    HOGENOMi HOG000233362.
    HOVERGENi HBG006137.
    KOi K05459.
    OMAi HTVSYIH.
    OrthoDBi EOG7TF7CG.

    Enzyme and pathway databases

    Reactomei REACT_174260. SHC-related events triggered by IGF1R.
    REACT_174261. IRS-related events triggered by IGF1R.
    REACT_174262. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

    Miscellaneous databases

    NextBioi 20895820.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022341. IGF-I.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02005. INSLNLIKEGF1.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Staten N.R.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovium.
    2. "Sequence of a cDNA encoding dog insulin-like growth factor I."
      Delafontaine P., Lou H., Harrison D.G., Bernstein K.E.
      Gene 130:305-306(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
    3. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiIGF1_CANFA
    AccessioniPrimary (citable) accession number: P33712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3