Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P33712 (IGF1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor I

Short name=IGF-I
Alternative name(s):
Somatomedin
Gene names
Name:IGF1
Synonyms:IGFIA
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation By similarity.

Subcellular location

Secreted.

Polymorphism

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

Sequence similarities

Belongs to the insulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Propeptide? – 48 By similarityPRO_0000330685
Chain49 – 11870Insulin-like growth factor I
PRO_0000015650
Propeptide119 – 15335E peptide
PRO_0000015651

Regions

Region49 – 7729B
Region78 – 8912C
Region90 – 11021A
Region111 – 1188D

Amino acid modifications

Disulfide bond54 ↔ 96 By similarity
Disulfide bond66 ↔ 109 By similarity
Disulfide bond95 ↔ 100 By similarity

Experimental info

Sequence conflict150 – 1534NYRM → TY in L08254. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P33712 [UniParc].

Last modified April 29, 2008. Version 2.
Checksum: 19D16DBF9151C0EF

FASTA15316,970
        10         20         30         40         50         60 
MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP ETLCGAELVD 

        70         80         90        100        110        120 
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS 

       130        140        150 
VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN YRM 

« Hide

References

« Hide 'large scale' references
[1]Staten N.R.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Synovium.
[2]"Sequence of a cDNA encoding dog insulin-like growth factor I."
Delafontaine P., Lou H., Harrison D.G., Bernstein K.E.
Gene 130:305-306(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
[3]"A single IGF1 allele is a major determinant of small size in dogs."
Sutter N.B., Bustamante C.D., Chase K., Gray M.M., Zhao K., Zhu L., Padhukasahasram B., Karlins E., Davis S., Jones P.G., Quignon P., Johnson G.S., Parker H.G., Fretwell N., Mosher D.S., Lawler D.F., Satyaraj E., Nordborg M. expand/collapse author list , Lark K.G., Wayne R.K., Ostrander E.A.
Science 316:112-115(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.

Web resources

Protein Spotlight

A dog's life - Issue 92 of March 2008

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DN380306 mRNA. No translation available.
L08254 mRNA. No translation available.
PIRPN0622.
RefSeqXP_853117.1. XM_848024.3.
UniGeneCfa.3888.

3D structure databases

ProteinModelPortalP33712.
SMRP33712. Positions 49-118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000010834.

Proteomic databases

PaxDbP33712.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000011690; ENSCAFP00000010833; ENSCAFG00000007304.
GeneID610255.
KEGGcfa:610255.

Organism-specific databases

CTD3479.

Phylogenomic databases

eggNOGNOG39886.
GeneTreeENSGT00530000063856.
HOGENOMHOG000233362.
HOVERGENHBG006137.
KOK05459.
OMAHTVSYIH.
OrthoDBEOG7TF7CG.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20895820.

Entry information

Entry nameIGF1_CANFA
AccessionPrimary (citable) accession number: P33712
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries