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Protein

Insulin-like growth factor I

Gene

IGF1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity).By similarity

GO - Biological processi

  1. negative regulation of apoptotic process Source: UniProtKB
  2. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  3. positive regulation of glucose import Source: UniProtKB
  4. positive regulation of glycogen biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_274699. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
REACT_279435. IRS-related events triggered by IGF1R.
REACT_295982. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
REACT_303853. Platelet degranulation.
REACT_323297. SHC-related events triggered by IGF1R.
REACT_335951. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
Synonyms:IGFIA
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48By similarityPRO_0000330685
Signal peptidei1 – ?Sequence Analysis
Chaini49 – 11870Insulin-like growth factor IPRO_0000015650Add
BLAST
Propeptidei119 – 15335E peptidePRO_0000015651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96By similarity
Disulfide bondi66 ↔ 109By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33712.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010834.

Structurei

3D structure databases

ProteinModelPortaliP33712.
SMRiP33712. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729BAdd
BLAST
Regioni78 – 8912CAdd
BLAST
Regioni90 – 11021AAdd
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39886.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP33712.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC
110 120 130 140 150
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN

YRM
Length:153
Mass (Da):16,970
Last modified:April 28, 2008 - v2
Checksum:i19D16DBF9151C0EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1534NYRM → TY in L08254 (PubMed:8359700).Curated

Polymorphismi

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN380306 mRNA. No translation available.
L08254 mRNA. No translation available.
PIRiPN0622.
RefSeqiXP_853117.1. XM_848024.3.
UniGeneiCfa.3888.

Genome annotation databases

EnsembliENSCAFT00000011690; ENSCAFP00000010833; ENSCAFG00000007304.
GeneIDi610255.
KEGGicfa:610255.

Cross-referencesi

Web resourcesi

Protein Spotlight

A dog's life - Issue 92 of March 2008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN380306 mRNA. No translation available.
L08254 mRNA. No translation available.
PIRiPN0622.
RefSeqiXP_853117.1. XM_848024.3.
UniGeneiCfa.3888.

3D structure databases

ProteinModelPortaliP33712.
SMRiP33712. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010834.

Proteomic databases

PaxDbiP33712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000011690; ENSCAFP00000010833; ENSCAFG00000007304.
GeneIDi610255.
KEGGicfa:610255.

Organism-specific databases

CTDi3479.

Phylogenomic databases

eggNOGiNOG39886.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
InParanoidiP33712.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.

Enzyme and pathway databases

ReactomeiREACT_274699. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
REACT_279435. IRS-related events triggered by IGF1R.
REACT_295982. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
REACT_303853. Platelet degranulation.
REACT_323297. SHC-related events triggered by IGF1R.
REACT_335951. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

NextBioi20895820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Staten N.R.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. "Sequence of a cDNA encoding dog insulin-like growth factor I."
    Delafontaine P., Lou H., Harrison D.G., Bernstein K.E.
    Gene 130:305-306(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
  3. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiIGF1_CANFA
AccessioniPrimary (citable) accession number: P33712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: April 28, 2008
Last modified: March 31, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.