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P33712

- IGF1_CANFA

UniProt

P33712 - IGF1_CANFA

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Protein
Insulin-like growth factor I
Gene
IGF1, IGFIA
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation By similarity.

GO - Biological processi

  1. negative regulation of apoptotic process Source: UniProtKB
  2. negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
  3. positive regulation of glucose import Source: UniProtKB
  4. positive regulation of glycogen biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_174260. SHC-related events triggered by IGF1R.
REACT_174261. IRS-related events triggered by IGF1R.
REACT_174262. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor I
Short name:
IGF-I
Alternative name(s):
Somatomedin
Gene namesi
Name:IGF1
Synonyms:IGFIA
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 15

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 48 By similarityPRO_0000330685
Signal peptidei1 – ? Reviewed prediction
Chaini49 – 11870Insulin-like growth factor I
PRO_0000015650Add
BLAST
Propeptidei119 – 15335E peptide
PRO_0000015651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 96 By similarity
Disulfide bondi66 ↔ 109 By similarity
Disulfide bondi95 ↔ 100 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33712.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010834.

Structurei

3D structure databases

ProteinModelPortaliP33712.
SMRiP33712. Positions 49-118.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 7729B
Add
BLAST
Regioni78 – 8912C
Add
BLAST
Regioni90 – 11021A
Add
BLAST
Regioni111 – 1188D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39886.
GeneTreeiENSGT00530000063856.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.
KOiK05459.
OMAiHTVSYIH.
OrthoDBiEOG7TF7CG.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33712-1 [UniParc]FASTAAdd to Basket

« Hide

MGKISSLPTQ LFKCCFCDFL KVKMHTVSSS HLFYLALCLL TFPSPATAGP    50
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC 100
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KAQKEVHLKN ASRGSAGNKN 150
YRM 153
Length:153
Mass (Da):16,970
Last modified:April 29, 2008 - v2
Checksum:i19D16DBF9151C0EF
GO

Polymorphismi

The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. A major quantitative trait locus (QTL) on chromosome 15 influences size variation within a single breed. In particular, a single-nucleotide polymorphism haplotype in IGF1 (synonymous SNP in exon 3) is common to all small breeds (less than 9 kg) and nearly absent from giant breeds (more than 30 kg), suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1534NYRM → TY in L08254. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DN380306 mRNA. No translation available.
L08254 mRNA. No translation available.
PIRiPN0622.
RefSeqiXP_853117.1. XM_848024.3.
UniGeneiCfa.3888.

Genome annotation databases

EnsembliENSCAFT00000011690; ENSCAFP00000010833; ENSCAFG00000007304.
GeneIDi610255.
KEGGicfa:610255.

Cross-referencesi

Web resourcesi

Protein Spotlight

A dog's life - Issue 92 of March 2008

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DN380306 mRNA. No translation available.
L08254 mRNA. No translation available.
PIRi PN0622.
RefSeqi XP_853117.1. XM_848024.3.
UniGenei Cfa.3888.

3D structure databases

ProteinModelPortali P33712.
SMRi P33712. Positions 49-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000010834.

Proteomic databases

PaxDbi P33712.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000011690 ; ENSCAFP00000010833 ; ENSCAFG00000007304 .
GeneIDi 610255.
KEGGi cfa:610255.

Organism-specific databases

CTDi 3479.

Phylogenomic databases

eggNOGi NOG39886.
GeneTreei ENSGT00530000063856.
HOGENOMi HOG000233362.
HOVERGENi HBG006137.
KOi K05459.
OMAi HTVSYIH.
OrthoDBi EOG7TF7CG.

Enzyme and pathway databases

Reactomei REACT_174260. SHC-related events triggered by IGF1R.
REACT_174261. IRS-related events triggered by IGF1R.
REACT_174262. Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).

Miscellaneous databases

NextBioi 20895820.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Staten N.R.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. "Sequence of a cDNA encoding dog insulin-like growth factor I."
    Delafontaine P., Lou H., Harrison D.G., Bernstein K.E.
    Gene 130:305-306(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-151.
  3. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiIGF1_CANFA
AccessioniPrimary (citable) accession number: P33712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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