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Protein

Somatotropin

Gene

GH1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45ZincBy similarity1
Metal bindingi198ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-1170546. Prolactin receptor signaling.
R-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-CFA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:GH1
Synonyms:GH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000003297827 – 216SomatotropinAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 189By similarity
Modified residuei131PhosphoserineBy similarity1
Disulfide bondi206 ↔ 214By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP33711.

Expressioni

Gene expression databases

BgeeiENSCAFG00000012681.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018659.

Structurei

3D structure databases

ProteinModelPortaliP33711.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP33711.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG091G0KPU.
TreeFamiTF332592.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR034975. Somatotropin.
IPR001400. Somatotropin/Prolactin.
IPR018116. Somatotropin_CS.
PANTHERiPTHR11417. PTHR11417. 1 hit.
PTHR11417:SF53. PTHR11417:SF53. 1 hit.
PfamiView protein in Pfam
PF00103. Hormone_1. 1 hit.
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASPRNSVL LAFALLCLPW PQEVGAFPAM PLSSLFANAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR VFTNSLVFGT SDRVYEKLKD LEEGIQALMR
160 170 180 190 200
ELEDGSPRAG QILKQTYDKF DTNLRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFV ESSCAF
Length:216
Mass (Da):24,468
Last modified:December 1, 2000 - v2
Checksum:iA8AD1DD59F1DAAED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4S → G in CAA80601 (PubMed:8206387).Curated1
Sequence conflicti7N → T in CAA80601 (PubMed:8206387).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23067 mRNA. Translation: CAA80601.1.
U92533 Genomic DNA. Translation: AAF21502.1.
AF069071 mRNA. Translation: AAD43366.1.
PIRiI46145.
RefSeqiNP_001003168.1. NM_001003168.1.
XP_005624232.1. XM_005624175.2.
UniGeneiCfa.3656.

Genome annotation databases

EnsembliENSCAFT00000020118; ENSCAFP00000018659; ENSCAFG00000012681.
GeneIDi403795.
KEGGicfa:403795.

Similar proteinsi

Entry informationi

Entry nameiSOMA_CANLF
AccessioniPrimary (citable) accession number: P33711
Secondary accession number(s): Q9TQT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families