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Protein

Somatotropin

Gene

GH1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451ZincBy similarity
Metal bindingi198 – 1981ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-1170546. Prolactin receptor signaling.
R-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-CFA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:GH1
Synonyms:GH
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 216190SomatotropinPRO_0000032978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 189By similarity
Modified residuei131 – 1311PhosphoserineBy similarity
Disulfide bondi206 ↔ 214By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP33711.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018659.

Structurei

3D structure databases

ProteinModelPortaliP33711.
SMRiP33711. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP33711.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASPRNSVL LAFALLCLPW PQEVGAFPAM PLSSLFANAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR VFTNSLVFGT SDRVYEKLKD LEEGIQALMR
160 170 180 190 200
ELEDGSPRAG QILKQTYDKF DTNLRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFV ESSCAF
Length:216
Mass (Da):24,468
Last modified:December 1, 2000 - v2
Checksum:iA8AD1DD59F1DAAED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41S → G in CAA80601 (PubMed:8206387).Curated
Sequence conflicti7 – 71N → T in CAA80601 (PubMed:8206387).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23067 mRNA. Translation: CAA80601.1.
U92533 Genomic DNA. Translation: AAF21502.1.
AF069071 mRNA. Translation: AAD43366.1.
PIRiI46145.
RefSeqiNP_001003168.1. NM_001003168.1.
XP_005624232.1. XM_005624175.2.
UniGeneiCfa.3656.

Genome annotation databases

EnsembliENSCAFT00000020118; ENSCAFP00000018659; ENSCAFG00000012681.
GeneIDi403795.
KEGGicfa:403795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23067 mRNA. Translation: CAA80601.1.
U92533 Genomic DNA. Translation: AAF21502.1.
AF069071 mRNA. Translation: AAD43366.1.
PIRiI46145.
RefSeqiNP_001003168.1. NM_001003168.1.
XP_005624232.1. XM_005624175.2.
UniGeneiCfa.3656.

3D structure databases

ProteinModelPortaliP33711.
SMRiP33711. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000018659.

Proteomic databases

PaxDbiP33711.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000020118; ENSCAFP00000018659; ENSCAFG00000012681.
GeneIDi403795.
KEGGicfa:403795.

Organism-specific databases

CTDi2688.

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP33711.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-CFA-1170546. Prolactin receptor signaling.
R-CFA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-CFA-982772. Growth hormone receptor signaling.

Miscellaneous databases

NextBioi20817292.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A dog growth hormone cDNA codes for a mature protein identical to pig growth hormone."
    Ascacio-Martinez J.A., Barrera-Saldana H.A.
    Gene 143:277-280(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Extrapituitary growth hormone expression in the dog is initiated at the normal pituitary transcription start site in the mammary gland and at multiple upstream sites in lymphoid cells."
    van Leeuwen I.S., Teske E., van Garderen E., Rutteman G.R., Mol J.A.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1."
    Lantinga-van Leeuwen I.S., Oudshoorn M., Mol J.A.
    Mol. Cell. Endocrinol. 150:121-128(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiSOMA_CANLF
AccessioniPrimary (citable) accession number: P33711
Secondary accession number(s): Q9TQT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: March 16, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.