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Protein

Erythropoietin

Gene

EPO

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:EPO
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 192166ErythropoietinPRO_0000008399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 187By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi55 ↔ 59By similarity
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000006359.

Structurei

3D structure databases

ProteinModelPortaliP33708.
SMRiP33708. Positions 27-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP33708.
KOiK05437.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCECPALL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILGAREAEN
60 70 80 90 100
VTMGCAEGCS FSENITVPDT KVNFYTWKRM DVGQQAVEVW QGLALLSEAI
110 120 130 140 150
LRGQALLANS SQPSETLQLH VDKAVSSLRS LTSLLRALGA QKEATSLPEA
160 170 180 190
TSAAPLRTFT VDTLCKLFRI YSNFLRGKLT LYTGEACRRG DR
Length:192
Mass (Da):20,914
Last modified:October 1, 1996 - v2
Checksum:i61C5EA0F5E937293
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → E in AAA30807 (PubMed:8364201).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00685 mRNA. Translation: AAA18282.1.
L10606 mRNA. Translation: AAA30807.1.
PIRiI46083.
RefSeqiNP_001009269.1. NM_001009269.1.

Genome annotation databases

GeneIDi493801.
KEGGifca:493801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00685 mRNA. Translation: AAA18282.1.
L10606 mRNA. Translation: AAA30807.1.
PIRiI46083.
RefSeqiNP_001009269.1. NM_001009269.1.

3D structure databases

ProteinModelPortaliP33708.
SMRiP33708. Positions 27-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000006359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493801.
KEGGifca:493801.

Organism-specific databases

CTDi2056.

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP33708.
KOiK05437.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A feline erythropoietin cDNA, cloned by RT/PCR amplification of kidney derived RNA with hybrid (human/mouse) primers."
    Goodman R.E., Bell R.G.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Erythropoietin structure-function relationships: high degree of sequence homology among mammals."
    Wen D., Boissel J.-P.R., Tracy T.E., Gruninger R.H., Mulcahy L.S., Czelusniak J., Goodman M., Bunn H.F.
    Blood 82:1507-1516(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-192.

Entry informationi

Entry nameiEPO_FELCA
AccessioniPrimary (citable) accession number: P33708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: December 9, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.