P33704 (ATP4B_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium-transporting ATPase subunit beta

Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain

Gene names

Name:

ATP4B

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Composed of two subunits: alpha (catalytic) and beta.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro proton transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Potassium-transporting ATPase subunit beta		PRO_0000219090
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 57	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	58 – 290	233	Extracellular Potential
Amino acid modifications
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	130	1	N-linked (GlcNAc...) Potential
	Glycosylation	146	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	221	1	N-linked (GlcNAc...) Potential
	Disulfide bond	131 ↔ 152		By similarity
	Disulfide bond	162 ↔ 178		By similarity
	Disulfide bond	201 ↔ 262		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P33704 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 51B9548362A94FC6	FASTA	290	33,481
	10 20 30 40 50 60 MAALQEKKSC SQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGIFALCIY 70 80 90 100 110 120 TLMCTLDPYT PDYQDQLKSP GVTLRPDVYG EKGLDISYNV SDNRTWVDLV NILHNFLEGY 130 140 150 160 170 180 SPTSQEDNIN CTSEKYFFQD VFGAPNHTKF SCKFMADMLQ NCSGLTDPNF GFAEGKPCFI 190 200 210 220 230 240 IKMNRIVNFL PSNSTAPRAD CTFLDQHKDD RPLQVEYYPP NGTFSLRYFP YYGKKAQPHY 250 260 270 280 290 SNPLVAAKLL NVPRNTEVLI VCKILADYVT FDNPHDPYEG KVEFKLTIQQ

References

[1]	"Molecular cloning and structural analysis of canine gastric H+,K(+)-ATPase." Song I., Mortell M.P., Gantz I., Brown D.R., Yamada T. Biochem. Biophys. Res. Commun. 196:1240-1247(1993) [PubMed: 8250881] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Stomach.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76486 mRNA. Translation: AAA16895.1.
PIR	JN0904.
RefSeq	NP_001003328.1. NM_001003328.1.
UniGene	Cfa.3897.
3D structure databases
ProteinModelPortal	P33704.
ModBase	Search...
Protein-protein interaction databases
STRING	P33704.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	404020.
KEGG	cfa:404020.
Organism-specific databases
CTD	496.
Phylogenomic databases
eggNOG	maNOG14696.
GeneTree	ENSGT00550000074530.
HOVERGEN	HBG050603.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01543.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP4B_CANFA

Accession

Primary (citable) accession number: P33704

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 16, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program