P33690 (COMQ_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Competence regulatory protein ComQ

Gene names

Name:	comQ
Ordered Locus Names:	BSU31710

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Involved in the maturation of ComX, part of a major quorum-sensing system that regulates the development of genetic competence. Ref.5
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Miscellaneous	The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus.

Ontologies

Keywords
Biological process	Competence
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	establishment of competence for transformation Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Competence regulatory protein ComQ		PRO_0000090014
Regions
	Transmembrane	148 – 168	21	Helical; Potential
Experimental info
	Sequence conflict	34	1	T → S in AAA22323. Ref.1
	Sequence conflict	34	1	T → S in CAB07902. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P33690 [UniParc]. Last modified July 7, 2009. Version 2. Checksum: FC8300C47D8790F8	FASTA	299	34,218
	10 20 30 40 50 60 MKEIVEQNIF NEDLSQLLYS FIDSKETFSF AESTILHYVV FGGENLDVAT RLGAGIEILI 70 80 90 100 110 120 LSSDIMDDLE DEDNHHALWM KINRSESLNA ALSLYTVGLT SIYSLNNNPL IFKYVLKYVN 130 140 150 160 170 180 EAMQGQHDDI TNKSKTEDES LEVIRLKCGS LIALANVAGV LLATGEYNET VERYSYYKGI 190 200 210 220 230 240 IAQISGDYYV LLSGNRSDIE KNKHTLIYLY LKRLFNDASE DLLYLISHKD LYYKSLLDKE 250 260 270 280 290 KFQEKLIKAG VTQYISVLLE IYKQKCISAI EQLNLDKEKK ELIKECLLSY TKGDTRCKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilis." Weinrauch Y., Msadek T., Kunst F., Dubnau D. J. Bacteriol. 173:5685-5693(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai)." Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H., Duesterhoeft A., Pohl T.M., Weitzenegger T. Microbiology 143:2769-2774(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 34.
[5]	"Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system." Tortosa P., Logsdon L., Kraigher B., Itoh Y., Mandic-Mulec I., Dubnau D. J. Bacteriol. 183:451-460(2001) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM IN COMX; COMQ AND COMP, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M71283 Genomic DNA. Translation: AAA22323.1. Z93932 Genomic DNA. Translation: CAB07902.1. AL009126 Genomic DNA. Translation: CAB15159.2.
PIR	A38111.
RefSeq	NP_391049.2. NC_000964.3.
3D structure databases
ProteinModelPortal	P33690.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU31710.
Proteomic databases
PaxDb	P33690.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB15159; CAB15159; BSU31710.
GeneID	937180.
KEGG	bsu:BSU31710.
PATRIC	18978312. VBIBacSub10457_3319.
Organism-specific databases
GenoList	BSU31710. [Micado]
Phylogenomic databases
eggNOG	COG0142.
HOGENOM	HOG000246977.
KO	K02251.
ProtClustDB	CLSK887806.
Enzyme and pathway databases
BioCyc	BSUB:BSU31710-MONOMER.
Family and domain databases
Gene3D	1.10.600.10. 1 hit.
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
PANTHER	PTHR12001. PTHR12001. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
SUPFAM	SSF48576. Terpenoid_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMQ_BACSU

Accession

Primary (citable) accession number: P33690

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program