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P33690

- COMQ_BACSU

UniProt

P33690 - COMQ_BACSU

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Protein

Competence regulatory protein ComQ

Gene

comQ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Involved in the maturation of ComX, part of a major quorum-sensing system that regulates the development of genetic competence.1 Publication

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
  2. isoprenoid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Competence

Enzyme and pathway databases

BioCyciBSUB:BSU31710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Competence regulatory protein ComQ
Gene namesi
Name:comQ
Ordered Locus Names:BSU31710
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU31710. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Competence regulatory protein ComQPRO_0000090014Add
BLAST

Proteomic databases

PaxDbiP33690.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU31710.

Structurei

3D structure databases

ProteinModelPortaliP33690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0142.
HOGENOMiHOG000246977.
KOiK02251.
OrthoDBiEOG64BQ3Q.

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
PANTHERiPTHR12001. PTHR12001. 1 hit.
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.

Sequencei

Sequence statusi: Complete.

P33690-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEIVEQNIF NEDLSQLLYS FIDSKETFSF AESTILHYVV FGGENLDVAT
60 70 80 90 100
RLGAGIEILI LSSDIMDDLE DEDNHHALWM KINRSESLNA ALSLYTVGLT
110 120 130 140 150
SIYSLNNNPL IFKYVLKYVN EAMQGQHDDI TNKSKTEDES LEVIRLKCGS
160 170 180 190 200
LIALANVAGV LLATGEYNET VERYSYYKGI IAQISGDYYV LLSGNRSDIE
210 220 230 240 250
KNKHTLIYLY LKRLFNDASE DLLYLISHKD LYYKSLLDKE KFQEKLIKAG
260 270 280 290
VTQYISVLLE IYKQKCISAI EQLNLDKEKK ELIKECLLSY TKGDTRCKT
Length:299
Mass (Da):34,218
Last modified:July 7, 2009 - v2
Checksum:iFC8300C47D8790F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341T → S in AAA22323. (PubMed:1715859)Curated
Sequence conflicti34 – 341T → S in CAB07902. (PubMed:9274030)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M71283 Genomic DNA. Translation: AAA22323.1.
Z93932 Genomic DNA. Translation: CAB07902.1.
AL009126 Genomic DNA. Translation: CAB15159.2.
PIRiA38111.
RefSeqiNP_391049.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB15159; CAB15159; BSU31710.
GeneIDi937180.
KEGGibsu:BSU31710.
PATRICi18978312. VBIBacSub10457_3319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M71283 Genomic DNA. Translation: AAA22323.1 .
Z93932 Genomic DNA. Translation: CAB07902.1 .
AL009126 Genomic DNA. Translation: CAB15159.2 .
PIRi A38111.
RefSeqi NP_391049.2. NC_000964.3.

3D structure databases

ProteinModelPortali P33690.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU31710.

Proteomic databases

PaxDbi P33690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB15159 ; CAB15159 ; BSU31710 .
GeneIDi 937180.
KEGGi bsu:BSU31710.
PATRICi 18978312. VBIBacSub10457_3319.

Organism-specific databases

GenoListi BSU31710. [Micado ]

Phylogenomic databases

eggNOGi COG0142.
HOGENOMi HOG000246977.
KOi K02251.
OrthoDBi EOG64BQ3Q.

Enzyme and pathway databases

BioCyci BSUB:BSU31710-MONOMER.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view ]
PANTHERi PTHR12001. PTHR12001. 1 hit.
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilis."
    Weinrauch Y., Msadek T., Kunst F., Dubnau D.
    J. Bacteriol. 173:5685-5693(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai)."
    Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., Hilbert H., Duesterhoeft A., Pohl T.M., Weitzenegger T.
    Microbiology 143:2769-2774(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 34.
  5. "Specificity and genetic polymorphism of the Bacillus competence quorum-sensing system."
    Tortosa P., Logsdon L., Kraigher B., Itoh Y., Mandic-Mulec I., Dubnau D.
    J. Bacteriol. 183:451-460(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM IN COMX; COMQ AND COMP, FUNCTION.

Entry informationi

Entry nameiCOMQ_BACSU
AccessioniPrimary (citable) accession number: P33690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The DNA sequences encoding comQ, comX and the N-terminal two-thirds of comP show a striking polymorphism, which determines the specificity of the quorum-sensing system in the different pherotypes of Bacillus.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

External Data

Dasty 3