P33685 (LACB1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-lactoglobulin-1
Short name=Beta-LG-1

Alternative name(s):
Beta-lactoglobulin I

Gene names

Name:

LGB1

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Synthesized in mammary gland and secreted in milk.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Secreted
Ligand	Retinol-binding
Molecular function	Milk protein
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	retinol binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Beta-lactoglobulin-1		PRO_0000201013
Amino acid modifications
	Disulfide bond	66 ↔ 159		By similarity
	Disulfide bond	106 ↔ 119		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P33685 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: BB775CC5F54332E6	FASTA	161	18,567
	10 20 30 40 50 60 IVVPRTMEDL DLQKVAGTWH SMAMAASDIS LLDSETAPLR VYIQELRPTP QDNLEIVLRK 70 80 90 100 110 120 WEDGRCAEQK VLAEKTEVPA EFKINYVEEN QIFLLDTDYD NYLFFCEMNA DAPQQSLMCQ 130 140 150 160 CLARTLEVDN EVMEKFNRAL KTLPVHMQLL NPTQAEEQCL I

References

[1]	"Feline beta-lactoglobulins I, II and III, and canine beta-lactoglobulins I and II: amino acid sequences provide evidence for the existence of more than one gene for beta-lactoglobulin in the cat and dog." Halliday J.A., Bell K., McAndrew K., Shaw D.C. Protein Seq. Data Anal. 5:201-205(1993) Cited for: PROTEIN SEQUENCE.
[2]	"Purification and characterization of the major whey proteins from the milks of the bottlenose dolphin (Tursiops truncatus), the Florida manatee (Trichechus manatus latirostris), and the beagle (Canis familiaris)." Pervaiz S., Brew K. Arch. Biochem. Biophys. 246:846-854(1986) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF N-TERMINUS, CHARACTERIZATION. Strain: Beagle.

Cross-references

Sequence databases
PIR	S33877.
3D structure databases
ProteinModelPortal	P33685.
SMR	P33685. Positions 1-161.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG73754.
HOGENOM	HOG000113272.
HOVERGEN	HBG104361.
OrthoDB	EOG4PNXJ2.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR002447. Blactoglobulin. IPR012674. Calycin. IPR011038. Calycin-like. IPR002345. Lipocalin. IPR022272. Lipocalin_CS. IPR000566. Lipocln_cytosolic_FA-bd_dom. [Graphical view]
PANTHER	PTHR11430:SF18. PTHR11430:SF18. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR01172. BLCTOGLOBULN. PR00179. LIPOCALIN.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LACB1_CANFA

Accession

Primary (citable) accession number: P33685

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program