Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pancreatic hormone

Gene

PPY

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic hormone
Short name:
PH
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Gene namesi
Name:PPY
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3636Pancreatic hormonePRO_0000044800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei36 – 361Tyrosine amideBy similarity

Keywords - PTMi

Amidation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000004281.

Structurei

3D structure databases

ProteinModelPortaliP33684.
SMRiP33684. Positions 1-36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG096195.
InParanoidiP33684.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
APLEPVYPGD NATPEQMAQY AADLRRYINM LTRPRY
Length:36
Mass (Da):4,183
Last modified:February 1, 1994 - v1
Checksum:i761B717671A7758F
GO

Sequence databases

PIRiC60071.

Cross-referencesi

Sequence databases

PIRiC60071.

3D structure databases

ProteinModelPortaliP33684.
SMRiP33684. Positions 1-36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000004281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG096195.
InParanoidiP33684.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rhesus monkey gastroenteropancreatic hormones: relationship to human sequences."
    Yu J.-H., Xin Y., Eng J., Yalow R.S.
    Regul. Pept. 32:39-45(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiPAHO_MACMU
AccessioniPrimary (citable) accession number: P33684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.