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P33682

- GUN1_STRHA

UniProt

P33682 - GUN1_STRHA

Protein

Endoglucanase 1

Gene

celA1

Organism
Streptomyces halstedii
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Implicated in the mechanism of induction exerted by cellobiose.

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101By similarity
    Active sitei149 – 1491Proton donorPROSITE-ProRule annotation
    Active sitei295 – 2951NucleophileBy similarity

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH6. Glycoside Hydrolase Family 6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase 1 (EC:3.2.1.4)
    Alternative name(s):
    CEL1
    CMCase I
    Cellulase I
    Endo-1,4-beta-glucanase 1
    Gene namesi
    Name:celA1
    OrganismiStreptomyces halstedii
    Taxonomic identifieri1944 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 321294Endoglucanase 1PRO_0000007906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi112 ↔ 156By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP33682.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.20.20.40. 1 hit.
    InterProiIPR016288. Beta_cellobiohydrolase.
    IPR001524. Glyco_hydro_6_CS.
    [Graphical view]
    PfamiPF01341. Glyco_hydro_6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
    PRINTSiPR00733. GLHYDRLASE6.
    SUPFAMiSSF51989. SSF51989. 1 hit.
    PROSITEiPS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33682-1 [UniParc]FASTAAdd to Basket

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    MSRKLRTLMA ALCALPLAFA AAPPAHAADP TTMTNGFYAD PDSSASRWAA    50
    ANPGDGRAAA INASIANTPM ARWFGSWSGA IGTAAGAYAG AADGRDKLPI 100
    LVAYNIYNRD YCGGHSAGGA ASPSAYADWI ARFAGGIAAR PAVVILEPDS 150
    LGDYGCMNPA QIDEREAMLT NALVQFNRQA PNTWVYMDAG NPRWADAATM 200
    ARRLHEAGLR QAHGFSLNVS NYITTAENTA YGNAVNNELA ARYGYTKPFV 250
    VDTSRNGNGS NGEWCNPSGR RIGTPTRTGG GAEMLLWIKT PGESDGNCGV 300
    GSGSTAGQFL PEVAYKMIYG Y 321
    Length:321
    Mass (Da):33,695
    Last modified:June 1, 1994 - v2
    Checksum:iDC5E39EF3CCD114C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12157 Genomic DNA. Translation: CAA78145.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12157 Genomic DNA. Translation: CAA78145.1 .

    3D structure databases

    ProteinModelPortali P33682.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH6. Glycoside Hydrolase Family 6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.40. 1 hit.
    InterProi IPR016288. Beta_cellobiohydrolase.
    IPR001524. Glyco_hydro_6_CS.
    [Graphical view ]
    Pfami PF01341. Glyco_hydro_6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001100. Beta_cellobiohydrolase. 1 hit.
    PRINTSi PR00733. GLHYDRLASE6.
    SUPFAMi SSF51989. SSF51989. 1 hit.
    PROSITEi PS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of celA1, and endo-beta-1,4-glucanase-encoding gene from Streptomyces halstedii JM8."
      Fernandez-Abalos J.M., Sanchez P., Coll-Fresno P.M., Villanueva J.R., Perez P., Santamaria R.I.
      J. Bacteriol. 174:6368-6376(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 28-33.
      Strain: JM8 / CECT3310.

    Entry informationi

    Entry nameiGUN1_STRHA
    AccessioniPrimary (citable) accession number: P33682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-9 is the initiator.Curated

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3