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Protein

Endoglucanase 1

Gene

celA1

Organism
Streptomyces halstedii
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in the mechanism of induction exerted by cellobiose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei110By similarity1
Active sitei149Proton donorPROSITE-ProRule annotation1
Active sitei295NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH6. Glycoside Hydrolase Family 6.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase 1 (EC:3.2.1.4)
Alternative name(s):
CEL1
CMCase I
Cellulase I
Endo-1,4-beta-glucanase 1
Gene namesi
Name:celA1
OrganismiStreptomyces halstedii
Taxonomic identifieri1944 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000790628 – 321Endoglucanase 1Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi112 ↔ 156By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP33682.

Structurei

3D structure databases

ProteinModelPortaliP33682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiIPR016288. Beta_cellobiohydrolase.
IPR001524. Glyco_hydro_6_CS.
[Graphical view]
PfamiPF01341. Glyco_hydro_6. 1 hit.
[Graphical view]
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.
PROSITEiPS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKLRTLMA ALCALPLAFA AAPPAHAADP TTMTNGFYAD PDSSASRWAA
60 70 80 90 100
ANPGDGRAAA INASIANTPM ARWFGSWSGA IGTAAGAYAG AADGRDKLPI
110 120 130 140 150
LVAYNIYNRD YCGGHSAGGA ASPSAYADWI ARFAGGIAAR PAVVILEPDS
160 170 180 190 200
LGDYGCMNPA QIDEREAMLT NALVQFNRQA PNTWVYMDAG NPRWADAATM
210 220 230 240 250
ARRLHEAGLR QAHGFSLNVS NYITTAENTA YGNAVNNELA ARYGYTKPFV
260 270 280 290 300
VDTSRNGNGS NGEWCNPSGR RIGTPTRTGG GAEMLLWIKT PGESDGNCGV
310 320
GSGSTAGQFL PEVAYKMIYG Y
Length:321
Mass (Da):33,695
Last modified:June 1, 1994 - v2
Checksum:iDC5E39EF3CCD114C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12157 Genomic DNA. Translation: CAA78145.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12157 Genomic DNA. Translation: CAA78145.1.

3D structure databases

ProteinModelPortaliP33682.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH6. Glycoside Hydrolase Family 6.

Proteomic databases

PRIDEiP33682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.40. 1 hit.
InterProiIPR016288. Beta_cellobiohydrolase.
IPR001524. Glyco_hydro_6_CS.
[Graphical view]
PfamiPF01341. Glyco_hydro_6. 1 hit.
[Graphical view]
PIRSFiPIRSF001100. Beta_cellobiohydrolase. 1 hit.
PRINTSiPR00733. GLHYDRLASE6.
SUPFAMiSSF51989. SSF51989. 1 hit.
PROSITEiPS00656. GLYCOSYL_HYDROL_F6_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUN1_STRHA
AccessioniPrimary (citable) accession number: P33682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: October 5, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.