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Protein

Guanylin

Gene

Guca2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Gene namesi
Name:Guca2a
Synonyms:Guca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:102738 Guca2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000001313724 – 101Add BLAST78
PeptideiPRO_0000013138102 – 116GuanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 83By similarity
Disulfide bondi105 ↔ 113By similarity
Disulfide bondi108 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33680
PeptideAtlasiP33680
PRIDEiP33680

Expressioni

Tissue specificityi

Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon.

Gene expression databases

BgeeiENSMUSG00000023247
CleanExiMM_GUCA2A
GenevisibleiP33680 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024015

Structurei

3D structure databases

ProteinModelPortaliP33680
SMRiP33680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111358
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiP33680
OMAiICANPSC
OrthoDBiEOG091G0WKF
PhylomeDBiP33680
TreeFamiTF330731

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNACVLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKKLK GLREVQEPRL
60 70 80 90 100
VSHKKFAPRL LQPVAPQLCS SHSALPEALR PVCEKPNAEE ILQRLEAIAQ
110
DPNTCEICAY AACTGC
Length:116
Mass (Da):12,467
Last modified:February 1, 1994 - v1
Checksum:i272E0D87C20869C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95175 mRNA Translation: AAA37758.1
L05516 mRNA Translation: AAA37715.1
U60528 Genomic DNA Translation: AAB05758.1
AK075814 mRNA Translation: BAC35981.1
BC012640 mRNA Translation: AAH12640.1
CCDSiCCDS18586.1
PIRiA55643 B46279
RefSeqiNP_032216.1, NM_008190.1
UniGeneiMm.2614

Genome annotation databases

EnsembliENSMUST00000024015; ENSMUSP00000024015; ENSMUSG00000023247
GeneIDi14915
KEGGimmu:14915
UCSCiuc008umv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGUC2A_MOUSE
AccessioniPrimary (citable) accession number: P33680
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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