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Protein

Guanylin

Gene

Guca2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Gene namesi
Name:Guca2a
Synonyms:Guca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:102738. Guca2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 10178PRO_0000013137Add
BLAST
Peptidei102 – 11615GuanylinPRO_0000013138Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 83By similarity
Disulfide bondi105 ↔ 113By similarity
Disulfide bondi108 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP33680.
PeptideAtlasiP33680.
PRIDEiP33680.

Expressioni

Tissue specificityi

Localized in both crypts and villi in the small intestine and to superficial epithelial cells in the colon.

Gene expression databases

BgeeiP33680.
CleanExiMM_GUCA2A.
GenevisibleiP33680. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024015.

Structurei

3D structure databases

ProteinModelPortaliP33680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP33680.
OMAiSCEICAF.
OrthoDBiEOG78PVCN.
PhylomeDBiP33680.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNACVLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKKLK GLREVQEPRL
60 70 80 90 100
VSHKKFAPRL LQPVAPQLCS SHSALPEALR PVCEKPNAEE ILQRLEAIAQ
110
DPNTCEICAY AACTGC
Length:116
Mass (Da):12,467
Last modified:February 1, 1994 - v1
Checksum:i272E0D87C20869C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95175 mRNA. Translation: AAA37758.1.
L05516 mRNA. Translation: AAA37715.1.
U60528 Genomic DNA. Translation: AAB05758.1.
AK075814 mRNA. Translation: BAC35981.1.
BC012640 mRNA. Translation: AAH12640.1.
CCDSiCCDS18586.1.
PIRiA55643. B46279.
RefSeqiNP_032216.1. NM_008190.1.
UniGeneiMm.2614.

Genome annotation databases

EnsembliENSMUST00000024015; ENSMUSP00000024015; ENSMUSG00000023247.
GeneIDi14915.
KEGGimmu:14915.
UCSCiuc008umv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95175 mRNA. Translation: AAA37758.1.
L05516 mRNA. Translation: AAA37715.1.
U60528 Genomic DNA. Translation: AAB05758.1.
AK075814 mRNA. Translation: BAC35981.1.
BC012640 mRNA. Translation: AAH12640.1.
CCDSiCCDS18586.1.
PIRiA55643. B46279.
RefSeqiNP_032216.1. NM_008190.1.
UniGeneiMm.2614.

3D structure databases

ProteinModelPortaliP33680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024015.

Proteomic databases

PaxDbiP33680.
PeptideAtlasiP33680.
PRIDEiP33680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024015; ENSMUSP00000024015; ENSMUSG00000023247.
GeneIDi14915.
KEGGimmu:14915.
UCSCiuc008umv.1. mouse.

Organism-specific databases

CTDi2980.
MGIiMGI:102738. Guca2a.

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP33680.
OMAiSCEICAF.
OrthoDBiEOG78PVCN.
PhylomeDBiP33680.
TreeFamiTF330731.

Miscellaneous databases

PROiP33680.
SOURCEiSearch...

Gene expression databases

BgeeiP33680.
CleanExiMM_GUCA2A.
GenevisibleiP33680. MM.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Precursor structure, expression, and tissue distribution of human guanylin."
    de Sauvage F.J., Keshav S., Kuang W.J., Gillett N., Henzel W., Goeddel D.V.
    Proc. Natl. Acad. Sci. U.S.A. 89:9089-9093(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  2. "Cloning of precursor cDNA for guanylin: an endogenous activator of intestinal guanylate cyclase."
    Kato J., Wiegand R.C., Currie M.G.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Genomic sequence of the murine guanylin gene."
    Sciaky D., Kosiba J.L., Cohen M.B.
    Genomics 24:583-587(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Small intestine.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiGUC2A_MOUSE
AccessioniPrimary (citable) accession number: P33680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.