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P33677

- FDH_PICAN

UniProt

P33677 - FDH_PICAN

Protein

Formate dehydrogenase

Gene

FMDH

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei258 – 2581By similarity
    Binding sitei282 – 2821NADBy similarity
    Active sitei311 – 3111Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 1752NADBy similarity
    Nucleotide bindingi256 – 2583NADBy similarity
    Nucleotide bindingi311 – 3144NADBy similarity

    GO - Molecular functioni

    1. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase (EC:1.2.1.2)
    Alternative name(s):
    NAD-dependent formate dehydrogenase
    Short name:
    FDH
    Gene namesi
    Name:FMDH
    OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
    Taxonomic identifieri870730 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedCurated
    Chaini2 – 362361Formate dehydrogenasePRO_0000076025Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP33677.
    SMRiP33677. Positions 2-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33677-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVVLVLYDA GKHAQDEERL YGCTENALGI RDWLEKQGHD VVVTSDKEGQ    50
    NSVLEKNISD ADVIISTPFH PAYITKERID KAKKLKLLVV AGVGSDHIDL 100
    DYINQSGRDI SVLEVTGSNV VSVAEHVVMT MLVLVRNFVP AHEQIISGGW 150
    NVAEIAKDSF DIEGKVIATI GAGRIGYRVL ERLVAFNPKE LLYYDYQSLS 200
    KEAEEKVGAR RVHDIKELVA QADIVTINCP LHAGSKGLVN AELLKHFKKG 250
    AWLVNTARGA ICVAEDVAAA VKSGQLRGYG GDVWFPQPAP KDHPWRSMAN 300
    KYGAGNAMTP HYSGSVIDAQ VRYAQGTKNI LESFFTQKFD YRPQDIILLN 350
    GKYKTKSYGA DK 362
    Length:362
    Mass (Da):39,911
    Last modified:January 23, 2007 - v2
    Checksum:i0037BFD132FC055B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    A06214 Unassigned DNA. Translation: CAA00531.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    A06214 Unassigned DNA. Translation: CAA00531.1 .

    3D structure databases

    ProteinModelPortali P33677.
    SMRi P33677. Positions 2-353.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA-molecules coding for FMDH control regions and structured gene for a protein having FMDH-activity and their uses."
      Hollenberg C.P., Janowicz Z.
      Patent number EP0299108, 18-JAN-1989
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

    Entry informationi

    Entry nameiFDH_PICAN
    AccessioniPrimary (citable) accession number: P33677
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3