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P33677 (FDH_PICAN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate dehydrogenase

EC=1.2.1.2
Alternative name(s):
NAD-dependent formate dehydrogenase
Short name=FDH
Gene names
Name:FMDH
OrganismPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifier870730 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Probable
Chain2 – 362361Formate dehydrogenase
PRO_0000076025

Regions

Nucleotide binding174 – 1752NAD By similarity
Nucleotide binding256 – 2583NAD By similarity
Nucleotide binding311 – 3144NAD By similarity

Sites

Active site2581 By similarity
Active site3111Proton donor By similarity
Binding site2821NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P33677 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 0037BFD132FC055B

FASTA36239,911
        10         20         30         40         50         60 
MKVVLVLYDA GKHAQDEERL YGCTENALGI RDWLEKQGHD VVVTSDKEGQ NSVLEKNISD 

        70         80         90        100        110        120 
ADVIISTPFH PAYITKERID KAKKLKLLVV AGVGSDHIDL DYINQSGRDI SVLEVTGSNV 

       130        140        150        160        170        180 
VSVAEHVVMT MLVLVRNFVP AHEQIISGGW NVAEIAKDSF DIEGKVIATI GAGRIGYRVL 

       190        200        210        220        230        240 
ERLVAFNPKE LLYYDYQSLS KEAEEKVGAR RVHDIKELVA QADIVTINCP LHAGSKGLVN 

       250        260        270        280        290        300 
AELLKHFKKG AWLVNTARGA ICVAEDVAAA VKSGQLRGYG GDVWFPQPAP KDHPWRSMAN 

       310        320        330        340        350        360 
KYGAGNAMTP HYSGSVIDAQ VRYAQGTKNI LESFFTQKFD YRPQDIILLN GKYKTKSYGA 


DK 

« Hide

References

[1]"DNA-molecules coding for FMDH control regions and structured gene for a protein having FMDH-activity and their uses."
Hollenberg C.P., Janowicz Z.
Patent number EP0299108, 18-JAN-1989
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
A06214 Unassigned DNA. Translation: CAA00531.1.

3D structure databases

ProteinModelPortalP33677.
SMRP33677. Positions 2-353.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDH_PICAN
AccessionPrimary (citable) accession number: P33677
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families