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Protein

Chitosanase

Gene

csn

Organism
Bacillus circulans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.

Catalytic activityi

Endohydrolysis of beta-(1->4)-linkages between D-glucosamine residues in a partly acetylated chitosan.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton donorPROSITE-ProRule annotation1
Active sitei97NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17652
BRENDAi3.2.1.132 649

Protein family/group databases

CAZyiGH46 Glycoside Hydrolase Family 46

Names & Taxonomyi

Protein namesi
Recommended name:
Chitosanase (EC:3.2.1.132)
Gene namesi
Name:csn
OrganismiBacillus circulans
Taxonomic identifieri1397 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

DrugBankiDB01296 Glucosamine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Add BLAST42
ChainiPRO_000001220643 – 301ChitosanaseAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi92 ↔ 166

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP33673

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 48Combined sources4
Helixi51 – 61Combined sources11
Helixi65 – 80Combined sources16
Beta strandi81 – 83Combined sources3
Helixi85 – 88Combined sources4
Beta strandi96 – 99Combined sources4
Turni104 – 107Combined sources4
Beta strandi115 – 117Combined sources3
Helixi120 – 130Combined sources11
Helixi138 – 144Combined sources7
Beta strandi149 – 152Combined sources4
Beta strandi155 – 158Combined sources4
Helixi162 – 170Combined sources9
Turni171 – 174Combined sources4
Helixi176 – 189Combined sources14
Helixi191 – 200Combined sources10
Helixi206 – 219Combined sources14
Beta strandi221 – 224Combined sources4
Helixi228 – 234Combined sources7
Helixi241 – 253Combined sources13
Turni254 – 257Combined sources4
Turni259 – 261Combined sources3
Helixi266 – 280Combined sources15
Helixi289 – 295Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QGIX-ray1.60A43-301[»]
2D05X-ray2.00A43-301[»]
5HWAX-ray1.35A43-301[»]
ProteinModelPortaliP33673
SMRiP33673
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33673

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 46 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01233

Family and domain databases

CDDicd00978 chitosanase_glyco_hydro_46, 1 hit
Gene3Di3.30.386.10, 1 hit
InterProiView protein in InterPro
IPR000400 Glyco_hydro_46
IPR023099 Glyco_hydro_46_N
IPR023346 Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF01374 Glyco_hydro_46, 1 hit
PIRSFiPIRSF036551 Chitosanase, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS60000 CHITOSANASE_46_80, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHMSNARPSK SRTKFLLAFL CFTLMASLFG ATALFGPSKA AAASPDDNFS
60 70 80 90 100
PETLQFLRNN TGLDGEQWNN IMKLINKPEQ DDLNWIKYYG YCEDIEDERG
110 120 130 140 150
YTIGLFGATT GGSRDTHPDG PDLFKAYDAA KGASNPSADG ALKRLGINGK
160 170 180 190 200
MKGSILEIKD SEKVFCGKIK KLQNDAAWRK AMWETFYNVY IRYSVEQARQ
210 220 230 240 250
RGFTSAVTIG SFVDTALNQG ATGGSDTLQG LLARSGSSSN EKTFMKNFHA
260 270 280 290 300
KRTLVVDTNK YNKPPNGKNR VKQWDTLVDM GKMNLKNVDS EIAQVTDWEM

K
Length:301
Mass (Da):33,426
Last modified:March 1, 2004 - v2
Checksum:i5B67FB8FF1D1F763
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10624 Genomic DNA Translation: BAA01474.2

Genome annotation databases

KEGGiag:BAA01474

Similar proteinsi

Entry informationi

Entry nameiCHIS_BACCI
AccessioniPrimary (citable) accession number: P33673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 1, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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