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Protein

Syndecan-3

Gene

Sdc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: RGD
  • regulation of cell migration Source: CACAO
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-3
Short name:
SYND3
Alternative name(s):
N-syndecan
Neuroglycan
Gene namesi
Name:Sdc3
Synonyms:Synd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621486. Sdc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 387343ExtracellularSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 44234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • cell surface Source: GO_Central
  • integral component of membrane Source: RGD
  • membrane Source: UniProtKB
  • neuron projection Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence analysisAdd
BLAST
Chaini45 – 442398Syndecan-3PRO_0000033509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi80 – 801O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi82 – 821O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi89 – 891O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi315 – 3151O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi367 – 3671O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Modified residuei409 – 4091PhosphotyrosineBy similarity
Modified residuei419 – 4191PhosphotyrosineBy similarity
Modified residuei431 – 4311PhosphotyrosineBy similarity
Modified residuei441 – 4411PhosphotyrosineBy similarity

Post-translational modificationi

O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei383 – 3842Cleavage of ectodomainSequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP33671.

PTM databases

iPTMnetiP33671.
PhosphoSiteiP33671.

Expressioni

Tissue specificityi

High levels in neonatal brain, heart, and Schwann cells, barely detectable in neonatal or adult liver, or adult brain.

Developmental stagei

Higher levels in developing tissues.

Interactioni

Subunit structurei

Interacts with TIAM1.By similarity

Protein-protein interaction databases

BioGridi250556. 2 interactions.
IntActiP33671. 3 interactions.
STRINGi10116.ENSRNOP00000041634.

Structurei

3D structure databases

ProteinModelPortaliP33671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi114 – 302189Ser/Thr-rich (mucin-like)Add
BLAST

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ0. Eukaryota.
ENOG410Y2QY. LUCA.
HOGENOMiHOG000049151.
HOVERGENiHBG004144.
InParanoidiP33671.
KOiK16337.
PhylomeDBiP33671.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031194. Syndecan-3.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 2 hits.
PTHR10915:SF7. PTHR10915:SF7. 2 hits.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPGPPRRGT AQGQRVDTAT HGPGARGLLL PPLLLLLLAG RAAGAQRWRN
60 70 80 90 100
ENFERPVDLE GSGDDDSFPD DELDDLYSGS GSGYFEQESG LETAMRFIPD
110 120 130 140 150
IALAAPTAPA MLPTTVIQPV DTPFEELLSE HPGPEPVTSP PLVTEVTEVV
160 170 180 190 200
EEPSQRATTI STTTSTTAAT TTGAPTMATA PATAATTAPS TPAAPPATAT
210 220 230 240 250
TADIRTTGIQ GLLPLPLTTA ATAKATTPAV PSPPTTVTTL DTEAPTPRLV
260 270 280 290 300
NTATSRPRAL PRPVTTQEPE VAERSTLPLG TTAPGPTEVA QTPTPESLLT
310 320 330 340 350
TTQDEPEVPV SGGPSGDFEL QEETTQPDTA NEVVAVEGAA AKPSPPLGTL
360 370 380 390 400
PKGARPGLGL HDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA
410 420 430 440
AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA
Length:442
Mass (Da):45,919
Last modified:November 1, 1997 - v3
Checksum:i4842C8BEAA0A338C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141Q → E in AAB03284 (Ref. 1) Curated
Sequence conflicti87 – 871Q → E in AAB03284 (Ref. 1) Curated
Sequence conflicti90 – 912GL → LR (PubMed:1556152).Curated
Sequence conflicti176 – 1761T → S (Ref. 1) Curated
Sequence conflicti178 – 1781A → D (Ref. 1) Curated
Sequence conflicti184 – 1841A → G in AAB03284 (Ref. 1) Curated
Sequence conflicti238 – 2381T → S in AAB03284 (Ref. 1) Curated
Sequence conflicti270 – 2701E → V in AAB03284 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52825 mRNA. Translation: AAB03284.1.
U73184 mRNA. Translation: AAB18192.1.
X63143 mRNA. Translation: CAA44848.1.
PIRiA41558.
RefSeqiNP_446345.3. NM_053893.3.
UniGeneiRn.10504.

Genome annotation databases

GeneIDi116673.
KEGGirno:116673.
UCSCiRGD:621486. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52825 mRNA. Translation: AAB03284.1.
U73184 mRNA. Translation: AAB18192.1.
X63143 mRNA. Translation: CAA44848.1.
PIRiA41558.
RefSeqiNP_446345.3. NM_053893.3.
UniGeneiRn.10504.

3D structure databases

ProteinModelPortaliP33671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250556. 2 interactions.
IntActiP33671. 3 interactions.
STRINGi10116.ENSRNOP00000041634.

PTM databases

iPTMnetiP33671.
PhosphoSiteiP33671.

Proteomic databases

PaxDbiP33671.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116673.
KEGGirno:116673.
UCSCiRGD:621486. rat.

Organism-specific databases

CTDi9672.
RGDi621486. Sdc3.

Phylogenomic databases

eggNOGiENOG410IJZ0. Eukaryota.
ENOG410Y2QY. LUCA.
HOGENOMiHOG000049151.
HOVERGENiHBG004144.
InParanoidiP33671.
KOiK16337.
PhylomeDBiP33671.

Miscellaneous databases

PROiP33671.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031194. Syndecan-3.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 2 hits.
PTHR10915:SF7. PTHR10915:SF7. 2 hits.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat and mouse syndecan-3 cDNAs."
    Kung C.E., Deuel T.F.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan."
    Carey D.J., Evans D.M., Stahl R.C., Asundi V.K., Conner K.J., Garbes P., Cizmeci-Smith G.
    J. Cell Biol. 117:191-201(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 90-442.
    Strain: Sprague-Dawley.
    Tissue: Schwann cell.

Entry informationi

Entry nameiSDC3_RAT
AccessioniPrimary (citable) accession number: P33671
Secondary accession number(s): P97614
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.