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Protein

Syndecan-3

Gene

Sdc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: RGD
  • regulation of cell migration Source: CACAO

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-3
Short name:
SYND3
Alternative name(s):
N-syndecan
Neuroglycan
Gene namesi
Name:Sdc3
Synonyms:Synd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621486 Sdc3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 387ExtracellularSequence analysisAdd BLAST343
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 442CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000003350945 – 442Syndecan-3Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi80O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi82O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi89O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi315O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi367O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Modified residuei409PhosphotyrosineBy similarity1
Modified residuei419PhosphotyrosineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei441PhosphotyrosineBy similarity1

Post-translational modificationi

O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei383 – 384Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP33671

PTM databases

iPTMnetiP33671
PhosphoSitePlusiP33671

Expressioni

Tissue specificityi

High levels in neonatal brain, heart, and Schwann cells, barely detectable in neonatal or adult liver, or adult brain.

Developmental stagei

Higher levels in developing tissues.

Interactioni

Subunit structurei

Interacts with TIAM1.By similarity

Protein-protein interaction databases

BioGridi250556, 4 interactors
IntActiP33671, 3 interactors
STRINGi10116.ENSRNOP00000041634

Structurei

3D structure databases

ProteinModelPortaliP33671
SMRiP33671
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi114 – 302Ser/Thr-rich (mucin-like)Add BLAST189

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ0 Eukaryota
ENOG410Y2QY LUCA
HOGENOMiHOG000049151
HOVERGENiHBG004144
InParanoidiP33671
KOiK16337
PhylomeDBiP33671

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031194 Syndecan-3
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF7 PTHR10915:SF7, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPGPPRRGT AQGQRVDTAT HGPGARGLLL PPLLLLLLAG RAAGAQRWRN
60 70 80 90 100
ENFERPVDLE GSGDDDSFPD DELDDLYSGS GSGYFEQESG LETAMRFIPD
110 120 130 140 150
IALAAPTAPA MLPTTVIQPV DTPFEELLSE HPGPEPVTSP PLVTEVTEVV
160 170 180 190 200
EEPSQRATTI STTTSTTAAT TTGAPTMATA PATAATTAPS TPAAPPATAT
210 220 230 240 250
TADIRTTGIQ GLLPLPLTTA ATAKATTPAV PSPPTTVTTL DTEAPTPRLV
260 270 280 290 300
NTATSRPRAL PRPVTTQEPE VAERSTLPLG TTAPGPTEVA QTPTPESLLT
310 320 330 340 350
TTQDEPEVPV SGGPSGDFEL QEETTQPDTA NEVVAVEGAA AKPSPPLGTL
360 370 380 390 400
PKGARPGLGL HDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA
410 420 430 440
AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA
Length:442
Mass (Da):45,919
Last modified:November 1, 1997 - v3
Checksum:i4842C8BEAA0A338C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14Q → E in AAB03284 (Ref. 1) Curated1
Sequence conflicti87Q → E in AAB03284 (Ref. 1) Curated1
Sequence conflicti90 – 91GL → LR (PubMed:1556152).Curated2
Sequence conflicti176T → S (Ref. 1) Curated1
Sequence conflicti178A → D (Ref. 1) Curated1
Sequence conflicti184A → G in AAB03284 (Ref. 1) Curated1
Sequence conflicti238T → S in AAB03284 (Ref. 1) Curated1
Sequence conflicti270E → V in AAB03284 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52825 mRNA Translation: AAB03284.1
U73184 mRNA Translation: AAB18192.1
X63143 mRNA Translation: CAA44848.1
PIRiA41558
RefSeqiNP_446345.3, NM_053893.3
UniGeneiRn.10504

Genome annotation databases

GeneIDi116673
KEGGirno:116673
UCSCiRGD:621486 rat

Similar proteinsi

Entry informationi

Entry nameiSDC3_RAT
AccessioniPrimary (citable) accession number: P33671
Secondary accession number(s): P97614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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