P33622 (APOC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-III
Short name=Apo-CIII
Short name=ApoC-III

Alternative name(s):
Apolipoprotein C3

Gene names

Name:

Apoc3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular location	Secreted.
Tissue specificity	Mainly VLDL and also in HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Sequence similarities	Belongs to the apolipoprotein C3 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Lipid transport Transport
Cellular component	Chylomicron Secreted VLDL
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara cholesterol efflux Inferred from electronic annotation. Source: Compara cholesterol homeostasis Inferred from electronic annotation. Source: Compara cholesterol metabolic process Inferred from mutant phenotype PubMed 11590213PubMed 8089130PubMed 8864964. Source: MGI chylomicron remnant clearance Inferred from electronic annotation. Source: Compara high-density lipoprotein particle remodeling Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara lipoprotein metabolic process Inferred from electronic annotation. Source: InterPro lipoprotein transport Inferred from electronic annotation. Source: Compara negative regulation of cholesterol import Inferred from electronic annotation. Source: Compara negative regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of high-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of lipoprotein lipase activity Inferred from electronic annotation. Source: Compara negative regulation of low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara negative regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara negative regulation of triglyceride catabolic process Inferred from electronic annotation. Source: Compara negative regulation of very-low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara phospholipid efflux Inferred from electronic annotation. Source: Compara regulation of Cdc42 protein signal transduction Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara triglyceride catabolic process Inferred from mutant phenotype PubMed 11590213. Source: MGI triglyceride homeostasis Inferred from electronic annotation. Source: Compara triglyceride mobilization Inferred from mutant phenotype PubMed 11551841PubMed 8864964. Source: MGI
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW intermediate-density lipoprotein particle Inferred from electronic annotation. Source: Compara spherical high-density lipoprotein particle Inferred from electronic annotation. Source: Compara very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipase inhibitor activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 99	79	Apolipoprotein C-III		PRO_0000002033
Regions
	Region	68 – 99	32	Lipid-binding By similarity
Experimental info
	Sequence conflict	57	1	V → A in L04150. Ref.1
	Sequence conflict	69	1	F → S in BAB22448. Ref.2
	Sequence conflict	69	1	F → S in BAB25563. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P33622 [UniParc]. Last modified November 7, 2003. Version 2. Checksum: BBC1690C055ADEC7	FASTA	99	10,982
	10 20 30 40 50 60 MQPRTLLTVA LLALLASARA EEVEGSLLLG SVQGYMEQAS KTVQDALSSV QESDIAVVAR 70 80 90 GWMDNHFRFL KGYWSKFTDK FTGFWDSNPE DQPTPAIES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: genomic, mRNA, and protein sequences with comparisons to other species." Januzzi J.L., Azrolan N., O'Connell A., Aalto-Setala K., Breslow J.L. Genomics 14:1081-1088(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney and Small intestine.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04149 Genomic DNA. No translation available. L04150 mRNA. No translation available. AK002908 mRNA. Translation: BAB22448.1. AK008260 mRNA. Translation: BAB25563.1. BC021776 mRNA. Translation: AAH21776.1.
IPI	IPI00885860.
PIR	B44364.
RefSeq	NP_075603.1. NM_023114.3.
UniGene	Mm.390161.
3D structure databases
ProteinModelPortal	P33622.
SMR	P33622. Positions 22-99.
ModBase	Search...
PTM databases
PhosphoSite	P33622.
Proteomic databases
PaxDb	P33622.
PRIDE	P33622.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034586; ENSMUSP00000034586; ENSMUSG00000032081. ENSMUST00000118649; ENSMUSP00000113058; ENSMUSG00000032081.
GeneID	11814.
KEGG	mmu:11814.
UCSC	uc009phc.1. mouse.
Organism-specific databases
CTD	345.
MGI	MGI:88055. Apoc3.
Phylogenomic databases
eggNOG	NOG39866.
GeneTree	ENSGT00390000015395.
HOGENOM	HOG000247042.
HOVERGEN	HBG050549.
InParanoid	P33622.
KO	K08759.
OrthoDB	EOG4WDDDG.
Gene expression databases
ArrayExpress	P33622.
Bgee	P33622.
CleanEx	MM_APOC3.
Genevestigator	P33622.
GermOnline	ENSMUSG00000032081. Mus musculus.
Family and domain databases
InterPro	IPR008403. Apo-CIII. [Graphical view]
PANTHER	PTHR14225. PTHR14225. 1 hit.
Pfam	PF05778. Apo-CIII. 1 hit. [Graphical view]
ProDom	PD010414. Apo-CIII. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
ChiTaRS	APOC3. mouse.
NextBio	279695.
SOURCE	Search...

Entry information

Entry name

APOC3_MOUSE

Accession

Primary (citable) accession number: P33622
Secondary accession number(s): Q8VC58, Q9CPP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	November 7, 2003
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program