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P33622

- APOC3_MOUSE

UniProt

P33622 - APOC3_MOUSE

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Protein
Apolipoprotein C-III
Gene
Apoc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

GO - Molecular functioni

  1. lipase inhibitor activity Source: Ensembl
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. cellular response to glucose stimulus Source: Ensembl
  3. cholesterol efflux Source: Ensembl
  4. cholesterol homeostasis Source: Ensembl
  5. cholesterol metabolic process Source: MGI
  6. chylomicron remnant clearance Source: Ensembl
  7. high-density lipoprotein particle remodeling Source: Ensembl
  8. inflammatory response Source: Ensembl
  9. lipoprotein metabolic process Source: InterPro
  10. lipoprotein transport Source: Ensembl
  11. negative regulation of cholesterol import Source: Ensembl
  12. negative regulation of fatty acid biosynthetic process Source: Ensembl
  13. negative regulation of high-density lipoprotein particle clearance Source: Ensembl
  14. negative regulation of lipoprotein lipase activity Source: Ensembl
  15. negative regulation of low-density lipoprotein particle clearance Source: Ensembl
  16. negative regulation of receptor-mediated endocytosis Source: Ensembl
  17. negative regulation of triglyceride catabolic process Source: Ensembl
  18. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
  19. phospholipid efflux Source: Ensembl
  20. regulation of Cdc42 protein signal transduction Source: Ensembl
  21. response to drug Source: Ensembl
  22. response to nutrient Source: Ensembl
  23. response to peptide hormone Source: Ensembl
  24. triglyceride catabolic process Source: MGI
  25. triglyceride homeostasis Source: Ensembl
  26. triglyceride metabolic process Source: MGI
  27. triglyceride mobilization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
Gene namesi
Name:Apoc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88055. Apoc3.

Subcellular locationi

GO - Cellular componenti

  1. chylomicron Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. extracellular region Source: Reactome
  4. intermediate-density lipoprotein particle Source: Ensembl
  5. spherical high-density lipoprotein particle Source: Ensembl
  6. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 9979Apolipoprotein C-III
PRO_0000002033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Methionine sulfoxide
Glycosylationi94 – 941O-linked (GalNAc...) By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

MaxQBiP33622.
PaxDbiP33622.
PRIDEiP33622.

PTM databases

PhosphoSiteiP33622.

Expressioni

Tissue specificityi

Mainly VLDL and also in HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Gene expression databases

BgeeiP33622.
CleanExiMM_APOC3.
GenevestigatoriP33622.

Interactioni

Protein-protein interaction databases

IntActiP33622. 1 interaction.
MINTiMINT-1858244.

Structurei

3D structure databases

ProteinModelPortaliP33622.
SMRiP33622. Positions 22-99.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 9932Lipid-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C3 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39866.
GeneTreeiENSGT00390000015395.
HOGENOMiHOG000247042.
HOVERGENiHBG050549.
InParanoidiP33622.
KOiK08759.
PhylomeDBiP33622.
TreeFamiTF338209.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33622-1 [UniParc]FASTAAdd to Basket

« Hide

MQPRTLLTVA LLALLASARA EEVEGSLLLG SVQGYMEQAS KTVQDALSSV   50
QESDIAVVAR GWMDNHFRFL KGYWSKFTDK FTGFWDSNPE DQPTPAIES 99
Length:99
Mass (Da):10,982
Last modified:November 7, 2003 - v2
Checksum:iBBC1690C055ADEC7
GO

Mass spectrometryi

Molecular mass is 8830.5±0.354 Da from positions 21 - 99. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 8891.4 Da from positions 21 - 99. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571V → A in L04150. 1 Publication
Sequence conflicti69 – 691F → S in BAB22448. 1 Publication
Sequence conflicti69 – 691F → S in BAB25563. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04149 Genomic DNA. No translation available.
L04150 mRNA. No translation available.
AK002908 mRNA. Translation: BAB22448.1.
AK008260 mRNA. Translation: BAB25563.1.
BC021776 mRNA. Translation: AAH21776.1.
CCDSiCCDS23141.1.
PIRiB44364.
RefSeqiNP_001276685.1. NM_001289756.1.
NP_075603.1. NM_023114.4.
UniGeneiMm.390161.

Genome annotation databases

EnsembliENSMUST00000034586; ENSMUSP00000034586; ENSMUSG00000032081.
ENSMUST00000118649; ENSMUSP00000113058; ENSMUSG00000032081.
GeneIDi11814.
KEGGimmu:11814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04149 Genomic DNA. No translation available.
L04150 mRNA. No translation available.
AK002908 mRNA. Translation: BAB22448.1 .
AK008260 mRNA. Translation: BAB25563.1 .
BC021776 mRNA. Translation: AAH21776.1 .
CCDSi CCDS23141.1.
PIRi B44364.
RefSeqi NP_001276685.1. NM_001289756.1.
NP_075603.1. NM_023114.4.
UniGenei Mm.390161.

3D structure databases

ProteinModelPortali P33622.
SMRi P33622. Positions 22-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P33622. 1 interaction.
MINTi MINT-1858244.

PTM databases

PhosphoSitei P33622.

Proteomic databases

MaxQBi P33622.
PaxDbi P33622.
PRIDEi P33622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034586 ; ENSMUSP00000034586 ; ENSMUSG00000032081 .
ENSMUST00000118649 ; ENSMUSP00000113058 ; ENSMUSG00000032081 .
GeneIDi 11814.
KEGGi mmu:11814.

Organism-specific databases

CTDi 345.
MGIi MGI:88055. Apoc3.

Phylogenomic databases

eggNOGi NOG39866.
GeneTreei ENSGT00390000015395.
HOGENOMi HOG000247042.
HOVERGENi HBG050549.
InParanoidi P33622.
KOi K08759.
PhylomeDBi P33622.
TreeFami TF338209.

Enzyme and pathway databases

Reactomei REACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Miscellaneous databases

ChiTaRSi APOC3. mouse.
NextBioi 279695.
PROi P33622.
SOURCEi Search...

Gene expression databases

Bgeei P33622.
CleanExi MM_APOC3.
Genevestigatori P33622.

Family and domain databases

InterProi IPR008403. Apo-CIII.
[Graphical view ]
PANTHERi PTHR14225. PTHR14225. 1 hit.
Pfami PF05778. Apo-CIII. 1 hit.
[Graphical view ]
ProDomi PD010414. Apo-CIII. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: genomic, mRNA, and protein sequences with comparisons to other species."
    Januzzi J.L., Azrolan N., O'Connell A., Aalto-Setala K., Breslow J.L.
    Genomics 14:1081-1088(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
    Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
    Biochim. Biophys. Acta 1764:1363-1371(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 42-68, MASS SPECTROMETRY, OXIDATION AT MET-63 TO METHIONINE SULFOXIDE.

Entry informationi

Entry nameiAPOC3_MOUSE
AccessioniPrimary (citable) accession number: P33622
Secondary accession number(s): Q8VC58, Q9CPP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 7, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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