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Protein

Apolipoprotein C-III

Gene

Apoc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiR-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-III
Short name:
Apo-CIII
Short name:
ApoC-III
Alternative name(s):
Apolipoprotein C3
Gene namesi
Name:Apoc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88055. Apoc3.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000203321 – 99Apolipoprotein C-IIIAdd BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Methionine sulfoxide1 Publication1
Glycosylationi94O-linked (GalNAc...)By similarity1

Post-translational modificationi

The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.By similarity

Keywords - PTMi

Glycoprotein, Oxidation

Proteomic databases

MaxQBiP33622.
PaxDbiP33622.
PeptideAtlasiP33622.
PRIDEiP33622.

PTM databases

iPTMnetiP33622.
PhosphoSitePlusiP33622.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032081.
CleanExiMM_APOC3.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP33622. 1 interactor.
MINTiMINT-1858244.
STRINGi10090.ENSMUSP00000034586.

Structurei

3D structure databases

ProteinModelPortaliP33622.
SMRiP33622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 99Lipid-bindingBy similarityAdd BLAST32

Sequence similaritiesi

Belongs to the apolipoprotein C3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOGENOMiHOG000247042.
HOVERGENiHBG050549.
InParanoidiP33622.
KOiK08759.
PhylomeDBiP33622.
TreeFamiTF338209.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPRTLLTVA LLALLASARA EEVEGSLLLG SVQGYMEQAS KTVQDALSSV
60 70 80 90
QESDIAVVAR GWMDNHFRFL KGYWSKFTDK FTGFWDSNPE DQPTPAIES
Length:99
Mass (Da):10,982
Last modified:November 7, 2003 - v2
Checksum:iBBC1690C055ADEC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → A in L04150 (PubMed:1478650).Curated1
Sequence conflicti69F → S in BAB22448 (PubMed:16141072).Curated1
Sequence conflicti69F → S in BAB25563 (PubMed:16141072).Curated1

Mass spectrometryi

Molecular mass is 8830.5±0.354 Da from positions 21 - 99. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 8891.4 Da from positions 21 - 99. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04149 Genomic DNA. No translation available.
L04150 mRNA. No translation available.
AK002908 mRNA. Translation: BAB22448.1.
AK008260 mRNA. Translation: BAB25563.1.
BC021776 mRNA. Translation: AAH21776.1.
CCDSiCCDS23141.1.
PIRiB44364.
RefSeqiNP_001276685.1. NM_001289756.1.
NP_075603.1. NM_023114.4.
UniGeneiMm.390161.

Genome annotation databases

GeneIDi11814.
KEGGimmu:11814.
UCSCiuc033jkf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04149 Genomic DNA. No translation available.
L04150 mRNA. No translation available.
AK002908 mRNA. Translation: BAB22448.1.
AK008260 mRNA. Translation: BAB25563.1.
BC021776 mRNA. Translation: AAH21776.1.
CCDSiCCDS23141.1.
PIRiB44364.
RefSeqiNP_001276685.1. NM_001289756.1.
NP_075603.1. NM_023114.4.
UniGeneiMm.390161.

3D structure databases

ProteinModelPortaliP33622.
SMRiP33622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP33622. 1 interactor.
MINTiMINT-1858244.
STRINGi10090.ENSMUSP00000034586.

PTM databases

iPTMnetiP33622.
PhosphoSitePlusiP33622.

Proteomic databases

MaxQBiP33622.
PaxDbiP33622.
PeptideAtlasiP33622.
PRIDEiP33622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11814.
KEGGimmu:11814.
UCSCiuc033jkf.1. mouse.

Organism-specific databases

CTDi345.
MGIiMGI:88055. Apoc3.

Phylogenomic databases

eggNOGiENOG410JE3N. Eukaryota.
ENOG4111APE. LUCA.
HOGENOMiHOG000247042.
HOVERGENiHBG050549.
InParanoidiP33622.
KOiK08759.
PhylomeDBiP33622.
TreeFamiTF338209.

Enzyme and pathway databases

ReactomeiR-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiApoc3. mouse.
PROiP33622.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032081.
CleanExiMM_APOC3.

Family and domain databases

InterProiIPR008403. Apo-CIII.
[Graphical view]
PANTHERiPTHR14225. PTHR14225. 1 hit.
PfamiPF05778. Apo-CIII. 1 hit.
[Graphical view]
ProDomiPD010414. Apo-CIII. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOC3_MOUSE
AccessioniPrimary (citable) accession number: P33622
Secondary accession number(s): Q8VC58, Q9CPP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 7, 2003
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.