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P33619

- KLK3_MACMU

UniProt

P33619 - KLK3_MACMU

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Protein
Prostate-specific antigen
Gene
KLK3, APS
Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum By similarity.

Catalytic activityi

Preferential cleavage: -Tyr-|-Xaa-.

Enzyme regulationi

Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system By similarity
Active sitei120 – 1201Charge relay system By similarity
Active sitei213 – 2131Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.77. 3126.

Protein family/group databases

MEROPSiS01.162.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate-specific antigen (EC:3.4.21.77)
Short name:
PSA
Alternative name(s):
Kallikrein-3
Semenogelase
Gene namesi
Name:KLK3
Synonyms:APS
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 246Activation peptide
PRO_0000027935
Chaini25 – 261237Prostate-specific antigen
PRO_0000027936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173 By similarity
Disulfide bondi50 ↔ 66 By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi152 ↔ 219 By similarity
Disulfide bondi184 ↔ 198 By similarity
Disulfide bondi209 ↔ 234 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Forms a heterodimer with SERPINA5 By similarity.

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000031500.

Structurei

3D structure databases

ProteinModelPortaliP33619.
SMRiP33619. Positions 25-261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP33619.
KOiK01351.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33619-1 [UniParc]FASTAAdd to Basket

« Hide

MWVLVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC    50
GGVLVHPQWV LTAAHCIRSN SVILLGRHNP YYPEDTGQVF QVSHSFPHPL 100
YNMSLLKNRY LGPGDDSSHD LMLLRLSEPA EITDAVQVLD LPTWEPELGT 150
TCYASGWGSI EPEEHLTPKK LQCVDLHIIS NDVCAQVHSQ KVTKFMLCAG 200
SWMGGKSTCS GDSGGPLVCD GVLQGITSWG SQPCALPRRP SLYTKVVRYR 250
KWIQDTIMAN P 261
Length:261
Mass (Da):28,816
Last modified:February 1, 1994 - v1
Checksum:i8525B14B15967E5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73560 mRNA. Translation: CAA51957.1.
PIRiS35711.
RefSeqiNP_001036241.1. NM_001042776.1.
UniGeneiMmu.3785.

Genome annotation databases

GeneIDi719444.
KEGGimcc:719444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73560 mRNA. Translation: CAA51957.1 .
PIRi S35711.
RefSeqi NP_001036241.1. NM_001042776.1.
UniGenei Mmu.3785.

3D structure databases

ProteinModelPortali P33619.
SMRi P33619. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000031500.

Protein family/group databases

MEROPSi S01.162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 719444.
KEGGi mcc:719444.

Organism-specific databases

CTDi 354.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P33619.
KOi K01351.

Enzyme and pathway databases

BRENDAi 3.4.21.77. 3126.

Miscellaneous databases

NextBioi 19980994.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of rhesus monkey prostate specific antigen cDNA."
    Gauthier E.R., Chapdelaine P., Tremblay R.R., Dube J.Y.
    Biochim. Biophys. Acta 1174:207-210(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKLK3_MACMU
AccessioniPrimary (citable) accession number: P33619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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