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P33619

- KLK3_MACMU

UniProt

P33619 - KLK3_MACMU

Protein

Prostate-specific antigen

Gene

KLK3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.By similarity

    Catalytic activityi

    Preferential cleavage: -Tyr-|-Xaa-.

    Enzyme regulationi

    Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei120 – 1201Charge relay systemBy similarity
    Active sitei213 – 2131Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.77. 3126.

    Protein family/group databases

    MEROPSiS01.162.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostate-specific antigen (EC:3.4.21.77)
    Short name:
    PSA
    Alternative name(s):
    Kallikrein-3
    Semenogelase
    Gene namesi
    Name:KLK3
    Synonyms:APS
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 246Activation peptidePRO_0000027935
    Chaini25 – 261237Prostate-specific antigenPRO_0000027936Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Forms a heterodimer with SERPINA5.By similarity

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000031500.

    Structurei

    3D structure databases

    ProteinModelPortaliP33619.
    SMRiP33619. Positions 25-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP33619.
    KOiK01351.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVLVVFLTL SVTWIGAAPL ILSRIVGGWE CEKHSQPWQV LVASRGRAVC    50
    GGVLVHPQWV LTAAHCIRSN SVILLGRHNP YYPEDTGQVF QVSHSFPHPL 100
    YNMSLLKNRY LGPGDDSSHD LMLLRLSEPA EITDAVQVLD LPTWEPELGT 150
    TCYASGWGSI EPEEHLTPKK LQCVDLHIIS NDVCAQVHSQ KVTKFMLCAG 200
    SWMGGKSTCS GDSGGPLVCD GVLQGITSWG SQPCALPRRP SLYTKVVRYR 250
    KWIQDTIMAN P 261
    Length:261
    Mass (Da):28,816
    Last modified:February 1, 1994 - v1
    Checksum:i8525B14B15967E5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73560 mRNA. Translation: CAA51957.1.
    PIRiS35711.
    RefSeqiNP_001036241.1. NM_001042776.1.
    UniGeneiMmu.3785.

    Genome annotation databases

    GeneIDi719444.
    KEGGimcc:719444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73560 mRNA. Translation: CAA51957.1 .
    PIRi S35711.
    RefSeqi NP_001036241.1. NM_001042776.1.
    UniGenei Mmu.3785.

    3D structure databases

    ProteinModelPortali P33619.
    SMRi P33619. Positions 25-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000031500.

    Protein family/group databases

    MEROPSi S01.162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 719444.
    KEGGi mcc:719444.

    Organism-specific databases

    CTDi 354.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P33619.
    KOi K01351.

    Enzyme and pathway databases

    BRENDAi 3.4.21.77. 3126.

    Miscellaneous databases

    NextBioi 19980994.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of rhesus monkey prostate specific antigen cDNA."
      Gauthier E.R., Chapdelaine P., Tremblay R.R., Dube J.Y.
      Biochim. Biophys. Acta 1174:207-210(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiKLK3_MACMU
    AccessioniPrimary (citable) accession number: P33619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3