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Protein

Kappa-casein

Gene

CSN3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2149. Ory c 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000450322 – 180Kappa-caseinAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi132O-linked (GalNAc...)By similarity1
Glycosylationi142O-linked (GalNAc...)By similarity1
Glycosylationi147O-linked (GalNAc...)By similarity1
Glycosylationi153O-linked (GalNAc...)By similarity1
Modified residuei160Phosphoserine; alternateBy similarity1
Glycosylationi160O-linked (GalNAc...); alternateBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Cleavage; by chymosin/renninBy similarity2

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP33618.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013028.

Structurei

3D structure databases

ProteinModelPortaliP33618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP33618.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33618-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKHFLLVVN ILAVTLPFLA ADIQNQEQTT CRENEERLFH QVTAPYIPVH
60 70 80 90 100
YVMNRYPQYE PSYYLRRQAV PTLNPFMLNP YYVKPIVFKP NVQVPHWQIL
110 120 130 140 150
PNIHQPKVGR HSHPFFMAIL PNKMQDKAVT PTTNTIAAVE PTPIPTTEPV
160 170 180
VSTEVIAEAS PELIISPETT TEATAASAAA
Length:180
Mass (Da):20,343
Last modified:February 1, 1994 - v1
Checksum:iA1F058E01725F56E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 57YP → HT in CAA54232 (Ref. 4) Curated2
Sequence conflicti166S → R in CAA54232 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18243 mRNA. Translation: CAA79145.1.
U44057, U44055, U44056 Genomic DNA. Translation: AAC48796.1.
AF033505 Genomic DNA. Translation: AAD48079.1.
X76910 mRNA. Translation: CAA54232.1.
PIRiJC4955.
RefSeqiNP_001076094.1. NM_001082625.3.
UniGeneiOcu.2081.

Genome annotation databases

EnsembliENSOCUT00000015158; ENSOCUP00000013028; ENSOCUG00000015167.
GeneIDi100009311.
KEGGiocu:100009311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18243 mRNA. Translation: CAA79145.1.
U44057, U44055, U44056 Genomic DNA. Translation: AAC48796.1.
AF033505 Genomic DNA. Translation: AAD48079.1.
X76910 mRNA. Translation: CAA54232.1.
PIRiJC4955.
RefSeqiNP_001076094.1. NM_001082625.3.
UniGeneiOcu.2081.

3D structure databases

ProteinModelPortaliP33618.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000013028.

Protein family/group databases

Allergomei2149. Ory c 8.

Proteomic databases

PRIDEiP33618.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000015158; ENSOCUP00000013028; ENSOCUG00000015167.
GeneIDi100009311.
KEGGiocu:100009311.

Organism-specific databases

CTDi1448.

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP33618.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_RABIT
AccessioniPrimary (citable) accession number: P33618
Secondary accession number(s): Q9TV51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.