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P33616

- CP1A1_MACFA

UniProt

P33616 - CP1A1_MACFA

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Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241SubstrateBy similarity
Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:CYP1A1
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Cytochrome P450 1A1PRO_0000051628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP33616.
SMRiP33616. Positions 32-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33616-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFRISMSAT EFLLASLIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HILTLGKNPH LALSRMSQRY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG
110 120 130 140 150
DDFKGRPNLY SFTLISNGQS MSFGPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSSSCYLE EHVSKEAEVL ISKLQEQMAG PGHFNPYRYV VISVANVICA
210 220 230 240 250
ICFGQRYDHN HQELLSLVNL SNNFGEVVGS GNPADFIPIL RYLPNRSLNG
260 270 280 290 300
FKDLNEKFHS FMQKMIKEHY KTFEKGYIRD ITDSLIEHCQ EKQLDENANI
310 320 330 340 350
QLSDEKIVNV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFITPDGAID KVLSEKVILF
460 470 480 490 500
GLGKRKCIGE TIARWEVFLF LAILLQRVEF SVPPGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Length:512
Mass (Da):58,155
Last modified:February 1, 1994 - v1
Checksum:i239A3237E3870ED7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771Y → H in BAA04500. 1 PublicationCurated
Sequence conflicti490 – 4901M → V in BAA04500. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17575 mRNA. Translation: BAA04500.1.
PIRiS21761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17575 mRNA. Translation: BAA04500.1 .
PIRi S21761.

3D structure databases

ProteinModelPortali P33616.
SMRi P33616. Positions 32-509.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of monkey P450 1A1 cDNA and expression in yeast."
    Komori M., Kikuchi O., Kitada M., Kamataki T.
    Biochim. Biophys. Acta 1131:23-29(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence analysis of cDNA encoding a crab-eating monkey (Macaca irus) cytochrome P-450."
    Ohmachi T., Sagami I., Kikuchi H., Fujii H., Suzaki Y., Fujiwara T., Watanabe M.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_MACFA
AccessioniPrimary (citable) accession number: P33616
Secondary accession number(s): Q29489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3