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Protein

Regulatory protein RecX

Gene

recX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro.1 Publication

GO - Molecular functioni

  • enzyme binding Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • DNA repair Source: UniProtKB-KW
  • negative regulation of catalytic activity Source: EcoCyc
  • regulation of DNA repair Source: InterPro
  • SOS response Source: EcoCyc

Keywordsi

Biological processDNA damage, DNA repair, SOS response

Enzyme and pathway databases

BioCyciEcoCyc:EG12080-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein RecX
Alternative name(s):
Protein OraA
Gene namesi
Name:recX
Synonyms:oraA
Ordered Locus Names:b2698, JW2668
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12080 recX

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001624291 – 166Regulatory protein RecXAdd BLAST166

Proteomic databases

PaxDbiP33596
PRIDEiP33596

Expressioni

Inductioni

By DNA damage, via LexA, as part of the SOS response.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fldAP619493EBI-1129990,EBI-550021

GO - Molecular functioni

  • enzyme binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4259217, 129 interactors
DIPiDIP-10410N
IntActiP33596, 5 interactors
STRINGi316385.ECDH10B_2866

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A7Zmodel-A1-166[»]
ProteinModelPortaliP33596
SMRiP33596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecX family.Curated

Phylogenomic databases

eggNOGiENOG4105Y3E Bacteria
COG2137 LUCA
HOGENOMiHOG000242561
InParanoidiP33596
KOiK03565
OMAiVRRTAMD
PhylomeDBiP33596

Family and domain databases

Gene3Di1.10.10.10, 3 hits
HAMAPiMF_01114 RecX, 1 hit
InterProiView protein in InterPro
IPR003783 Regulatory_RecX
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR33602 PTHR33602, 1 hit
PfamiView protein in Pfam
PF02631 RecX, 1 hit

Sequencei

Sequence statusi: Complete.

P33596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID
60 70 80 90 100
ATAEDYERVI AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG
110 120 130 140 150
ISREATEKAM RECDIDWCAL ARDQATRKYG EPLPTVFSEK VKIQRFLLYR
160
GYLMEDIQEI WRNFAD
Length:166
Mass (Da):19,424
Last modified:November 1, 1997 - v2
Checksum:i172E4AED81712E62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19V → L in AAA19106 (PubMed:7512687).Curated1
Sequence conflicti120L → P in AAA19106 (PubMed:7512687).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25853 Unassigned DNA Translation: AAA19106.1
U00096 Genomic DNA Translation: AAC75740.1
AP009048 Genomic DNA Translation: BAA16560.1
PIRiF65049
RefSeqiNP_417178.1, NC_000913.3
WP_000140508.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75740; AAC75740; b2698
BAA16560; BAA16560; BAA16560
GeneIDi947172
KEGGiecj:JW2668
eco:b2698
PATRICifig|1411691.4.peg.4044

Similar proteinsi

Entry informationi

Entry nameiRECX_ECOLI
AccessioniPrimary (citable) accession number: P33596
Secondary accession number(s): P77798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health