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Protein

Regulatory protein RecX

Gene

recX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro.1 Publication

GO - Molecular functioni

  • enzyme binding Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • DNA repair Source: UniProtKB-KW
  • negative regulation of catalytic activity Source: EcoCyc
  • regulation of DNA repair Source: UniProtKB-HAMAP
  • SOS response Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, SOS response

Enzyme and pathway databases

BioCyciEcoCyc:EG12080-MONOMER.
ECOL316407:JW2668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein RecX
Alternative name(s):
Protein OraA
Gene namesi
Name:recX
Synonyms:oraA
Ordered Locus Names:b2698, JW2668
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12080. recX.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Regulatory protein RecXPRO_0000162429Add
BLAST

Proteomic databases

PaxDbiP33596.

Expressioni

Inductioni

By DNA damage, via LexA, as part of the SOS response.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
fldAP619493EBI-1129990,EBI-550021

GO - Molecular functioni

  • enzyme binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4259217. 128 interactions.
DIPiDIP-10410N.
IntActiP33596. 5 interactions.
STRINGi511145.b2698.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A7Zmodel-A1-166[»]
ProteinModelPortaliP33596.
SMRiP33596. Positions 9-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecX family.Curated

Phylogenomic databases

eggNOGiENOG4105Y3E. Bacteria.
COG2137. LUCA.
HOGENOMiHOG000242561.
InParanoidiP33596.
KOiK03565.
OMAiVIAWCYE.
PhylomeDBiP33596.

Family and domain databases

Gene3Di1.10.10.10. 3 hits.
HAMAPiMF_01114. RecX. 1 hit.
InterProiIPR003783. Regulatory_RecX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02631. RecX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESTSRRPA YARLLDRAVR ILAVRDHSEQ ELRRKLAAPI MGKNGPEEID
60 70 80 90 100
ATAEDYERVI AWCHEHGYLD DSRFVARFIA SRSRKGYGPA RIRQELNQKG
110 120 130 140 150
ISREATEKAM RECDIDWCAL ARDQATRKYG EPLPTVFSEK VKIQRFLLYR
160
GYLMEDIQEI WRNFAD
Length:166
Mass (Da):19,424
Last modified:November 1, 1997 - v2
Checksum:i172E4AED81712E62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191V → L in AAA19106 (PubMed:7512687).Curated
Sequence conflicti120 – 1201L → P in AAA19106 (PubMed:7512687).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25853 Unassigned DNA. Translation: AAA19106.1.
U00096 Genomic DNA. Translation: AAC75740.1.
AP009048 Genomic DNA. Translation: BAA16560.1.
PIRiF65049.
RefSeqiNP_417178.1. NC_000913.3.
WP_000140508.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75740; AAC75740; b2698.
BAA16560; BAA16560; BAA16560.
GeneIDi947172.
KEGGiecj:JW2668.
eco:b2698.
PATRICi32120794. VBIEscCol129921_2789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25853 Unassigned DNA. Translation: AAA19106.1.
U00096 Genomic DNA. Translation: AAC75740.1.
AP009048 Genomic DNA. Translation: BAA16560.1.
PIRiF65049.
RefSeqiNP_417178.1. NC_000913.3.
WP_000140508.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A7Zmodel-A1-166[»]
ProteinModelPortaliP33596.
SMRiP33596. Positions 9-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259217. 128 interactions.
DIPiDIP-10410N.
IntActiP33596. 5 interactions.
STRINGi511145.b2698.

Proteomic databases

PaxDbiP33596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75740; AAC75740; b2698.
BAA16560; BAA16560; BAA16560.
GeneIDi947172.
KEGGiecj:JW2668.
eco:b2698.
PATRICi32120794. VBIEscCol129921_2789.

Organism-specific databases

EchoBASEiEB2005.
EcoGeneiEG12080. recX.

Phylogenomic databases

eggNOGiENOG4105Y3E. Bacteria.
COG2137. LUCA.
HOGENOMiHOG000242561.
InParanoidiP33596.
KOiK03565.
OMAiVIAWCYE.
PhylomeDBiP33596.

Enzyme and pathway databases

BioCyciEcoCyc:EG12080-MONOMER.
ECOL316407:JW2668-MONOMER.

Miscellaneous databases

PROiP33596.

Family and domain databases

Gene3Di1.10.10.10. 3 hits.
HAMAPiMF_01114. RecX. 1 hit.
InterProiIPR003783. Regulatory_RecX.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02631. RecX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRECX_ECOLI
AccessioniPrimary (citable) accession number: P33596
Secondary accession number(s): P77798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.