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Protein

HTH-type transcriptional regulator SgrR

Gene

sgrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi26 – 49H-T-H motifBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12094-MONOMER.
ECOL316407:JW0068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator SgrR
Gene namesi
Name:sgrR
Synonyms:yabN
Ordered Locus Names:b0069, JW0068
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12094. sgrR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685221 – 551HTH-type transcriptional regulator SgrRAdd BLAST551

Proteomic databases

PaxDbiP33595.
PRIDEiP33595.

Interactioni

Protein-protein interaction databases

BioGridi4263126. 4 interactors.
IntActiP33595. 2 interactors.
STRINGi511145.b0069.

Structurei

3D structure databases

ProteinModelPortaliP33595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116HTH marR-typeAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 492Solute-bindingSequence analysisAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KNR. Bacteria.
COG4533. LUCA.
HOGENOMiHOG000271136.
InParanoidiP33595.
KOiK11925.
OMAiARPTHCE.
PhylomeDBiP33595.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01449. HTH_type_SgrR. 1 hit.
InterProiIPR000914. SBP_5_dom.
IPR025370. SgrR_HTH_N.
IPR023767. Tscrpt_reg_SgrR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
PF12793. SgrR_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR
60 70 80 90 100
GWLTWEAEVG RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK
110 120 130 140 150
ATVRQMLVSH LGRSFRQGRH ILRVLYYRPL RNLLPGSALR RSETHIARQI
160 170 180 190 200
FSSLTRINEE NGELEADIAH HWQQISPLHW RFFLRPGVHF HHGRELEMDD
210 220 230 240 250
VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP LLLGQVPAMI
260 270 280 290 300
LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
310 320 330 340 350
VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ
360 370 380 390 400
QVRDWVSYVL SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG
410 420 430 440 450
LESLTLTFYQ DHSEHRVIAG IMQQILASHQ VTLKIKEIDY DQWHTGEIES
460 470 480 490 500
DIWLNSANFT LPLDFSVFAH LCEVPLLQHC IPIDWQADAA RWRNGEMNLA
510 520 530 540 550
NWCQQLVASK AMVPLLHHWL IIQGQRSMRG LRMNTLGWFD FKSAWFAPPD

P
Length:551
Mass (Da):63,975
Last modified:August 29, 2003 - v2
Checksum:i0F4FAA1AAFC4E731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73180.1.
AP009048 Genomic DNA. Translation: BAB96638.2.
PIRiE64728.
RefSeqiNP_414611.1. NC_000913.3.
WP_001138624.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73180; AAC73180; b0069.
BAB96638; BAB96638; BAB96638.
GeneIDi944788.
KEGGiecj:JW0068.
eco:b0069.
PATRICi32115239. VBIEscCol129921_0071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73180.1.
AP009048 Genomic DNA. Translation: BAB96638.2.
PIRiE64728.
RefSeqiNP_414611.1. NC_000913.3.
WP_001138624.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263126. 4 interactors.
IntActiP33595. 2 interactors.
STRINGi511145.b0069.

Proteomic databases

PaxDbiP33595.
PRIDEiP33595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73180; AAC73180; b0069.
BAB96638; BAB96638; BAB96638.
GeneIDi944788.
KEGGiecj:JW0068.
eco:b0069.
PATRICi32115239. VBIEscCol129921_0071.

Organism-specific databases

EchoBASEiEB2018.
EcoGeneiEG12094. sgrR.

Phylogenomic databases

eggNOGiENOG4105KNR. Bacteria.
COG4533. LUCA.
HOGENOMiHOG000271136.
InParanoidiP33595.
KOiK11925.
OMAiARPTHCE.
PhylomeDBiP33595.

Enzyme and pathway databases

BioCyciEcoCyc:EG12094-MONOMER.
ECOL316407:JW0068-MONOMER.

Miscellaneous databases

PROiP33595.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01449. HTH_type_SgrR. 1 hit.
InterProiIPR000914. SBP_5_dom.
IPR025370. SgrR_HTH_N.
IPR023767. Tscrpt_reg_SgrR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
PF12793. SgrR_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGRR_ECOLI
AccessioniPrimary (citable) accession number: P33595
Secondary accession number(s): P75638
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 29, 2003
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds specifically to sgrS promoter in vitro.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.