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Protein

HTH-type transcriptional regulator SgrR

Gene

sgrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.2 Publications

Miscellaneous

Binds specifically to sgrS promoter in vitro.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi26 – 49H-T-H motifBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12094-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator SgrR
Gene namesi
Name:sgrR
Synonyms:yabN
Ordered Locus Names:b0069, JW0068
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12094 sgrR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001685221 – 551HTH-type transcriptional regulator SgrRAdd BLAST551

Proteomic databases

PaxDbiP33595
PRIDEiP33595

Interactioni

Protein-protein interaction databases

BioGridi4263126, 4 interactors
IntActiP33595, 2 interactors
STRINGi316407.85674314

Structurei

3D structure databases

ProteinModelPortaliP33595
SMRiP33595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116HTH marR-typeAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 492Solute-bindingSequence analysisAdd BLAST330

Phylogenomic databases

eggNOGiENOG4105KNR Bacteria
COG4533 LUCA
HOGENOMiHOG000271136
InParanoidiP33595
KOiK11925
OMAiWLTWQAE
PhylomeDBiP33595

Family and domain databases

HAMAPiMF_01449 HTH_type_SgrR, 1 hit
InterProiView protein in InterPro
IPR000914 SBP_5_dom
IPR025370 SgrR_HTH_N
IPR023767 Tscrpt_reg_SgrR
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PF12793 SgrR_N, 1 hit

Sequencei

Sequence statusi: Complete.

P33595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSARLQQQF IRLWQCCEGK SQDTTLNELA ALLSCSRRHM RTLLNTMQDR
60 70 80 90 100
GWLTWEAEVG RGKRSRLTFL YTGLALQQQR AEDLLEQDRI DQLVQLVGDK
110 120 130 140 150
ATVRQMLVSH LGRSFRQGRH ILRVLYYRPL RNLLPGSALR RSETHIARQI
160 170 180 190 200
FSSLTRINEE NGELEADIAH HWQQISPLHW RFFLRPGVHF HHGRELEMDD
210 220 230 240 250
VIASLKRINT LPLYSHIADI VSPTPWTLDI HLTQPDRWLP LLLGQVPAMI
260 270 280 290 300
LPREWETLSN FASHPIGTGP YAVIRNSTNQ LKIQAFDDFF GYRALIDEVN
310 320 330 340 350
VWVLPEIADE PAGGLMLKGP QGEEKEIESR LEEGCYYLLF DSRTHRGANQ
360 370 380 390 400
QVRDWVSYVL SPTNLVYFAE EQYQQLWFPA YGLLPRWHHA RTIKSEKPAG
410 420 430 440 450
LESLTLTFYQ DHSEHRVIAG IMQQILASHQ VTLKIKEIDY DQWHTGEIES
460 470 480 490 500
DIWLNSANFT LPLDFSVFAH LCEVPLLQHC IPIDWQADAA RWRNGEMNLA
510 520 530 540 550
NWCQQLVASK AMVPLLHHWL IIQGQRSMRG LRMNTLGWFD FKSAWFAPPD

P
Length:551
Mass (Da):63,975
Last modified:August 29, 2003 - v2
Checksum:i0F4FAA1AAFC4E731
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73180.1
AP009048 Genomic DNA Translation: BAB96638.2
PIRiE64728
RefSeqiNP_414611.1, NC_000913.3
WP_001138624.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73180; AAC73180; b0069
BAB96638; BAB96638; BAB96638
GeneIDi944788
KEGGiecj:JW0068
eco:b0069
PATRICifig|1411691.4.peg.2213

Similar proteinsi

Entry informationi

Entry nameiSGRR_ECOLI
AccessioniPrimary (citable) accession number: P33595
Secondary accession number(s): P75638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 29, 2003
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health