ID NIKA_ECOLI Reviewed; 524 AA. AC P33590; Q2M7D9; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 27-MAR-2024, entry version 177. DE RecName: Full=Nickel-binding periplasmic protein; DE Flags: Precursor; GN Name=nikA; OrderedLocusNames=b3476, JW3441; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=K12; RX PubMed=7934931; DOI=10.1111/j.1365-2958.1993.tb01247.x; RA Navarro C., Wu L.-F., Mandrand-Berthelot M.-A.; RT "The nik operon of Escherichia coli encodes a periplasmic binding-protein- RT dependent transport system for nickel."; RL Mol. Microbiol. 9:1181-1191(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=8041620; DOI=10.1093/nar/22.13.2576; RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.; RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region RT from 76.0 to 81.5 minutes."; RL Nucleic Acids Res. 22:2576-2586(1994). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). RN [5] RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 23-524. RX PubMed=12960164; DOI=10.1074/jbc.m307941200; RA Heddle J., Scott D.J., Unzai S., Park S.Y., Tame J.R.; RT "Crystal structures of the liganded and unliganded nickel-binding protein RT NikA from Escherichia coli."; RL J. Biol. Chem. 278:50322-50329(2003). CC -!- FUNCTION: Involved in a nickel transport system, probably represents CC the nickel binder. CC -!- INTERACTION: CC P33590; P0CE47: tufA; NbExp=2; IntAct=EBI-555182, EBI-301077; CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}. CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 5 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X73143; CAA51659.1; -; Genomic_DNA. DR EMBL; U00039; AAB18451.1; -; Genomic_DNA. DR EMBL; U00096; AAC76501.1; -; Genomic_DNA. DR EMBL; AP009048; BAE77817.1; -; Genomic_DNA. DR PIR; S39594; S39594. DR RefSeq; NP_417933.1; NC_000913.3. DR RefSeq; WP_000953361.1; NZ_SSZK01000008.1. DR PDB; 1UIU; X-ray; 1.85 A; A/B=23-524. DR PDB; 1UIV; X-ray; 1.95 A; A/B=23-524. DR PDB; 1ZLQ; X-ray; 1.80 A; A/B=23-524. DR PDB; 2NOO; X-ray; 1.65 A; A=23-524. DR PDB; 3DP8; X-ray; 2.50 A; A/B/C=23-524. DR PDB; 3E3K; X-ray; 2.80 A; A/B/C=23-524. DR PDB; 3MVW; X-ray; 1.79 A; A/B=23-524. DR PDB; 3MVX; X-ray; 1.70 A; A/B=23-524. DR PDB; 3MVY; X-ray; 2.50 A; A/B=23-524. DR PDB; 3MVZ; X-ray; 1.70 A; A/B=23-524. DR PDB; 3MW0; X-ray; 2.30 A; A/B=23-524. DR PDB; 3MZ9; X-ray; 1.80 A; A/B=23-524. DR PDB; 3MZB; X-ray; 1.70 A; A/B=23-523. DR PDB; 3QIM; X-ray; 2.10 A; A/B=23-524. DR PDB; 4DCX; X-ray; 2.00 A; A/B=23-524. DR PDB; 4DCY; X-ray; 2.00 A; A/B=23-524. DR PDB; 4I8C; X-ray; 2.50 A; A/B/C=23-524. DR PDB; 4I9D; X-ray; 1.70 A; A/B=23-524. DR PDB; 5L8D; X-ray; 1.80 A; A/B=23-524. DR PDB; 5MWU; X-ray; 1.80 A; A/B=23-524. DR PDB; 5ON0; X-ray; 1.90 A; A/B=23-524. DR PDB; 5ON1; X-ray; 1.70 A; A/B=23-524. DR PDB; 5ON4; X-ray; 2.30 A; A/B=23-524. DR PDB; 5ON5; X-ray; 1.70 A; A/B=23-524. DR PDB; 5ON8; X-ray; 1.60 A; A/B=23-524. DR PDB; 5ON9; X-ray; 1.70 A; A/B=23-524. DR PDB; 6R4Q; X-ray; 1.90 A; A/B=23-524. DR PDB; 7A0C; X-ray; 1.90 A; A/B=23-524. DR PDBsum; 1UIU; -. DR PDBsum; 1UIV; -. DR PDBsum; 1ZLQ; -. DR PDBsum; 2NOO; -. DR PDBsum; 3DP8; -. DR PDBsum; 3E3K; -. DR PDBsum; 3MVW; -. DR PDBsum; 3MVX; -. DR PDBsum; 3MVY; -. DR PDBsum; 3MVZ; -. DR PDBsum; 3MW0; -. DR PDBsum; 3MZ9; -. DR PDBsum; 3MZB; -. DR PDBsum; 3QIM; -. DR PDBsum; 4DCX; -. DR PDBsum; 4DCY; -. DR PDBsum; 4I8C; -. DR PDBsum; 4I9D; -. DR PDBsum; 5L8D; -. DR PDBsum; 5MWU; -. DR PDBsum; 5ON0; -. DR PDBsum; 5ON1; -. DR PDBsum; 5ON4; -. DR PDBsum; 5ON5; -. DR PDBsum; 5ON8; -. DR PDBsum; 5ON9; -. DR PDBsum; 6R4Q; -. DR PDBsum; 7A0C; -. DR AlphaFoldDB; P33590; -. DR BMRB; P33590; -. DR SMR; P33590; -. DR BioGRID; 4262491; 49. DR ComplexPortal; CPX-4348; Nickel ABC transporter complex. DR DIP; DIP-10340N; -. DR IntAct; P33590; 1. DR STRING; 511145.b3476; -. DR DrugBank; DB03374; 3,5-Diiodotyrosine. DR TCDB; 3.A.1.5.3; the atp-binding cassette (abc) superfamily. DR jPOST; P33590; -. DR PaxDb; 511145-b3476; -. DR EnsemblBacteria; AAC76501; AAC76501; b3476. DR GeneID; 947981; -. DR KEGG; ecj:JW3441; -. DR KEGG; eco:b3476; -. DR PATRIC; fig|1411691.4.peg.3249; -. DR EchoBASE; EB2000; -. DR eggNOG; COG0747; Bacteria. DR HOGENOM; CLU_017028_7_5_6; -. DR InParanoid; P33590; -. DR OMA; CHATDPN; -. DR OrthoDB; 9801912at2; -. DR PhylomeDB; P33590; -. DR BioCyc; EcoCyc:NIKA-MONOMER; -. DR BioCyc; MetaCyc:NIKA-MONOMER; -. DR EvolutionaryTrace; P33590; -. DR PRO; PR:P33590; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; NAS:ComplexPortal. DR GO; GO:0016020; C:membrane; NAS:ComplexPortal. DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc. DR GO; GO:0042597; C:periplasmic space; IDA:EcoliWiki. DR GO; GO:0020037; F:heme binding; IDA:EcoliWiki. DR GO; GO:0051540; F:metal cluster binding; IDA:EcoCyc. DR GO; GO:0016151; F:nickel cation binding; IDA:EcoliWiki. DR GO; GO:1904680; F:peptide transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0046914; F:transition metal ion binding; IDA:EcoliWiki. DR GO; GO:0050919; P:negative chemotaxis; IMP:EcoliWiki. DR GO; GO:0098716; P:nickel cation import across plasma membrane; NAS:ComplexPortal. DR GO; GO:0015833; P:peptide transport; IBA:GO_Central. DR CDD; cd08489; PBP2_NikA; 1. DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1. DR InterPro; IPR011980; NikA_ABC_Ni-bd. DR InterPro; IPR030678; Peptide/Ni-bd. DR InterPro; IPR039424; SBP_5. DR InterPro; IPR023765; SBP_5_CS. DR InterPro; IPR000914; SBP_5_dom. DR NCBIfam; TIGR02294; nickel_nikA; 1. DR PANTHER; PTHR30290:SF37; NICKEL-BINDING PERIPLASMIC PROTEIN; 1. DR PANTHER; PTHR30290; PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER; 1. DR Pfam; PF00496; SBP_bac_5; 1. DR PIRSF; PIRSF002741; MppA; 1. DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1. DR PROSITE; PS01040; SBP_BACTERIAL_5; 1. PE 1: Evidence at protein level; KW 3D-structure; Nickel; Periplasm; Reference proteome; Signal; Transport. FT SIGNAL 1..22 FT CHAIN 23..524 FT /note="Nickel-binding periplasmic protein" FT /id="PRO_0000031800" FT STRAND 27..34 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 46..48 FT /evidence="ECO:0007829|PDB:2NOO" FT HELIX 49..55 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 59..62 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 68..78 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 80..82 FT /evidence="ECO:0007829|PDB:1UIU" FT STRAND 84..89 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 96..98 FT /evidence="ECO:0007829|PDB:3DP8" FT HELIX 103..114 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 115..120 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 125..128 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 129..146 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 151..155 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 157..161 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 166..168 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 170..172 FT /evidence="ECO:0007829|PDB:1UIV" FT STRAND 173..180 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 184..193 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 194..196 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 197..202 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 215..220 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 224..232 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 233..235 FT /evidence="ECO:0007829|PDB:3E3K" FT STRAND 237..242 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 243..245 FT /evidence="ECO:0007829|PDB:2NOO" FT HELIX 248..256 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 261..264 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 269..275 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 280..283 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 285..294 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 297..304 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 305..307 FT /evidence="ECO:0007829|PDB:2NOO" FT STRAND 309..311 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 314..316 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 334..343 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 363..369 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 373..387 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 388..390 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 392..398 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 400..409 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 413..418 FT /evidence="ECO:0007829|PDB:5ON8" FT TURN 422..426 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 427..432 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 435..438 FT /evidence="ECO:0007829|PDB:2NOO" FT HELIX 439..444 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 450..461 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 466..482 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 486..492 FT /evidence="ECO:0007829|PDB:5ON8" FT STRAND 495..498 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 500..502 FT /evidence="ECO:0007829|PDB:5ON8" FT HELIX 516..518 FT /evidence="ECO:0007829|PDB:5ON8" SQ SEQUENCE 524 AA; 58719 MW; CB2E3C1CDCE42396 CRC64; MLSTLRRTLF ALLACASFIV HAAAPDEITT AWPVNVGPLN PHLYTPNQMF AQSMVYEPLV KYQADGSVIP WLAKSWTHSE DGKTWTFTLR DDVKFSNGEP FDAEAAAENF RAVLDNRQRH AWLELANQIV DVKALSKTEL QITLKSAYYP FLQELALPRP FRFIAPSQFK NHETMNGIKA PIGTGPWILQ ESKLNQYDVF VRNENYWGEK PAIKKITFNV IPDPTTRAVA FETGDIDLLY GNEGLLPLDT FARFSQNPAY HTQLSQPIET VMLALNTAKA PTNELAVREA LNYAVNKKSL IDNALYGTQQ VADTLFAPSV PYANLGLKPS QYDPQKAKAL LEKAGWTLPA GKDIREKNGQ PLRIELSFIG TDALSKSMAE IIQADMRQIG ADVSLIGEEE SSIYARQRDG RFGMIFHRTW GAPYDPHAFL SSMRVPSHAD FQAQQGLADK PLIDKEIGEV LATHDETQRQ ALYRDILTRL HDEAVYLPIS YISMMVVSKP ELGNIPYAPI ATEIPFEQIK PVKP //