ID   VSP1_AGKBI              Reviewed;          20 AA.
AC   P33588;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Ancrod;
DE            EC=3.4.21.74;
DE   AltName: Full=Venombin-A;
DE   AltName: Full=Protein C activator;
DE   AltName: Full=ACC-C;
DE   Flags: Fragment;
OS   Agkistrodon bilineatus (Cantil) (Tropical moccasin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea;
OC   Viperidae; Crotalinae; Agkistrodon.
OX   NCBI_TaxID=8718;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   MEDLINE=90350102; PubMed=2385829; DOI=10.1016/0049-3848(90)90305-V;
RA   Nakagaki T., Kazim A.L., Kisiel W.;
RT   "Isolation and characterization of a protein C activator from tropical
RT   moccasin venom.";
RL   Thromb. Res. 58:593-602(1990).
CC   -!- FUNCTION: Thrombin-like snake venom serine protease. Activates
CC       protein C.
CC   -!- CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Xaa bond in
CC       fibrinogen, to form fibrin, and release fibrinopeptide A. The
CC       specificity of further degradation of fibrinogen varies with
CC       species origin of the enzyme.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 peptidase S1 domain.
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DR   PIR; A60489; A60489.
DR   MEROPS; S01.178; -.
DR   HOVERGEN; P33588; -.
DR   BRENDA; 3.4.21.74; 279476.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   PROSITE; PS50240; TRYPSIN_DOM; PARTIAL.
DR   PROSITE; PS00134; TRYPSIN_HIS; PARTIAL.
DR   PROSITE; PS00135; TRYPSIN_SER; PARTIAL.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protease; Secreted;
KW   Serine protease; Toxin.
FT   CHAIN         1    >20       Ancrod.
FT                                /FTId=PRO_0000088724.
FT   DOMAIN        1    >20       Peptidase S1.
FT   NON_TER      20     20
SQ   SEQUENCE   20 AA;  2191 MW;  6E99F8B4CC53EFE1 CRC64;
     VVGGDECNIN EHRSLALMYA
//