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P33552 (CKS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinases regulatory subunit 2

Short name=CKS-2
Gene names
Name:CKS2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length79 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Subunit structure

Forms a homohexamer that can probably bind six kinase subunits.

Sequence similarities

Belongs to the CKS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 7978Cyclin-dependent kinases regulatory subunit 2
PRO_0000206237

Amino acid modifications

Modified residue21N-acetylalanine Ref.8
Modified residue41N6-acetyllysine Ref.8

Experimental info

Sequence conflict201R → L in CAG28558. Ref.4

Secondary structure

....... 79
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P33552 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 811B5927691EEC5C

FASTA799,860
        10         20         30         40         50         60 
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH 

        70 
EPEPHILLFR RPLPKDQQK 

« Hide

References

« Hide 'large scale' references
[1]"Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIEHS SNPs program
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control."
Parge H.E., Arvai A.S., Murtari D.J., Reed S.I., Tainer J.A.
Science 262:387-395(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR407630 mRNA. Translation: CAG28558.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.
PIRB36670.
RefSeqNP_001818.1. NM_001827.1.
UniGeneHs.83758.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
ProteinModelPortalP33552.
SMRP33552. Positions 2-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107583. 19 interactions.
IntActP33552. 9 interactions.
MINTMINT-1372463.
STRING9606.ENSP00000364976.

PTM databases

PhosphoSiteP33552.

Proteomic databases

PaxDbP33552.
PRIDEP33552.

Protocols and materials databases

DNASU1164.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314355; ENSP00000364976; ENSG00000123975.
GeneID1164.
KEGGhsa:1164.
UCSCuc004aqh.3. human.

Organism-specific databases

CTD1164.
GeneCardsGC09P091926.
HGNCHGNC:2000. CKS2.
HPAHPA030762.
MIM116901. gene.
neXtProtNX_P33552.
PharmGKBPA26536.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272189.
HOVERGENHBG003626.
InParanoidP33552.
KOK02219.
OMAFDDKFEY.
OrthoDBEOG735413.
PhylomeDBP33552.
TreeFamTF101142.

Gene expression databases

BgeeP33552.
CleanExHS_CKS2.
GenevestigatorP33552.

Family and domain databases

Gene3D3.30.170.10. 1 hit.
InterProIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamPF01111. CKS. 1 hit.
[Graphical view]
PRINTSPR00296. CYCLINKINASE.
SMARTSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMSSF55637. SSF55637. 1 hit.
PROSITEPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP33552.
GeneWikiCKS2.
GenomeRNAi1164.
NextBio4834.
PROP33552.
SOURCESearch...

Entry information

Entry nameCKS2_HUMAN
AccessionPrimary (citable) accession number: P33552
Secondary accession number(s): Q6FGI9, Q6LET5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM