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P33552

- CKS2_HUMAN

UniProt

P33552 - CKS2_HUMAN

Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

CKS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB
    2. cell proliferation Source: ProtInc
    3. meiosis I Source: Ensembl
    4. phosphatidylinositol-mediated signaling Source: UniProtKB
    5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
    6. spindle organization Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinases regulatory subunit 2
    Short name:
    CKS-2
    Gene namesi
    Name:CKS2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:2000. CKS2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26536.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 2PRO_0000206237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei4 – 41N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP33552.
    PaxDbiP33552.
    PRIDEiP33552.

    PTM databases

    PhosphoSiteiP33552.

    Expressioni

    Gene expression databases

    BgeeiP33552.
    CleanExiHS_CKS2.
    GenevestigatoriP33552.

    Organism-specific databases

    HPAiHPA030762.

    Interactioni

    Subunit structurei

    Forms a homohexamer that can probably bind six kinase subunits.

    Protein-protein interaction databases

    BioGridi107583. 19 interactions.
    IntActiP33552. 9 interactions.
    MINTiMINT-1372463.
    STRINGi9606.ENSP00000364976.

    Structurei

    Secondary structure

    1
    79
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 305
    Beta strandi34 – 363
    Helixi40 – 467

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CKSX-ray2.10A/B/C1-79[»]
    ProteinModelPortaliP33552.
    SMRiP33552. Positions 2-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP33552.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CKS family.Curated

    Phylogenomic databases

    eggNOGiNOG272189.
    HOVERGENiHBG003626.
    InParanoidiP33552.
    KOiK02219.
    OMAiFDDKFEY.
    OrthoDBiEOG735413.
    PhylomeDBiP33552.
    TreeFamiTF101142.

    Family and domain databases

    Gene3Di3.30.170.10. 1 hit.
    InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view]
    PfamiPF01111. CKS. 1 hit.
    [Graphical view]
    PRINTSiPR00296. CYCLINKINASE.
    SMARTiSM01084. CKS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55637. SSF55637. 1 hit.
    PROSITEiPS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ   50
    SLGWVHYMIH EPEPHILLFR RPLPKDQQK 79
    Length:79
    Mass (Da):9,860
    Last modified:February 1, 1994 - v1
    Checksum:i811B5927691EEC5C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201R → L in CAG28558. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54942 mRNA. Translation: CAA38703.1.
    AF506708 Genomic DNA. Translation: AAM22232.1.
    BT006630 mRNA. Translation: AAP35276.1.
    CR407630 mRNA. Translation: CAG28558.1.
    CR542118 mRNA. Translation: CAG46915.1.
    AL160054 Genomic DNA. Translation: CAI41365.1.
    CH471089 Genomic DNA. Translation: EAW62762.1.
    BC006458 mRNA. Translation: AAH06458.1.
    CCDSiCCDS6682.1.
    PIRiB36670.
    RefSeqiNP_001818.1. NM_001827.1.
    UniGeneiHs.83758.

    Genome annotation databases

    EnsembliENST00000314355; ENSP00000364976; ENSG00000123975.
    GeneIDi1164.
    KEGGihsa:1164.
    UCSCiuc004aqh.3. human.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54942 mRNA. Translation: CAA38703.1 .
    AF506708 Genomic DNA. Translation: AAM22232.1 .
    BT006630 mRNA. Translation: AAP35276.1 .
    CR407630 mRNA. Translation: CAG28558.1 .
    CR542118 mRNA. Translation: CAG46915.1 .
    AL160054 Genomic DNA. Translation: CAI41365.1 .
    CH471089 Genomic DNA. Translation: EAW62762.1 .
    BC006458 mRNA. Translation: AAH06458.1 .
    CCDSi CCDS6682.1.
    PIRi B36670.
    RefSeqi NP_001818.1. NM_001827.1.
    UniGenei Hs.83758.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CKS X-ray 2.10 A/B/C 1-79 [» ]
    ProteinModelPortali P33552.
    SMRi P33552. Positions 2-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107583. 19 interactions.
    IntActi P33552. 9 interactions.
    MINTi MINT-1372463.
    STRINGi 9606.ENSP00000364976.

    PTM databases

    PhosphoSitei P33552.

    Proteomic databases

    MaxQBi P33552.
    PaxDbi P33552.
    PRIDEi P33552.

    Protocols and materials databases

    DNASUi 1164.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314355 ; ENSP00000364976 ; ENSG00000123975 .
    GeneIDi 1164.
    KEGGi hsa:1164.
    UCSCi uc004aqh.3. human.

    Organism-specific databases

    CTDi 1164.
    GeneCardsi GC09P091926.
    HGNCi HGNC:2000. CKS2.
    HPAi HPA030762.
    MIMi 116901. gene.
    neXtProti NX_P33552.
    PharmGKBi PA26536.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272189.
    HOVERGENi HBG003626.
    InParanoidi P33552.
    KOi K02219.
    OMAi FDDKFEY.
    OrthoDBi EOG735413.
    PhylomeDBi P33552.
    TreeFami TF101142.

    Miscellaneous databases

    EvolutionaryTracei P33552.
    GeneWikii CKS2.
    GenomeRNAii 1164.
    NextBioi 4834.
    PROi P33552.
    SOURCEi Search...

    Gene expression databases

    Bgeei P33552.
    CleanExi HS_CKS2.
    Genevestigatori P33552.

    Family and domain databases

    Gene3Di 3.30.170.10. 1 hit.
    InterProi IPR000789. Cyclin-dep_kinase_reg-sub.
    [Graphical view ]
    Pfami PF01111. CKS. 1 hit.
    [Graphical view ]
    PRINTSi PR00296. CYCLINKINASE.
    SMARTi SM01084. CKS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55637. SSF55637. 1 hit.
    PROSITEi PS00944. CKS_1. 1 hit.
    PS00945. CKS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
      Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIEHS SNPs program
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control."
      Parge H.E., Arvai A.S., Murtari D.J., Reed S.I., Tainer J.A.
      Science 262:387-395(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

    Entry informationi

    Entry nameiCKS2_HUMAN
    AccessioniPrimary (citable) accession number: P33552
    Secondary accession number(s): Q6FGI9, Q6LET5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3