P33552 (CKS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name=CKS-2

Gene names

Name:

CKS2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Subunit structure	Forms a homohexamer that can probably bind six kinase subunits.
Sequence similarities	Belongs to the CKS family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
PTM	Acetylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement Ref.10. Source: ProtInc meiosis I Inferred from electronic annotation. Source: Compara phosphatidylinositol-mediated signaling Non-traceable author statement PubMed 15504738. Source: UniProtKB regulation of cyclin-dependent protein serine/threonine kinase activity Traceable author statement Ref.1. Source: ProtInc spindle organization Non-traceable author statement PubMed 15504738. Source: UniProtKB
Molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.8

Chain

2 – 79

78

Cyclin-dependent kinases regulatory subunit 2

PRO_0000206237

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.8

Modified residue

4

1

N6-acetyllysine Ref.8

Secondary structure

1

.

.

.

.

.

.

.

79

Helix Strand Turn

Details...

Helix

26 – 30

5

Beta strand

34 – 36

3

Helix

40 – 46

7

Sequences

	Sequence		Length	Mass (Da)
	P33552 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 811B5927691EEC5C	FASTA	79	9,860
	10 20 30 40 50 60 MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH 70 EPEPHILLFR RPLPKDQQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe." Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I. Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIEHS SNPs program Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control." Parge H.E., Arvai A.S., Murtari D.J., Reed S.I., Tainer J.A. Science 262:387-395(1993) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.

IPI

IPI00015105.

PIR

B36670.

RefSeq

NP_001818.1. NM_001827.1.

UniGene

Hs.83758.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CKS	X-ray	2.10	A/B/C	1-79	[»]

ProteinModelPortal

P33552.

ModBase

Search...

Protein-protein interaction databases

IntAct

P33552. 7 interactions.

MINT

MINT-1372463.

STRING

9606.ENSP00000364976.

PTM databases

PhosphoSite

P33552.

Polymorphism databases

DMDM

461747.

Proteomic databases

PaxDb

P33552.

PRIDE

P33552.

Protocols and materials databases

DNASU

1164.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000314355; ENSP00000364976; ENSG00000123975.

GeneID

1164.

KEGG

hsa:1164.

UCSC

uc004aqh.3. human.

Organism-specific databases

CTD

1164.

GeneCards

GC09P091926.

HGNC

HGNC:2000. CKS2.

HPA

HPA030762.

MIM

116901. gene.

neXtProt

NX_P33552.

PharmGKB

PA26536.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG272189.

HOVERGEN

HBG003626.

InParanoid

P33552.

KO

K02219.

OMA

DEQYEYR.

OrthoDB

EOG4JM7RB.

PhylomeDB

P33552.

Gene expression databases

ArrayExpress

P33552.

Bgee

P33552.

CleanEx

HS_CKS2.

Genevestigator

P33552.

GermOnline

ENSG00000123975. Homo sapiens.

Family and domain databases

Gene3D

3.30.170.10. 1 hit.

InterPro

IPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]

Pfam

PF01111. CKS. 1 hit.
[Graphical view]

PRINTS

PR00296. CYCLINKINASE.

SMART

SM01084. CKS. 1 hit.
[Graphical view]

SUPFAM

SSF55637. Cyc_dep_kin_rsub. 1 hit.

PROSITE

PS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P33552.

GenomeRNAi

1164.

NextBio

4834.

SOURCE

Search...

Entry information

Entry name

CKS2_HUMAN

Accession

Primary (citable) accession number: P33552
Secondary accession number(s): Q6FGI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.