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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

CKS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123975-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:CKS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2000. CKS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi1164.
OpenTargetsiENSG00000123975.
PharmGKBiPA26536.

Polymorphism and mutation databases

BioMutaiCKS2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062371 – 79Cyclin-dependent kinases regulatory subunit 2Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP33552.
PaxDbiP33552.
PeptideAtlasiP33552.
PRIDEiP33552.
TopDownProteomicsiP33552.

PTM databases

iPTMnetiP33552.
PhosphoSitePlusiP33552.

Expressioni

Gene expression databases

BgeeiENSG00000123975.
CleanExiHS_CKS2.
GenevisibleiP33552. HS.

Organism-specific databases

HPAiHPA030762.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107583. 35 interactors.
IntActiP33552. 11 interactors.
MINTiMINT-1372463.
STRINGi9606.ENSP00000364976.

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi15 – 23Combined sources9
Helixi26 – 30Combined sources5
Beta strandi34 – 36Combined sources3
Helixi40 – 46Combined sources7
Beta strandi55 – 58Combined sources4
Beta strandi66 – 72Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
4Y72X-ray2.30C1-79[»]
4YC3X-ray2.70C1-79[»]
5HQ0X-ray2.30C1-79[»]
ProteinModelPortaliP33552.
SMRiP33552.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33552.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP33552.
KOiK02219.
OMAiKHVPKSH.
OrthoDBiEOG091G18GQ.
PhylomeDBiP33552.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKDQQK
Length:79
Mass (Da):9,860
Last modified:February 1, 1994 - v1
Checksum:i811B5927691EEC5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20R → L in CAG28558 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR407630 mRNA. Translation: CAG28558.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.
CCDSiCCDS6682.1.
PIRiB36670.
RefSeqiNP_001818.1. NM_001827.2.
UniGeneiHs.83758.

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975.
GeneIDi1164.
KEGGihsa:1164.
UCSCiuc004aqh.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR407630 mRNA. Translation: CAG28558.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.
CCDSiCCDS6682.1.
PIRiB36670.
RefSeqiNP_001818.1. NM_001827.2.
UniGeneiHs.83758.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
4Y72X-ray2.30C1-79[»]
4YC3X-ray2.70C1-79[»]
5HQ0X-ray2.30C1-79[»]
ProteinModelPortaliP33552.
SMRiP33552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107583. 35 interactors.
IntActiP33552. 11 interactors.
MINTiMINT-1372463.
STRINGi9606.ENSP00000364976.

PTM databases

iPTMnetiP33552.
PhosphoSitePlusiP33552.

Polymorphism and mutation databases

BioMutaiCKS2.

Proteomic databases

EPDiP33552.
PaxDbiP33552.
PeptideAtlasiP33552.
PRIDEiP33552.
TopDownProteomicsiP33552.

Protocols and materials databases

DNASUi1164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975.
GeneIDi1164.
KEGGihsa:1164.
UCSCiuc004aqh.3. human.

Organism-specific databases

CTDi1164.
DisGeNETi1164.
GeneCardsiCKS2.
HGNCiHGNC:2000. CKS2.
HPAiHPA030762.
MIMi116901. gene.
neXtProtiNX_P33552.
OpenTargetsiENSG00000123975.
PharmGKBiPA26536.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP33552.
KOiK02219.
OMAiKHVPKSH.
OrthoDBiEOG091G18GQ.
PhylomeDBiP33552.
TreeFamiTF101142.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000123975-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP33552.
GeneWikiiCKS2.
GenomeRNAii1164.
PROiP33552.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123975.
CleanExiHS_CKS2.
GenevisibleiP33552. HS.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS2_HUMAN
AccessioniPrimary (citable) accession number: P33552
Secondary accession number(s): Q6FGI9, Q6LET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.