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Protein

Cyclin-dependent kinases regulatory subunit 2

Gene

CKS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. cell proliferation Source: ProtInc
  3. meiosis I Source: Ensembl
  4. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 2
Short name:
CKS-2
Gene namesi
Name:CKS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2000. CKS2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26536.

Polymorphism and mutation databases

BioMutaiCKS2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7978Cyclin-dependent kinases regulatory subunit 2PRO_0000206237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei4 – 41N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP33552.
PaxDbiP33552.
PRIDEiP33552.

PTM databases

PhosphoSiteiP33552.

Expressioni

Gene expression databases

BgeeiP33552.
CleanExiHS_CKS2.
GenevestigatoriP33552.

Organism-specific databases

HPAiHPA030762.

Interactioni

Subunit structurei

Forms a homohexamer that can probably bind six kinase subunits.

Protein-protein interaction databases

BioGridi107583. 25 interactions.
IntActiP33552. 9 interactions.
MINTiMINT-1372463.
STRINGi9606.ENSP00000364976.

Structurei

Secondary structure

1
79
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 305Combined sources
Beta strandi34 – 363Combined sources
Helixi40 – 467Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
SMRiP33552. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33552.

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP33552.
KOiK02219.
OMAiFRRKHVE.
OrthoDBiEOG735413.
PhylomeDBiP33552.
TreeFamiTF101142.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ
60 70
SLGWVHYMIH EPEPHILLFR RPLPKDQQK
Length:79
Mass (Da):9,860
Last modified:February 1, 1994 - v1
Checksum:i811B5927691EEC5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201R → L in CAG28558 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR407630 mRNA. Translation: CAG28558.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.
CCDSiCCDS6682.1.
PIRiB36670.
RefSeqiNP_001818.1. NM_001827.2.
UniGeneiHs.83758.

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975.
GeneIDi1164.
KEGGihsa:1164.
UCSCiuc004aqh.3. human.

Polymorphism and mutation databases

BioMutaiCKS2.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54942 mRNA. Translation: CAA38703.1.
AF506708 Genomic DNA. Translation: AAM22232.1.
BT006630 mRNA. Translation: AAP35276.1.
CR407630 mRNA. Translation: CAG28558.1.
CR542118 mRNA. Translation: CAG46915.1.
AL160054 Genomic DNA. Translation: CAI41365.1.
CH471089 Genomic DNA. Translation: EAW62762.1.
BC006458 mRNA. Translation: AAH06458.1.
CCDSiCCDS6682.1.
PIRiB36670.
RefSeqiNP_001818.1. NM_001827.2.
UniGeneiHs.83758.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CKSX-ray2.10A/B/C1-79[»]
SMRiP33552. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107583. 25 interactions.
IntActiP33552. 9 interactions.
MINTiMINT-1372463.
STRINGi9606.ENSP00000364976.

PTM databases

PhosphoSiteiP33552.

Polymorphism and mutation databases

BioMutaiCKS2.

Proteomic databases

MaxQBiP33552.
PaxDbiP33552.
PRIDEiP33552.

Protocols and materials databases

DNASUi1164.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314355; ENSP00000364976; ENSG00000123975.
GeneIDi1164.
KEGGihsa:1164.
UCSCiuc004aqh.3. human.

Organism-specific databases

CTDi1164.
GeneCardsiGC09P091926.
HGNCiHGNC:2000. CKS2.
HPAiHPA030762.
MIMi116901. gene.
neXtProtiNX_P33552.
PharmGKBiPA26536.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272189.
GeneTreeiENSGT00390000011006.
HOVERGENiHBG003626.
InParanoidiP33552.
KOiK02219.
OMAiFRRKHVE.
OrthoDBiEOG735413.
PhylomeDBiP33552.
TreeFamiTF101142.

Miscellaneous databases

EvolutionaryTraceiP33552.
GeneWikiiCKS2.
GenomeRNAii1164.
NextBioi4834.
PROiP33552.
SOURCEiSearch...

Gene expression databases

BgeeiP33552.
CleanExiHS_CKS2.
GenevestigatoriP33552.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Richardson H.E., Stueland C.S., Thomas J., Russell P., Reed S.I.
    Genes Dev. 4:1332-1344(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIEHS SNPs program
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control."
    Parge H.E., Arvai A.S., Murtari D.J., Reed S.I., Tainer J.A.
    Science 262:387-395(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

Entry informationi

Entry nameiCKS2_HUMAN
AccessioniPrimary (citable) accession number: P33552
Secondary accession number(s): Q6FGI9, Q6LET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 29, 2015
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.