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Protein

Probable mannosyltransferase KTR2

Gene

KTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in N-linked glycosylation.

Catalytic activityi

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei313 – 3131NucleophileSequence analysis

GO - Molecular functioni

  • alpha-1,2-mannosyltransferase activity Source: GO_Central
  • mannosyltransferase activity Source: SGD

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: SGD
  • protein N-linked glycosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-32029-MONOMER.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR2 (EC:2.4.1.-)
Gene namesi
Name:KTR2
Ordered Locus Names:YKR061W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR061W.
SGDiS000001769. KTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3320Helical; Signal-anchor for type II membrane proteinAdd
BLAST
Topological domaini34 – 425392LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Probable mannosyltransferase KTR2PRO_0000208243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP33550.

PTM databases

iPTMnetiP33550.

Interactioni

Protein-protein interaction databases

BioGridi34192. 25 interactions.
IntActiP33550. 1 interaction.
MINTiMINT-7544504.

Structurei

3D structure databases

ProteinModelPortaliP33550.
SMRiP33550. Positions 83-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 8956Stem regionBy similarityAdd
BLAST
Regioni90 – 425336CatalyticBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 15 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
InParanoidiP33550.
KOiK03854.
OMAiRSYRNMC.
OrthoDBiEOG092C3H4I.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR31121. PTHR31121. 1 hit.
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P33550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQICKVFLTQ VKKLLFVSLL FCLIAQTCWL ALVPYQRQLS LDSYFFRRSR
60 70 80 90 100
EVSSRYDFTR RRHMNQTLKL SSNTYNDEPL NKTKGIKNQR ENATLLMLVR
110 120 130 140 150
NWELSGALRS MRSLEDRFNK NYQYDWTFLN DVPFDQEFIE ATTAMASGRT
160 170 180 190 200
QYALIPAEDW NRPSWINETL FEEALQLMEE KNILYGGSKS YRNMCRFNSG
210 220 230 240 250
FFFRQKILDP YDFYFRVEPD VEYFCDFPYD PFKVMRQNNK KYGFVITMYE
260 270 280 290 300
YEDTIPSLWE AVEEYLEETE SADIDMESNA FGFVSNFDFI GKSFGVIDSN
310 320 330 340 350
SGYNLCHFWT NFEIGDLNFF RSEKYIRFFE YLDSKGGFYY ERWGDAPVHS
360 370 380 390 400
IAASLLLKKD EIIHFDELGY KHMPFGTCPS AYYLRLQQRC LCDSNHPDNI
410 420
DLNVISCLRR WWKDGSGKYF LKHDS
Length:425
Mass (Da):50,651
Last modified:February 1, 1994 - v1
Checksum:iCF48E73E5BB0F832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17083 Unassigned DNA. Translation: AAA16119.1.
Z28286 Genomic DNA. Translation: CAA82140.1.
BK006944 Genomic DNA. Translation: DAA09212.1.
PIRiS38193.
RefSeqiNP_012987.3. NM_001179851.3.

Genome annotation databases

EnsemblFungiiYKR061W; YKR061W; YKR061W.
GeneIDi853935.
KEGGisce:YKR061W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17083 Unassigned DNA. Translation: AAA16119.1.
Z28286 Genomic DNA. Translation: CAA82140.1.
BK006944 Genomic DNA. Translation: DAA09212.1.
PIRiS38193.
RefSeqiNP_012987.3. NM_001179851.3.

3D structure databases

ProteinModelPortaliP33550.
SMRiP33550. Positions 83-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34192. 25 interactions.
IntActiP33550. 1 interaction.
MINTiMINT-7544504.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

PTM databases

iPTMnetiP33550.

Proteomic databases

MaxQBiP33550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR061W; YKR061W; YKR061W.
GeneIDi853935.
KEGGisce:YKR061W.

Organism-specific databases

EuPathDBiFungiDB:YKR061W.
SGDiS000001769. KTR2.

Phylogenomic databases

GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
InParanoidiP33550.
KOiK03854.
OMAiRSYRNMC.
OrthoDBiEOG092C3H4I.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciYEAST:G3O-32029-MONOMER.

Miscellaneous databases

PROiP33550.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR31121. PTHR31121. 1 hit.
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKTR2_YEAST
AccessioniPrimary (citable) accession number: P33550
Secondary accession number(s): D6VXC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.