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Protein

Probable mannosyltransferase KTR2

Gene

KTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei313NucleophileSequence analysis1

GO - Molecular functioni

  • alpha-1,2-mannosyltransferase activity Source: GO_Central
  • mannosyltransferase activity Source: SGD

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: SGD
  • protein N-linked glycosylation Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-32029-MONOMER
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT15 Glycosyltransferase Family 15

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR2 (EC:2.4.1.-)
Gene namesi
Name:KTR2
Ordered Locus Names:YKR061W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR061W
SGDiS000001769 KTR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 33Helical; Signal-anchor for type II membrane proteinAdd BLAST20
Topological domaini34 – 425LumenalSequence analysisAdd BLAST392

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082431 – 425Probable mannosyltransferase KTR2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP33550
PaxDbiP33550
PRIDEiP33550

PTM databases

iPTMnetiP33550

Interactioni

Protein-protein interaction databases

BioGridi34192, 105 interactors
IntActiP33550, 1 interactor
MINTiP33550
STRINGi4932.YKR061W

Structurei

3D structure databases

ProteinModelPortaliP33550
SMRiP33550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 89Stem regionBy similarityAdd BLAST56
Regioni90 – 425CatalyticBy similarityAdd BLAST336

Sequence similaritiesi

Belongs to the glycosyltransferase 15 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000000831
HOGENOMiHOG000160667
InParanoidiP33550
KOiK03854
OMAiFWRHPLV
OrthoDBiEOG092C3H4I

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002685 Glyco_trans_15
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR31121 PTHR31121, 1 hit
PfamiView protein in Pfam
PF01793 Glyco_transf_15, 1 hit
PIRSFiPIRSF018153 Glyco_trans_15, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P33550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQICKVFLTQ VKKLLFVSLL FCLIAQTCWL ALVPYQRQLS LDSYFFRRSR
60 70 80 90 100
EVSSRYDFTR RRHMNQTLKL SSNTYNDEPL NKTKGIKNQR ENATLLMLVR
110 120 130 140 150
NWELSGALRS MRSLEDRFNK NYQYDWTFLN DVPFDQEFIE ATTAMASGRT
160 170 180 190 200
QYALIPAEDW NRPSWINETL FEEALQLMEE KNILYGGSKS YRNMCRFNSG
210 220 230 240 250
FFFRQKILDP YDFYFRVEPD VEYFCDFPYD PFKVMRQNNK KYGFVITMYE
260 270 280 290 300
YEDTIPSLWE AVEEYLEETE SADIDMESNA FGFVSNFDFI GKSFGVIDSN
310 320 330 340 350
SGYNLCHFWT NFEIGDLNFF RSEKYIRFFE YLDSKGGFYY ERWGDAPVHS
360 370 380 390 400
IAASLLLKKD EIIHFDELGY KHMPFGTCPS AYYLRLQQRC LCDSNHPDNI
410 420
DLNVISCLRR WWKDGSGKYF LKHDS
Length:425
Mass (Da):50,651
Last modified:February 1, 1994 - v1
Checksum:iCF48E73E5BB0F832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17083 Unassigned DNA Translation: AAA16119.1
Z28286 Genomic DNA Translation: CAA82140.1
BK006944 Genomic DNA Translation: DAA09212.1
PIRiS38193
RefSeqiNP_012987.3, NM_001179851.3

Genome annotation databases

EnsemblFungiiYKR061W; YKR061W; YKR061W
GeneIDi853935
KEGGisce:YKR061W

Similar proteinsi

Entry informationi

Entry nameiKTR2_YEAST
AccessioniPrimary (citable) accession number: P33550
Secondary accession number(s): D6VXC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health