P33535 (OPRM_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mu-type opioid receptor
Short name=M-OR-1
Short name=MOR-1

Alternative name(s):
Opioid receptor B

Gene names

Name:	Oprm1
Synonyms:	Ror-b

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
Subunit structure	Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Brain. Is expressed in the cerebral cortex, caudate putamen, nucleus accumbens, septal nuclei, thalamus, hippocampus, and habenula. Not detected in cerebellum.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAQ77387.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	opioid receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P33535-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P33535-2)

Also known as: MOR1A;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → VCAF

Isoform 3 (identifier: P33535-3)

Also known as: MOR1R;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → GAEL

Isoform 4 (identifier: P33535-4)

Also known as: MOR1B;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → KIVLF

Isoform 5 (identifier: P33535-5)

Also known as: MOR1B2;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → EPQSVET

Isoform 6 (identifier: P33535-6)

Also known as: MOR1C1;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → PALAVSVAQI...ALIYNNVNFI

Isoform 7 (identifier: P33535-7)

Also known as: MOR-1C2;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → PALAVSVAQI...MPAHVLVRPW

Isoform 8 (identifier: P33535-8)

Also known as: rMOR-1D;

The sequence of this isoform differs from the canonical sequence as follows:
     387-398: LENLEAETAPLP → T

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Mu-type opioid receptor		PRO_0000069978
Regions
	Topological domain	1 – 64	64	Extracellular Potential
	Transmembrane	65 – 94	30	Helical; Name=1; Potential
	Topological domain	95 – 103	9	Cytoplasmic Potential
	Transmembrane	104 – 121	18	Helical; Name=2; Potential
	Topological domain	122 – 143	22	Extracellular Potential
	Transmembrane	144 – 163	20	Helical; Name=3; Potential
	Topological domain	164 – 193	30	Cytoplasmic Potential
	Transmembrane	194 – 209	16	Helical; Name=4; Potential
	Topological domain	210 – 234	25	Extracellular Potential
	Transmembrane	235 – 257	23	Helical; Name=5; Potential
	Topological domain	258 – 280	23	Cytoplasmic Potential
	Transmembrane	281 – 303	23	Helical; Name=6; Potential
	Topological domain	304 – 311	8	Extracellular Potential
	Transmembrane	312 – 328	17	Helical; Name=7; Potential
	Topological domain	329 – 398	70	Cytoplasmic Potential
Amino acid modifications
	Lipidation	351	1	S-palmitoyl cysteine Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Disulfide bond	140 ↔ 217		By similarity
Natural variations
	Alternative sequence	387 – 398	12	LENLE…TAPLP → VCAF in isoform 2.		VSP_041828
	Alternative sequence	387 – 398	12	LENLE…TAPLP → GAEL in isoform 3.		VSP_041829
	Alternative sequence	387 – 398	12	LENLE…TAPLP → KIVLF in isoform 4.		VSP_041830
	Alternative sequence	387 – 398	12	LENLE…TAPLP → EPQSVET in isoform 5.		VSP_041831
	Alternative sequence	387 – 398	12	LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NVNFI in isoform 6.		VSP_041832
	Alternative sequence	387 – 398	12	LENLE…TAPLP → PALAVSVAQIFTGYPSPTHG EKPCKSYRDRPRPCGRTWSL KSRAESNVEHFHCGAALIYN NELKIGPVSWLQMPAHVLVR PW in isoform 7.		VSP_041833
	Alternative sequence	387 – 398	12	LENLE…TAPLP → T in isoform 8.		VSP_041834
Experimental info
	Sequence conflict	237	1	F → G in AAA79180. Ref.6
	Sequence conflict	238	1	I → V in AAQ77386. Ref.7
	Sequence conflict	245	1	V → I in AAA41630. Ref.3
	Sequence conflict	245	1	V → I in AAA70049. Ref.4
	Sequence conflict	245	1	V → I in S77863. Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 9C916DE7C1C33743	FASTA	398	44,494
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP
	Isoform 2 (MOR1A) [UniParc]. Checksum: 1880D1C9918035A4	FASTA	390	43,636
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 QNSTRVRQNT REHPSTANTV DRTNHQVCAF
	Isoform 3 (MOR1R) [UniParc]. Checksum: 166612B3218035A4	FASTA	390	43,586
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 QNSTRVRQNT REHPSTANTV DRTNHQGAEL
	Isoform 4 (MOR1B) [UniParc]. Checksum: 81767FCF38618035	FASTA	391	43,816
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 QNSTRVRQNT REHPSTANTV DRTNHQKIVL F
	Isoform 5 (MOR1B2) [UniParc]. Checksum: A9819A64EBC80041	FASTA	393	43,986
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 QNSTRVRQNT REHPSTANTV DRTNHQEPQS VET
	Isoform 6 (MOR1C1) [UniParc]. Checksum: F1130789E14DF1F7	FASTA	451	50,445
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 400 410 420 QNSTRVRQNT REHPSTANTV DRTNHQPALA VSVAQIFTGY PSPTHGEKPC KSYRDRPRPC 430 440 450 GRTWSLKSRA ESNVEHFHCG AALIYNNVNF I
	Isoform 7 (MOR-1C2) [UniParc]. Checksum: 55F763EE13B2B6D1	FASTA	468	52,410
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 390 400 410 420 QNSTRVRQNT REHPSTANTV DRTNHQPALA VSVAQIFTGY PSPTHGEKPC KSYRDRPRPC 430 440 450 460 GRTWSLKSRA ESNVEHFHCG AALIYNNELK IGPVSWLQMP AHVLVRPW
	Isoform 8 (rMOR-1D) [UniParc]. Checksum: BAF18035A454EB66	FASTA	387	43,317
	10 20 30 40 50 60 MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 70 80 90 100 110 120 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 130 140 150 160 170 180 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 190 200 210 220 230 240 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 250 260 270 280 290 300 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 310 320 330 340 350 360 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 370 380 QNSTRVRQNT REHPSTANTV DRTNHQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes." Fukuda K., Kato S., Mori K., Nishi M., Takeshima H. FEBS Lett. 327:311-314(1993) [PubMed: 8394245] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Mu opiate receptor: cDNA cloning and expression." Wang J.-B., Imai Y., Epler M.C., Gregor P., Spivak C., Uhl G.R. Proc. Natl. Acad. Sci. U.S.A. 90:10230-10234(1993) [PubMed: 8234282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Molecular cloning and functional expression of a mu-opioid receptor from rat brain." Chen Y., Mestek A., Liu J., Hurley J.A., Yu L. Mol. Pharmacol. 44:8-12(1993) [PubMed: 8393525] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[4]	Bunzow J.R., Grandy D.K., Kelly M. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Sprague-Dawley. Tissue: Brain.
[5]	"Cloning and pharmacological characterization of a rat mu opioid receptor." Thompson R.C., Mansour A., Akil H., Watson S.J. Neuron 11:903-913(1993) [PubMed: 8240812] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: Sprague-Dawley. Tissue: Olfactory bulb.
[6]	"Cloning, characterization, and distribution of a mu-opioid receptor in rat brain." Zastawny R.L., George S.R., Nguyen T., Cheng R., Tsatsos J., Briones-Urbina R., O'Dowd B.F. J. Neurochem. 62:2099-2105(1994) [PubMed: 8189219] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Identification and characterization of two new alternatively spliced variants from the rat mu opioid receptor gene, Oprm." Pan Y.-X., Xu J., Pasternak G.W. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5). Strain: Sprague-Dawley.
[8]	"Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy." Pasternak D.A., Pan L., Xu J., Yu R., Xu M.M., Pasternak G.W., Pan Y.X. J. Neurochem. 91:881-890(2004) [PubMed: 15525342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 6; 7 AND 8). Strain: Sprague-Dawley.
[9]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed: 15057822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[10]	"Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages." Sedqi M., Roy S., Ramakrishnan S., Elde R., Loh H.H. Biochem. Biophys. Res. Commun. 209:563-574(1995) [PubMed: 7733926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-340. Tissue: Macrophage.
[11]	"Cloning and expression of an isoform of the rat mu opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1." Zimprich A., Simon T., Hoellt V. FEBS Lett. 359:142-146(1995) [PubMed: 7532594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 356-398 (ISOFORM 4).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16349 mRNA. Translation: BAA03852.1. L20684 mRNA. Translation: AAA41643.1. L13069 mRNA. Translation: AAA41630.1. U02083 mRNA. Translation: AAA70049.1. L22455 mRNA. Translation: AAA16075.1. U35424 mRNA. Translation: AAA79180.1. AY309003 mRNA. Translation: AAQ77387.1. Frameshift. AY309004 mRNA. Translation: AAQ77388.1. AY225402 mRNA. Translation: AAP44725.1. AY225403 mRNA. Translation: AAP44726.1. AY309000 mRNA. Translation: AAQ77384.1. AY309002 mRNA. Translation: AAQ77386.1. S77863 mRNA. No translation available. S75669 mRNA. Translation: AAB33530.2.
IPI	IPI00655338.
PIR	I56504. I56517. S69010.
RefSeq	NP_001033686.1. NM_001038597.2. NP_001033688.2. NM_001038599.2. NP_001033689.1. NM_001038600.2. NP_001033690.1. NM_001038601.2. NP_037203.1. NM_013071.2.
UniGene	Rn.10118.
3D structure databases
ProteinModelPortal	P33535.
ModBase	Search...
Protein-protein interaction databases
STRING	P33535.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P33535.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000044912; ENSRNOP00000043569; ENSRNOG00000018191. ENSRNOT00000051837; ENSRNOP00000051290; ENSRNOG00000018191. ENSRNOT00000060637; ENSRNOP00000057371; ENSRNOG00000018191. ENSRNOT00000064376; ENSRNOP00000063119; ENSRNOG00000018191. ENSRNOT00000066989; ENSRNOP00000061636; ENSRNOG00000018191.
GeneID	25601.
KEGG	rno:25601.
UCSC	NM_013071. rat.
Organism-specific databases
CTD	4988.
RGD	3234. Oprm1.
Phylogenomic databases
eggNOG	roNOG08631.
GeneTree	ENSGT00600000084010.
HOVERGEN	HBG106919.
OrthoDB	EOG4KD6MF.
Gene expression databases
ArrayExpress	P33535.
Genevestigator	P33535.
GermOnline	ENSRNOG00000018191. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000105. Mu_opioid_rcpt. IPR001418. Opioid_rcpt. [Graphical view]
KO	K04215.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00537. MUOPIOIDR. PR00384. OPIOIDR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607309.

Entry information

Entry name

OPRM_RAT

Accession

Primary (citable) accession number: P33535
Secondary accession number(s): Q2TV20 , Q2TV21, Q4VWM5, Q4VWM7, Q4VWX7, Q4VWX8, Q62846, Q64064, Q64120

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	January 25, 2012
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program