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Protein

Delta-type opioid receptor

Gene

Oprd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.2 Publications

GO - Molecular functioni

  • enkephalin receptor activity Source: RGD
  • neuropeptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-type opioid receptor
Short name:
D-OR-1
Short name:
DOR-1
Alternative name(s):
Opioid receptor A
Gene namesi
Name:Oprd1
Synonyms:Ror-a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3233. Oprd1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularBy similarityAdd BLAST47
Transmembranei48 – 75Helical; Name=1By similarityAdd BLAST28
Topological domaini76 – 85CytoplasmicBy similarity10
Transmembranei86 – 110Helical; Name=2By similarityAdd BLAST25
Topological domaini111 – 122ExtracellularBy similarityAdd BLAST12
Transmembranei123 – 144Helical; Name=3By similarityAdd BLAST22
Topological domaini145 – 163CytoplasmicBy similarityAdd BLAST19
Transmembranei164 – 186Helical; Name=4By similarityAdd BLAST23
Topological domaini187 – 206ExtracellularBy similarityAdd BLAST20
Transmembranei207 – 238Helical; Name=5By similarityAdd BLAST32
Topological domaini239 – 261CytoplasmicBy similarityAdd BLAST23
Transmembranei262 – 284Helical; Name=6By similarityAdd BLAST23
Topological domaini285 – 299ExtracellularBy similarityAdd BLAST15
Transmembranei300 – 321Helical; Name=7By similarityAdd BLAST22
Topological domaini322 – 372CytoplasmicBy similarityAdd BLAST51

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: RGD
  • dendrite membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • membrane raft Source: RGD
  • plasma membrane Source: RGD
  • postsynaptic membrane Source: RGD
  • vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL269.
GuidetoPHARMACOLOGYi317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699651 – 372Delta-type opioid receptorAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi333S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

PaxDbiP33533.

PTM databases

iPTMnetiP33533.
PhosphoSitePlusiP33533.

Expressioni

Tissue specificityi

Detected in brain, brain stem and brain cortex.2 Publications

Gene expression databases

BgeeiENSRNOG00000010531.
GenevisibleiP33533. RN.

Interactioni

Subunit structurei

May form homooligomers. Forms a heterodimer with OPRM1. Interacts with GPRASP1. Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014084.

Chemistry databases

BindingDBiP33533.

Structurei

3D structure databases

ProteinModelPortaliP33533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP33533.
KOiK04213.
OMAiIVRYTKL.
OrthoDBiEOG091G0HEN.
PhylomeDBiP33533.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI
60 70 80 90 100
AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS
110 120 130 140 150
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV
160 170 180 190 200
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCTL
210 220 230 240 250
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK
260 270 280 290 300
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL
310 320 330 340 350
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ
360 370
ATARERVTAC TPSDGPGGGA AA
Length:372
Mass (Da):40,450
Last modified:February 1, 1994 - v1
Checksum:iF578BD1F64C61D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16348 mRNA. Translation: BAA03851.1.
U00475 mRNA. Translation: AAA19939.1.
PIRiS34592.
RefSeqiNP_036749.1. NM_012617.1.
UniGeneiRn.10310.

Genome annotation databases

EnsembliENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
GeneIDi24613.
KEGGirno:24613.
UCSCiRGD:3233. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16348 mRNA. Translation: BAA03851.1.
U00475 mRNA. Translation: AAA19939.1.
PIRiS34592.
RefSeqiNP_036749.1. NM_012617.1.
UniGeneiRn.10310.

3D structure databases

ProteinModelPortaliP33533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014084.

Chemistry databases

BindingDBiP33533.
ChEMBLiCHEMBL269.
GuidetoPHARMACOLOGYi317.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP33533.
PhosphoSitePlusiP33533.

Proteomic databases

PaxDbiP33533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
GeneIDi24613.
KEGGirno:24613.
UCSCiRGD:3233. rat.

Organism-specific databases

CTDi4985.
RGDi3233. Oprd1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP33533.
KOiK04213.
OMAiIVRYTKL.
OrthoDBiEOG091G0HEN.
PhylomeDBiP33533.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP33533.

Gene expression databases

BgeeiENSRNOG00000010531.
GenevisibleiP33533. RN.

Family and domain databases

InterProiIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPRD_RAT
AccessioniPrimary (citable) accession number: P33533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.