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P33533 (OPRD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-type opioid receptor

Short name=D-OR-1
Short name=DOR-1
Alternative name(s):
Opioid receptor A
Gene names
Name:Oprd1
Synonyms:Ror-a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Ref.1 Ref.2

Subunit structure

May form homooligomers. Interacts with GPRASP1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1 Ref.2.

Tissue specificity

Detected in brain, brain stem and brain cortex. Ref.1 Ref.2

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

adult locomotory behavior

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from expression pattern PubMed 7562535. Source: RGD

neuropeptide signaling pathway

Inferred from electronic annotation. Source: Ensembl

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 9572309. Source: UniProtKB

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of calcium ion transport

Inferred from mutant phenotype PubMed 10493735. Source: RGD

regulation of sensory perception of pain

Inferred from direct assay PubMed 12710986. Source: RGD

   Cellular_componentaxon terminus

Inferred from direct assay PubMed 9183814. Source: RGD

cytoplasm

Inferred from direct assay PubMed 16192372. Source: RGD

dendrite membrane

Inferred from direct assay PubMed 9183814. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intrinsic component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

membrane raft

Inferred from direct assay PubMed 17141202. Source: RGD

plasma membrane

Inferred from direct assay PubMed 16192372. Source: RGD

postsynaptic membrane

Inferred from direct assay PubMed 9183814. Source: RGD

vesicle

Inferred from direct assay PubMed 9183814. Source: RGD

   Molecular_functionenkephalin receptor activity

Inferred from direct assay Ref.2. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Delta-type opioid receptor
PRO_0000069965

Regions

Topological domain1 – 4747Extracellular By similarity
Transmembrane48 – 7528Helical; Name=1; By similarity
Topological domain76 – 8510Cytoplasmic By similarity
Transmembrane86 – 11025Helical; Name=2; By similarity
Topological domain111 – 12212Extracellular By similarity
Transmembrane123 – 14422Helical; Name=3; By similarity
Topological domain145 – 16319Cytoplasmic By similarity
Transmembrane164 – 18623Helical; Name=4; By similarity
Topological domain187 – 20620Extracellular By similarity
Transmembrane207 – 23832Helical; Name=5; By similarity
Topological domain239 – 26123Cytoplasmic By similarity
Transmembrane262 – 28423Helical; Name=6; By similarity
Topological domain285 – 29915Extracellular By similarity
Transmembrane300 – 32122Helical; Name=7; By similarity
Topological domain322 – 37251Cytoplasmic By similarity

Amino acid modifications

Lipidation3331S-palmitoyl cysteine Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
P33533 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F578BD1F64C61D50

FASTA37240,450
        10         20         30         40         50         60 
MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI AITALYSAVC 

        70         80         90        100        110        120 
AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL 

       130        140        150        160        170        180 
CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG 

       190        200        210        220        230        240 
VPIMVMAVTQ PRDGAVVCTL QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL 

       250        260        270        280        290        300 
RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL 

       310        320        330        340        350        360 
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ ATARERVTAC 

       370 
TPSDGPGGGA AA 

« Hide

References

[1]"Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes."
Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.
FEBS Lett. 327:311-314(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Molecular cloning and expression of a delta-opioid receptor from rat brain."
Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.
J. Neurosci. Res. 37:714-719(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16348 mRNA. Translation: BAA03851.1.
U00475 mRNA. Translation: AAA19939.1.
PIRS34592.
RefSeqNP_036749.1. NM_012617.1.
UniGeneRn.10310.

3D structure databases

ProteinModelPortalP33533.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014084.

Chemistry

BindingDBP33533.
ChEMBLCHEMBL269.
GuidetoPHARMACOLOGY317.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP33533.

Proteomic databases

PaxDbP33533.
PRIDEP33533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
GeneID24613.
KEGGrno:24613.
UCSCRGD:3233. rat.

Organism-specific databases

CTD4985.
RGD3233. Oprd1.

Phylogenomic databases

eggNOGNOG241795.
GeneTreeENSGT00630000089574.
HOGENOMHOG000230486.
HOVERGENHBG106919.
InParanoidP33533.
KOK04213.
OMALCRKPCG.
OrthoDBEOG7BKCVQ.
PhylomeDBP33533.
TreeFamTF315737.

Gene expression databases

GenevestigatorP33533.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603852.
PROP33533.

Entry information

Entry nameOPRD_RAT
AccessionPrimary (citable) accession number: P33533
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries