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P33533

- OPRD_RAT

UniProt

P33533 - OPRD_RAT

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Protein

Delta-type opioid receptor

Gene
Oprd1, Ror-a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.2 Publications

GO - Molecular functioni

  1. enkephalin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  2. adult locomotory behavior Source: Ensembl
  3. cellular response to growth factor stimulus Source: RGD
  4. neuropeptide signaling pathway Source: Ensembl
  5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  6. protein import into nucleus, translocation Source: Ensembl
  7. regulation of calcium ion transport Source: RGD
  8. regulation of sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-type opioid receptor
Short name:
D-OR-1
Short name:
DOR-1
Alternative name(s):
Opioid receptor A
Gene namesi
Name:Oprd1
Synonyms:Ror-a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi3233. Oprd1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Extracellular By similarityAdd
BLAST
Transmembranei48 – 7528Helical; Name=1; By similarityAdd
BLAST
Topological domaini76 – 8510Cytoplasmic By similarity
Transmembranei86 – 11025Helical; Name=2; By similarityAdd
BLAST
Topological domaini111 – 12212Extracellular By similarityAdd
BLAST
Transmembranei123 – 14422Helical; Name=3; By similarityAdd
BLAST
Topological domaini145 – 16319Cytoplasmic By similarityAdd
BLAST
Transmembranei164 – 18623Helical; Name=4; By similarityAdd
BLAST
Topological domaini187 – 20620Extracellular By similarityAdd
BLAST
Transmembranei207 – 23832Helical; Name=5; By similarityAdd
BLAST
Topological domaini239 – 26123Cytoplasmic By similarityAdd
BLAST
Transmembranei262 – 28423Helical; Name=6; By similarityAdd
BLAST
Topological domaini285 – 29915Extracellular By similarityAdd
BLAST
Transmembranei300 – 32122Helical; Name=7; By similarityAdd
BLAST
Topological domaini322 – 37251Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. axon terminus Source: RGD
  2. cytoplasm Source: RGD
  3. dendrite membrane Source: RGD
  4. integral component of membrane Source: UniProtKB-KW
  5. intrinsic component of plasma membrane Source: Ensembl
  6. membrane raft Source: RGD
  7. plasma membrane Source: RGD
  8. postsynaptic membrane Source: RGD
  9. vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Delta-type opioid receptorPRO_0000069965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi121 ↔ 198 By similarity
Lipidationi333 – 3331S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP33533.
PRIDEiP33533.

PTM databases

PhosphoSiteiP33533.

Expressioni

Tissue specificityi

Detected in brain, brain stem and brain cortex.2 Publications

Gene expression databases

GenevestigatoriP33533.

Interactioni

Subunit structurei

May form homooligomers. Interacts with GPRASP1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014084.

Structurei

3D structure databases

ProteinModelPortaliP33533.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG241795.
GeneTreeiENSGT00630000089574.
HOGENOMiHOG000230486.
HOVERGENiHBG106919.
InParanoidiP33533.
KOiK04213.
OMAiLCRKPCG.
OrthoDBiEOG7BKCVQ.
PhylomeDBiP33533.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33533-1 [UniParc]FASTAAdd to Basket

« Hide

MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI    50
AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS 100
TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 150
CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCTL 200
QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 250
EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL 300
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ 350
ATARERVTAC TPSDGPGGGA AA 372
Length:372
Mass (Da):40,450
Last modified:February 1, 1994 - v1
Checksum:iF578BD1F64C61D50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16348 mRNA. Translation: BAA03851.1.
U00475 mRNA. Translation: AAA19939.1.
PIRiS34592.
RefSeqiNP_036749.1. NM_012617.1.
UniGeneiRn.10310.

Genome annotation databases

EnsembliENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
GeneIDi24613.
KEGGirno:24613.
UCSCiRGD:3233. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16348 mRNA. Translation: BAA03851.1 .
U00475 mRNA. Translation: AAA19939.1 .
PIRi S34592.
RefSeqi NP_036749.1. NM_012617.1.
UniGenei Rn.10310.

3D structure databases

ProteinModelPortali P33533.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014084.

Chemistry

BindingDBi P33533.
ChEMBLi CHEMBL269.
GuidetoPHARMACOLOGYi 317.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P33533.

Proteomic databases

PaxDbi P33533.
PRIDEi P33533.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014084 ; ENSRNOP00000014084 ; ENSRNOG00000010531 .
GeneIDi 24613.
KEGGi rno:24613.
UCSCi RGD:3233. rat.

Organism-specific databases

CTDi 4985.
RGDi 3233. Oprd1.

Phylogenomic databases

eggNOGi NOG241795.
GeneTreei ENSGT00630000089574.
HOGENOMi HOG000230486.
HOVERGENi HBG106919.
InParanoidi P33533.
KOi K04213.
OMAi LCRKPCG.
OrthoDBi EOG7BKCVQ.
PhylomeDBi P33533.
TreeFami TF315737.

Miscellaneous databases

NextBioi 603852.
PROi P33533.

Gene expression databases

Genevestigatori P33533.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes."
    Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.
    FEBS Lett. 327:311-314(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Molecular cloning and expression of a delta-opioid receptor from rat brain."
    Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.
    J. Neurosci. Res. 37:714-719(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiOPRD_RAT
AccessioniPrimary (citable) accession number: P33533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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