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P33533 (OPRD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Delta-type opioid receptor
Short name=D-OR-1
Short name=DOR-1
Alternative name(s):
Opioid receptor A
Gene names
Name:Oprd1
Synonyms:Ror-a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins.

Subunit structure

Interacts with GPRASP1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Compara

adult locomotory behavior

Inferred from electronic annotation. Source: Compara

cellular response to growth factor stimulus

Inferred from expression pattern PubMed 7562535. Source: RGD

neuropeptide signaling pathway

Inferred from electronic annotation. Source: Compara

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 9572309. Source: UniProtKB

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Compara

regulation of calcium ion transport

Inferred from mutant phenotype PubMed 10493735. Source: RGD

regulation of sensory perception of pain

Inferred from direct assay PubMed 12710986. Source: RGD

   Cellular_componentaxon terminus

Inferred from direct assay PubMed 9183814. Source: RGD

cytoplasm

Inferred from direct assay PubMed 16192372. Source: RGD

dendrite membrane

Inferred from direct assay PubMed 9183814. Source: RGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from direct assay PubMed 17141202. Source: RGD

postsynaptic membrane

Inferred from direct assay PubMed 9183814. Source: RGD

vesicle

Inferred from direct assay PubMed 9183814. Source: RGD

   Molecular_functionenkephalin receptor activity

Inferred from direct assay Ref.2. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Delta-type opioid receptor
PRO_0000069965

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 7530Helical; Name=1; Potential
Topological domain76 – 849Cytoplasmic Potential
Transmembrane85 – 10218Helical; Name=2; Potential
Topological domain103 – 12422Extracellular Potential
Transmembrane125 – 14420Helical; Name=3; Potential
Topological domain145 – 17430Cytoplasmic Potential
Transmembrane175 – 19016Helical; Name=4; Potential
Topological domain191 – 21525Extracellular Potential
Transmembrane216 – 23823Helical; Name=5; Potential
Topological domain239 – 26123Cytoplasmic Potential
Transmembrane262 – 28423Helical; Name=6; Potential
Topological domain285 – 2939Extracellular Potential
Transmembrane294 – 31017Helical; Name=7; Potential
Topological domain311 – 37262Cytoplasmic Potential

Amino acid modifications

Lipidation3331S-palmitoyl cysteine Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation331N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 198 By similarity

Sequences

Sequence LengthMass (Da)Tools
P33533 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F578BD1F64C61D50

FASTA37240,450
        10         20         30         40         50         60 
MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI AITALYSAVC 

        70         80         90        100        110        120 
AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL 

       130        140        150        160        170        180 
CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG 

       190        200        210        220        230        240 
VPIMVMAVTQ PRDGAVVCTL QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL 

       250        260        270        280        290        300 
RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL 

       310        320        330        340        350        360 
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ ATARERVTAC 

       370 
TPSDGPGGGA AA

« Hide

References

[1]"Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes."
Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.
FEBS Lett. 327:311-314(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Molecular cloning and expression of a delta-opioid receptor from rat brain."
Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.
J. Neurosci. Res. 37:714-719(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D16348 mRNA. Translation: BAA03851.1.
U00475 mRNA. Translation: AAA19939.1.
IPIIPI00192496.
PIRS34592.
RefSeqNP_036749.1. NM_012617.1.
UniGeneRn.10310.

3D structure databases

ProteinModelPortalP33533.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014084.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP33533.

Proteomic databases

PaxDbP33533.
PRIDEP33533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
GeneID24613.
KEGGrno:24613.
UCSCRGD:3233. rat.

Organism-specific databases

CTD4985.
RGD3233. Oprd1.

Phylogenomic databases

eggNOGNOG241795.
GeneTreeENSGT00630000089574.
HOGENOMHOG000230486.
HOVERGENHBG106919.
InParanoidP33533.
KOK04213.
OMALCRKPCG.
OrthoDBEOG4XWFZ5.

Gene expression databases

GenevestigatorP33533.
GermOnlineENSRNOG00000010531. Rattus norvegicus.

Family and domain databases

InterProIPR000321. Delta_opi_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001418. Opioid_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00525. DELTAOPIOIDR.
PR00237. GPCRRHODOPSN.
PR00384. OPIOIDR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP33533.
ChEMBLCHEMBL269.
NextBio603852.

Entry information

Entry nameOPRD_RAT
AccessionPrimary (citable) accession number: P33533
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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