Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P33533

- OPRD_RAT

UniProt

P33533 - OPRD_RAT

Protein

Delta-type opioid receptor

Gene

Oprd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.2 Publications

    GO - Molecular functioni

    1. enkephalin receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
    2. adult locomotory behavior Source: Ensembl
    3. cellular response to growth factor stimulus Source: RGD
    4. neuropeptide signaling pathway Source: Ensembl
    5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    6. protein import into nucleus, translocation Source: Ensembl
    7. regulation of calcium ion transport Source: RGD
    8. regulation of sensory perception of pain Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-type opioid receptor
    Short name:
    D-OR-1
    Short name:
    DOR-1
    Alternative name(s):
    Opioid receptor A
    Gene namesi
    Name:Oprd1
    Synonyms:Ror-a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi3233. Oprd1.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. axon terminus Source: RGD
    2. cytoplasm Source: RGD
    3. dendrite membrane Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. intrinsic component of plasma membrane Source: Ensembl
    6. membrane raft Source: RGD
    7. plasma membrane Source: RGD
    8. postsynaptic membrane Source: RGD
    9. vesicle Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Delta-type opioid receptorPRO_0000069965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
    Lipidationi333 – 3331S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP33533.
    PRIDEiP33533.

    PTM databases

    PhosphoSiteiP33533.

    Expressioni

    Tissue specificityi

    Detected in brain, brain stem and brain cortex.2 Publications

    Gene expression databases

    GenevestigatoriP33533.

    Interactioni

    Subunit structurei

    May form homooligomers. Interacts with GPRASP1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014084.

    Structurei

    3D structure databases

    ProteinModelPortaliP33533.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularBy similarityAdd
    BLAST
    Topological domaini76 – 8510CytoplasmicBy similarity
    Topological domaini111 – 12212ExtracellularBy similarityAdd
    BLAST
    Topological domaini145 – 16319CytoplasmicBy similarityAdd
    BLAST
    Topological domaini187 – 20620ExtracellularBy similarityAdd
    BLAST
    Topological domaini239 – 26123CytoplasmicBy similarityAdd
    BLAST
    Topological domaini285 – 29915ExtracellularBy similarityAdd
    BLAST
    Topological domaini322 – 37251CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7528Helical; Name=1By similarityAdd
    BLAST
    Transmembranei86 – 11025Helical; Name=2By similarityAdd
    BLAST
    Transmembranei123 – 14422Helical; Name=3By similarityAdd
    BLAST
    Transmembranei164 – 18623Helical; Name=4By similarityAdd
    BLAST
    Transmembranei207 – 23832Helical; Name=5By similarityAdd
    BLAST
    Transmembranei262 – 28423Helical; Name=6By similarityAdd
    BLAST
    Transmembranei300 – 32122Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241795.
    GeneTreeiENSGT00630000089574.
    HOGENOMiHOG000230486.
    HOVERGENiHBG106919.
    InParanoidiP33533.
    KOiK04213.
    OMAiLCRKPCG.
    OrthoDBiEOG7BKCVQ.
    PhylomeDBiP33533.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000321. Delta_opi_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00525. DELTAOPIOIDR.
    PR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33533-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPVPSARAE LQFSLLANVS DTFPSAFPSA SANASGSPGA RSASSLALAI    50
    AITALYSAVC AVGLLGNVLV MFGIVRYTKL KTATNIYIFN LALADALATS 100
    TLPFQSAKYL METWPFGELL CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV 150
    CHPVKALDFR TPAKAKLINI CIWVLASGVG VPIMVMAVTQ PRDGAVVCTL 200
    QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL RSVRLLSGSK 250
    EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDIN RRDPLVVAAL 300
    HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRAPCGGQ EPGSLRRPRQ 350
    ATARERVTAC TPSDGPGGGA AA 372
    Length:372
    Mass (Da):40,450
    Last modified:February 1, 1994 - v1
    Checksum:iF578BD1F64C61D50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16348 mRNA. Translation: BAA03851.1.
    U00475 mRNA. Translation: AAA19939.1.
    PIRiS34592.
    RefSeqiNP_036749.1. NM_012617.1.
    UniGeneiRn.10310.

    Genome annotation databases

    EnsembliENSRNOT00000014084; ENSRNOP00000014084; ENSRNOG00000010531.
    GeneIDi24613.
    KEGGirno:24613.
    UCSCiRGD:3233. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16348 mRNA. Translation: BAA03851.1 .
    U00475 mRNA. Translation: AAA19939.1 .
    PIRi S34592.
    RefSeqi NP_036749.1. NM_012617.1.
    UniGenei Rn.10310.

    3D structure databases

    ProteinModelPortali P33533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014084.

    Chemistry

    BindingDBi P33533.
    ChEMBLi CHEMBL269.
    GuidetoPHARMACOLOGYi 317.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P33533.

    Proteomic databases

    PaxDbi P33533.
    PRIDEi P33533.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014084 ; ENSRNOP00000014084 ; ENSRNOG00000010531 .
    GeneIDi 24613.
    KEGGi rno:24613.
    UCSCi RGD:3233. rat.

    Organism-specific databases

    CTDi 4985.
    RGDi 3233. Oprd1.

    Phylogenomic databases

    eggNOGi NOG241795.
    GeneTreei ENSGT00630000089574.
    HOGENOMi HOG000230486.
    HOVERGENi HBG106919.
    InParanoidi P33533.
    KOi K04213.
    OMAi LCRKPCG.
    OrthoDBi EOG7BKCVQ.
    PhylomeDBi P33533.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 603852.
    PROi P33533.

    Gene expression databases

    Genevestigatori P33533.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000321. Delta_opi_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001418. Opioid_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00525. DELTAOPIOIDR.
    PR00237. GPCRRHODOPSN.
    PR00384. OPIOIDR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes."
      Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.
      FEBS Lett. 327:311-314(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Molecular cloning and expression of a delta-opioid receptor from rat brain."
      Abood M.E., Noel M.A., Farnsworth J.S., Tao Q.
      J. Neurosci. Res. 37:714-719(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiOPRD_RAT
    AccessioniPrimary (citable) accession number: P33533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3