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P33527

- MRP1_HUMAN

UniProt

P33527 - MRP1_HUMAN

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Protein
Multidrug resistance-associated protein 1
Gene
ABCC1, MRP, MRP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei653 – 6531ATP 1
Binding sitei713 – 7131ATP 1

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi678 – 6858ATP 1
Nucleotide bindingi1327 – 13348ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: ProtInc
  2. ATPase activity Source: UniProtKB
  3. ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
  4. transporter activity Source: ProtInc

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. arachidonic acid metabolic process Source: Reactome
  3. cobalamin metabolic process Source: Reactome
  4. leukotriene metabolic process Source: Reactome
  5. response to drug Source: ProtInc
  6. small molecule metabolic process Source: Reactome
  7. transmembrane transport Source: Reactome
  8. transport Source: ProtInc
  9. vitamin metabolic process Source: Reactome
  10. water-soluble vitamin metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_15480. ABC-family proteins mediated transport.
REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Protein family/group databases

TCDBi3.A.1.208.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP, MRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:51. ABCC1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular3 Publications
Add
BLAST
Transmembranei34 – 5421Helical; Name=1
Add
BLAST
Topological domaini55 – 7420Cytoplasmic3 Publications
Add
BLAST
Transmembranei75 – 9521Helical; Name=2
Add
BLAST
Topological domaini96 – 1005Extracellular3 Publications
Transmembranei101 – 12121Helical; Name=3
Add
BLAST
Topological domaini122 – 13312Cytoplasmic3 Publications
Add
BLAST
Transmembranei134 – 15421Helical; Name=4
Add
BLAST
Topological domaini155 – 17218Extracellular3 Publications
Add
BLAST
Transmembranei173 – 19321Helical; Name=5
Add
BLAST
Topological domaini194 – 316123Cytoplasmic3 Publications
Add
BLAST
Transmembranei317 – 33721Helical; Name=6
Add
BLAST
Topological domaini338 – 36326Extracellular3 Publications
Add
BLAST
Transmembranei364 – 38421Helical; Name=7
Add
BLAST
Topological domaini385 – 44056Cytoplasmic3 Publications
Add
BLAST
Transmembranei441 – 46121Helical; Name=8
Add
BLAST
Topological domaini462 – 4643Extracellular3 Publications
Transmembranei465 – 48521Helical; Name=9
Add
BLAST
Topological domaini486 – 54762Cytoplasmic3 Publications
Add
BLAST
Transmembranei548 – 56821Helical; Name=10
Add
BLAST
Topological domaini569 – 59022Extracellular3 Publications
Add
BLAST
Transmembranei591 – 61121Helical; Name=11
Add
BLAST
Topological domaini612 – 967356Cytoplasmic3 Publications
Add
BLAST
Transmembranei968 – 98821Helical; Name=12
Add
BLAST
Topological domaini989 – 102537Extracellular3 Publications
Add
BLAST
Transmembranei1026 – 104621Helical; Name=13
Add
BLAST
Topological domaini1047 – 108943Cytoplasmic3 Publications
Add
BLAST
Transmembranei1090 – 111021Helical; Name=14
Add
BLAST
Topological domaini1111 – 11111Extracellular3 Publications
Transmembranei1112 – 113221Helical; Name=15
Add
BLAST
Topological domaini1133 – 120371Cytoplasmic3 Publications
Add
BLAST
Transmembranei1204 – 122421Helical; Name=16
Add
BLAST
Topological domaini1225 – 12262Extracellular3 Publications
Transmembranei1227 – 124721Helical; Name=17
Add
BLAST
Topological domaini1248 – 1531284Cytoplasmic3 Publications
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi580 – 5801Q → A: No effect. 1 Publication
Mutagenesisi581 – 5811T → A: No effect. 1 Publication
Mutagenesisi585 – 5851S → A: No effect. 1 Publication
Mutagenesisi597 – 5971N → A: Increases resistance to vincristine and decreases resistance to VP-16. 1 Publication
Mutagenesisi604 – 6041S → A: Increases estradiol glucuronide transport. 1 Publication
Mutagenesisi605 – 6051S → A: Decreases resistance to vincristine, VP-16 and doxorubicin. 1 Publication
Mutagenesisi792 – 7921D → A: Only partially affects protein maturation; impairs leukotriene C4 transport. 1 Publication
Mutagenesisi792 – 7921D → L: Impairs protein maturation and leukotriene C4 transport. 1 Publication
Mutagenesisi793 – 7931D → L: No effect on protein maturation and leukotriene C4 transport. 1 Publication
Mutagenesisi1046 – 10461R → D: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
Mutagenesisi1084 – 10841D → R: Impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
Mutagenesisi1089 – 10891E → A, L, N or Q: Decreases resistance to anthracyclines. 1 Publication
Mutagenesisi1089 – 10891E → D: No effect. 1 Publication
Mutagenesisi1089 – 10891E → K: Abolishes resistance to anthracyclines. 1 Publication
Mutagenesisi1131 – 11311R → E: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
Mutagenesisi1138 – 11381R → E or K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication
Mutagenesisi1141 – 11411K → E: Reduced transport of leukotriene C4 and of glutathione. 1 Publication
Mutagenesisi1141 – 11411K → R: Reduced transport of glutathione. 1 Publication
Mutagenesisi1142 – 11421R → E or K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication
Mutagenesisi1246 – 12461W → A, F or Y: Impairs estradiol glucuronide transport. 1 Publication
Mutagenesisi1246 – 12461W → C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite. 1 Publication
Mutagenesisi1333 – 13331K → L: Impairs leukotriene C4 transport. 1 Publication
Mutagenesisi1454 – 14552DE → LL: Impairs leukotriene C4 transport.

Organism-specific databases

PharmGKBiPA244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15311531Multidrug resistance-associated protein 1
PRO_0000093351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)1 Publication
Glycosylationi23 – 231N-linked (GlcNAc...)1 Publication
Modified residuei503 – 5031N6-succinyllysine By similarity
Modified residuei905 – 9051Phosphoserine1 Publication
Modified residuei915 – 9151Phosphoserine1 Publication
Modified residuei930 – 9301Phosphoserine2 Publications
Glycosylationi1006 – 10061N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP33527.
PaxDbiP33527.
PRIDEiP33527.

PTM databases

PhosphoSiteiP33527.

Expressioni

Tissue specificityi

Lung, testis and peripheral blood mononuclear cells.

Gene expression databases

ArrayExpressiP33527.
BgeeiP33527.
CleanExiHS_ABCC1.
GenevestigatoriP33527.

Organism-specific databases

HPAiCAB016097.
HPA002380.

Interactioni

Protein-protein interaction databases

BioGridi110503. 30 interactions.
IntActiP33527. 5 interactions.
MINTiMINT-2802626.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi644 – 65310
Beta strandi660 – 6689
Beta strandi673 – 6775
Helixi684 – 6918
Beta strandi695 – 70410
Beta strandi708 – 7114
Beta strandi719 – 7213
Helixi722 – 7276
Helixi736 – 7438
Helixi747 – 7504
Helixi756 – 7583
Beta strandi759 – 7624
Helixi770 – 78415
Beta strandi787 – 7937
Turni794 – 7974
Helixi800 – 80910
Turni816 – 8194
Beta strandi820 – 8256
Helixi832 – 8343
Beta strandi835 – 8428
Beta strandi845 – 8506
Helixi852 – 8587
Helixi861 – 8688

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CBZX-ray1.50A642-871[»]
ProteinModelPortaliP33527.
SMRiP33527. Positions 642-871.

Miscellaneous databases

EvolutionaryTraceiP33527.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini325 – 608284ABC transmembrane type-1 1
Add
BLAST
Domaini644 – 868225ABC transporter 1
Add
BLAST
Domaini975 – 1256282ABC transmembrane type-1 2
Add
BLAST
Domaini1293 – 1527235ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
HOVERGENiHBG108314.
KOiK05665.
OMAiLIQCERR.
OrthoDBiEOG7MWGW0.
PhylomeDBiP33527.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P33527-1) [UniParc]FASTAAdd to Basket

Also known as: Allexons

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF     50
PFYFLYLSRH DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI 100
FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALVCAL 150
AILRSKIMTA LKEDAQVDLF RDITFYVYFS LLLIQLVLSC FSDRSPLFSE 200
TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS 250
EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL 300
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI 350
KFVNDTKAPD WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI 400
GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ 450
VILALYLLWL NLGPSVLAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN 500
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLSAVGT 550
FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP 600
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT 650
FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG 700
HVAIKGSVAY VPQQAWIQND SLRENILFGC QLEEPYYRSV IQACALLPDL 750
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNADIYL FDDPLSAVDA 800
HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG 850
SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM 900
LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA 950
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT 1000
DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV 1050
DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN 1100
VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP 1150
VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA 1200
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM 1250
SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL 1300
RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE 1350
IIIDGINIAK IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW 1400
TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI 1450
LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL 1500
DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V 1531
Length:1,531
Mass (Da):171,591
Last modified:May 18, 2010 - v3
Checksum:i46A7CB643B9478C4
GO
Isoform 2 (identifier: P33527-2) [UniParc]FASTAAdd to Basket

Also known as: Delexon-17

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.

Show »
Length:1,472
Mass (Da):164,971
Checksum:i143FA6CB7F3123EF
GO
Isoform 3 (identifier: P33527-3) [UniParc]FASTAAdd to Basket

Also known as: Delexon-18

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.

Show »
Length:1,475
Mass (Da):165,569
Checksum:iF49C1B33B976D008
GO
Isoform 4 (identifier: P33527-4) [UniParc]FASTAAdd to Basket

Also known as: Delexon-30

The sequence of this isoform differs from the canonical sequence as follows:
     1431-1495: Missing.

Show »
Length:1,466
Mass (Da):164,304
Checksum:i314A53D4242BAF1B
GO
Isoform 5 (identifier: P33527-5) [UniParc]FASTAAdd to Basket

Also known as: Delexon-17-18

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.

Show »
Length:1,416
Mass (Da):158,949
Checksum:i6CAB8926692A0377
GO
Isoform 6 (identifier: P33527-6) [UniParc]FASTAAdd to Basket

Also known as: Delexon-17-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     1431-1495: Missing.

Show »
Length:1,407
Mass (Da):157,683
Checksum:iE76D558115609C22
GO
Isoform 7 (identifier: P33527-7) [UniParc]FASTAAdd to Basket

Also known as: Delexon-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,410
Mass (Da):158,282
Checksum:i6AAC80E7E87AD25D
GO
Isoform 8 (identifier: P33527-8) [UniParc]FASTAAdd to Basket

Also known as: Delexon-17-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,351
Mass (Da):151,661
Checksum:iB3FD697CE71EBB51
GO
Isoform 9 (identifier: P33527-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: G → GSTVMDEEEAG

Note: No experimental confirmation available.

Show »
Length:1,541
Mass (Da):172,640
Checksum:i5AE3F0E657F948F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431C → S.1 Publication
Corresponds to variant rs41395947 [ dbSNP | Ensembl ].
VAR_013317
Natural varianti73 – 731T → I.1 Publication
Corresponds to variant rs41494447 [ dbSNP | Ensembl ].
VAR_013318
Natural varianti117 – 1171M → T.3 Publications
VAR_013319
Natural varianti433 – 4331R → S.2 Publications
Corresponds to variant rs60782127 [ dbSNP | Ensembl ].
VAR_013320
Natural varianti633 – 6331R → Q.1 Publication
Corresponds to variant rs112282109 [ dbSNP | Ensembl ].
VAR_011488
Natural varianti671 – 6711G → V No effect on leukotriene C4 and estradiol glucuronide transport. 4 Publications
Corresponds to variant rs45511401 [ dbSNP | Ensembl ].
VAR_011489
Natural varianti723 – 7231R → Q.2 Publications
Corresponds to variant rs4148356 [ dbSNP | Ensembl ].
VAR_013321
Natural varianti861 – 8611A → T.1 Publication
Corresponds to variant rs45517537 [ dbSNP | Ensembl ].
VAR_055384
Natural varianti1047 – 10471C → S.1 Publication
Corresponds to variant rs13337489 [ dbSNP | Ensembl ].
VAR_055385
Natural varianti1058 – 10581R → Q.1 Publication
Corresponds to variant rs41410450 [ dbSNP | Ensembl ].
VAR_013322
Natural varianti1146 – 11461V → I.1 Publication
Corresponds to variant rs28706727 [ dbSNP | Ensembl ].
VAR_055386
Natural varianti1512 – 15121S → L.1 Publication
VAR_013323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei706 – 76459Missing in isoform 2, isoform 5, isoform 6 and isoform 8.
VSP_000037Add
BLAST
Alternative sequencei765 – 82056Missing in isoform 3, isoform 5, isoform 7 and isoform 8.
VSP_000038Add
BLAST
Alternative sequencei882 – 8821G → GSTVMDEEEAG in isoform 9.
VSP_017014
Alternative sequencei1431 – 149565Missing in isoform 4, isoform 6, isoform 7 and isoform 8.
VSP_000039Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05628 mRNA. Translation: AAB46616.1.
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA. Translation: AAB83979.1.
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA. Translation: AAB83980.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA. Translation: AAB83981.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA. Translation: AAB83983.1.
EF419769 Genomic DNA. Translation: ABN79590.1.
AC025778 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
AC136624 Genomic DNA. No translation available.
AB209120 mRNA. Translation: BAD92357.1.
U91318 Genomic DNA. Translation: AAC15784.1.
AC003026 Genomic DNA. Translation: AAC05808.1.
CCDSiCCDS42122.1. [P33527-1]
PIRiA44231. DVHUAR.
RefSeqiNP_004987.2. NM_004996.3. [P33527-1]
XP_005255386.1. XM_005255329.1. [P33527-2]
XP_006720947.1. XM_006720884.1. [P33527-4]
UniGeneiHs.391464.

Genome annotation databases

EnsembliENST00000345148; ENSP00000263014; ENSG00000103222. [P33527-4]
ENST00000346370; ENSP00000263019; ENSG00000103222. [P33527-3]
ENST00000349029; ENSP00000263016; ENSG00000103222. [P33527-5]
ENST00000351154; ENSP00000263017; ENSG00000103222. [P33527-2]
ENST00000399408; ENSP00000382340; ENSG00000103222. [P33527-9]
ENST00000399410; ENSP00000382342; ENSG00000103222. [P33527-1]
GeneIDi4363.
KEGGihsa:4363.
UCSCiuc010bvi.3. human. [P33527-1]

Polymorphism databases

DMDMi296439301.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L05628 mRNA. Translation: AAB46616.1 .
AF022853
, AF022827 , AF022828 , AF022829 , AF022831 , AF022833 , AF022835 , AF022837 , AF022839 , AF022841 , AF022850 , AF022849 , AF022848 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022852 , AF022851 , AF022840 , AF022838 , AF022836 , AF022834 , AF022832 , AF022826 , AF022825 , AF022824 , AF022830 Genomic DNA. Translation: AAB83979.1 .
AF022853
, AF022824 , AF022825 , AF022826 , AF022828 , AF022830 , AF022832 , AF022834 , AF022836 , AF022838 , AF022848 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022841 , AF022839 , AF022852 , AF022851 , AF022850 , AF022849 , AF022837 , AF022835 , AF022833 , AF022831 , AF022829 , AF022827 Genomic DNA. Translation: AAB83980.1 .
AF022853
, AF022824 , AF022825 , AF022826 , AF022827 , AF022829 , AF022831 , AF022833 , AF022835 , AF022837 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022841 , AF022840 , AF022838 , AF022852 , AF022851 , AF022850 , AF022849 , AF022848 , AF022836 , AF022834 , AF022832 , AF022830 , AF022828 Genomic DNA. Translation: AAB83981.1 .
AF022853
, AF022824 , AF022825 , AF022826 , AF022827 , AF022828 , AF022829 , AF022830 , AF022831 , AF022832 , AF022833 , AF022834 , AF022835 , AF022836 , AF022837 , AF022838 , AF022839 , AF022840 , AF022841 , AF022842 , AF022843 , AF022844 , AF022845 , AF022846 , AF022847 , AF022848 , AF022849 , AF022850 , AF022851 Genomic DNA. Translation: AAB83983.1 .
EF419769 Genomic DNA. Translation: ABN79590.1 .
AC025778 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
AC136624 Genomic DNA. No translation available.
AB209120 mRNA. Translation: BAD92357.1 .
U91318 Genomic DNA. Translation: AAC15784.1 .
AC003026 Genomic DNA. Translation: AAC05808.1 .
CCDSi CCDS42122.1. [P33527-1 ]
PIRi A44231. DVHUAR.
RefSeqi NP_004987.2. NM_004996.3. [P33527-1 ]
XP_005255386.1. XM_005255329.1. [P33527-2 ]
XP_006720947.1. XM_006720884.1. [P33527-4 ]
UniGenei Hs.391464.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CBZ X-ray 1.50 A 642-871 [» ]
ProteinModelPortali P33527.
SMRi P33527. Positions 642-871.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110503. 30 interactions.
IntActi P33527. 5 interactions.
MINTi MINT-2802626.

Chemistry

ChEMBLi CHEMBL3004.
DrugBanki DB00694. Daunorubicin.
DB01016. Glibenclamide.
DB01032. Probenecid.
DB01232. Saquinavir.
DB01138. Sulfinpyrazone.

Protein family/group databases

TCDBi 3.A.1.208.8. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei P33527.

Polymorphism databases

DMDMi 296439301.

Proteomic databases

MaxQBi P33527.
PaxDbi P33527.
PRIDEi P33527.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345148 ; ENSP00000263014 ; ENSG00000103222 . [P33527-4 ]
ENST00000346370 ; ENSP00000263019 ; ENSG00000103222 . [P33527-3 ]
ENST00000349029 ; ENSP00000263016 ; ENSG00000103222 . [P33527-5 ]
ENST00000351154 ; ENSP00000263017 ; ENSG00000103222 . [P33527-2 ]
ENST00000399408 ; ENSP00000382340 ; ENSG00000103222 . [P33527-9 ]
ENST00000399410 ; ENSP00000382342 ; ENSG00000103222 . [P33527-1 ]
GeneIDi 4363.
KEGGi hsa:4363.
UCSCi uc010bvi.3. human. [P33527-1 ]

Organism-specific databases

CTDi 4363.
GeneCardsi GC16P016043.
H-InvDB HIX0134370.
HGNCi HGNC:51. ABCC1.
HPAi CAB016097.
HPA002380.
MIMi 158343. gene.
neXtProti NX_P33527.
PharmGKBi PA244.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
HOVERGENi HBG108314.
KOi K05665.
OMAi LIQCERR.
OrthoDBi EOG7MWGW0.
PhylomeDBi P33527.
TreeFami TF105199.

Enzyme and pathway databases

Reactomei REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_15480. ABC-family proteins mediated transport.
REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

ChiTaRSi ABCC1. human.
EvolutionaryTracei P33527.
GeneWikii ABCC1.
GenomeRNAii 4363.
NextBioi 17171.
PROi P33527.
SOURCEi Search...

Gene expression databases

ArrayExpressi P33527.
Bgeei P33527.
CleanExi HS_ABCC1.
Genevestigatori P33527.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line."
    Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G.
    Science 258:1650-1654(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-117.
  2. "Multidrug resistance-associated protein: sequence correction."
    Cole S.P.C., Deeley R.G.
    Science 260:879-879(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
    Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G.
    Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT THR-117.
  4. NIEHS SNPs program
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-671; GLN-723; THR-861; SER-1047 AND ILE-1146.
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-1531 (ISOFORM 9).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 516-1531.
  8. "Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus."
    Hipfner D.R., Almquist K.C., Leslie E.M., Gerlach J.H., Grant C.E., Deeley R.G., Cole S.P.C.
    J. Biol. Chem. 272:23623-23630(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-19; ASN-23 AND ASN-1006.
  9. "Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence."
    Kast C., Gros P.
    J. Biol. Chem. 272:26479-26487(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  10. "Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein."
    Kast C., Gros P.
    Biochemistry 37:2305-2313(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.
  11. "Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1."
    Sjoelinder M., Tornhamre S., Claesson H.-E., Hydman J., Lindgren J.A.
    J. Lipid Res. 40:439-446(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes."
    Robbiani D.F., Finch R.A., Jaeger D., Muller W.A., Sartorelli A.C., Randolph G.J.
    Cell 103:757-768(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation."
    Cui L., Hou Y.-X., Riordan J.R., Chang X.-B.
    Arch. Biochem. Biophys. 392:153-161(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ASP-792; ASP-793; LYS-1333 AND 1454-ASP-GLU-1455.
  14. "Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport."
    Ito K., Olsen S.L., Qiu W., Deeley R.G., Cole S.P.C.
    J. Biol. Chem. 276:15616-15624(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TRP-1246.
  15. "Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines."
    Zhang D.-W., Cole S.P.C., Deeley R.G.
    J. Biol. Chem. 276:13231-13239(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF GLU-1089.
  16. "Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter."
    Situ D., Haimeur A., Conseil G., Sparks K.E., Zhang D.-W., Deeley R.G., Cole S.P.C.
    J. Biol. Chem. 279:38871-38880(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-1046; ASP-1084 AND ARG-1131.
  17. "Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1."
    Zhang D.-W., Nunoya K., Vasa M., Gu H.-M., Theis A., Cole S.P.C., Deeley R.G.
    Biochemistry 43:9413-9425(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF GLN-580; THR-581; SER-585; ASN-597; SER-604 AND SER-605.
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1)."
    Conseil G., Deeley R.G., Cole S.P.
    J. Biol. Chem. 281:43-50(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ARG-1138; LYS-1141 AND ARG-1142, SUBCELLULAR LOCATION.
  20. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-905 AND SER-930, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. "Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site."
    Ramaen O., Leulliot N., Sizun C., Ulryck N., Pamlard O., Lallemand J.-Y., Tilbeurgh H., Jacquet E.
    J. Mol. Biol. 359:940-949(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 642-871 IN COMPLEX WITH MG-ATP.
  27. Cited for: VARIANTS GLN-633 AND VAL-671.
  28. "Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter."
    Ringpfeil F., Lebwohl M.G., Christiano A.M., Uitto J.
    Proc. Natl. Acad. Sci. U.S.A. 97:6001-6006(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-671.
  29. "Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution."
    Conrad S., Kauffmann H.-M., Ito K., Deeley R.G., Cole S.P.C., Schrenk D.
    J. Hum. Genet. 46:656-663(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-433, CHARACTERIZATION OF VARIANT VAL-671.
  30. "Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum."
    Perdu J., Germain D.P.
    Hum. Mutat. 17:74-75(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-117 AND LEU-1512.
  31. "Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
    Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K.
    Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SER-43; ILE-73; GLN-723 AND GLN-1058.
  32. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-433.

Entry informationi

Entry nameiMRP1_HUMAN
AccessioniPrimary (citable) accession number: P33527
Secondary accession number(s): A3RJX2
, C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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