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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATP 11
Binding sitei713ATP 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 18
Nucleotide bindingi1327 – 1334ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATPase activity, coupled to transmembrane movement of substances Source: Reactome
  • ATPase-coupled anion transmembrane transporter activity Source: Reactome
  • ATP binding Source: ProtInc
  • cobalamin-transporting ATPase activity Source: Reactome
  • transporter activity Source: ProtInc

GO - Biological processi

  • cobalamin metabolic process Source: Reactome
  • leukotriene metabolic process Source: Reactome
  • response to drug Source: ProtInc
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103222-MONOMER.
ReactomeiR-HSA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.
R-HSA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-HSA-382556. ABC-family proteins mediated transport.
SIGNORiP33527.

Protein family/group databases

TCDBi3.A.1.208.8. the atp-binding cassette (abc) superfamily.

Chemistry databases

SwissLipidsiSLP:000000404.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP, MRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:51. ABCC1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularAdd BLAST33
Transmembranei34 – 54Helical; Name=1Add BLAST21
Topological domaini55 – 74CytoplasmicAdd BLAST20
Transmembranei75 – 95Helical; Name=2Add BLAST21
Topological domaini96 – 100Extracellular5
Transmembranei101 – 121Helical; Name=3Add BLAST21
Topological domaini122 – 133CytoplasmicAdd BLAST12
Transmembranei134 – 154Helical; Name=4Add BLAST21
Topological domaini155 – 172ExtracellularAdd BLAST18
Transmembranei173 – 193Helical; Name=5Add BLAST21
Topological domaini194 – 316CytoplasmicAdd BLAST123
Transmembranei317 – 337Helical; Name=6Add BLAST21
Topological domaini338 – 363ExtracellularAdd BLAST26
Transmembranei364 – 384Helical; Name=7Add BLAST21
Topological domaini385 – 440CytoplasmicAdd BLAST56
Transmembranei441 – 461Helical; Name=8Add BLAST21
Topological domaini462 – 464Extracellular3
Transmembranei465 – 485Helical; Name=9Add BLAST21
Topological domaini486 – 547CytoplasmicAdd BLAST62
Transmembranei548 – 568Helical; Name=10Add BLAST21
Topological domaini569 – 590ExtracellularAdd BLAST22
Transmembranei591 – 611Helical; Name=11Add BLAST21
Topological domaini612 – 967CytoplasmicAdd BLAST356
Transmembranei968 – 988Helical; Name=12Add BLAST21
Topological domaini989 – 1025ExtracellularAdd BLAST37
Transmembranei1026 – 1046Helical; Name=13Add BLAST21
Topological domaini1047 – 1089CytoplasmicAdd BLAST43
Transmembranei1090 – 1110Helical; Name=14Add BLAST21
Topological domaini1111Extracellular1
Transmembranei1112 – 1132Helical; Name=15Add BLAST21
Topological domaini1133 – 1203CytoplasmicAdd BLAST71
Transmembranei1204 – 1224Helical; Name=16Add BLAST21
Topological domaini1225 – 1226Extracellular2
Transmembranei1227 – 1247Helical; Name=17Add BLAST21
Topological domaini1248 – 1531CytoplasmicAdd BLAST284

GO - Cellular componenti

  • basolateral plasma membrane Source: CACAO
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi580Q → A: No effect. 1 Publication1
Mutagenesisi581T → A: No effect. 1 Publication1
Mutagenesisi585S → A: No effect. 1 Publication1
Mutagenesisi597N → A: Increases resistance to vincristine and decreases resistance to VP-16. 1 Publication1
Mutagenesisi604S → A: Increases estradiol glucuronide transport. 1 Publication1
Mutagenesisi605S → A: Decreases resistance to vincristine, VP-16 and doxorubicin. 1 Publication1
Mutagenesisi792D → A: Only partially affects protein maturation; impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi792D → L: Impairs protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi793D → L: No effect on protein maturation and leukotriene C4 transport. 1 Publication1
Mutagenesisi1046R → D: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1084D → R: Impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1089E → A, L, N or Q: Decreases resistance to anthracyclines. 1 Publication1
Mutagenesisi1089E → D: No effect. 1 Publication1
Mutagenesisi1089E → K: Abolishes resistance to anthracyclines. 1 Publication1
Mutagenesisi1131R → E: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication1
Mutagenesisi1138R → E or K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1141K → E: Reduced transport of leukotriene C4 and of glutathione. 1 Publication1
Mutagenesisi1141K → R: Reduced transport of glutathione. 1 Publication1
Mutagenesisi1142R → E or K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication1
Mutagenesisi1246W → A, F or Y: Impairs estradiol glucuronide transport. 1 Publication1
Mutagenesisi1246W → C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite. 1 Publication1
Mutagenesisi1333K → L: Impairs leukotriene C4 transport. 1 Publication1
Mutagenesisi1454 – 1455DE → LL: Impairs leukotriene C4 transport. 1 Publication2

Organism-specific databases

DisGeNETi4363.
OpenTargetsiENSG00000103222.
ENSG00000278183.
PharmGKBiPA244.

Chemistry databases

ChEMBLiCHEMBL3004.
DrugBankiDB05812. Abiraterone.
DB00345. Aminohippurate.
DB00701. Amprenavir.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB02659. Cholic Acid.
DB01394. Colchicine.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00970. Dactinomycin.
DB00694. Daunorubicin.
DB00586. Diclofenac.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00445. Epirubicin.
DB00199. Erythromycin.
DB00773. Etoposide.
DB00693. Fluorescein.
DB00143. Glutathione.
DB01016. Glyburide.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00563. Methotrexate.
DB00834. Mifepristone.
DB01204. Mitoxantrone.
DB01165. Ofloxacin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB01032. Probenecid.
DB00396. Progesterone.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB06335. Saxagliptin.
DB01138. Sulfinpyrazone.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
DB00399. Zoledronate.
GuidetoPHARMACOLOGYi779.

Polymorphism and mutation databases

BioMutaiABCC1.
DMDMi296439301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933511 – 1531Multidrug resistance-associated protein 1Add BLAST1531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)1 Publication1
Glycosylationi23N-linked (GlcNAc...)1 Publication1
Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei905PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Glycosylationi1006N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP33527.
MaxQBiP33527.
PaxDbiP33527.
PeptideAtlasiP33527.
PRIDEiP33527.

PTM databases

iPTMnetiP33527.
PhosphoSitePlusiP33527.
SwissPalmiP33527.

Expressioni

Tissue specificityi

Lung, testis and peripheral blood mononuclear cells.

Gene expression databases

BgeeiENSG00000103222.
CleanExiHS_ABCC1.
ExpressionAtlasiP33527. baseline and differential.
GenevisibleiP33527. HS.

Organism-specific databases

HPAiHPA002380.

Interactioni

Protein-protein interaction databases

BioGridi110503. 51 interactors.
IntActiP33527. 14 interactors.
MINTiMINT-2802626.
STRINGi9606.ENSP00000382342.

Chemistry databases

BindingDBiP33527.

Structurei

Secondary structure

11531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi644 – 653Combined sources10
Beta strandi660 – 668Combined sources9
Beta strandi673 – 677Combined sources5
Helixi684 – 691Combined sources8
Beta strandi695 – 704Combined sources10
Beta strandi708 – 711Combined sources4
Beta strandi719 – 721Combined sources3
Helixi722 – 727Combined sources6
Helixi736 – 743Combined sources8
Helixi747 – 750Combined sources4
Helixi756 – 758Combined sources3
Beta strandi759 – 762Combined sources4
Helixi770 – 784Combined sources15
Beta strandi787 – 793Combined sources7
Turni794 – 797Combined sources4
Helixi800 – 809Combined sources10
Turni816 – 819Combined sources4
Beta strandi820 – 825Combined sources6
Helixi832 – 834Combined sources3
Beta strandi835 – 842Combined sources8
Beta strandi845 – 850Combined sources6
Helixi852 – 858Combined sources7
Helixi861 – 868Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CBZX-ray1.50A642-871[»]
4C3ZX-ray2.10A628-881[»]
ProteinModelPortaliP33527.
SMRiP33527.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33527.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1256ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1293 – 1527ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiP33527.
KOiK05665.
OMAiMFSGPQI.
OrthoDBiEOG091G00IN.
PhylomeDBiP33527.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P33527-1) [UniParc]FASTAAdd to basket
Also known as: Allexons

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF
60 70 80 90 100
PFYFLYLSRH DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI
110 120 130 140 150
FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALVCAL
160 170 180 190 200
AILRSKIMTA LKEDAQVDLF RDITFYVYFS LLLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL
310 320 330 340 350
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI
360 370 380 390 400
KFVNDTKAPD WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLSAVGT
560 570 580 590 600
FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT
660 670 680 690 700
FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVAIKGSVAY VPQQAWIQND SLRENILFGC QLEEPYYRSV IQACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNADIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM
910 920 930 940 950
LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA
960 970 980 990 1000
DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT
1010 1020 1030 1040 1050
DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV
1060 1070 1080 1090 1100
DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN
1110 1120 1130 1140 1150
VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP
1160 1170 1180 1190 1200
VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA
1210 1220 1230 1240 1250
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM
1260 1270 1280 1290 1300
SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL
1310 1320 1330 1340 1350
RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE
1360 1370 1380 1390 1400
IIIDGINIAK IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW
1410 1420 1430 1440 1450
TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI
1460 1470 1480 1490 1500
LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL
1510 1520 1530
DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V
Length:1,531
Mass (Da):171,591
Last modified:May 18, 2010 - v3
Checksum:i46A7CB643B9478C4
GO
Isoform 2 (identifier: P33527-2) [UniParc]FASTAAdd to basket
Also known as: Delexon-17

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.

Show »
Length:1,472
Mass (Da):164,971
Checksum:i143FA6CB7F3123EF
GO
Isoform 3 (identifier: P33527-3) [UniParc]FASTAAdd to basket
Also known as: Delexon-18

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.

Show »
Length:1,475
Mass (Da):165,569
Checksum:iF49C1B33B976D008
GO
Isoform 4 (identifier: P33527-4) [UniParc]FASTAAdd to basket
Also known as: Delexon-30

The sequence of this isoform differs from the canonical sequence as follows:
     1431-1495: Missing.

Show »
Length:1,466
Mass (Da):164,304
Checksum:i314A53D4242BAF1B
GO
Isoform 5 (identifier: P33527-5) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.

Show »
Length:1,416
Mass (Da):158,949
Checksum:i6CAB8926692A0377
GO
Isoform 6 (identifier: P33527-6) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     1431-1495: Missing.

Show »
Length:1,407
Mass (Da):157,683
Checksum:iE76D558115609C22
GO
Isoform 7 (identifier: P33527-7) [UniParc]FASTAAdd to basket
Also known as: Delexon-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,410
Mass (Da):158,282
Checksum:i6AAC80E7E87AD25D
GO
Isoform 8 (identifier: P33527-8) [UniParc]FASTAAdd to basket
Also known as: Delexon-17-18-30

The sequence of this isoform differs from the canonical sequence as follows:
     706-764: Missing.
     765-820: Missing.
     1431-1495: Missing.

Show »
Length:1,351
Mass (Da):151,661
Checksum:iB3FD697CE71EBB51
GO
Isoform 9 (identifier: P33527-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     882-882: G → GSTVMDEEEAG

Note: No experimental confirmation available.
Show »
Length:1,541
Mass (Da):172,640
Checksum:i5AE3F0E657F948F8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01331743C → S.1 PublicationCorresponds to variant rs41395947dbSNPEnsembl.1
Natural variantiVAR_01331873T → I.1 PublicationCorresponds to variant rs41494447dbSNPEnsembl.1
Natural variantiVAR_013319117M → T.3 Publications1
Natural variantiVAR_013320433R → S.2 PublicationsCorresponds to variant rs60782127dbSNPEnsembl.1
Natural variantiVAR_011488633R → Q.1 PublicationCorresponds to variant rs112282109dbSNPEnsembl.1
Natural variantiVAR_011489671G → V No effect on leukotriene C4 and estradiol glucuronide transport. 4 PublicationsCorresponds to variant rs45511401dbSNPEnsembl.1
Natural variantiVAR_013321723R → Q.2 PublicationsCorresponds to variant rs4148356dbSNPEnsembl.1
Natural variantiVAR_055384861A → T.1 PublicationCorresponds to variant rs45517537dbSNPEnsembl.1
Natural variantiVAR_0553851047C → S.1 PublicationCorresponds to variant rs13337489dbSNPEnsembl.1
Natural variantiVAR_0133221058R → Q.1 PublicationCorresponds to variant rs41410450dbSNPEnsembl.1
Natural variantiVAR_0553861146V → I.1 PublicationCorresponds to variant rs28706727dbSNPEnsembl.1
Natural variantiVAR_0133231512S → L.1 PublicationCorresponds to variant rs369410659dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000037706 – 764Missing in isoform 2, isoform 5, isoform 6 and isoform 8. CuratedAdd BLAST59
Alternative sequenceiVSP_000038765 – 820Missing in isoform 3, isoform 5, isoform 7 and isoform 8. CuratedAdd BLAST56
Alternative sequenceiVSP_017014882G → GSTVMDEEEAG in isoform 9. 1 Publication1
Alternative sequenceiVSP_0000391431 – 1495Missing in isoform 4, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05628 mRNA. Translation: AAB46616.1.
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA. Translation: AAB83979.1.
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA. Translation: AAB83980.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA. Translation: AAB83981.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA. Translation: AAB83983.1.
EF419769 Genomic DNA. Translation: ABN79590.1.
AC025778 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
AC136624 Genomic DNA. No translation available.
AB209120 mRNA. Translation: BAD92357.1.
U91318 Genomic DNA. Translation: AAC15784.1.
AC003026 Genomic DNA. Translation: AAC05808.1.
CCDSiCCDS42122.1. [P33527-1]
PIRiA44231. DVHUAR.
RefSeqiNP_004987.2. NM_004996.3. [P33527-1]
UniGeneiHs.391464.

Genome annotation databases

EnsembliENST00000399410; ENSP00000382342; ENSG00000103222. [P33527-1]
ENST00000621144; ENSP00000483316; ENSG00000278183. [P33527-1]
GeneIDi4363.
KEGGihsa:4363.
UCSCiuc010bvi.4. human. [P33527-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05628 mRNA. Translation: AAB46616.1.
AF022853
, AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA. Translation: AAB83979.1.
AF022853
, AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA. Translation: AAB83980.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA. Translation: AAB83981.1.
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA. Translation: AAB83983.1.
EF419769 Genomic DNA. Translation: ABN79590.1.
AC025778 Genomic DNA. No translation available.
AC130651 Genomic DNA. No translation available.
AC136624 Genomic DNA. No translation available.
AB209120 mRNA. Translation: BAD92357.1.
U91318 Genomic DNA. Translation: AAC15784.1.
AC003026 Genomic DNA. Translation: AAC05808.1.
CCDSiCCDS42122.1. [P33527-1]
PIRiA44231. DVHUAR.
RefSeqiNP_004987.2. NM_004996.3. [P33527-1]
UniGeneiHs.391464.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CBZX-ray1.50A642-871[»]
4C3ZX-ray2.10A628-881[»]
ProteinModelPortaliP33527.
SMRiP33527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110503. 51 interactors.
IntActiP33527. 14 interactors.
MINTiMINT-2802626.
STRINGi9606.ENSP00000382342.

Chemistry databases

BindingDBiP33527.
ChEMBLiCHEMBL3004.
DrugBankiDB05812. Abiraterone.
DB00345. Aminohippurate.
DB00701. Amprenavir.
DB01072. Atazanavir.
DB01076. Atorvastatin.
DB02659. Cholic Acid.
DB01394. Colchicine.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB00970. Dactinomycin.
DB00694. Daunorubicin.
DB00586. Diclofenac.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00445. Epirubicin.
DB00199. Erythromycin.
DB00773. Etoposide.
DB00693. Fluorescein.
DB00143. Glutathione.
DB01016. Glyburide.
DB01050. Ibuprofen.
DB01177. Idarubicin.
DB00224. Indinavir.
DB00328. Indomethacin.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00563. Methotrexate.
DB00834. Mifepristone.
DB01204. Mitoxantrone.
DB01165. Ofloxacin.
DB01229. Paclitaxel.
DB01174. Phenobarbital.
DB01032. Probenecid.
DB00396. Progesterone.
DB01045. Rifampicin.
DB00503. Ritonavir.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB06335. Saxagliptin.
DB01138. Sulfinpyrazone.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB00661. Verapamil.
DB00570. Vinblastine.
DB00541. Vincristine.
DB00399. Zoledronate.
GuidetoPHARMACOLOGYi779.
SwissLipidsiSLP:000000404.

Protein family/group databases

TCDBi3.A.1.208.8. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP33527.
PhosphoSitePlusiP33527.
SwissPalmiP33527.

Polymorphism and mutation databases

BioMutaiABCC1.
DMDMi296439301.

Proteomic databases

EPDiP33527.
MaxQBiP33527.
PaxDbiP33527.
PeptideAtlasiP33527.
PRIDEiP33527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399410; ENSP00000382342; ENSG00000103222. [P33527-1]
ENST00000621144; ENSP00000483316; ENSG00000278183. [P33527-1]
GeneIDi4363.
KEGGihsa:4363.
UCSCiuc010bvi.4. human. [P33527-1]

Organism-specific databases

CTDi4363.
DisGeNETi4363.
GeneCardsiABCC1.
H-InvDBHIX0134370.
HGNCiHGNC:51. ABCC1.
HPAiHPA002380.
MIMi158343. gene.
neXtProtiNX_P33527.
OpenTargetsiENSG00000103222.
ENSG00000278183.
PharmGKBiPA244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiP33527.
KOiK05665.
OMAiMFSGPQI.
OrthoDBiEOG091G00IN.
PhylomeDBiP33527.
TreeFamiTF105199.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103222-MONOMER.
ReactomeiR-HSA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.
R-HSA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-HSA-382556. ABC-family proteins mediated transport.
SIGNORiP33527.

Miscellaneous databases

ChiTaRSiABCC1. human.
EvolutionaryTraceiP33527.
GeneWikiiABCC1.
GenomeRNAii4363.
PROiP33527.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103222.
CleanExiHS_ABCC1.
ExpressionAtlasiP33527. baseline and differential.
GenevisibleiP33527. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP1_HUMAN
AccessioniPrimary (citable) accession number: P33527
Secondary accession number(s): A3RJX2
, C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 179 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.