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P33527

- MRP1_HUMAN

UniProt

P33527 - MRP1_HUMAN

Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei653 – 6531ATP 1
    Binding sitei713 – 7131ATP 1

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi678 – 6858ATP 1
    Nucleotide bindingi1327 – 13348ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
    3. ATP binding Source: ProtInc
    4. transporter activity Source: ProtInc

    GO - Biological processi

    1. arachidonic acid metabolic process Source: Reactome
    2. ATP catabolic process Source: GOC
    3. cobalamin metabolic process Source: Reactome
    4. leukotriene metabolic process Source: Reactome
    5. response to drug Source: ProtInc
    6. small molecule metabolic process Source: Reactome
    7. transmembrane transport Source: Reactome
    8. transport Source: ProtInc
    9. vitamin metabolic process Source: Reactome
    10. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    REACT_15480. ABC-family proteins mediated transport.
    REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

    Protein family/group databases

    TCDBi3.A.1.208.8. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 1
    Alternative name(s):
    ATP-binding cassette sub-family C member 1
    Leukotriene C(4) transporter
    Short name:
    LTC4 transporter
    Gene namesi
    Name:ABCC1
    Synonyms:MRP, MRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:51. ABCC1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: UniProtKB
    4. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi580 – 5801Q → A: No effect. 1 Publication
    Mutagenesisi581 – 5811T → A: No effect. 1 Publication
    Mutagenesisi585 – 5851S → A: No effect. 1 Publication
    Mutagenesisi597 – 5971N → A: Increases resistance to vincristine and decreases resistance to VP-16. 1 Publication
    Mutagenesisi604 – 6041S → A: Increases estradiol glucuronide transport. 1 Publication
    Mutagenesisi605 – 6051S → A: Decreases resistance to vincristine, VP-16 and doxorubicin. 1 Publication
    Mutagenesisi792 – 7921D → A: Only partially affects protein maturation; impairs leukotriene C4 transport. 1 Publication
    Mutagenesisi792 – 7921D → L: Impairs protein maturation and leukotriene C4 transport. 1 Publication
    Mutagenesisi793 – 7931D → L: No effect on protein maturation and leukotriene C4 transport. 1 Publication
    Mutagenesisi1046 – 10461R → D: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
    Mutagenesisi1084 – 10841D → R: Impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
    Mutagenesisi1089 – 10891E → A, L, N or Q: Decreases resistance to anthracyclines. 1 Publication
    Mutagenesisi1089 – 10891E → D: No effect. 1 Publication
    Mutagenesisi1089 – 10891E → K: Abolishes resistance to anthracyclines. 1 Publication
    Mutagenesisi1131 – 11311R → E: Slightly impairs leukotriene C4 and estradiol glucuronide transport. 1 Publication
    Mutagenesisi1138 – 11381R → E or K: Strongly reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication
    Mutagenesisi1141 – 11411K → E: Reduced transport of leukotriene C4 and of glutathione. 1 Publication
    Mutagenesisi1141 – 11411K → R: Reduced transport of glutathione. 1 Publication
    Mutagenesisi1142 – 11421R → E or K: Reduced transport of leukotriene C4, estradiol glucuronide and of glutathione. 1 Publication
    Mutagenesisi1246 – 12461W → A, F or Y: Impairs estradiol glucuronide transport. 1 Publication
    Mutagenesisi1246 – 12461W → C: Impairs estradiol glucuronide transport; loss of resistance to alkaloid vincristine, cationic anthracyclines, epipodophyllotoxin VP-16, but not potassium antimony tartrate; partial loss of resistance to sodium arsenite. 1 Publication
    Mutagenesisi1333 – 13331K → L: Impairs leukotriene C4 transport. 1 Publication
    Mutagenesisi1454 – 14552DE → LL: Impairs leukotriene C4 transport.

    Organism-specific databases

    PharmGKBiPA244.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15311531Multidrug resistance-associated protein 1PRO_0000093351Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)1 Publication
    Glycosylationi23 – 231N-linked (GlcNAc...)1 Publication
    Modified residuei503 – 5031N6-succinyllysineBy similarity
    Modified residuei905 – 9051Phosphoserine1 Publication
    Modified residuei915 – 9151Phosphoserine1 Publication
    Modified residuei930 – 9301Phosphoserine2 Publications
    Glycosylationi1006 – 10061N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP33527.
    PaxDbiP33527.
    PRIDEiP33527.

    PTM databases

    PhosphoSiteiP33527.

    Expressioni

    Tissue specificityi

    Lung, testis and peripheral blood mononuclear cells.

    Gene expression databases

    ArrayExpressiP33527.
    BgeeiP33527.
    CleanExiHS_ABCC1.
    GenevestigatoriP33527.

    Organism-specific databases

    HPAiCAB016097.
    HPA002380.

    Interactioni

    Protein-protein interaction databases

    BioGridi110503. 30 interactions.
    IntActiP33527. 5 interactions.
    MINTiMINT-2802626.

    Structurei

    Secondary structure

    1
    1531
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi644 – 65310
    Beta strandi660 – 6689
    Beta strandi673 – 6775
    Helixi684 – 6918
    Beta strandi695 – 70410
    Beta strandi708 – 7114
    Beta strandi719 – 7213
    Helixi722 – 7276
    Helixi736 – 7438
    Helixi747 – 7504
    Helixi756 – 7583
    Beta strandi759 – 7624
    Helixi770 – 78415
    Beta strandi787 – 7937
    Turni794 – 7974
    Helixi800 – 80910
    Turni816 – 8194
    Beta strandi820 – 8256
    Helixi832 – 8343
    Beta strandi835 – 8428
    Beta strandi845 – 8506
    Helixi852 – 8587
    Helixi861 – 8688

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CBZX-ray1.50A642-871[»]
    ProteinModelPortaliP33527.
    SMRiP33527. Positions 642-871.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP33527.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularAdd
    BLAST
    Topological domaini55 – 7420CytoplasmicAdd
    BLAST
    Topological domaini96 – 1005Extracellular
    Topological domaini122 – 13312CytoplasmicAdd
    BLAST
    Topological domaini155 – 17218ExtracellularAdd
    BLAST
    Topological domaini194 – 316123CytoplasmicAdd
    BLAST
    Topological domaini338 – 36326ExtracellularAdd
    BLAST
    Topological domaini385 – 44056CytoplasmicAdd
    BLAST
    Topological domaini462 – 4643Extracellular
    Topological domaini486 – 54762CytoplasmicAdd
    BLAST
    Topological domaini569 – 59022ExtracellularAdd
    BLAST
    Topological domaini612 – 967356CytoplasmicAdd
    BLAST
    Topological domaini989 – 102537ExtracellularAdd
    BLAST
    Topological domaini1047 – 108943CytoplasmicAdd
    BLAST
    Topological domaini1111 – 11111Extracellular
    Topological domaini1133 – 120371CytoplasmicAdd
    BLAST
    Topological domaini1225 – 12262Extracellular
    Topological domaini1248 – 1531284CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Add
    BLAST
    Transmembranei75 – 9521Helical; Name=2Add
    BLAST
    Transmembranei101 – 12121Helical; Name=3Add
    BLAST
    Transmembranei134 – 15421Helical; Name=4Add
    BLAST
    Transmembranei173 – 19321Helical; Name=5Add
    BLAST
    Transmembranei317 – 33721Helical; Name=6Add
    BLAST
    Transmembranei364 – 38421Helical; Name=7Add
    BLAST
    Transmembranei441 – 46121Helical; Name=8Add
    BLAST
    Transmembranei465 – 48521Helical; Name=9Add
    BLAST
    Transmembranei548 – 56821Helical; Name=10Add
    BLAST
    Transmembranei591 – 61121Helical; Name=11Add
    BLAST
    Transmembranei968 – 98821Helical; Name=12Add
    BLAST
    Transmembranei1026 – 104621Helical; Name=13Add
    BLAST
    Transmembranei1090 – 111021Helical; Name=14Add
    BLAST
    Transmembranei1112 – 113221Helical; Name=15Add
    BLAST
    Transmembranei1204 – 122421Helical; Name=16Add
    BLAST
    Transmembranei1227 – 124721Helical; Name=17Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini325 – 608284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini644 – 868225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini975 – 1256282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1293 – 1527235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG108314.
    KOiK05665.
    OMAiLIQCERR.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiP33527.
    TreeFamiTF105199.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: P33527-1) [UniParc]FASTAAdd to Basket

    Also known as: Allexons

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF     50
    PFYFLYLSRH DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI 100
    FLAPVFLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALVCAL 150
    AILRSKIMTA LKEDAQVDLF RDITFYVYFS LLLIQLVLSC FSDRSPLFSE 200
    TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD LWSLNKEDTS 250
    EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL 300
    IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI 350
    KFVNDTKAPD WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI 400
    GAVYRKALVI TNSARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ 450
    VILALYLLWL NLGPSVLAGV AVMVLMVPVN AVMAMKTKTY QVAHMKSKDN 500
    RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLSAVGT 550
    FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP 600
    MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT 650
    FTWARSDPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG 700
    HVAIKGSVAY VPQQAWIQND SLRENILFGC QLEEPYYRSV IQACALLPDL 750
    EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNADIYL FDDPLSAVDA 800
    HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV MSGGKISEMG 850
    SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM 900
    LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA 950
    DKAQTGQVKL SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT 1000
    DDPIVNGTQE HTKVRLSVYG ALGISQGIAV FGYSMAVSIG GILASRCLHV 1050
    DLLHSILRSP MSFFERTPSG NLVNRFSKEL DTVDSMIPEV IKMFMGSLFN 1100
    VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL KRLESVSRSP 1150
    VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA 1200
    VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM 1250
    SSEMETNIVA VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL 1300
    RYREDLDFVL RHINVTINGG EKVGIVGRTG AGKSSLTLGL FRINESAEGE 1350
    IIIDGINIAK IGLHDLRFKI TIIPQDPVLF SGSLRMNLDP FSQYSDEEVW 1400
    TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL ARALLRKTKI 1450
    LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL 1500
    DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V 1531
    Length:1,531
    Mass (Da):171,591
    Last modified:May 18, 2010 - v3
    Checksum:i46A7CB643B9478C4
    GO
    Isoform 2 (identifier: P33527-2) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-17

    The sequence of this isoform differs from the canonical sequence as follows:
         706-764: Missing.

    Show »
    Length:1,472
    Mass (Da):164,971
    Checksum:i143FA6CB7F3123EF
    GO
    Isoform 3 (identifier: P33527-3) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-18

    The sequence of this isoform differs from the canonical sequence as follows:
         765-820: Missing.

    Show »
    Length:1,475
    Mass (Da):165,569
    Checksum:iF49C1B33B976D008
    GO
    Isoform 4 (identifier: P33527-4) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-30

    The sequence of this isoform differs from the canonical sequence as follows:
         1431-1495: Missing.

    Show »
    Length:1,466
    Mass (Da):164,304
    Checksum:i314A53D4242BAF1B
    GO
    Isoform 5 (identifier: P33527-5) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-17-18

    The sequence of this isoform differs from the canonical sequence as follows:
         706-764: Missing.
         765-820: Missing.

    Show »
    Length:1,416
    Mass (Da):158,949
    Checksum:i6CAB8926692A0377
    GO
    Isoform 6 (identifier: P33527-6) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-17-30

    The sequence of this isoform differs from the canonical sequence as follows:
         706-764: Missing.
         1431-1495: Missing.

    Show »
    Length:1,407
    Mass (Da):157,683
    Checksum:iE76D558115609C22
    GO
    Isoform 7 (identifier: P33527-7) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-18-30

    The sequence of this isoform differs from the canonical sequence as follows:
         765-820: Missing.
         1431-1495: Missing.

    Show »
    Length:1,410
    Mass (Da):158,282
    Checksum:i6AAC80E7E87AD25D
    GO
    Isoform 8 (identifier: P33527-8) [UniParc]FASTAAdd to Basket

    Also known as: Delexon-17-18-30

    The sequence of this isoform differs from the canonical sequence as follows:
         706-764: Missing.
         765-820: Missing.
         1431-1495: Missing.

    Show »
    Length:1,351
    Mass (Da):151,661
    Checksum:iB3FD697CE71EBB51
    GO
    Isoform 9 (identifier: P33527-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         882-882: G → GSTVMDEEEAG

    Note: No experimental confirmation available.

    Show »
    Length:1,541
    Mass (Da):172,640
    Checksum:i5AE3F0E657F948F8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431C → S.1 Publication
    Corresponds to variant rs41395947 [ dbSNP | Ensembl ].
    VAR_013317
    Natural varianti73 – 731T → I.1 Publication
    Corresponds to variant rs41494447 [ dbSNP | Ensembl ].
    VAR_013318
    Natural varianti117 – 1171M → T.3 Publications
    VAR_013319
    Natural varianti433 – 4331R → S.2 Publications
    Corresponds to variant rs60782127 [ dbSNP | Ensembl ].
    VAR_013320
    Natural varianti633 – 6331R → Q.1 Publication
    Corresponds to variant rs112282109 [ dbSNP | Ensembl ].
    VAR_011488
    Natural varianti671 – 6711G → V No effect on leukotriene C4 and estradiol glucuronide transport. 3 Publications
    Corresponds to variant rs45511401 [ dbSNP | Ensembl ].
    VAR_011489
    Natural varianti723 – 7231R → Q.2 Publications
    Corresponds to variant rs4148356 [ dbSNP | Ensembl ].
    VAR_013321
    Natural varianti861 – 8611A → T.1 Publication
    Corresponds to variant rs45517537 [ dbSNP | Ensembl ].
    VAR_055384
    Natural varianti1047 – 10471C → S.1 Publication
    Corresponds to variant rs13337489 [ dbSNP | Ensembl ].
    VAR_055385
    Natural varianti1058 – 10581R → Q.1 Publication
    Corresponds to variant rs41410450 [ dbSNP | Ensembl ].
    VAR_013322
    Natural varianti1146 – 11461V → I.1 Publication
    Corresponds to variant rs28706727 [ dbSNP | Ensembl ].
    VAR_055386
    Natural varianti1512 – 15121S → L.1 Publication
    VAR_013323

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei706 – 76459Missing in isoform 2, isoform 5, isoform 6 and isoform 8. CuratedVSP_000037Add
    BLAST
    Alternative sequencei765 – 82056Missing in isoform 3, isoform 5, isoform 7 and isoform 8. CuratedVSP_000038Add
    BLAST
    Alternative sequencei882 – 8821G → GSTVMDEEEAG in isoform 9. 1 PublicationVSP_017014
    Alternative sequencei1431 – 149565Missing in isoform 4, isoform 6, isoform 7 and isoform 8. CuratedVSP_000039Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05628 mRNA. Translation: AAB46616.1.
    AF022853
    , AF022827, AF022828, AF022829, AF022831, AF022833, AF022835, AF022837, AF022839, AF022841, AF022850, AF022849, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022852, AF022851, AF022840, AF022838, AF022836, AF022834, AF022832, AF022826, AF022825, AF022824, AF022830 Genomic DNA. Translation: AAB83979.1.
    AF022853
    , AF022824, AF022825, AF022826, AF022828, AF022830, AF022832, AF022834, AF022836, AF022838, AF022848, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022839, AF022852, AF022851, AF022850, AF022849, AF022837, AF022835, AF022833, AF022831, AF022829, AF022827 Genomic DNA. Translation: AAB83980.1.
    AF022853
    , AF022824, AF022825, AF022826, AF022827, AF022829, AF022831, AF022833, AF022835, AF022837, AF022847, AF022846, AF022845, AF022844, AF022843, AF022842, AF022841, AF022840, AF022838, AF022852, AF022851, AF022850, AF022849, AF022848, AF022836, AF022834, AF022832, AF022830, AF022828 Genomic DNA. Translation: AAB83981.1.
    AF022853
    , AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022839, AF022840, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851 Genomic DNA. Translation: AAB83983.1.
    EF419769 Genomic DNA. Translation: ABN79590.1.
    AC025778 Genomic DNA. No translation available.
    AC130651 Genomic DNA. No translation available.
    AC136624 Genomic DNA. No translation available.
    AB209120 mRNA. Translation: BAD92357.1.
    U91318 Genomic DNA. Translation: AAC15784.1.
    AC003026 Genomic DNA. Translation: AAC05808.1.
    CCDSiCCDS42122.1. [P33527-1]
    PIRiA44231. DVHUAR.
    RefSeqiNP_004987.2. NM_004996.3. [P33527-1]
    XP_005255386.1. XM_005255329.1. [P33527-2]
    XP_006720947.1. XM_006720884.1. [P33527-4]
    UniGeneiHs.391464.

    Genome annotation databases

    EnsembliENST00000399408; ENSP00000382340; ENSG00000103222. [P33527-9]
    ENST00000399410; ENSP00000382342; ENSG00000103222. [P33527-1]
    GeneIDi4363.
    KEGGihsa:4363.
    UCSCiuc010bvi.3. human. [P33527-1]

    Polymorphism databases

    DMDMi296439301.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPs
    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05628 mRNA. Translation: AAB46616.1 .
    AF022853
    , AF022827 , AF022828 , AF022829 , AF022831 , AF022833 , AF022835 , AF022837 , AF022839 , AF022841 , AF022850 , AF022849 , AF022848 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022852 , AF022851 , AF022840 , AF022838 , AF022836 , AF022834 , AF022832 , AF022826 , AF022825 , AF022824 , AF022830 Genomic DNA. Translation: AAB83979.1 .
    AF022853
    , AF022824 , AF022825 , AF022826 , AF022828 , AF022830 , AF022832 , AF022834 , AF022836 , AF022838 , AF022848 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022841 , AF022839 , AF022852 , AF022851 , AF022850 , AF022849 , AF022837 , AF022835 , AF022833 , AF022831 , AF022829 , AF022827 Genomic DNA. Translation: AAB83980.1 .
    AF022853
    , AF022824 , AF022825 , AF022826 , AF022827 , AF022829 , AF022831 , AF022833 , AF022835 , AF022837 , AF022847 , AF022846 , AF022845 , AF022844 , AF022843 , AF022842 , AF022841 , AF022840 , AF022838 , AF022852 , AF022851 , AF022850 , AF022849 , AF022848 , AF022836 , AF022834 , AF022832 , AF022830 , AF022828 Genomic DNA. Translation: AAB83981.1 .
    AF022853
    , AF022824 , AF022825 , AF022826 , AF022827 , AF022828 , AF022829 , AF022830 , AF022831 , AF022832 , AF022833 , AF022834 , AF022835 , AF022836 , AF022837 , AF022838 , AF022839 , AF022840 , AF022841 , AF022842 , AF022843 , AF022844 , AF022845 , AF022846 , AF022847 , AF022848 , AF022849 , AF022850 , AF022851 Genomic DNA. Translation: AAB83983.1 .
    EF419769 Genomic DNA. Translation: ABN79590.1 .
    AC025778 Genomic DNA. No translation available.
    AC130651 Genomic DNA. No translation available.
    AC136624 Genomic DNA. No translation available.
    AB209120 mRNA. Translation: BAD92357.1 .
    U91318 Genomic DNA. Translation: AAC15784.1 .
    AC003026 Genomic DNA. Translation: AAC05808.1 .
    CCDSi CCDS42122.1. [P33527-1 ]
    PIRi A44231. DVHUAR.
    RefSeqi NP_004987.2. NM_004996.3. [P33527-1 ]
    XP_005255386.1. XM_005255329.1. [P33527-2 ]
    XP_006720947.1. XM_006720884.1. [P33527-4 ]
    UniGenei Hs.391464.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CBZ X-ray 1.50 A 642-871 [» ]
    ProteinModelPortali P33527.
    SMRi P33527. Positions 642-871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110503. 30 interactions.
    IntActi P33527. 5 interactions.
    MINTi MINT-2802626.

    Chemistry

    ChEMBLi CHEMBL3004.
    DrugBanki DB05812. Abiraterone.
    DB00345. Aminohippurate.
    DB00701. Amprenavir.
    DB01072. Atazanavir.
    DB01076. Atorvastatin.
    DB01394. Colchicine.
    DB00286. Conjugated Estrogens.
    DB00091. Cyclosporine.
    DB00970. Dactinomycin.
    DB00694. Daunorubicin.
    DB00586. Diclofenac.
    DB01248. Docetaxel.
    DB00997. Doxorubicin.
    DB00445. Epirubicin.
    DB00199. Erythromycin.
    DB00773. Etoposide.
    DB00693. Fluorescein.
    DB00143. Glutathione.
    DB01016. Glyburide.
    DB01050. Ibuprofen.
    DB01177. Idarubicin.
    DB00224. Indinavir.
    DB00328. Indomethacin.
    DB00762. Irinotecan.
    DB00602. Ivermectin.
    DB00709. Lamivudine.
    DB00563. Methotrexate.
    DB00834. Mifepristone.
    DB01204. Mitoxantrone.
    DB01165. Ofloxacin.
    DB01229. Paclitaxel.
    DB01174. Phenobarbital.
    DB01032. Probenecid.
    DB00396. Progesterone.
    DB01045. Rifampicin.
    DB00503. Ritonavir.
    DB01098. Rosuvastatin.
    DB01232. Saquinavir.
    DB06335. Saxagliptin.
    DB01138. Sulfinpyrazone.
    DB05294. Vandetanib.
    DB08881. Vemurafenib.
    DB00661. Verapamil.
    DB00570. Vinblastine.
    DB00541. Vincristine.
    DB00399. Zoledronate.

    Protein family/group databases

    TCDBi 3.A.1.208.8. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei P33527.

    Polymorphism databases

    DMDMi 296439301.

    Proteomic databases

    MaxQBi P33527.
    PaxDbi P33527.
    PRIDEi P33527.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399408 ; ENSP00000382340 ; ENSG00000103222 . [P33527-9 ]
    ENST00000399410 ; ENSP00000382342 ; ENSG00000103222 . [P33527-1 ]
    GeneIDi 4363.
    KEGGi hsa:4363.
    UCSCi uc010bvi.3. human. [P33527-1 ]

    Organism-specific databases

    CTDi 4363.
    GeneCardsi GC16P016043.
    H-InvDB HIX0134370.
    HGNCi HGNC:51. ABCC1.
    HPAi CAB016097.
    HPA002380.
    MIMi 158343. gene.
    neXtProti NX_P33527.
    PharmGKBi PA244.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG108314.
    KOi K05665.
    OMAi LIQCERR.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi P33527.
    TreeFami TF105199.

    Enzyme and pathway databases

    Reactomei REACT_150420. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    REACT_15480. ABC-family proteins mediated transport.
    REACT_163862. Cobalamin (Cbl, vitamin B12) transport and metabolism.

    Miscellaneous databases

    ChiTaRSi ABCC1. human.
    EvolutionaryTracei P33527.
    GeneWikii ABCC1.
    GenomeRNAii 4363.
    NextBioi 17171.
    PROi P33527.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P33527.
    Bgeei P33527.
    CleanExi HS_ABCC1.
    Genevestigatori P33527.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line."
      Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G.
      Science 258:1650-1654(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-117.
    2. "Multidrug resistance-associated protein: sequence correction."
      Cole S.P.C., Deeley R.G.
      Science 260:879-879(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
      Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G.
      Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, VARIANT THR-117.
    4. NIEHS SNPs program
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-671; GLN-723; THR-861; SER-1047 AND ILE-1146.
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-1531 (ISOFORM 9).
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 516-1531.
    8. "Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus."
      Hipfner D.R., Almquist K.C., Leslie E.M., Gerlach J.H., Grant C.E., Deeley R.G., Cole S.P.C.
      J. Biol. Chem. 272:23623-23630(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY, GLYCOSYLATION AT ASN-19; ASN-23 AND ASN-1006.
    9. "Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence."
      Kast C., Gros P.
      J. Biol. Chem. 272:26479-26487(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    10. "Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein."
      Kast C., Gros P.
      Biochemistry 37:2305-2313(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY.
    11. "Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1."
      Sjoelinder M., Tornhamre S., Claesson H.-E., Hydman J., Lindgren J.A.
      J. Lipid Res. 40:439-446(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes."
      Robbiani D.F., Finch R.A., Jaeger D., Muller W.A., Sartorelli A.C., Randolph G.J.
      Cell 103:757-768(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation."
      Cui L., Hou Y.-X., Riordan J.R., Chang X.-B.
      Arch. Biochem. Biophys. 392:153-161(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ASP-792; ASP-793; LYS-1333 AND 1454-ASP-GLU-1455.
    14. "Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport."
      Ito K., Olsen S.L., Qiu W., Deeley R.G., Cole S.P.C.
      J. Biol. Chem. 276:15616-15624(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF TRP-1246.
    15. "Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines."
      Zhang D.-W., Cole S.P.C., Deeley R.G.
      J. Biol. Chem. 276:13231-13239(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLU-1089.
    16. "Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter."
      Situ D., Haimeur A., Conseil G., Sparks K.E., Zhang D.-W., Deeley R.G., Cole S.P.C.
      J. Biol. Chem. 279:38871-38880(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ARG-1046; ASP-1084 AND ARG-1131.
    17. "Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1."
      Zhang D.-W., Nunoya K., Vasa M., Gu H.-M., Theis A., Cole S.P.C., Deeley R.G.
      Biochemistry 43:9413-9425(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLN-580; THR-581; SER-585; ASN-597; SER-604 AND SER-605.
    18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    19. "Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1)."
      Conseil G., Deeley R.G., Cole S.P.
      J. Biol. Chem. 281:43-50(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF ARG-1138; LYS-1141 AND ARG-1142, SUBCELLULAR LOCATION.
    20. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-915, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-905 AND SER-930, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    26. "Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site."
      Ramaen O., Leulliot N., Sizun C., Ulryck N., Pamlard O., Lallemand J.-Y., Tilbeurgh H., Jacquet E.
      J. Mol. Biol. 359:940-949(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 642-871 IN COMPLEX WITH MG-ATP.
    27. Cited for: VARIANTS GLN-633 AND VAL-671.
    28. "Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter."
      Ringpfeil F., Lebwohl M.G., Christiano A.M., Uitto J.
      Proc. Natl. Acad. Sci. U.S.A. 97:6001-6006(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-671.
    29. "Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution."
      Conrad S., Kauffmann H.-M., Ito K., Deeley R.G., Cole S.P.C., Schrenk D.
      J. Hum. Genet. 46:656-663(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-433, CHARACTERIZATION OF VARIANT VAL-671.
    30. "Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum."
      Perdu J., Germain D.P.
      Hum. Mutat. 17:74-75(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-117 AND LEU-1512.
    31. "Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects."
      Ito S., Ieiri I., Tanabe M., Suzuki A., Higuchi S., Otsubo K.
      Pharmacogenetics 11:175-184(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-43; ILE-73; GLN-723 AND GLN-1058.
    32. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-433.

    Entry informationi

    Entry nameiMRP1_HUMAN
    AccessioniPrimary (citable) accession number: P33527
    Secondary accession number(s): A3RJX2
    , C9JPJ4, O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99, Q9UQA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 155 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3