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P33520

- RES1_SCHPO

UniProt

P33520 - RES1_SCHPO

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Protein
Cell division cycle-related protein res1/sct1
Gene
res1, sct1, SPBC725.16
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi37 – 5822H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. chromatin binding Source: PomBase
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  2. traversing start control point of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-related protein res1/sct1
Alternative name(s):
p72sct1
Gene namesi
Name:res1
Synonyms:sct1
ORF Names:SPBC725.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC725.16.

Subcellular locationi

GO - Cellular componenti

  1. MBF transcription complex Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi56 – 561E → K: Renders the cell independent of cdc10 function for the execution of start. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Cell division cycle-related protein res1/sct1
PRO_0000067072Add
BLAST

Proteomic databases

MaxQBiP33520.

Interactioni

Subunit structurei

DSC1 contains cdc10 and sct1/res1.

Binary interactionsi

WithEntry#Exp.IntActNotes
cig2P366303EBI-1149288,EBI-1149212
res2P414122EBI-1149288,EBI-1149177

Protein-protein interaction databases

BioGridi277668. 494 interactions.
DIPiDIP-210N.
IntActiP33520. 3 interactions.
MINTiMINT-4688521.
STRINGi4896.SPBC725.16-1.

Structurei

3D structure databases

ProteinModelPortaliP33520.
SMRiP33520. Positions 5-103.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 112107HTH APSES-type
Add
BLAST
Repeati236 – 26530ANK 1
Add
BLAST
Repeati357 – 38630ANK 2
Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
KOiK06867.
OMAiISISCNI.
OrthoDBiEOG7ZSJ36.
PhylomeDBiP33520.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
PS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33520-1 [UniParc]FASTAAdd to Basket

« Hide

MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR    50
RTRILEKFAQ KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL 100
IEYSGSAFMP MSTFTPQSNR KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS 150
NNMTSTSRMS GIHDALSLQS DFTRSPDMPS DSFTGSLHDI KASPFSSNNY 200
AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA LHWAAAMGNL 250
EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI 300
CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI 350
INLQDDHGDT ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS 400
KDMSFPENDD SPLNSKIEDN LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH 450
QTLPNVFTQL SELSKCHEAS LAEKQLTYNL AMEALEQTVR ETETCQRLWN 500
ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL HQLKKYVTYF 550
SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL 600
VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS 637
Length:637
Mass (Da):72,442
Last modified:February 1, 1994 - v1
Checksum:i91FAEBC78E777A04
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09270 mRNA. Translation: AAA35340.1.
X68789 mRNA. Translation: CAA48683.1.
CU329671 Genomic DNA. Translation: CAA22188.1.
PIRiA45777.
RefSeqiNP_595496.1. NM_001021407.2.

Genome annotation databases

EnsemblFungiiSPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
GeneIDi2541153.
KEGGispo:SPBC725.16.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L09270 mRNA. Translation: AAA35340.1 .
X68789 mRNA. Translation: CAA48683.1 .
CU329671 Genomic DNA. Translation: CAA22188.1 .
PIRi A45777.
RefSeqi NP_595496.1. NM_001021407.2.

3D structure databases

ProteinModelPortali P33520.
SMRi P33520. Positions 5-103.
ModBasei Search...

Protein-protein interaction databases

BioGridi 277668. 494 interactions.
DIPi DIP-210N.
IntActi P33520. 3 interactions.
MINTi MINT-4688521.
STRINGi 4896.SPBC725.16-1.

Proteomic databases

MaxQBi P33520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC725.16.1 ; SPBC725.16.1:pep ; SPBC725.16 .
GeneIDi 2541153.
KEGGi spo:SPBC725.16.

Organism-specific databases

PomBasei SPBC725.16.

Phylogenomic databases

eggNOGi COG0666.
KOi K06867.
OMAi ISISCNI.
OrthoDBi EOG7ZSJ36.
PhylomeDBi P33520.

Miscellaneous databases

NextBioi 20802266.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
PS51299. HTH_APSES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation."
    Caligiuri M., Beach D.
    Cell 72:607-619(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLU-56.
  2. "A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products."
    Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H., Okayama H.
    EMBO J. 11:4923-4932(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiRES1_SCHPO
AccessioniPrimary (citable) accession number: P33520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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