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Protein

Cell division cycle-related protein res1/sct1

Gene

res1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 58H-T-H motifPROSITE-ProRule annotationAdd BLAST22

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: PomBase
  • transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: PomBase

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: PomBase
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-related protein res1/sct1
Alternative name(s):
p72sct1
Gene namesi
Name:res1
Synonyms:sct1
ORF Names:SPBC725.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC725.16
PomBaseiSPBC725.16 res1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56E → K: Renders the cell independent of cdc10 function for the execution of start. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000670721 – 637Cell division cycle-related protein res1/sct1Add BLAST637

Proteomic databases

MaxQBiP33520
PaxDbiP33520
PRIDEiP33520

PTM databases

iPTMnetiP33520

Interactioni

Subunit structurei

DSC1 contains cdc10 and sct1/res1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi277668, 495 interactors
DIPiDIP-210N
IntActiP33520, 3 interactors
MINTiP33520
STRINGi4896.SPBC725.16.1

Structurei

3D structure databases

ProteinModelPortaliP33520
SMRiP33520
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 112HTH APSES-typePROSITE-ProRule annotationAdd BLAST107
Repeati236 – 265ANK 1Add BLAST30
Repeati357 – 386ANK 2Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoidiP33520
OMAiSKCHEAS
OrthoDBiEOG092C16YL
PhylomeDBiP33520

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
3.10.260.10, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036887 HTH_APSES_sf
IPR018004 KilA_N/APSES_HTH
IPR029793 Mbp1/Res1/Res2
IPR003163 Tscrpt_reg_HTH_APSES-type
PANTHERiPTHR43828:SF1 PTHR43828:SF1, 2 hits
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF04383 KilA-N, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM01252 KilA-N, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF54616 SSF54616, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 2 hits
PS50088 ANK_REPEAT, 1 hit
PS51299 HTH_APSES, 1 hit

Sequencei

Sequence statusi: Complete.

P33520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR
60 70 80 90 100
RTRILEKFAQ KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL
110 120 130 140 150
IEYSGSAFMP MSTFTPQSNR KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS
160 170 180 190 200
NNMTSTSRMS GIHDALSLQS DFTRSPDMPS DSFTGSLHDI KASPFSSNNY
210 220 230 240 250
AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA LHWAAAMGNL
260 270 280 290 300
EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI
310 320 330 340 350
CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI
360 370 380 390 400
INLQDDHGDT ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS
410 420 430 440 450
KDMSFPENDD SPLNSKIEDN LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH
460 470 480 490 500
QTLPNVFTQL SELSKCHEAS LAEKQLTYNL AMEALEQTVR ETETCQRLWN
510 520 530 540 550
ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL HQLKKYVTYF
560 570 580 590 600
SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL
610 620 630
VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS
Length:637
Mass (Da):72,442
Last modified:February 1, 1994 - v1
Checksum:i91FAEBC78E777A04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09270 mRNA Translation: AAA35340.1
X68789 mRNA Translation: CAA48683.1
CU329671 Genomic DNA Translation: CAA22188.1
PIRiA45777
RefSeqiNP_595496.1, NM_001021407.2

Genome annotation databases

EnsemblFungiiSPBC725.16.1; SPBC725.16.1:pep; SPBC725.16
GeneIDi2541153
KEGGispo:SPBC725.16

Similar proteinsi

Entry informationi

Entry nameiRES1_SCHPO
AccessioniPrimary (citable) accession number: P33520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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