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P33520 (RES1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle-related protein res1/sct1
Alternative name(s):
p72sct1
Gene names
Name:res1
Synonyms:sct1
ORF Names:SPBC725.16
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.

Subunit structure

DSC1 contains cdc10 and sct1/res1.

Sequence similarities

Contains 2 ANK repeats.

Contains 1 HTH APSES-type DNA-binding domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Cell division cycle-related protein res1/sct1
PRO_0000067072

Regions

Domain6 – 112107HTH APSES-type
Repeat236 – 26530ANK 1
Repeat357 – 38630ANK 2
DNA binding37 – 5822H-T-H motif By similarity

Experimental info

Mutagenesis561E → K: Renders the cell independent of cdc10 function for the execution of start. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P33520 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 91FAEBC78E777A04

FASTA63772,442
        10         20         30         40         50         60 
MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR RTRILEKFAQ 

        70         80         90        100        110        120 
KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL IEYSGSAFMP MSTFTPQSNR 

       130        140        150        160        170        180 
KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS NNMTSTSRMS GIHDALSLQS DFTRSPDMPS 

       190        200        210        220        230        240 
DSFTGSLHDI KASPFSSNNY AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA 

       250        260        270        280        290        300 
LHWAAAMGNL EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI 

       310        320        330        340        350        360 
CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI INLQDDHGDT 

       370        380        390        400        410        420 
ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS KDMSFPENDD SPLNSKIEDN 

       430        440        450        460        470        480 
LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH QTLPNVFTQL SELSKCHEAS LAEKQLTYNL 

       490        500        510        520        530        540 
AMEALEQTVR ETETCQRLWN ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL 

       550        560        570        580        590        600 
HQLKKYVTYF SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL 

       610        620        630 
VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS 

« Hide

References

« Hide 'large scale' references
[1]"Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation."
Caligiuri M., Beach D.
Cell 72:607-619(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLU-56.
[2]"A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products."
Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H., Okayama H.
EMBO J. 11:4923-4932(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 972 / ATCC 24843.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L09270 mRNA. Translation: AAA35340.1.
X68789 mRNA. Translation: CAA48683.1.
CU329671 Genomic DNA. Translation: CAA22188.1.
PIRA45777.
RefSeqNP_595496.1. NM_001021407.2.

3D structure databases

ProteinModelPortalP33520.
SMRP33520. Positions 5-103.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277668. 494 interactions.
DIPDIP-210N.
IntActP33520. 3 interactions.
MINTMINT-4688521.
STRING4896.SPBC725.16-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
GeneID2541153.
KEGGspo:SPBC725.16.

Organism-specific databases

PomBaseSPBC725.16.

Phylogenomic databases

eggNOGCOG0666.
KOK06867.
OMAISISCNI.
OrthoDBEOG7ZSJ36.
PhylomeDBP33520.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamPF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
PS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802266.

Entry information

Entry nameRES1_SCHPO
AccessionPrimary (citable) accession number: P33520
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names