P33520 (RES1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division cycle-related protein res1/sct1

Alternative name(s):
p72sct1

Gene names

Name:	res1
Synonyms:	sct1
ORF Names:	SPBC725.16

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.
Subunit structure	DSC1 contains cdc10 and sct1/res1.
Sequence similarities	Contains 2 ANK repeats. Contains 1 HTH APSES-type DNA-binding domain.

Ontologies

Keywords
Biological process	Cell cycle
Domain	ANK repeat Repeat
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1 phase of mitotic cell cycle Non-traceable author statement. Source: PomBase positive regulation of transcription during mitosis Inferred from direct assay Ref.2. Source: PomBase positive regulation of transcription involved in G1/S phase of mitotic cell cycle Inferred by curator PubMed 19714215. Source: PomBase regulation of transcription during meiosis Traceable author statement PubMed 9343385. Source: PomBase traversing start control point of mitotic cell cycle Inferred from mutant phenotype Ref.1. Source: PomBase
Cellular_component	MBF transcription complex Traceable author statement Ref.1. Source: PomBase
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
cig2	P36630	3	EBI-1149288,EBI-1149212
res2	P41412	2	EBI-1149288,EBI-1149177

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	Cell division cycle-related protein res1/sct1		PRO_0000067072
Regions
	Domain	6 – 112	107	HTH APSES-type
	Repeat	236 – 265	30	ANK 1
	Repeat	357 – 386	30	ANK 2
	DNA binding	37 – 58	22	H-T-H motif By similarity
Experimental info
	Mutagenesis	56	1	E → K: Renders the cell independent of cdc10 function for the execution of start. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P33520 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 91FAEBC78E777A04	FASTA	637	72,442
	10 20 30 40 50 60 MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR RTRILEKFAQ 70 80 90 100 110 120 KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL IEYSGSAFMP MSTFTPQSNR 130 140 150 160 170 180 KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS NNMTSTSRMS GIHDALSLQS DFTRSPDMPS 190 200 210 220 230 240 DSFTGSLHDI KASPFSSNNY AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA 250 260 270 280 290 300 LHWAAAMGNL EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI 310 320 330 340 350 360 CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI INLQDDHGDT 370 380 390 400 410 420 ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS KDMSFPENDD SPLNSKIEDN 430 440 450 460 470 480 LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH QTLPNVFTQL SELSKCHEAS LAEKQLTYNL 490 500 510 520 530 540 AMEALEQTVR ETETCQRLWN ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL 550 560 570 580 590 600 HQLKKYVTYF SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL 610 620 630 VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation." Caligiuri M., Beach D. Cell 72:607-619(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLU-56.
[2]	"A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products." Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H., Okayama H. EMBO J. 11:4923-4932(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 972 / ATCC 24843.
[3]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L09270 mRNA. Translation: AAA35340.1. X68789 mRNA. Translation: CAA48683.1. CU329671 Genomic DNA. Translation: CAA22188.1.
PIR	A45777.
RefSeq	NP_595496.1. NM_001021407.2.
3D structure databases
ProteinModelPortal	P33520.
SMR	P33520. Positions 5-103.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-210N.
IntAct	P33520. 2 interactions.
STRING	4896.SPBC725.16-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
GeneID	2541153.
KEGG	spo:SPBC725.16.
Organism-specific databases
PomBase	SPBC725.16.
Phylogenomic databases
eggNOG	COG0666.
KO	K06867.
OrthoDB	EOG4PRWZZ.
Family and domain databases
Gene3D	1.25.40.20. 1 hit. 3.10.260.10. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR018004. KilA_N/APSES_HTH. IPR003163. Tscrpt_reg_HTH_APSES-type. [Graphical view]
Pfam	PF00023. Ank. 2 hits. PF04383. KilA-N. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF54616. Mlu1-box-bd_prot_DNA-bd. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 1 hit. PS51299. HTH_APSES. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20802266.

Entry information

Entry name

RES1_SCHPO

Accession

Primary (citable) accession number: P33520

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program