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P33520

- RES1_SCHPO

UniProt

P33520 - RES1_SCHPO

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Protein

Cell division cycle-related protein res1/sct1

Gene

res1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi37 – 5822H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: PomBase
  2. DNA binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: PomBase

GO - Biological processi

  1. positive regulation of G1/S transition of mitotic cell cycle Source: PomBase
  2. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  3. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
  4. traversing start control point of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-related protein res1/sct1
Alternative name(s):
p72sct1
Gene namesi
Name:res1
Synonyms:sct1
ORF Names:SPBC725.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC725.16.

Subcellular locationi

GO - Cellular componenti

  1. MBF transcription complex Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi56 – 561E → K: Renders the cell independent of cdc10 function for the execution of start. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 637637Cell division cycle-related protein res1/sct1PRO_0000067072Add
BLAST

Proteomic databases

MaxQBiP33520.

Interactioni

Subunit structurei

DSC1 contains cdc10 and sct1/res1.

Binary interactionsi

WithEntry#Exp.IntActNotes
cig2P366303EBI-1149288,EBI-1149212
res2P414122EBI-1149288,EBI-1149177

Protein-protein interaction databases

BioGridi277668. 494 interactions.
DIPiDIP-210N.
IntActiP33520. 3 interactions.
MINTiMINT-4688521.
STRINGi4896.SPBC725.16-1.

Structurei

3D structure databases

ProteinModelPortaliP33520.
SMRiP33520. Positions 5-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 112107HTH APSES-typePROSITE-ProRule annotationAdd
BLAST
Repeati236 – 26530ANK 1Add
BLAST
Repeati357 – 38630ANK 2Add
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
InParanoidiP33520.
KOiK06867.
OMAiISISCNI.
OrthoDBiEOG7ZSJ36.
PhylomeDBiP33520.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
PS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33520-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR
60 70 80 90 100
RTRILEKFAQ KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL
110 120 130 140 150
IEYSGSAFMP MSTFTPQSNR KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS
160 170 180 190 200
NNMTSTSRMS GIHDALSLQS DFTRSPDMPS DSFTGSLHDI KASPFSSNNY
210 220 230 240 250
AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA LHWAAAMGNL
260 270 280 290 300
EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI
310 320 330 340 350
CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI
360 370 380 390 400
INLQDDHGDT ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS
410 420 430 440 450
KDMSFPENDD SPLNSKIEDN LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH
460 470 480 490 500
QTLPNVFTQL SELSKCHEAS LAEKQLTYNL AMEALEQTVR ETETCQRLWN
510 520 530 540 550
ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL HQLKKYVTYF
560 570 580 590 600
SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL
610 620 630
VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS
Length:637
Mass (Da):72,442
Last modified:February 1, 1994 - v1
Checksum:i91FAEBC78E777A04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09270 mRNA. Translation: AAA35340.1.
X68789 mRNA. Translation: CAA48683.1.
CU329671 Genomic DNA. Translation: CAA22188.1.
PIRiA45777.
RefSeqiNP_595496.1. NM_001021407.2.

Genome annotation databases

EnsemblFungiiSPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
GeneIDi2541153.
KEGGispo:SPBC725.16.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09270 mRNA. Translation: AAA35340.1 .
X68789 mRNA. Translation: CAA48683.1 .
CU329671 Genomic DNA. Translation: CAA22188.1 .
PIRi A45777.
RefSeqi NP_595496.1. NM_001021407.2.

3D structure databases

ProteinModelPortali P33520.
SMRi P33520. Positions 5-103.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277668. 494 interactions.
DIPi DIP-210N.
IntActi P33520. 3 interactions.
MINTi MINT-4688521.
STRINGi 4896.SPBC725.16-1.

Proteomic databases

MaxQBi P33520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC725.16.1 ; SPBC725.16.1:pep ; SPBC725.16 .
GeneIDi 2541153.
KEGGi spo:SPBC725.16.

Organism-specific databases

PomBasei SPBC725.16.

Phylogenomic databases

eggNOGi COG0666.
InParanoidi P33520.
KOi K06867.
OMAi ISISCNI.
OrthoDBi EOG7ZSJ36.
PhylomeDBi P33520.

Miscellaneous databases

NextBioi 20802266.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.10.260.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view ]
Pfami PF00023. Ank. 2 hits.
PF04383. KilA-N. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF54616. SSF54616. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 1 hit.
PS51299. HTH_APSES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation."
    Caligiuri M., Beach D.
    Cell 72:607-619(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLU-56.
  2. "A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products."
    Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H., Okayama H.
    EMBO J. 11:4923-4932(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiRES1_SCHPO
AccessioniPrimary (citable) accession number: P33520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3