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P33520

- RES1_SCHPO

UniProt

P33520 - RES1_SCHPO

Protein

Cell division cycle-related protein res1/sct1

Gene

res1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi37 – 5822H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: PomBase
    2. DNA binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: PomBase
    2. traversing start control point of mitotic cell cycle Source: PomBase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle-related protein res1/sct1
    Alternative name(s):
    p72sct1
    Gene namesi
    Name:res1
    Synonyms:sct1
    ORF Names:SPBC725.16
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC725.16.

    Subcellular locationi

    GO - Cellular componenti

    1. MBF transcription complex Source: PomBase
    2. nucleus Source: PomBase

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi56 – 561E → K: Renders the cell independent of cdc10 function for the execution of start. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 637637Cell division cycle-related protein res1/sct1PRO_0000067072Add
    BLAST

    Proteomic databases

    MaxQBiP33520.

    Interactioni

    Subunit structurei

    DSC1 contains cdc10 and sct1/res1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    cig2P366303EBI-1149288,EBI-1149212
    res2P414122EBI-1149288,EBI-1149177

    Protein-protein interaction databases

    BioGridi277668. 494 interactions.
    DIPiDIP-210N.
    IntActiP33520. 3 interactions.
    MINTiMINT-4688521.
    STRINGi4896.SPBC725.16-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP33520.
    SMRiP33520. Positions 5-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 112107HTH APSES-typePROSITE-ProRule annotationAdd
    BLAST
    Repeati236 – 26530ANK 1Add
    BLAST
    Repeati357 – 38630ANK 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    KOiK06867.
    OMAiISISCNI.
    OrthoDBiEOG7ZSJ36.
    PhylomeDBiP33520.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR018004. KilA_N/APSES_HTH.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF04383. KilA-N. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF54616. SSF54616. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33520-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNDQIHKIT YSGVEVFEYT INGFPLMKRC HDNWLNATQI LKIAELDKPR    50
    RTRILEKFAQ KGLHEKIQGG CGKYQGTWVP SERAVELAHE YNVFDLIQPL 100
    IEYSGSAFMP MSTFTPQSNR KPTEAYRRNS PVKKSFSRPS HSLLYPYTSS 150
    NNMTSTSRMS GIHDALSLQS DFTRSPDMPS DSFTGSLHDI KASPFSSNNY 200
    AQSLLDYFLL PNTTQPPDFV YDRPSDWDVN AGIDEDGHTA LHWAAAMGNL 250
    EMMHALLQAG ANVVAVNYLQ QTSLMRCVMF TMNYDLQTFE VVSELLQSAI 300
    CMNDSFGQTV FHHIALLASS KSKMEAARYY MDILLQNLTA TQSVDVAAQI 350
    INLQDDHGDT ALLICARNGA KKCARLLLSF YASSSIPNNQ GQYPTDFLSS 400
    KDMSFPENDD SPLNSKIEDN LIDNLKYPQS LDDHLSSKKP ISYFSNKLTH 450
    QTLPNVFTQL SELSKCHEAS LAEKQLTYNL AMEALEQTVR ETETCQRLWN 500
    ERTNNDENYL VNQREDLIHQ CKKFLHTLKT ARYYLETVQL HQLKKYVTYF 550
    SQIWSTDELA DISETKNLVG HDTKTNRSSL SSKHEVDLFT AENEAAREKL 600
    VEQLCSLQAQ RKQKINEILN LLSMGMYNTI NTDQSGS 637
    Length:637
    Mass (Da):72,442
    Last modified:February 1, 1994 - v1
    Checksum:i91FAEBC78E777A04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09270 mRNA. Translation: AAA35340.1.
    X68789 mRNA. Translation: CAA48683.1.
    CU329671 Genomic DNA. Translation: CAA22188.1.
    PIRiA45777.
    RefSeqiNP_595496.1. NM_001021407.2.

    Genome annotation databases

    EnsemblFungiiSPBC725.16.1; SPBC725.16.1:pep; SPBC725.16.
    GeneIDi2541153.
    KEGGispo:SPBC725.16.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L09270 mRNA. Translation: AAA35340.1 .
    X68789 mRNA. Translation: CAA48683.1 .
    CU329671 Genomic DNA. Translation: CAA22188.1 .
    PIRi A45777.
    RefSeqi NP_595496.1. NM_001021407.2.

    3D structure databases

    ProteinModelPortali P33520.
    SMRi P33520. Positions 5-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277668. 494 interactions.
    DIPi DIP-210N.
    IntActi P33520. 3 interactions.
    MINTi MINT-4688521.
    STRINGi 4896.SPBC725.16-1.

    Proteomic databases

    MaxQBi P33520.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC725.16.1 ; SPBC725.16.1:pep ; SPBC725.16 .
    GeneIDi 2541153.
    KEGGi spo:SPBC725.16.

    Organism-specific databases

    PomBasei SPBC725.16.

    Phylogenomic databases

    eggNOGi COG0666.
    KOi K06867.
    OMAi ISISCNI.
    OrthoDBi EOG7ZSJ36.
    PhylomeDBi P33520.

    Miscellaneous databases

    NextBioi 20802266.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.10.260.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR018004. KilA_N/APSES_HTH.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF04383. KilA-N. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF54616. SSF54616. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 1 hit.
    PS51299. HTH_APSES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation."
      Caligiuri M., Beach D.
      Cell 72:607-619(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLU-56.
    2. "A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products."
      Tanaka K., Okazaki K., Okazaki N., Ueda T., Sugiyama A., Nojima H., Okayama H.
      EMBO J. 11:4923-4932(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 972 / ATCC 24843.
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiRES1_SCHPO
    AccessioniPrimary (citable) accession number: P33520
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3