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Protein

Cytochrome c oxidase polypeptide 1

Gene

coxA2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi117Iron (heme A axial ligand)Curated1
Metal bindingi294Copper BCurated1
Metal bindingi298Copper BCurated1
Metal bindingi343Copper BCurated1
Metal bindingi344Copper BCurated1
Metal bindingi429Iron (heme A3 axial ligand)Curated1
Metal bindingi431Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Protein family/group databases

TCDBi3.D.4.3.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:coxA2
Ordered Locus Names:VNG_0657G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Proteomesi
  • UP000000554 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei358 – 378HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834651 – 593Cytochrome c oxidase polypeptide 1Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki294 ↔ 2981'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP33518

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG0657G

Structurei

3D structure databases

ProteinModelPortaliP33518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG01237 Archaea
COG0843 LUCA
InParanoidiP33518
KOiK02274
OMAiMSFWLLP
OrthoDBiPOG093Z024Y
PhylomeDBiP33518

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P33518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASSITL TVLMGVLLVG VVAVLARLED WRSYTPLSDV GGGLGERTGY
60 70 80 90 100
THEEKPGGII RWFTTVDHKD IGILYGVYGT IAFAWGGVSV LLMRTELATS
110 120 130 140 150
SETLISPSLY NGLLTSHGIT MLFLFGTPMI AAFGNYFIPL LIDADDMAFP
160 170 180 190 200
RINAIAFWLL PPGAILIWSG FLIPGIATAQ TSWTMYTPLS LQMSSPAVDM
210 220 230 240 250
MMLGLHLTGV SATMGAINFI ATIFTERGED VGWPDLDIFS WTMLTQSGLI
260 270 280 290 300
LFAFPLFGSA LIMLLLDRNF GTTFFTVAGG DPIFWQHLFW FFGHPEVYVL
310 320 330 340 350
VLPPMGIVSL ILPKFSGRKL FGFKFVVYST LAIGVLSFGV WAHHMFTTGI
360 370 380 390 400
DPRIRSSFMA VSLAISIPSA VKVFNWITTM WNGKLRLTAP MLFCIGFVQN
410 420 430 440 450
FIIGGVTGVF LAVIPIDLIL HDTYYVVGHF HFIVYGAIGF ALFAASYYWF
460 470 480 490 500
PMVTGRMYQK RLAHAHFWTA LVGSNATFLA MLWLGYGGMP RRYATYIPQF
510 520 530 540 550
ATAHRLATVG AFLIGVSTLI WLFNMATSWR EGPRVDSTDP WDLEETDQFT
560 570 580 590
NDWAWFRAKE ETTVLPDGGD EAQSEADAVT DGGQPAADSD TES
Length:593
Mass (Da):65,294
Last modified:February 1, 1994 - v1
Checksum:iDCEC7CF007ACD326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10611 Genomic DNA Translation: BAA01466.1
AE004437 Genomic DNA Translation: AAG19154.1
PIRiF84223
JT0974
RefSeqiWP_010902450.1, NC_002607.1

Genome annotation databases

EnsemblBacteriaiAAG19154; AAG19154; VNG_0657G
GeneIDi5952628
KEGGihal:VNG_0657G
PATRICifig|64091.14.peg.502

Similar proteinsi

Entry informationi

Entry nameiCOX1_HALSA
AccessioniPrimary (citable) accession number: P33518
Secondary accession number(s): Q9HRK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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