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Protein

Cytochrome c oxidase polypeptide 1

Gene

coxA2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi117 – 1171Iron (heme A axial ligand)Curated
Metal bindingi294 – 2941Copper BCurated
Metal bindingi298 – 2981Copper BCurated
Metal bindingi343 – 3431Copper BCurated
Metal bindingi344 – 3441Copper BCurated
Metal bindingi429 – 4291Iron (heme A3 axial ligand)Curated
Metal bindingi431 – 4311Iron (heme A axial ligand)Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.3.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:coxA2
Ordered Locus Names:VNG_0657G
OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Taxonomic identifieri64091 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
ProteomesiUP000000554 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST
Transmembranei358 – 37821HelicalSequence AnalysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence AnalysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Cytochrome c oxidase polypeptide 1PRO_0000183465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki294 ↔ 2981'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP33518.
PRIDEiP33518.

Interactioni

Protein-protein interaction databases

STRINGi64091.VNG0657G.

Structurei

3D structure databases

ProteinModelPortaliP33518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
InParanoidiP33518.
KOiK02274.
OMAiATQIFFL.
PhylomeDBiP33518.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASSITL TVLMGVLLVG VVAVLARLED WRSYTPLSDV GGGLGERTGY
60 70 80 90 100
THEEKPGGII RWFTTVDHKD IGILYGVYGT IAFAWGGVSV LLMRTELATS
110 120 130 140 150
SETLISPSLY NGLLTSHGIT MLFLFGTPMI AAFGNYFIPL LIDADDMAFP
160 170 180 190 200
RINAIAFWLL PPGAILIWSG FLIPGIATAQ TSWTMYTPLS LQMSSPAVDM
210 220 230 240 250
MMLGLHLTGV SATMGAINFI ATIFTERGED VGWPDLDIFS WTMLTQSGLI
260 270 280 290 300
LFAFPLFGSA LIMLLLDRNF GTTFFTVAGG DPIFWQHLFW FFGHPEVYVL
310 320 330 340 350
VLPPMGIVSL ILPKFSGRKL FGFKFVVYST LAIGVLSFGV WAHHMFTTGI
360 370 380 390 400
DPRIRSSFMA VSLAISIPSA VKVFNWITTM WNGKLRLTAP MLFCIGFVQN
410 420 430 440 450
FIIGGVTGVF LAVIPIDLIL HDTYYVVGHF HFIVYGAIGF ALFAASYYWF
460 470 480 490 500
PMVTGRMYQK RLAHAHFWTA LVGSNATFLA MLWLGYGGMP RRYATYIPQF
510 520 530 540 550
ATAHRLATVG AFLIGVSTLI WLFNMATSWR EGPRVDSTDP WDLEETDQFT
560 570 580 590
NDWAWFRAKE ETTVLPDGGD EAQSEADAVT DGGQPAADSD TES
Length:593
Mass (Da):65,294
Last modified:February 1, 1994 - v1
Checksum:iDCEC7CF007ACD326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10611 Genomic DNA. Translation: BAA01466.1.
AE004437 Genomic DNA. Translation: AAG19154.1.
PIRiF84223.
JT0974.
RefSeqiNP_279674.1. NC_002607.1.
WP_010902450.1. NC_002607.1.

Genome annotation databases

EnsemblBacteriaiAAG19154; AAG19154; VNG_0657G.
GeneIDi1447460.
KEGGihal:VNG0657G.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10611 Genomic DNA. Translation: BAA01466.1.
AE004437 Genomic DNA. Translation: AAG19154.1.
PIRiF84223.
JT0974.
RefSeqiNP_279674.1. NC_002607.1.
WP_010902450.1. NC_002607.1.

3D structure databases

ProteinModelPortaliP33518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi64091.VNG0657G.

Protein family/group databases

TCDBi3.D.4.3.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP33518.
PRIDEiP33518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG19154; AAG19154; VNG_0657G.
GeneIDi1447460.
KEGGihal:VNG0657G.

Phylogenomic databases

eggNOGiCOG0843.
InParanoidiP33518.
KOiK02274.
OMAiATQIFFL.
PhylomeDBiP33518.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cytochrome aa3 gene from the archaeon (Archaebacterium) Halobacterium halobium."
    Denda K., Fujiwara T., Seki M., Yoshida M., Fukumori Y., Yamanaka T.
    Biochem. Biophys. Res. Commun. 181:316-322(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700922 / JCM 11081 / NRC-1.

Entry informationi

Entry nameiCOX1_HALSA
AccessioniPrimary (citable) accession number: P33518
Secondary accession number(s): Q9HRK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.