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P33518

- COX1_HALSA

UniProt

P33518 - COX1_HALSA

Protein

Cytochrome c oxidase polypeptide 1

Gene

coxA2

Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi117 – 1171Iron (heme A axial ligand)Curated
    Metal bindingi294 – 2941Copper BCurated
    Metal bindingi298 – 2981Copper BCurated
    Metal bindingi343 – 3431Copper BCurated
    Metal bindingi344 – 3441Copper BCurated
    Metal bindingi429 – 4291Iron (heme A3 axial ligand)Curated
    Metal bindingi431 – 4311Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Protein family/group databases

    TCDBi3.D.4.3.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:coxA2
    Ordered Locus Names:VNG_0657G
    OrganismiHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium)
    Taxonomic identifieri64091 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
    ProteomesiUP000000554: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Cytochrome c oxidase polypeptide 1PRO_0000183465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki294 ↔ 2981'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Proteomic databases

    PaxDbiP33518.
    PRIDEiP33518.

    Interactioni

    Protein-protein interaction databases

    STRINGi64091.VNG0657G.

    Structurei

    3D structure databases

    ProteinModelPortaliP33518.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    KOiK02274.
    OMAiMVYGYEG.
    PhylomeDBiP33518.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33518-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASSITL TVLMGVLLVG VVAVLARLED WRSYTPLSDV GGGLGERTGY    50
    THEEKPGGII RWFTTVDHKD IGILYGVYGT IAFAWGGVSV LLMRTELATS 100
    SETLISPSLY NGLLTSHGIT MLFLFGTPMI AAFGNYFIPL LIDADDMAFP 150
    RINAIAFWLL PPGAILIWSG FLIPGIATAQ TSWTMYTPLS LQMSSPAVDM 200
    MMLGLHLTGV SATMGAINFI ATIFTERGED VGWPDLDIFS WTMLTQSGLI 250
    LFAFPLFGSA LIMLLLDRNF GTTFFTVAGG DPIFWQHLFW FFGHPEVYVL 300
    VLPPMGIVSL ILPKFSGRKL FGFKFVVYST LAIGVLSFGV WAHHMFTTGI 350
    DPRIRSSFMA VSLAISIPSA VKVFNWITTM WNGKLRLTAP MLFCIGFVQN 400
    FIIGGVTGVF LAVIPIDLIL HDTYYVVGHF HFIVYGAIGF ALFAASYYWF 450
    PMVTGRMYQK RLAHAHFWTA LVGSNATFLA MLWLGYGGMP RRYATYIPQF 500
    ATAHRLATVG AFLIGVSTLI WLFNMATSWR EGPRVDSTDP WDLEETDQFT 550
    NDWAWFRAKE ETTVLPDGGD EAQSEADAVT DGGQPAADSD TES 593
    Length:593
    Mass (Da):65,294
    Last modified:February 1, 1994 - v1
    Checksum:iDCEC7CF007ACD326
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10611 Genomic DNA. Translation: BAA01466.1.
    AE004437 Genomic DNA. Translation: AAG19154.1.
    PIRiF84223.
    JT0974.
    RefSeqiNP_279674.1. NC_002607.1.
    WP_010902450.1. NC_002607.1.

    Genome annotation databases

    EnsemblBacteriaiAAG19154; AAG19154; VNG_0657G.
    GeneIDi1447460.
    KEGGihal:VNG0657G.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10611 Genomic DNA. Translation: BAA01466.1 .
    AE004437 Genomic DNA. Translation: AAG19154.1 .
    PIRi F84223.
    JT0974.
    RefSeqi NP_279674.1. NC_002607.1.
    WP_010902450.1. NC_002607.1.

    3D structure databases

    ProteinModelPortali P33518.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 64091.VNG0657G.

    Protein family/group databases

    TCDBi 3.D.4.3.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    PaxDbi P33518.
    PRIDEi P33518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG19154 ; AAG19154 ; VNG_0657G .
    GeneIDi 1447460.
    KEGGi hal:VNG0657G.

    Phylogenomic databases

    eggNOGi COG0843.
    KOi K02274.
    OMAi MVYGYEG.
    PhylomeDBi P33518.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cytochrome aa3 gene from the archaeon (Archaebacterium) Halobacterium halobium."
      Denda K., Fujiwara T., Seki M., Yoshida M., Fukumori Y., Yamanaka T.
      Biochem. Biophys. Res. Commun. 181:316-322(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700922 / JCM 11081 / NRC-1.

    Entry informationi

    Entry nameiCOX1_HALSA
    AccessioniPrimary (citable) accession number: P33518
    Secondary accession number(s): Q9HRK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3