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P33518 (COX1_HALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase polypeptide 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:coxA2
Ordered Locus Names:VNG_0657G
OrganismHalobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) [Reference proteome] [HAMAP]
Taxonomic identifier64091 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Cytochrome c oxidase polypeptide 1
PRO_0000183465

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane204 – 22421Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane358 – 37821Helical; Potential
Transmembrane401 – 42121Helical; Potential
Transmembrane425 – 44521Helical; Potential
Transmembrane467 – 48721Helical; Potential
Transmembrane506 – 52621Helical; Potential

Sites

Metal binding1171Iron (heme A axial ligand) Probable
Metal binding2941Copper B Probable
Metal binding2981Copper B Probable
Metal binding3431Copper B Probable
Metal binding3441Copper B Probable
Metal binding4291Iron (heme A3 axial ligand) Probable
Metal binding4311Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link294 ↔ 2981'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P33518 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: DCEC7CF007ACD326

FASTA59365,294
        10         20         30         40         50         60 
MATAASSITL TVLMGVLLVG VVAVLARLED WRSYTPLSDV GGGLGERTGY THEEKPGGII 

        70         80         90        100        110        120 
RWFTTVDHKD IGILYGVYGT IAFAWGGVSV LLMRTELATS SETLISPSLY NGLLTSHGIT 

       130        140        150        160        170        180 
MLFLFGTPMI AAFGNYFIPL LIDADDMAFP RINAIAFWLL PPGAILIWSG FLIPGIATAQ 

       190        200        210        220        230        240 
TSWTMYTPLS LQMSSPAVDM MMLGLHLTGV SATMGAINFI ATIFTERGED VGWPDLDIFS 

       250        260        270        280        290        300 
WTMLTQSGLI LFAFPLFGSA LIMLLLDRNF GTTFFTVAGG DPIFWQHLFW FFGHPEVYVL 

       310        320        330        340        350        360 
VLPPMGIVSL ILPKFSGRKL FGFKFVVYST LAIGVLSFGV WAHHMFTTGI DPRIRSSFMA 

       370        380        390        400        410        420 
VSLAISIPSA VKVFNWITTM WNGKLRLTAP MLFCIGFVQN FIIGGVTGVF LAVIPIDLIL 

       430        440        450        460        470        480 
HDTYYVVGHF HFIVYGAIGF ALFAASYYWF PMVTGRMYQK RLAHAHFWTA LVGSNATFLA 

       490        500        510        520        530        540 
MLWLGYGGMP RRYATYIPQF ATAHRLATVG AFLIGVSTLI WLFNMATSWR EGPRVDSTDP 

       550        560        570        580        590 
WDLEETDQFT NDWAWFRAKE ETTVLPDGGD EAQSEADAVT DGGQPAADSD TES 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10611 Genomic DNA. Translation: BAA01466.1.
AE004437 Genomic DNA. Translation: AAG19154.1.
PIRF84223.
JT0974.
RefSeqNP_279674.1. NC_002607.1.

3D structure databases

ProteinModelPortalP33518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING64091.VNG0657G.

Protein family/group databases

TCDB3.D.4.3.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbP33518.
PRIDEP33518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG19154; AAG19154; VNG_0657G.
GeneID1447460.
KEGGhal:VNG0657G.

Phylogenomic databases

eggNOGCOG0843.
KOK02274.
OMAMIPIMIG.
PhylomeDBP33518.
ProtClustDBCLSK511177.

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_HALSA
AccessionPrimary (citable) accession number: P33518
Secondary accession number(s): Q9HRK4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways