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P33517

- COX1_RHOSH

UniProt

P33517 - COX1_RHOSH

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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme A axial ligand)Curated
Metal bindingi284 – 2841Copper BCurated
Metal bindingi288 – 2881Copper BCurated
Metal bindingi333 – 3331Copper BCurated
Metal bindingi334 – 3341Copper BCurated
Metal bindingi419 – 4191Iron (heme A3 axial ligand)Curated
Metal bindingi421 – 4211Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Cytochrome c oxidase subunit 1PRO_0000183459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki284 ↔ 2881'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

DIPiDIP-38013N.
IntActiP33517. 3 interactions.

Structurei

Secondary structure

1
566
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 205
Helixi26 – 5530
Beta strandi57 – 593
Beta strandi61 – 644
Helixi65 – 695
Helixi72 – 787
Helixi85 – 873
Helixi92 – 10918
Helixi111 – 1155
Turni116 – 1183
Helixi119 – 12810
Helixi136 – 15621
Beta strandi159 – 1613
Helixi162 – 1643
Beta strandi165 – 1673
Turni171 – 1744
Helixi178 – 1814
Beta strandi183 – 1853
Helixi186 – 21429
Turni222 – 2243
Helixi227 – 25832
Helixi266 – 2683
Helixi272 – 30635
Helixi313 – 32614
Helixi331 – 3344
Turni336 – 3394
Helixi342 – 35413
Helixi356 – 37015
Helixi379 – 40224
Helixi404 – 4107
Helixi414 – 42411
Turni425 – 4273
Helixi428 – 44417
Beta strandi445 – 4473
Helixi450 – 47627
Beta strandi480 – 4823
Helixi488 – 4903
Helixi491 – 52131
Helixi538 – 5414
Helixi557 – 5593

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30A/G1-566[»]
1M57X-ray3.00A/G1-566[»]
2GSMX-ray2.00A/C1-566[»]
3DTUX-ray2.15A/C1-566[»]
3FYEX-ray2.15A/C1-566[»]
3FYIX-ray2.20A/C1-566[»]
ProteinModelPortaliP33517.
SMRiP33517. Positions 14-560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33517.

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence AnalysisAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence AnalysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33517-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY
60 70 80 90 100
MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT
110 120 130 140 150
GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT
160 170 180 190 200
SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS
210 220 230 240 250
SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI
260 270 280 290 300
TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH
310 320 330 340 350
VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM
360 370 380 390 400
ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV
410 420 430 440 450
LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE
460 470 480 490 500
WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG
510 520 530 540 550
AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT
560
FEQLPKREDW ERAPAH
Length:566
Mass (Da):63,147
Last modified:January 17, 2003 - v2
Checksum:i65A74DBCC5C550B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2.
PIRiS20534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2 .
PIRi S20534.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M56 X-ray 2.30 A/G 1-566 [» ]
1M57 X-ray 3.00 A/G 1-566 [» ]
2GSM X-ray 2.00 A/C 1-566 [» ]
3DTU X-ray 2.15 A/C 1-566 [» ]
3FYE X-ray 2.15 A/C 1-566 [» ]
3FYI X-ray 2.20 A/C 1-566 [» ]
ProteinModelPortali P33517.
SMRi P33517. Positions 14-560.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38013N.
IntActi P33517. 3 interactions.

Protein family/group databases

TCDBi 3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

EvolutionaryTracei P33517.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and deletion from the chromosome of the gene encoding subunit I of the aa3-type cytochrome c oxidase of Rhodobacter sphaeroides."
    Shapleigh J.P., Gennis R.B.
    Mol. Microbiol. 6:635-642(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Ga.
  2. Shapleigh J.P., Gennis R.B.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 436-439 AND 518-521.

Entry informationi

Entry nameiCOX1_RHOSH
AccessioniPrimary (citable) accession number: P33517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 17, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3