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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Iron (heme A axial ligand)Curated1
Metal bindingi284Copper BCurated1
Metal bindingi288Copper BCurated1
Metal bindingi333Copper BCurated1
Metal bindingi334Copper BCurated1
Metal bindingi419Iron (heme A3 axial ligand)Curated1
Metal bindingi421Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834591 – 566Cytochrome c oxidase subunit 1Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki284 ↔ 2881'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Protein-protein interaction databases

DIPiDIP-38013N.
IntActiP33517. 3 interactors.
STRINGi349102.Rsph17025_0664.

Structurei

Secondary structure

1566
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 20Combined sources5
Helixi26 – 55Combined sources30
Beta strandi57 – 59Combined sources3
Beta strandi61 – 64Combined sources4
Helixi65 – 69Combined sources5
Helixi72 – 78Combined sources7
Helixi85 – 87Combined sources3
Helixi92 – 109Combined sources18
Helixi111 – 115Combined sources5
Turni116 – 118Combined sources3
Helixi119 – 128Combined sources10
Helixi136 – 156Combined sources21
Beta strandi159 – 161Combined sources3
Helixi162 – 164Combined sources3
Beta strandi165 – 167Combined sources3
Turni171 – 174Combined sources4
Helixi178 – 181Combined sources4
Beta strandi183 – 185Combined sources3
Helixi186 – 214Combined sources29
Turni222 – 224Combined sources3
Helixi227 – 258Combined sources32
Helixi266 – 268Combined sources3
Helixi272 – 306Combined sources35
Helixi313 – 326Combined sources14
Helixi331 – 334Combined sources4
Turni336 – 339Combined sources4
Helixi342 – 354Combined sources13
Helixi356 – 370Combined sources15
Helixi379 – 402Combined sources24
Helixi404 – 410Combined sources7
Helixi414 – 424Combined sources11
Turni425 – 427Combined sources3
Helixi428 – 444Combined sources17
Beta strandi445 – 447Combined sources3
Helixi450 – 476Combined sources27
Beta strandi480 – 482Combined sources3
Helixi488 – 490Combined sources3
Helixi491 – 521Combined sources31
Helixi538 – 541Combined sources4
Helixi557 – 559Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30A/G1-566[»]
1M57X-ray3.00A/G1-566[»]
2GSMX-ray2.00A/C1-566[»]
3DTUX-ray2.15A/C1-566[»]
3FYEX-ray2.15A/C1-566[»]
3FYIX-ray2.20A/C1-566[»]
ProteinModelPortaliP33517.
SMRiP33517.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33517.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY
60 70 80 90 100
MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT
110 120 130 140 150
GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT
160 170 180 190 200
SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS
210 220 230 240 250
SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI
260 270 280 290 300
TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH
310 320 330 340 350
VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM
360 370 380 390 400
ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV
410 420 430 440 450
LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE
460 470 480 490 500
WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG
510 520 530 540 550
AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT
560
FEQLPKREDW ERAPAH
Length:566
Mass (Da):63,147
Last modified:January 17, 2003 - v2
Checksum:i65A74DBCC5C550B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2.
PIRiS20534.
RefSeqiWP_011337048.1. NZ_CP015210.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2.
PIRiS20534.
RefSeqiWP_011337048.1. NZ_CP015210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30A/G1-566[»]
1M57X-ray3.00A/G1-566[»]
2GSMX-ray2.00A/C1-566[»]
3DTUX-ray2.15A/C1-566[»]
3FYEX-ray2.15A/C1-566[»]
3FYIX-ray2.20A/C1-566[»]
ProteinModelPortaliP33517.
SMRiP33517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-38013N.
IntActiP33517. 3 interactors.
STRINGi349102.Rsph17025_0664.

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00705.

Miscellaneous databases

EvolutionaryTraceiP33517.

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1_RHOSH
AccessioniPrimary (citable) accession number: P33517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 17, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.