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P33517

- COX1_RHOSH

UniProt

P33517 - COX1_RHOSH

Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Iron (heme A axial ligand)Curated
    Metal bindingi284 – 2841Copper BCurated
    Metal bindingi288 – 2881Copper BCurated
    Metal bindingi333 – 3331Copper BCurated
    Metal bindingi334 – 3341Copper BCurated
    Metal bindingi419 – 4191Iron (heme A3 axial ligand)Curated
    Metal bindingi421 – 4211Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Protein family/group databases

    TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
    Taxonomic identifieri1063 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Cytochrome c oxidase subunit 1PRO_0000183459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki284 ↔ 2881'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-38013N.
    IntActiP33517. 3 interactions.

    Structurei

    Secondary structure

    1
    566
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 205
    Helixi26 – 5530
    Beta strandi57 – 593
    Beta strandi61 – 644
    Helixi65 – 695
    Helixi72 – 787
    Helixi85 – 873
    Helixi92 – 10918
    Helixi111 – 1155
    Turni116 – 1183
    Helixi119 – 12810
    Helixi136 – 15621
    Beta strandi159 – 1613
    Helixi162 – 1643
    Beta strandi165 – 1673
    Turni171 – 1744
    Helixi178 – 1814
    Beta strandi183 – 1853
    Helixi186 – 21429
    Turni222 – 2243
    Helixi227 – 25832
    Helixi266 – 2683
    Helixi272 – 30635
    Helixi313 – 32614
    Helixi331 – 3344
    Turni336 – 3394
    Helixi342 – 35413
    Helixi356 – 37015
    Helixi379 – 40224
    Helixi404 – 4107
    Helixi414 – 42411
    Turni425 – 4273
    Helixi428 – 44417
    Beta strandi445 – 4473
    Helixi450 – 47627
    Beta strandi480 – 4823
    Helixi488 – 4903
    Helixi491 – 52131
    Helixi538 – 5414
    Helixi557 – 5593

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M56X-ray2.30A/G1-566[»]
    1M57X-ray3.00A/G1-566[»]
    2GSMX-ray2.00A/C1-566[»]
    3DTUX-ray2.15A/C1-566[»]
    3FYEX-ray2.15A/C1-566[»]
    3FYIX-ray2.20A/C1-566[»]
    ProteinModelPortaliP33517.
    SMRiP33517. Positions 14-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP33517.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33517-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY    50
    MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT 100
    GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT 150
    SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS 200
    SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI 250
    TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH 300
    VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM 350
    ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV 400
    LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE 450
    WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG 500
    AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT 550
    FEQLPKREDW ERAPAH 566
    Length:566
    Mass (Da):63,147
    Last modified:January 17, 2003 - v2
    Checksum:i65A74DBCC5C550B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62645 Genomic DNA. Translation: CAA44514.2.
    PIRiS20534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62645 Genomic DNA. Translation: CAA44514.2 .
    PIRi S20534.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M56 X-ray 2.30 A/G 1-566 [» ]
    1M57 X-ray 3.00 A/G 1-566 [» ]
    2GSM X-ray 2.00 A/C 1-566 [» ]
    3DTU X-ray 2.15 A/C 1-566 [» ]
    3FYE X-ray 2.15 A/C 1-566 [» ]
    3FYI X-ray 2.20 A/C 1-566 [» ]
    ProteinModelPortali P33517.
    SMRi P33517. Positions 14-560.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-38013N.
    IntActi P33517. 3 interactions.

    Protein family/group databases

    TCDBi 3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    EvolutionaryTracei P33517.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and deletion from the chromosome of the gene encoding subunit I of the aa3-type cytochrome c oxidase of Rhodobacter sphaeroides."
      Shapleigh J.P., Gennis R.B.
      Mol. Microbiol. 6:635-642(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Ga.
    2. Shapleigh J.P., Gennis R.B.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 436-439 AND 518-521.

    Entry informationi

    Entry nameiCOX1_RHOSH
    AccessioniPrimary (citable) accession number: P33517
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3