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P33517

- COX1_RHOSH

UniProt

P33517 - COX1_RHOSH

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Protein
Cytochrome c oxidase subunit 1
Gene
ctaD
Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme A axial ligand) Inferred
Metal bindingi284 – 2841Copper B Inferred
Metal bindingi288 – 2881Copper B Inferred
Metal bindingi333 – 3331Copper B Inferred
Metal bindingi334 – 3341Copper B Inferred
Metal bindingi419 – 4191Iron (heme A3 axial ligand) Inferred
Metal bindingi421 – 4211Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Transmembranei227 – 24721Helical; Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei348 – 36821Helical; Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Reviewed prediction
Add
BLAST
Transmembranei420 – 44021Helical; Reviewed prediction
Add
BLAST
Transmembranei455 – 47521Helical; Reviewed prediction
Add
BLAST
Transmembranei499 – 51921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Cytochrome c oxidase subunit 1
PRO_0000183459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki284 ↔ 2881'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Protein-protein interaction databases

DIPiDIP-38013N.
IntActiP33517. 3 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 205
Helixi26 – 5530
Beta strandi57 – 593
Beta strandi61 – 644
Helixi65 – 695
Helixi72 – 787
Helixi85 – 873
Helixi92 – 10918
Helixi111 – 1155
Turni116 – 1183
Helixi119 – 12810
Helixi136 – 15621
Beta strandi159 – 1613
Helixi162 – 1643
Beta strandi165 – 1673
Turni171 – 1744
Helixi178 – 1814
Beta strandi183 – 1853
Helixi186 – 21429
Turni222 – 2243
Helixi227 – 25832
Helixi266 – 2683
Helixi272 – 30635
Helixi313 – 32614
Helixi331 – 3344
Turni336 – 3394
Helixi342 – 35413
Helixi356 – 37015
Helixi379 – 40224
Helixi404 – 4107
Helixi414 – 42411
Turni425 – 4273
Helixi428 – 44417
Beta strandi445 – 4473
Helixi450 – 47627
Beta strandi480 – 4823
Helixi488 – 4903
Helixi491 – 52131
Helixi538 – 5414
Helixi557 – 5593

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M56X-ray2.30A/G1-566[»]
1M57X-ray3.00A/G1-566[»]
2GSMX-ray2.00A/C1-566[»]
3DTUX-ray2.15A/C1-566[»]
3FYEX-ray2.15A/C1-566[»]
3FYIX-ray2.20A/C1-566[»]
ProteinModelPortaliP33517.
SMRiP33517. Positions 14-560.

Miscellaneous databases

EvolutionaryTraceiP33517.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33517-1 [UniParc]FASTAAdd to Basket

« Hide

MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY    50
MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT 100
GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT 150
SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS 200
SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI 250
TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH 300
VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM 350
ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV 400
LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE 450
WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG 500
AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT 550
FEQLPKREDW ERAPAH 566
Length:566
Mass (Da):63,147
Last modified:January 17, 2003 - v2
Checksum:i65A74DBCC5C550B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2.
PIRiS20534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62645 Genomic DNA. Translation: CAA44514.2 .
PIRi S20534.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M56 X-ray 2.30 A/G 1-566 [» ]
1M57 X-ray 3.00 A/G 1-566 [» ]
2GSM X-ray 2.00 A/C 1-566 [» ]
3DTU X-ray 2.15 A/C 1-566 [» ]
3FYE X-ray 2.15 A/C 1-566 [» ]
3FYI X-ray 2.20 A/C 1-566 [» ]
ProteinModelPortali P33517.
SMRi P33517. Positions 14-560.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-38013N.
IntActi P33517. 3 interactions.

Protein family/group databases

TCDBi 3.D.4.6.2. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

EvolutionaryTracei P33517.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and deletion from the chromosome of the gene encoding subunit I of the aa3-type cytochrome c oxidase of Rhodobacter sphaeroides."
    Shapleigh J.P., Gennis R.B.
    Mol. Microbiol. 6:635-642(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Ga.
  2. Shapleigh J.P., Gennis R.B.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 436-439 AND 518-521.

Entry informationi

Entry nameiCOX1_RHOSH
AccessioniPrimary (citable) accession number: P33517
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 17, 2003
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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