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P33508 (COX3_ANOQU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COIII
Encoded onMitochondrion
OrganismAnopheles quadrimaculatus (Common malaria mosquito)
Taxonomic identifier7166 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cytochrome c oxidase subunit 3
PRO_0000183733

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane163 – 18321Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane240 – 26021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P33508 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: EAE85C6059567823

FASTA26230,172
        10         20         30         40         50         60 
MSAHANHPFH LVDYSPWPLT GAIGAMTTVS GLVQWFHQYT MTLFILGNII TILTMYQWWR 

        70         80         90        100        110        120 
DISREGTFQG LHTFPVTIGL RWGMILFIVS EIFFFISFFW AFFHSSLSPT IELGMTWPPV 

       130        140        150        160        170        180 
GIIAFNPFQI PLLNTAILLA SGVTVTWAHH ALMESNHSQA TQGLFFTIVL GIYFSILQAY 

       190        200        210        220        230        240 
EYIEAPFTIA DAVYGSTFYM ATGFHGLHVL IGTTFLLICF LRHINFHFSK NHHFGFEAAA 

       250        260 
WYWHFVDVVW LFLYISIYWW GS 

« Hide

References

[1]"Cloning of the mitochondrial genome of Anopheles quadrimaculatus."
Cockburn A.F., Mitchell S.E., Seawright J.A.
Arch. Insect Biochem. Physiol. 14:31-36(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Orlando.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04272 Genomic DNA. Translation: AAA93545.2. Sequence problems.

3D structure databases

ProteinModelPortalP33508.
SMRP33508. Positions 4-262.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_ANOQU
AccessionPrimary (citable) accession number: P33508
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families