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Protein

Cytochrome c oxidase subunit 3

Gene

COIII

Organism
Anopheles quadrimaculatus (Common malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COIII
Encoded oniMitochondrion
OrganismiAnopheles quadrimaculatus (Common malaria mosquito)
Taxonomic identifieri7166 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837331 – 262Cytochrome c oxidase subunit 3Add BLAST262

Structurei

3D structure databases

ProteinModelPortaliP33508.
SMRiP33508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

P33508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAHANHPFH LVDYSPWPLT GAIGAMTTVS GLVQWFHQYT MTLFILGNII
60 70 80 90 100
TILTMYQWWR DISREGTFQG LHTFPVTIGL RWGMILFIVS EIFFFISFFW
110 120 130 140 150
AFFHSSLSPT IELGMTWPPV GIIAFNPFQI PLLNTAILLA SGVTVTWAHH
160 170 180 190 200
ALMESNHSQA TQGLFFTIVL GIYFSILQAY EYIEAPFTIA DAVYGSTFYM
210 220 230 240 250
ATGFHGLHVL IGTTFLLICF LRHINFHFSK NHHFGFEAAA WYWHFVDVVW
260
LFLYISIYWW GS
Length:262
Mass (Da):30,172
Last modified:February 1, 1994 - v1
Checksum:iEAE85C6059567823
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04272 Genomic DNA. Translation: AAA93545.2. Sequence problems.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOX3_ANOQU
AccessioniPrimary (citable) accession number: P33508
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 12, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families