P33508 (COX3_ANOQU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COIII

Encoded on

Mitochondrion

Organism

Anopheles quadrimaculatus (Common malaria mosquito)

Taxonomic identifier

7166 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Anopheles › Angusticorn › Anopheles › maculipennis group › maculipennis subgroup › quadrimaculatus species complex

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cytochrome c oxidase subunit 3		PRO_0000183733
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	201 – 221	21	Helical; Potential
	Transmembrane	240 – 260	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P33508 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: EAE85C6059567823	FASTA	262	30,172
	10 20 30 40 50 60 MSAHANHPFH LVDYSPWPLT GAIGAMTTVS GLVQWFHQYT MTLFILGNII TILTMYQWWR 70 80 90 100 110 120 DISREGTFQG LHTFPVTIGL RWGMILFIVS EIFFFISFFW AFFHSSLSPT IELGMTWPPV 130 140 150 160 170 180 GIIAFNPFQI PLLNTAILLA SGVTVTWAHH ALMESNHSQA TQGLFFTIVL GIYFSILQAY 190 200 210 220 230 240 EYIEAPFTIA DAVYGSTFYM ATGFHGLHVL IGTTFLLICF LRHINFHFSK NHHFGFEAAA 250 260 WYWHFVDVVW LFLYISIYWW GS

References

[1]	"Cloning of the mitochondrial genome of Anopheles quadrimaculatus." Cockburn A.F., Mitchell S.E., Seawright J.A. Arch. Insect Biochem. Physiol. 14:31-36(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Orlando.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L04272 Genomic DNA. Translation: AAA93545.2. Sequence problems.
3D structure databases
ProteinModelPortal	P33508.
SMR	P33508. Positions 4-262.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	MTH00155.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_ANOQU

Accession

Primary (citable) accession number: P33508

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)