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P33505 (COX2_ANOQU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COXII
Synonyms:COII
Encoded onMitochondrion
OrganismAnopheles quadrimaculatus (Common malaria mosquito)
Taxonomic identifier7166 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Cytochrome c oxidase subunit 2
PRO_0000183493

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 6013Mitochondrial matrix Potential
Transmembrane61 – 8121Helical; Potential
Topological domain82 – 228147Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P33505 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 1DCCDB0E3B6A370C

FASTA22826,243
        10         20         30         40         50         60 
MATWANLGLQ DSSSPLMEQL NFFHDHTLLI LTMITILVGY IMGMLMFNQF TNRYLLHGQT 

        70         80         90        100        110        120 
IEIIWTVLPA IILMFIALPS LRLLYLMDEI NTPSITLKSV GHQWYWSYEY SDFLNLEFDS 

       130        140        150        160        170        180 
YMIPTNELET NGFRLLDVDN RVVLPVNNQI RILVTATDVL HSWTVPSLGV KVDATPGRLN 

       190        200        210        220 
QLNFLINRPG LFFGQCSEIC GANHSFMPIV IESIPMNYFI KWITNMTN 

« Hide

References

[1]"Cloning of the mitochondrial genome of Anopheles quadrimaculatus."
Cockburn A.F., Mitchell S.E., Seawright J.A.
Arch. Insect Biochem. Physiol. 14:31-36(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Orlando.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L04272 Genomic DNA. Translation: AAA93542.2. Sequence problems.

3D structure databases

ProteinModelPortalP33505.
SMRP33505. Positions 1-226.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_ANOQU
AccessionPrimary (citable) accession number: P33505
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families