SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P33504

- COX1_ANOQU

UniProt

P33504 - COX1_ANOQU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Anopheles quadrimaculatus (Common malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand) Inferred
Metal bindingi239 – 2391Copper B Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi289 – 2891Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi375 – 3751Iron (heme A3 axial ligand) Inferred
Metal bindingi377 – 3771Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiAnopheles quadrimaculatus (Common malaria mosquito)
Taxonomic identifieri7166 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Transmembranei55 – 7521Helical; Reviewed predictionAdd
BLAST
Transmembranei101 – 12121Helical; Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Transmembranei233 – 25321Helical; Reviewed predictionAdd
BLAST
Transmembranei267 – 28721Helical; Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Transmembranei337 – 35721Helical; Reviewed predictionAdd
BLAST
Transmembranei379 – 39921Helical; Reviewed predictionAdd
BLAST
Transmembranei413 – 43321Helical; Reviewed predictionAdd
BLAST
Transmembranei451 – 47121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000183283Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP33504.
SMRiP33504. Positions 4-506.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33504-1 [UniParc]FASTAAdd to Basket

« Hide

MSRQWLFSTN HKDIGTLYFI FGAWAGMVGT SLSILIRAEL GHPGAFIGDD    50
QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
FWMLPPSLTL LISSSMVENG AGTGWTVYPP LSSGIAHAGA SVDLAIFSLH 150
LAGISSILGA VNFITTVINM RAPGITLDRM PLFVWSVVIT AVLLLLSLPV 200
LAGAITMLLT DRNLNTSFFD PAGGGEPNLY QHLFWFFGHP EVYILILPGF 250
GMISHIITQE SGKKETFGNL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT 300
RAYFTSATMI IAVPTGIKIF SWLATMHGTQ LTYSPAMLWA FGFVFLFTVG 350
GLTGVVLANS SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLLT 400
GLTMNPNWLK LQFAMMFVGV NLTFFPQHFL GLAGMPRRYS DFPDSYLAWN 450
IVSSLGSTIS LFAILYFLFI IWESMITQRT PAFPMQLSSS IEWYHTLPPA 500
EHTYAELPLL TNNF 514
Length:514
Mass (Da):56,871
Last modified:February 1, 1994 - v1
Checksum:iD00A0F6F3D52B266
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04272 Genomic DNA. Translation: AAA93541.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L04272 Genomic DNA. Translation: AAA93541.1 .

3D structure databases

ProteinModelPortali P33504.
SMRi P33504. Positions 4-506.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the mitochondrial genome of Anopheles quadrimaculatus."
    Cockburn A.F., Mitchell S.E., Seawright J.A.
    Arch. Insect Biochem. Physiol. 14:31-36(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Orlando.

Entry informationi

Entry nameiCOX1_ANOQU
AccessioniPrimary (citable) accession number: P33504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi