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P33486

- LYS_BPMV1

UniProt

P33486 - LYS_BPMV1

Protein

Lysozyme

Gene

lysA

Organism
Lactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (30 May 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81PROSITE-ProRule annotation
    Active sitei99 – 991PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell wall macromolecule catabolic process Source: InterPro
    3. cytolysis Source: UniProtKB-KW
    4. defense response to bacterium Source: UniProtKB-KW
    5. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH25. Glycoside Hydrolase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme (EC:3.2.1.17)
    Alternative name(s):
    Endolysin
    MV1 lysin
    Muramidase
    Gene namesi
    Name:lysA
    OrganismiLactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
    Taxonomic identifieri33769 [NCBI]
    Taxonomic lineageiVirusesunclassified phages
    Virus hostiLactobacillus delbrueckii [TaxID: 1584]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202LysozymePRO_0000208262Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP33486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 25 family.Curated

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01183. Glyco_hydro_25. 1 hit.
    [Graphical view]
    SMARTiSM00641. Glyco_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33486-1 [UniParc]FASTAAdd to Basket

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    MTKTYGVDVA VYQPIDLAAY HKAGASFAIV KLTEGVDYVN RRGPSRWTAP    50
    GLTTSTLMPT ISRSFGSSVS RAKKEAAYFL KEAKKQDISK KRMLWLDWEA 100
    GSGNVVTGSK SSNTAAILDF MDAIKAAGWR PGLYSGASLM RTAIDTKQVV 150
    KKYGTCLWVA SYPTMAAVST ADFGYFRQWT GSPSGSLPVT AWPGRRRERC 200
    SG 202
    Length:202
    Mass (Da):21,985
    Last modified:May 30, 2000 - v3
    Checksum:iF40F125D936D6E8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60167 Genomic DNA. Translation: AAA32264.1.
    PIRiJQ0789. MUBPM1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60167 Genomic DNA. Translation: AAA32264.1 .
    PIRi JQ0789. MUBPM1.

    3D structure databases

    ProteinModelPortali P33486.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH25. Glycoside Hydrolase Family 25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01183. Glyco_hydro_25. 1 hit.
    [Graphical view ]
    SMARTi SM00641. Glyco_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and sequence analysis of an endolysin-encoding gene of Lactobacillus bulgaricus bacteriophage mv1."
      Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
      Gene 94:61-67(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    2. Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO C-TERMINUS.

    Entry informationi

    Entry nameiLYS_BPMV1
    AccessioniPrimary (citable) accession number: P33486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3