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P33486

- LYS_BPMV1

UniProt

P33486 - LYS_BPMV1

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Protein

Lysozyme

Gene

lysA

Organism
Lactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81PROSITE-ProRule annotation
Active sitei99 – 991PROSITE-ProRule annotation

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall macromolecule catabolic process Source: InterPro
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme (EC:3.2.1.17)
Alternative name(s):
Endolysin
MV1 lysin
Muramidase
Gene namesi
Name:lysA
OrganismiLactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Taxonomic identifieri33769 [NCBI]
Taxonomic lineageiVirusesunclassified phages
Virus hostiLactobacillus delbrueckii [TaxID: 1584]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202LysozymePRO_0000208262Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP33486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SMARTiSM00641. Glyco_25. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33486-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTYGVDVA VYQPIDLAAY HKAGASFAIV KLTEGVDYVN RRGPSRWTAP
60 70 80 90 100
GLTTSTLMPT ISRSFGSSVS RAKKEAAYFL KEAKKQDISK KRMLWLDWEA
110 120 130 140 150
GSGNVVTGSK SSNTAAILDF MDAIKAAGWR PGLYSGASLM RTAIDTKQVV
160 170 180 190 200
KKYGTCLWVA SYPTMAAVST ADFGYFRQWT GSPSGSLPVT AWPGRRRERC

SG
Length:202
Mass (Da):21,985
Last modified:May 30, 2000 - v3
Checksum:iF40F125D936D6E8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60167 Genomic DNA. Translation: AAA32264.1.
PIRiJQ0789. MUBPM1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60167 Genomic DNA. Translation: AAA32264.1 .
PIRi JQ0789. MUBPM1.

3D structure databases

ProteinModelPortali P33486.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01183. Glyco_hydro_25. 1 hit.
[Graphical view ]
SMARTi SM00641. Glyco_25. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, expression and sequence analysis of an endolysin-encoding gene of Lactobacillus bulgaricus bacteriophage mv1."
    Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
    Gene 94:61-67(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
  2. Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.

Entry informationi

Entry nameiLYS_BPMV1
AccessioniPrimary (citable) accession number: P33486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2000
Last modified: October 1, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3