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P33486 (LYS_BPMV1) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme

EC=3.2.1.17
Alternative name(s):
Endolysin
MV1 lysin
Muramidase
Gene names
Name:lysA
OrganismLactococcus phage mv1 (Lactococcus delbrueckii bacteriophage mv1)
Taxonomic identifier33769 [NCBI]
Taxonomic lineageVirusesunclassified phages
Virus hostLactobacillus delbrueckii [TaxID: 1584]

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Helps to release the mature phage particles from the cell wall by breaking down the peptidoglycan.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Lysozyme
PRO_0000208262

Sites

Active site81 By similarity
Active site991 By similarity

Sequences

Sequence LengthMass (Da)Tools
P33486 [UniParc].

Last modified May 30, 2000. Version 3.
Checksum: F40F125D936D6E8B

FASTA20221,985
        10         20         30         40         50         60 
MTKTYGVDVA VYQPIDLAAY HKAGASFAIV KLTEGVDYVN RRGPSRWTAP GLTTSTLMPT 

        70         80         90        100        110        120 
ISRSFGSSVS RAKKEAAYFL KEAKKQDISK KRMLWLDWEA GSGNVVTGSK SSNTAAILDF 

       130        140        150        160        170        180 
MDAIKAAGWR PGLYSGASLM RTAIDTKQVV KKYGTCLWVA SYPTMAAVST ADFGYFRQWT 

       190        200 
GSPSGSLPVT AWPGRRRERC SG 

« Hide

References

[1]"Cloning, expression and sequence analysis of an endolysin-encoding gene of Lactobacillus bulgaricus bacteriophage mv1."
Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
Gene 94:61-67(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]Boizet B., Lahbib-Mansais Y., Dupont L., Ritzenthaler P., Mata M.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO C-TERMINUS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M60167 Genomic DNA. Translation: AAA32264.1.
PIRMUBPM1. JQ0789.

3D structure databases

ProteinModelPortalP33486.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SMARTSM00641. Glyco_25. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS_BPMV1
AccessionPrimary (citable) accession number: P33486
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2000
Last modified: October 16, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries