P33483 (V_MUMPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-structural protein V

Alternative name(s):
Non-structural protein NS1

Gene names

Name:

P/V

Organism

Mumps virus (strain SBL) (MuV)

Taxonomic identifier

33729 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Rubulavirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Blocks host interferon signaling. Interacts with host IFIH1/MDA5 to block its activity in the transduction pathway which leads to the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state By similarity.
Subunit structure	Interacts with host IFIH1/MDA5 By similarity.
Sequence similarities	Belongs to the paramyxoviruses V protein family.
RNA editing	Edited at position 155. Partially edited. RNA editing at this position consists of an insertion of two guanine nucleotides. The sequence displayed here is the V protein, derived from the unedited RNA. The edited RNA gives rise to the P protein (AC P60166). Ref.1

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host IFN-mediated response initiation by virus Inhibition of host MDA5 by virus Inhibition of host STAT1 by virus Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Interferon antiviral system evasion Viral immunoevasion
Coding sequence diversity	RNA editing
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	evasion by virus of host immune response Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Non-structural protein V		PRO_0000142821
Sites
	Metal binding	170	1	Zinc 1 By similarity
	Metal binding	189	1	Zinc 1 By similarity
	Metal binding	193	1	Zinc 2 By similarity
	Metal binding	205	1	Zinc 2 By similarity
	Metal binding	207	1	Zinc 2 By similarity
	Metal binding	210	1	Zinc 2 By similarity
	Metal binding	214	1	Zinc 1 By similarity
	Metal binding	217	1	Zinc 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P33483 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: E7162A8617D14713	FASTA	224	24,011
	10 20 30 40 50 60 MDQFIKQDET GDLIETGMNV ANHFLSAPIQ GTNSLSKASI IPGVAPVLIG NPEQKNIQHP 70 80 90 100 110 120 TASHQGSKSK GSGSGVRSII VPPSEAGNGG TQDPEPLFAQ TGQGGIVTTV YQDPTIQPTG 130 140 150 160 170 180 SSRSVELAKI GKERMINRFV EKPRISTPVT EFKRGAGSGC SRPDNPRGGH RREWSLSWVQ 190 200 210 220 GEVRVFEWCN PICSPITAAA RFHSCKCGNC PAKCDQCERD YGPP

References

[1]

"Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1 (V) and NS2." Elliott G.D., Yeo R.P., Afzal M.A., Simpson E.J.B., Curran J.A., Rima B.K. J. Gen. Virol. 71:1555-1560(1990) [PubMed: 2165137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], RNA EDITING.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00663 Genomic RNA. Translation: BAA00559.1.
PIR	JQ0597.
3D structure databases
ProteinModelPortal	P33483.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR024279. Paramyx_V_Zn-bd. [Graphical view]
Pfam	PF13008. zf-Paramyx-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

V_MUMPS

Accession

Primary (citable) accession number: P33483

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	October 19, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program