Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P33477 (ANX11_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A11
Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name=CAP-50
Gene names
Name:ANXA11
Synonyms:ANX11
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for midbody formation and completion of the terminal phase of cytokinesis By similarity. Binds specifically to calcyclin in a calcium-dependent manner.

Subunit structure

Interacts with PDCD6 in a calcium-dependent manner By similarity. Interacts with KIF23 during cytokinesis By similarity. Interacts with S100A6. Ref.3

Subcellular location

Cytoplasm By similarity. Melanosome By similarity. Nucleus envelope By similarity. Nucleusnucleoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity. Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus By similarity. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool By similarity. Localization to the nuclear envelope is cell-cycle dependent By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Annexin A11
PRO_0000067512

Regions

Repeat207 – 26761Annexin 1
Repeat279 – 33961Annexin 2
Repeat363 – 42361Annexin 3
Repeat438 – 49861Annexin 4

Amino acid modifications

Modified residue2461N6-acetyllysine By similarity
Modified residue2531N6-acetyllysine By similarity
Modified residue4771N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P33477 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 44C15F290770AC9F

FASTA50354,034
        10         20         30         40         50         60 
MSYPGYPPPP GGYPPAPGGG AWGGAGYPPP SMPPIGLDNV ANYAGQFNQD YLSGMAANMS 

        70         80         90        100        110        120 
GTFGGANVPP NLYPGAPGGG YPPVPPGGFG QPPPTQPSVP PYGVYPPPGG NPPSGVPSYP 

       130        140        150        160        170        180 
PFPGAPVPGQ PMPPPGHQPP GPYPGQLPVT YPGQSPVPPP GQQPMPSYPG YPGSGTVTPA 

       190        200        210        220        230        240 
VPPVQFGNRG TITDASGFDP LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF 

       250        260        270        280        290        300 
KTAYGKDLIK DLKSELSGNF EKTILALMKT PILFDAYEIK EAIKGAGTDE ACLIEILASR 

       310        320        330        340        350        360 
SNEHIRELNK AYKTEFKKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV DMSLVQRDVQ 

       370        380        390        400        410        420 
ELYAAGENRL GTDESKFNAV LCSRSRAHLV AVFNEYQRMT GRDIEKSICR EMSGDLEQGM 

       430        440        450        460        470        480 
LAVVKCLKNT PAFFAERLNR AMRGAGTKDR TLIRIMVSRS EIDLLDIRAE YKRMYGKSLY 

       490        500 
HDISGDTSGD YRKILLKICG GND 

« Hide

References

[1]"Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein."
Tokumitsu H., Mizutani A., Muramatsu M.-A., Yokota T., Arai K., Hidaka H.
Biochem. Biophys. Res. Commun. 186:1227-1235(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Lung.
[2]"A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family."
Tokumitsu H., Mizutani A., Minami H., Kobayashi R., Hidaka H.
J. Biol. Chem. 267:8919-8924(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[3]"Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms."
Sudo T., Hidaka H.
J. Biol. Chem. 273:6351-6357(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH S100A6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10883 mRNA. Translation: BAA01705.1.
PIRLURB11. JH0694.
RefSeqNP_001076208.1. NM_001082739.1.
UniGeneOcu.6390.

3D structure databases

ProteinModelPortalP33477.
SMRP33477. Positions 190-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000019019.

Proteomic databases

PRIDEP33477.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009511.

Organism-specific databases

CTD311.

Phylogenomic databases

eggNOGNOG267770.
HOGENOMHOG000158803.
HOVERGENHBG061815.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERPTHR10502:SF29. PTHR10502:SF29. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameANX11_RABIT
AccessionPrimary (citable) accession number: P33477
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families