Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P33477

- ANX11_RABIT

UniProt

P33477 - ANX11_RABIT

Protein

Annexin A11

Gene

ANXA11

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for midbody formation and completion of the terminal phase of cytokinesis By similarity. Binds specifically to calcyclin in a calcium-dependent manner.By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. S100 protein binding Source: UniProtKB

    GO - Biological processi

    1. cytokinesis, completion of separation Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A11
    Alternative name(s):
    Annexin XI
    Annexin-11
    Calcyclin-associated annexin 50
    Short name:
    CAP-50
    Gene namesi
    Name:ANXA11
    Synonyms:ANX11
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Melanosome By similarity. Nucleus envelope By similarity. Nucleusnucleoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity

    GO - Cellular componenti

    1. melanosome Source: UniProtKB-SubCell
    2. midbody Source: UniProtKB
    3. nuclear envelope Source: UniProtKB-SubCell
    4. nucleoplasm Source: UniProtKB-SubCell
    5. spindle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Annexin A11PRO_0000067512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei246 – 2461N6-acetyllysineBy similarity
    Modified residuei253 – 2531N6-acetyllysineBy similarity
    Modified residuei477 – 4771N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP33477.

    Interactioni

    Subunit structurei

    Interacts with PDCD6 in a calcium-dependent manner By similarity. Interacts with KIF23 during cytokinesis By similarity. Interacts with S100A6.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000019019.

    Structurei

    3D structure databases

    ProteinModelPortaliP33477.
    SMRiP33477. Positions 190-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati207 – 26761Annexin 1Add
    BLAST
    Repeati279 – 33961Annexin 2Add
    BLAST
    Repeati363 – 42361Annexin 3Add
    BLAST
    Repeati438 – 49861Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR008157. AnnexinXI.
    [Graphical view]
    PANTHERiPTHR10502:SF29. PTHR10502:SF29. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR01810. ANNEXINXI.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33477-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYPGYPPPP GGYPPAPGGG AWGGAGYPPP SMPPIGLDNV ANYAGQFNQD    50
    YLSGMAANMS GTFGGANVPP NLYPGAPGGG YPPVPPGGFG QPPPTQPSVP 100
    PYGVYPPPGG NPPSGVPSYP PFPGAPVPGQ PMPPPGHQPP GPYPGQLPVT 150
    YPGQSPVPPP GQQPMPSYPG YPGSGTVTPA VPPVQFGNRG TITDASGFDP 200
    LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK 250
    DLKSELSGNF EKTILALMKT PILFDAYEIK EAIKGAGTDE ACLIEILASR 300
    SNEHIRELNK AYKTEFKKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV 350
    DMSLVQRDVQ ELYAAGENRL GTDESKFNAV LCSRSRAHLV AVFNEYQRMT 400
    GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNR AMRGAGTKDR 450
    TLIRIMVSRS EIDLLDIRAE YKRMYGKSLY HDISGDTSGD YRKILLKICG 500
    GND 503
    Length:503
    Mass (Da):54,034
    Last modified:February 1, 1994 - v1
    Checksum:i44C15F290770AC9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10883 mRNA. Translation: BAA01705.1.
    PIRiJH0694. LURB11.
    RefSeqiNP_001076208.1. NM_001082739.1.
    UniGeneiOcu.6390.

    Genome annotation databases

    GeneIDi100009511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10883 mRNA. Translation: BAA01705.1 .
    PIRi JH0694. LURB11.
    RefSeqi NP_001076208.1. NM_001082739.1.
    UniGenei Ocu.6390.

    3D structure databases

    ProteinModelPortali P33477.
    SMRi P33477. Positions 190-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000019019.

    Proteomic databases

    PRIDEi P33477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100009511.

    Organism-specific databases

    CTDi 311.

    Phylogenomic databases

    eggNOGi NOG267770.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR008157. AnnexinXI.
    [Graphical view ]
    PANTHERi PTHR10502:SF29. PTHR10502:SF29. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR01810. ANNEXINXI.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein."
      Tokumitsu H., Mizutani A., Muramatsu M.-A., Yokota T., Arai K., Hidaka H.
      Biochem. Biophys. Res. Commun. 186:1227-1235(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Lung.
    2. "A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family."
      Tokumitsu H., Mizutani A., Minami H., Kobayashi R., Hidaka H.
      J. Biol. Chem. 267:8919-8924(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
    3. "Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms."
      Sudo T., Hidaka H.
      J. Biol. Chem. 273:6351-6357(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH S100A6.

    Entry informationi

    Entry nameiANX11_RABIT
    AccessioniPrimary (citable) accession number: P33477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3