Annexin A11 - Oryctolagus cuniculus (Rabbit)

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P33477 (ANX11_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Annexin A11

Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name=CAP-50

Gene names

Name:	ANXA11
Synonyms:	ANX11

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for midbody formation and completion of the terminal phase of cytokinesis By similarity. Binds specifically to calcyclin in a calcium-dependent manner.
Subunit structure	Interacts with PDCD6 in a calcium-dependent manner By similarity. Interacts with KIF23 during cytokinesis By similarity. Interacts with S100A6. Ref.3
Subcellular location	Cytoplasm By similarity. Melanosome By similarity. Nucleus envelope By similarity. Nucleus › nucleoplasm By similarity. Cytoplasm › cytoskeleton › spindle By similarity. Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus By similarity. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool By similarity. Localization to the nuclear envelope is cell-cycle dependent By similarity.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similarities	Belongs to the annexin family. Contains 4 annexin repeats.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton Nucleus
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis, completion of separation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell midbody Inferred from sequence or structural similarity. Source: UniProtKB nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	S100 protein binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 503

503

Annexin A11

PRO_0000067512

Regions

Repeat

207 – 267

Annexin 1

Repeat

279 – 339

Annexin 2

Repeat

363 – 423

Annexin 3

Repeat

438 – 498

Annexin 4

Amino acid modifications

Modified residue

246

N6-acetyllysine By similarity

Modified residue

253

N6-acetyllysine By similarity

Modified residue

477

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P33477 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 44C15F290770AC9F
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FASTA

503

54,034

        10         20         30         40         50         60 
MSYPGYPPPP GGYPPAPGGG AWGGAGYPPP SMPPIGLDNV ANYAGQFNQD YLSGMAANMS 

        70         80         90        100        110        120 
GTFGGANVPP NLYPGAPGGG YPPVPPGGFG QPPPTQPSVP PYGVYPPPGG NPPSGVPSYP 

       130        140        150        160        170        180 
PFPGAPVPGQ PMPPPGHQPP GPYPGQLPVT YPGQSPVPPP GQQPMPSYPG YPGSGTVTPA 

       190        200        210        220        230        240 
VPPVQFGNRG TITDASGFDP LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF 

       250        260        270        280        290        300 
KTAYGKDLIK DLKSELSGNF EKTILALMKT PILFDAYEIK EAIKGAGTDE ACLIEILASR 

       310        320        330        340        350        360 
SNEHIRELNK AYKTEFKKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV DMSLVQRDVQ 

       370        380        390        400        410        420 
ELYAAGENRL GTDESKFNAV LCSRSRAHLV AVFNEYQRMT GRDIEKSICR EMSGDLEQGM 

       430        440        450        460        470        480 
LAVVKCLKNT PAFFAERLNR AMRGAGTKDR TLIRIMVSRS EIDLLDIRAE YKRMYGKSLY 

       490        500 
HDISGDTSGD YRKILLKICG GND

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References

[1]	"Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein." Tokumitsu H., Mizutani A., Muramatsu M.-A., Yokota T., Arai K., Hidaka H. Biochem. Biophys. Res. Commun. 186:1227-1235(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Lung.
[2]	"A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family." Tokumitsu H., Mizutani A., Minami H., Kobayashi R., Hidaka H. J. Biol. Chem. 267:8919-8924(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[3]	"Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms." Sudo T., Hidaka H. J. Biol. Chem. 273:6351-6357(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH S100A6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D10883 mRNA. Translation: BAA01705.1.
PIR	LURB11. JH0694.
RefSeq	NP_001076208.1. NM_001082739.1.
UniGene	Ocu.6390.
3D structure databases
ProteinModelPortal	P33477.
SMR	P33477. Positions 190-503.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000019019.
Proteomic databases
PRIDE	P33477.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100009511.
Organism-specific databases
CTD	311.
Phylogenomic databases
eggNOG	NOG267770.
HOGENOM	HOG000158803.
HOVERGEN	HBG061815.
Family and domain databases
Gene3D	1.10.220.10. 4 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR008157. AnnexinXI. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit. PTHR10502:SF29. PTHR10502:SF29. 1 hit.
Pfam	PF00191. Annexin. 4 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR01810. ANNEXINXI.
SMART	SM00335. ANX. 4 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 1 hit.
PROSITE	PS00223. ANNEXIN. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANX11_RABIT

Accession

Primary (citable) accession number: P33477

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents