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P33477

- ANX11_RABIT

UniProt

P33477 - ANX11_RABIT

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Protein

Annexin A11

Gene

ANXA11

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner.By similarity

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. S100 protein binding Source: UniProtKB

GO - Biological processi

  1. cytokinesis, completion of separation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A11
Alternative name(s):
Annexin XI
Annexin-11
Calcyclin-associated annexin 50
Short name:
CAP-50
Gene namesi
Name:ANXA11
Synonyms:ANX11
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cytoplasm By similarity. Melanosome By similarity. Nucleus envelope By similarity. Nucleusnucleoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. midbody Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
  4. spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Annexin A11PRO_0000067512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei246 – 2461N6-acetyllysineBy similarity
Modified residuei253 – 2531N6-acetyllysineBy similarity
Modified residuei477 – 4771N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP33477.

Interactioni

Subunit structurei

Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with KIF23 during cytokinesis (By similarity). Interacts with S100A6.By similarity1 Publication

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000019019.

Structurei

3D structure databases

ProteinModelPortaliP33477.
SMRiP33477. Positions 190-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati207 – 26761Annexin 1Add
BLAST
Repeati279 – 33961Annexin 2Add
BLAST
Repeati363 – 42361Annexin 3Add
BLAST
Repeati438 – 49861Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP33477.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view]
PANTHERiPTHR10502:SF29. PTHR10502:SF29. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33477 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYPGYPPPP GGYPPAPGGG AWGGAGYPPP SMPPIGLDNV ANYAGQFNQD
60 70 80 90 100
YLSGMAANMS GTFGGANVPP NLYPGAPGGG YPPVPPGGFG QPPPTQPSVP
110 120 130 140 150
PYGVYPPPGG NPPSGVPSYP PFPGAPVPGQ PMPPPGHQPP GPYPGQLPVT
160 170 180 190 200
YPGQSPVPPP GQQPMPSYPG YPGSGTVTPA VPPVQFGNRG TITDASGFDP
210 220 230 240 250
LRDAEVLRKA MKGFGTDEQA IIDCLGSRSN KQRQQILLSF KTAYGKDLIK
260 270 280 290 300
DLKSELSGNF EKTILALMKT PILFDAYEIK EAIKGAGTDE ACLIEILASR
310 320 330 340 350
SNEHIRELNK AYKTEFKKTL EEAIRSDTSG HFQRLLISLS QGNRDESTNV
360 370 380 390 400
DMSLVQRDVQ ELYAAGENRL GTDESKFNAV LCSRSRAHLV AVFNEYQRMT
410 420 430 440 450
GRDIEKSICR EMSGDLEQGM LAVVKCLKNT PAFFAERLNR AMRGAGTKDR
460 470 480 490 500
TLIRIMVSRS EIDLLDIRAE YKRMYGKSLY HDISGDTSGD YRKILLKICG

GND
Length:503
Mass (Da):54,034
Last modified:February 1, 1994 - v1
Checksum:i44C15F290770AC9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10883 mRNA. Translation: BAA01705.1.
PIRiJH0694. LURB11.
RefSeqiNP_001076208.1. NM_001082739.1.
UniGeneiOcu.6390.

Genome annotation databases

GeneIDi100009511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10883 mRNA. Translation: BAA01705.1 .
PIRi JH0694. LURB11.
RefSeqi NP_001076208.1. NM_001082739.1.
UniGenei Ocu.6390.

3D structure databases

ProteinModelPortali P33477.
SMRi P33477. Positions 190-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000019019.

Proteomic databases

PRIDEi P33477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009511.

Organism-specific databases

CTDi 311.

Phylogenomic databases

eggNOGi NOG267770.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P33477.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR008157. AnnexinXI.
[Graphical view ]
PANTHERi PTHR10502:SF29. PTHR10502:SF29. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR01810. ANNEXINXI.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of rabbit CAP-50, a calcyclin-associated annexin protein."
    Tokumitsu H., Mizutani A., Muramatsu M.-A., Yokota T., Arai K., Hidaka H.
    Biochem. Biophys. Res. Commun. 186:1227-1235(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Lung.
  2. "A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family."
    Tokumitsu H., Mizutani A., Minami H., Kobayashi R., Hidaka H.
    J. Biol. Chem. 267:8919-8924(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  3. "Regulation of calcyclin (S100A6) binding by alternative splicing in the N-terminal regulatory domain of annexin XI isoforms."
    Sudo T., Hidaka H.
    J. Biol. Chem. 273:6351-6357(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH S100A6.

Entry informationi

Entry nameiANX11_RABIT
AccessioniPrimary (citable) accession number: P33477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3