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P33455 (GP_SEOU8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein
Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismSeoul virus (strain 80-39)
Taxonomic identifier12557 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Bunyaviridae › Hantavirus ›
Virus hostHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Protein attributes

Sequence length1133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the hantavirus envelope glycoprotein family.

Contains 1 ITAM domain.

Ontologies

Keywords
   Biological processFusion of virus membrane with host endosomal membrane
Fusion of virus membrane with host membrane
Host-virus interaction
Inhibition of host IFN-mediated response initiation by virus
Inhibition of host TRAFs by virus
Inhibition of host innate immune response by virus
Viral attachment to host cell
Viral immunoevasion
Viral penetration into host cytoplasm
Virus entry into host cell
   Cellular componentHost Golgi apparatus
Host endoplasmic reticulum
Host membrane
Membrane
Virion
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

suppression by virus of host TRAF activity

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host type I interferon production

Inferred from electronic annotation. Source: UniProtKB-KW

viral attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 11331116Envelope glycoprotein
PRO_0000036838
Chain18 – 646629Glycoprotein G1 By similarity
PRO_0000036839
Chain647 – 1133487Glycoprotein G2 By similarity
PRO_0000036840

Regions

Topological domain18 – 484467Lumenal Potential
Transmembrane485 – 50420Helical; Potential
Topological domain505 – 646142Cytoplasmic Potential
Topological domain647 – 1104458Lumenal Potential
Transmembrane1105 – 112521Helical; Potential
Topological domain1126 – 11338Cytoplasmic Potential
Domain609 – 63224ITAM

Sites

Site646 – 6472Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation1321N-linked (GlcNAc...); by host Potential
Glycosylation2331N-linked (GlcNAc...); by host Potential
Glycosylation3451N-linked (GlcNAc...); by host Potential
Glycosylation3971N-linked (GlcNAc...); by host Potential
Glycosylation9261N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P33455 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 3FD0695189E75DA9

FASTA1,133125,776
        10         20         30         40         50         60 
MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VKFGETSVSG YTELPPLSLQ EAEQLVPESS 

        70         80         90        100        110        120 
CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFELMESE VSFKGLCMLK HRMVEESYRN 

       130        140        150        160        170        180 
RRSVICYDLA CNSTFCKPTV YMIVPIHACN MMKSCLIGLG PYRVQVVYER TYCTTGILTE 

       190        200        210        220        230        240 
GKCFVPDKAV VSALKRGMYA IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ 

       250        260        270        280        290        300 
GYYICIIGGN SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI 

       310        320        330        340        350        360 
PHTVSSKNLK LTAFAGIPSY SSTSILTASE DGRFIFSPGL FPNLNQSVCD NNALPLIWRG 

       370        380        390        400        410        420 
LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS PMCLVSKQNR FRAAEQQISF 

       430        440        450        460        470        480 
VCQRVDMDII VYCNGQKKTI LTKTLVIGQC IYTITSLFSL LPGVAHSIAI ELCVPGFHGW 

       490        500        510        520        530        540 
ATAALLITFC FGWVLIPACT LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS 

       550        560        570        580        590        600 
MVCEICKYEC ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK 

       610        620        630        640        650        660 
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP LVPLWTDNAH 

       670        680        690        700        710        720 
GVGSVPMHTD LELDFSLPSS SRYTYKRHLT NPVNDQQSVS LHIEIESQGI GADVHHLGHW 

       730        740        750        760        770        780 
YDARLNLKTS FHCYGACTKY QYPWHTAKCH FEKDYEYENS WACNPPDCPG VGTGCTACGL 

       790        800        810        820        830        840 
YLDQLKPVGT AFKIISVRYS RKVCVQFGEE YLCKTIDMND CFVTRHAKIC IIGTVSKFSQ 

       850        860        870        880        890        900 
GDTLLFLGPM EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP 

       910        920        930        940        950        960 
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI NIVISKDIDF 

       970        980        990       1000       1010       1020 
ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT FLTSIRACDM AICYGAESVT 

      1030       1040       1050       1060       1070       1080 
LSRGQNTVKI TGKGGHSGSS FKCCHGKECS LTGLQASAPH LDKVNGISEL ENEKVYDDGA 

      1090       1100       1110       1120       1130 
PECGITCWFK KSGEWVMGII NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS

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References

[1]"Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway."
Antic D., Lim B.U., Kang C.Y.
Virus Res. 19:47-58(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		S47716 Genomic RNA. Translation: AAB19434.1.
PIRA43964.
RefSeqNP_942557.1. NC_005237.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3648453.

Family and domain databases

InterProIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFPIRSF003945. M_poly_HantaV. 1 hit.
ProDomPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS51055. ITAM_1. False negative.
PS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_SEOU8
AccessionPrimary (citable) accession number: P33455
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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