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P33455

- GP_SEOU8

UniProt

P33455 - GP_SEOU8

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Protein
Envelope glycoprotein
Gene
GP
Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host TRAF activity Source: UniProtKB-KW
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiSeoul virus (strain 80-39)
Taxonomic identifieri12557 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 484467Lumenal Reviewed prediction
Add
BLAST
Transmembranei485 – 50420Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 646142Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini647 – 1104458Lumenal Reviewed prediction
Add
BLAST
Transmembranei1105 – 112521Helical; Reviewed prediction
Add
BLAST
Topological domaini1126 – 11338Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 11331116Envelope glycoprotein
PRO_0000036838Add
BLAST
Chaini18 – 646629Glycoprotein G1 By similarity
PRO_0000036839Add
BLAST
Chaini647 – 1133487Glycoprotein G2 By similarity
PRO_0000036840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi345 – 3451N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi926 – 9261N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33455-1 [UniParc]FASTAAdd to Basket

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MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VKFGETSVSG YTELPPLSLQ     50
EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFELMESE 100
VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPIHACN 150
MMKSCLIGLG PYRVQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI 300
PHTVSSKNLK LTAFAGIPSY SSTSILTASE DGRFIFSPGL FPNLNQSVCD 350
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC 450
IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MVCEICKYEC 550
ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK 600
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SRYTYKRHLT NPVNDQQSVS 700
LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH 750
FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS 800
RKVCVQFGEE YLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM 850
EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP 900
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI 950
NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT 1000
FLTSIRACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS 1050
LTGLQASAPH LDKVNGISEL ENEKVYDDGA PECGITCWFK KSGEWVMGII 1100
NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS 1133
Length:1,133
Mass (Da):125,776
Last modified:February 1, 1994 - v1
Checksum:i3FD0695189E75DA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47716 Genomic RNA. Translation: AAB19434.1.
PIRiA43964.
RefSeqiNP_942557.1. NC_005237.1.

Genome annotation databases

GeneIDi3648453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47716 Genomic RNA. Translation: AAB19434.1 .
PIRi A43964.
RefSeqi NP_942557.1. NC_005237.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3648453.

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway."
    Antic D., Lim B.U., Kang C.Y.
    Virus Res. 19:47-58(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_SEOU8
AccessioniPrimary (citable) accession number: P33455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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