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P33455

- GP_SEOU8

UniProt

P33455 - GP_SEOU8

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Protein

Envelope glycoprotein

Gene

GP

Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiSeoul virus (strain 80-39)
Taxonomic identifieri12557 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 11331116Envelope glycoproteinPRO_0000036838Add
BLAST
Chaini18 – 646629Glycoprotein G1By similarityPRO_0000036839Add
BLAST
Chaini647 – 1133487Glycoprotein G2By similarityPRO_0000036840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi926 – 9261N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 484467LumenalSequence AnalysisAdd
BLAST
Topological domaini505 – 646142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini647 – 1104458LumenalSequence AnalysisAdd
BLAST
Topological domaini1126 – 11338CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei485 – 50420HelicalSequence AnalysisAdd
BLAST
Transmembranei1105 – 112521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33455-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VKFGETSVSG YTELPPLSLQ
60 70 80 90 100
EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFELMESE
110 120 130 140 150
VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPIHACN
160 170 180 190 200
MMKSCLIGLG PYRVQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA
210 220 230 240 250
IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN
260 270 280 290 300
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI
310 320 330 340 350
PHTVSSKNLK LTAFAGIPSY SSTSILTASE DGRFIFSPGL FPNLNQSVCD
360 370 380 390 400
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS
410 420 430 440 450
PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC
460 470 480 490 500
IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT
510 520 530 540 550
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MVCEICKYEC
560 570 580 590 600
ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK
610 620 630 640 650
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP
660 670 680 690 700
LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SRYTYKRHLT NPVNDQQSVS
710 720 730 740 750
LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH
760 770 780 790 800
FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS
810 820 830 840 850
RKVCVQFGEE YLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM
860 870 880 890 900
EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP
910 920 930 940 950
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI
960 970 980 990 1000
NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT
1010 1020 1030 1040 1050
FLTSIRACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS
1060 1070 1080 1090 1100
LTGLQASAPH LDKVNGISEL ENEKVYDDGA PECGITCWFK KSGEWVMGII
1110 1120 1130
NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS
Length:1,133
Mass (Da):125,776
Last modified:February 1, 1994 - v1
Checksum:i3FD0695189E75DA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47716 Genomic RNA. Translation: AAB19434.1.
PIRiA43964.
RefSeqiNP_942557.1. NC_005237.1.

Genome annotation databases

GeneIDi3648453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S47716 Genomic RNA. Translation: AAB19434.1 .
PIRi A43964.
RefSeqi NP_942557.1. NC_005237.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3648453.

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway."
    Antic D., Lim B.U., Kang C.Y.
    Virus Res. 19:47-58(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_SEOU8
AccessioniPrimary (citable) accession number: P33455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3