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P33455

- GP_SEOU8

UniProt

P33455 - GP_SEOU8

Protein

Envelope glycoprotein

Gene

GP

Organism
Seoul virus (strain 80-39)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. signal transduction Source: InterPro
    3. suppression by virus of host innate immune response Source: UniProtKB-KW
    4. suppression by virus of host TRAF activity Source: UniProtKB-KW
    5. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiSeoul virus (strain 80-39)
    Taxonomic identifieri12557 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]
    Rattus rattus (Black rat) [TaxID: 10117]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 11331116Envelope glycoproteinPRO_0000036838Add
    BLAST
    Chaini18 – 646629Glycoprotein G1By similarityPRO_0000036839Add
    BLAST
    Chaini647 – 1133487Glycoprotein G2By similarityPRO_0000036840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi926 – 9261N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 484467LumenalSequence AnalysisAdd
    BLAST
    Topological domaini505 – 646142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini647 – 1104458LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1126 – 11338CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei485 – 50420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1105 – 112521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P33455-1 [UniParc]FASTAAdd to Basket

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    MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VKFGETSVSG YTELPPLSLQ     50
    EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFELMESE 100
    VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPIHACN 150
    MMKSCLIGLG PYRVQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
    IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
    SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI 300
    PHTVSSKNLK LTAFAGIPSY SSTSILTASE DGRFIFSPGL FPNLNQSVCD 350
    NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
    PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC 450
    IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
    LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MVCEICKYEC 550
    ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK 600
    KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
    LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SRYTYKRHLT NPVNDQQSVS 700
    LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH 750
    FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS 800
    RKVCVQFGEE YLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM 850
    EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP 900
    VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI 950
    NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT 1000
    FLTSIRACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS 1050
    LTGLQASAPH LDKVNGISEL ENEKVYDDGA PECGITCWFK KSGEWVMGII 1100
    NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS 1133
    Length:1,133
    Mass (Da):125,776
    Last modified:February 1, 1994 - v1
    Checksum:i3FD0695189E75DA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S47716 Genomic RNA. Translation: AAB19434.1.
    PIRiA43964.
    RefSeqiNP_942557.1. NC_005237.1.

    Genome annotation databases

    GeneIDi3648453.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S47716 Genomic RNA. Translation: AAB19434.1 .
    PIRi A43964.
    RefSeqi NP_942557.1. NC_005237.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3648453.

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the M genomic segment of the Seoul 80-39 virus; nucleotide and amino acid sequence comparisons with other hantaviruses reveal the evolutionary pathway."
      Antic D., Lim B.U., Kang C.Y.
      Virus Res. 19:47-58(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_SEOU8
    AccessioniPrimary (citable) accession number: P33455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3