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P33453

- L_UUKS

UniProt

P33453 - L_UUKS

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Protein

RNA-directed RNA polymerase L

Gene
L
Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiUukuniemi virus (strain S23) (Uuk)
Taxonomic identifieri487099 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]
ProteomesiUP000008595: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21032103RNA-directed RNA polymerase LPRO_0000222028Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini978 – 1175198RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33453-1 [UniParc]FASTAAdd to Basket

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MLLAICSRTI RQQGLNCPPA VTFTSSHMRP PIPSFLLWTE GSDVLMDFDL     50
DTIPAGSVTG SSIGPKFKIK TQAASSFVHD FTFAHWCDAS DMPLRDHFPL 100
VNDTFDHWTP DFISQRLDGS KVVVEFTTNR SDQEQSLISA FNTKVGKYEV 150
ALHNRSTTSS ILFGVVVVSE TTVVTNLNLN QQEVDELCFR FLVARAVHLE 200
MTTKMIIPEY DDEDEDKRSR EVKAAFHSVQ PDWNVTEANF APFSRRMFSN 250
FAQMEPDKEY LAHIILDSLK QAQADLDGNH YLNESLTEQA RLDRNREESL 300
NMVKDFERDF NNAAQRSAWS HKSTVPFPGV IPKVSGDTTS LSRLVELPVI 350
TGGSDATIRA WRSAYGSVSN GTVERCDEDV ERERRAALCS LTVEELEESK 400
ALRMKYHRCK IDNGMMDKLD LAMQGVEAKE FKNHPSIIKK RSKSKKTFPL 450
TADTRDIDLF LHHDDLMFNN EHSQTPPAAM IEAVKAGADA QSLHGLDKSA 500
NPWYASALWF LGLPIGLWLF MCTCIGVELS ISLKQHCGRQ KFIIKKLRFF 550
DIFLLIKPTN SGSHVFYSIA FPESAILGKL HRSQCFKGLQ FEDGWFWTEF 600
SSFKMSKLTN VVKCLSTGFN LFWFWRDYYE VPFWAGNEKD FQTGKQRANK 650
MFKFCLLMLL EDKARTEEIA TLSRYVMMEG FVSPPCIPKP QKMIEKLPNL 700
ARTKFQVWLI SRMLQTIIRV SDYPFKITAG HKSANWTGMF NWVTGEPIES 750
TQKLISLFYL GYLKNKEESP ERNASIGMYK KILEYEDKHP GRYTYLGLGD 800
PPSDDTRFHE YSISLLKHLC IHAEHDLRRN WGESFKAMIS RDIVDAIASL 850
DLERLATLKA SSNFNEEWYQ KRGDGKTYHR SKVLEKVSKY VKKSSSHVHH 900
IMEECLRKVE SQGCMHVCLF KKPQHGGLRE IYVLGFEERV VQLVIETIAR 950
QICKRFKSET LTNPKQKLAI PETHGLRAVK TCGIHHETVA TSDDAAKWNQ 1000
CHHVTKFALM LCHFTDPLFH GFIIRGCSMF MKKRIMIDQS LIDIIDSHTT 1050
LETSDAYLQK IHRGYHGSLD DQPRWISRGG AFVQTETGMM QGILHYTSSL 1100
LHTLLQEWLR TFSQRFIRTR VSVDQRPDVL VDVLQSSDDS GMMISFPSTD 1150
KGATGKYRYL SALIFKYKKV IGKYLGIYSS VKSTNNTLHL LEFNSEFFFH 1200
INHNRPLLRW ITACDTISEQ ESLASRQEEM YNNLTSVLEG GGSFSLVSFC 1250
QFGQLLLHYT LLGMTVSPLF LEYIKLVSEI KDPSLGYFLM DHPFGSGLSG 1300
FKYNVWVAVQ NSILGSRYRS LLEAIQNSDS AAPKKTLDTT TSGTFVQSTI 1350
IRFGDRKKWQ RLVDRLNLPE DWLDVIDKNP EIVYRRPRDG FEVSLRIAEK 1400
VHSPGVSNSL SKGNCIIRVI SSSVYILSRS ILSDGLAWLY DEEEEVKRPL 1450
LYKVMNQPEL DLHSRLTPAQ LSTLFPMMAE FEKLQTHLRS YMKIEGEFIS 1500
KKKVITQTRV NILETERFLR ARPEDLIADK WFGFTRTRMT PRTFKEEWEN 1550
LTSVFPWLTG NPSETLELSP FQHHVQLRNF FSRLDLKGRD IRIIGAPIKK 1600
SSGVSNVSTA IRDNFFPRFV LTHIPDEAAM ERIEAAGILK HALFLTVTGP 1650
YTDQSKLDMC RDFITSSEPI TLKPNHGKTR TNVLSLFQDY FSKRGPDIIF 1700
NRIQMANCGV IGGFTSPQKP KEVDGKIVYT GDGVWRGIVD GFQIQLVITY 1750
MPKQKSNELK SITVNSDRCI SALSSFCQSW CKEMGVFNTE DFSKTQRFSK 1800
ASFFMHKFKI SGSKQTLGAP IFIVSEKIFR PICWDPSKLE FRVRGNTLNL 1850
TYKEVNPGAG QRMFNILSYT VKDTDVSDEN AFKLMSLSPR HKFHGREPST 1900
SWICMRALPI STIDKLLERI LNRERISGSI DNERLAECFK NVMESTLRRK 1950
GVFLSEFSRA TQKMLDGLSR DMLDFFAEAG LNDDLLLEEE PWLSGLDTFM 2000
LDDEAYLEEY NLGPFGVFSV EQEMNTKYYH HLLLDSLVED VIQKLSLDGL 2050
RKLFQEEEAP LEYKKEVIRL LNILQRDASQ IKWKSRDLLS ENMGLDVDDD 2100
MFG 2103
Length:2,103
Mass (Da):241,041
Last modified:February 1, 1994 - v1
Checksum:iB0EA708451B0B6BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10759 Genomic RNA. Translation: BAA01590.1.
PIRiJQ1621.
RefSeqiNP_941973.1. NC_005214.1.

Genome annotation databases

GeneIDi2943071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10759 Genomic RNA. Translation: BAA01590.1 .
PIRi JQ1621.
RefSeqi NP_941973.1. NC_005214.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943071.

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and coding strategy of the Uukuniemi virus L RNA segment."
    Elliott R.M., Dunn E., Simons J.F., Pettersson R.F.
    J. Gen. Virol. 73:1745-1752(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_UUKS
AccessioniPrimary (citable) accession number: P33453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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