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P33453

- L_UUKS

UniProt

P33453 - L_UUKS

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleoside binding Source: InterPro
  2. nucleotide binding Source: UniProtKB-KW
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiUukuniemi virus (strain S23) (Uuk)
Taxonomic identifieri487099 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]
ProteomesiUP000008595: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21032103RNA-directed RNA polymerase LPRO_0000222028Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini978 – 1175198RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phlebovirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFiPIRSF000826. L_PhleboV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33453-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLLAICSRTI RQQGLNCPPA VTFTSSHMRP PIPSFLLWTE GSDVLMDFDL
60 70 80 90 100
DTIPAGSVTG SSIGPKFKIK TQAASSFVHD FTFAHWCDAS DMPLRDHFPL
110 120 130 140 150
VNDTFDHWTP DFISQRLDGS KVVVEFTTNR SDQEQSLISA FNTKVGKYEV
160 170 180 190 200
ALHNRSTTSS ILFGVVVVSE TTVVTNLNLN QQEVDELCFR FLVARAVHLE
210 220 230 240 250
MTTKMIIPEY DDEDEDKRSR EVKAAFHSVQ PDWNVTEANF APFSRRMFSN
260 270 280 290 300
FAQMEPDKEY LAHIILDSLK QAQADLDGNH YLNESLTEQA RLDRNREESL
310 320 330 340 350
NMVKDFERDF NNAAQRSAWS HKSTVPFPGV IPKVSGDTTS LSRLVELPVI
360 370 380 390 400
TGGSDATIRA WRSAYGSVSN GTVERCDEDV ERERRAALCS LTVEELEESK
410 420 430 440 450
ALRMKYHRCK IDNGMMDKLD LAMQGVEAKE FKNHPSIIKK RSKSKKTFPL
460 470 480 490 500
TADTRDIDLF LHHDDLMFNN EHSQTPPAAM IEAVKAGADA QSLHGLDKSA
510 520 530 540 550
NPWYASALWF LGLPIGLWLF MCTCIGVELS ISLKQHCGRQ KFIIKKLRFF
560 570 580 590 600
DIFLLIKPTN SGSHVFYSIA FPESAILGKL HRSQCFKGLQ FEDGWFWTEF
610 620 630 640 650
SSFKMSKLTN VVKCLSTGFN LFWFWRDYYE VPFWAGNEKD FQTGKQRANK
660 670 680 690 700
MFKFCLLMLL EDKARTEEIA TLSRYVMMEG FVSPPCIPKP QKMIEKLPNL
710 720 730 740 750
ARTKFQVWLI SRMLQTIIRV SDYPFKITAG HKSANWTGMF NWVTGEPIES
760 770 780 790 800
TQKLISLFYL GYLKNKEESP ERNASIGMYK KILEYEDKHP GRYTYLGLGD
810 820 830 840 850
PPSDDTRFHE YSISLLKHLC IHAEHDLRRN WGESFKAMIS RDIVDAIASL
860 870 880 890 900
DLERLATLKA SSNFNEEWYQ KRGDGKTYHR SKVLEKVSKY VKKSSSHVHH
910 920 930 940 950
IMEECLRKVE SQGCMHVCLF KKPQHGGLRE IYVLGFEERV VQLVIETIAR
960 970 980 990 1000
QICKRFKSET LTNPKQKLAI PETHGLRAVK TCGIHHETVA TSDDAAKWNQ
1010 1020 1030 1040 1050
CHHVTKFALM LCHFTDPLFH GFIIRGCSMF MKKRIMIDQS LIDIIDSHTT
1060 1070 1080 1090 1100
LETSDAYLQK IHRGYHGSLD DQPRWISRGG AFVQTETGMM QGILHYTSSL
1110 1120 1130 1140 1150
LHTLLQEWLR TFSQRFIRTR VSVDQRPDVL VDVLQSSDDS GMMISFPSTD
1160 1170 1180 1190 1200
KGATGKYRYL SALIFKYKKV IGKYLGIYSS VKSTNNTLHL LEFNSEFFFH
1210 1220 1230 1240 1250
INHNRPLLRW ITACDTISEQ ESLASRQEEM YNNLTSVLEG GGSFSLVSFC
1260 1270 1280 1290 1300
QFGQLLLHYT LLGMTVSPLF LEYIKLVSEI KDPSLGYFLM DHPFGSGLSG
1310 1320 1330 1340 1350
FKYNVWVAVQ NSILGSRYRS LLEAIQNSDS AAPKKTLDTT TSGTFVQSTI
1360 1370 1380 1390 1400
IRFGDRKKWQ RLVDRLNLPE DWLDVIDKNP EIVYRRPRDG FEVSLRIAEK
1410 1420 1430 1440 1450
VHSPGVSNSL SKGNCIIRVI SSSVYILSRS ILSDGLAWLY DEEEEVKRPL
1460 1470 1480 1490 1500
LYKVMNQPEL DLHSRLTPAQ LSTLFPMMAE FEKLQTHLRS YMKIEGEFIS
1510 1520 1530 1540 1550
KKKVITQTRV NILETERFLR ARPEDLIADK WFGFTRTRMT PRTFKEEWEN
1560 1570 1580 1590 1600
LTSVFPWLTG NPSETLELSP FQHHVQLRNF FSRLDLKGRD IRIIGAPIKK
1610 1620 1630 1640 1650
SSGVSNVSTA IRDNFFPRFV LTHIPDEAAM ERIEAAGILK HALFLTVTGP
1660 1670 1680 1690 1700
YTDQSKLDMC RDFITSSEPI TLKPNHGKTR TNVLSLFQDY FSKRGPDIIF
1710 1720 1730 1740 1750
NRIQMANCGV IGGFTSPQKP KEVDGKIVYT GDGVWRGIVD GFQIQLVITY
1760 1770 1780 1790 1800
MPKQKSNELK SITVNSDRCI SALSSFCQSW CKEMGVFNTE DFSKTQRFSK
1810 1820 1830 1840 1850
ASFFMHKFKI SGSKQTLGAP IFIVSEKIFR PICWDPSKLE FRVRGNTLNL
1860 1870 1880 1890 1900
TYKEVNPGAG QRMFNILSYT VKDTDVSDEN AFKLMSLSPR HKFHGREPST
1910 1920 1930 1940 1950
SWICMRALPI STIDKLLERI LNRERISGSI DNERLAECFK NVMESTLRRK
1960 1970 1980 1990 2000
GVFLSEFSRA TQKMLDGLSR DMLDFFAEAG LNDDLLLEEE PWLSGLDTFM
2010 2020 2030 2040 2050
LDDEAYLEEY NLGPFGVFSV EQEMNTKYYH HLLLDSLVED VIQKLSLDGL
2060 2070 2080 2090 2100
RKLFQEEEAP LEYKKEVIRL LNILQRDASQ IKWKSRDLLS ENMGLDVDDD

MFG
Length:2,103
Mass (Da):241,041
Last modified:February 1, 1994 - v1
Checksum:iB0EA708451B0B6BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10759 Genomic RNA. Translation: BAA01590.1.
PIRiJQ1621.
RefSeqiNP_941973.1. NC_005214.1.

Genome annotation databases

GeneIDi2943071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10759 Genomic RNA. Translation: BAA01590.1 .
PIRi JQ1621.
RefSeqi NP_941973.1. NC_005214.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943071.

Family and domain databases

InterProi IPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view ]
PIRSFi PIRSF000826. L_PhleboV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence and coding strategy of the Uukuniemi virus L RNA segment."
    Elliott R.M., Dunn E., Simons J.F., Pettersson R.F.
    J. Gen. Virol. 73:1745-1752(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_UUKS
AccessioniPrimary (citable) accession number: P33453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3