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P33453

- L_UUKS

UniProt

P33453 - L_UUKS

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Uukuniemi virus (strain S23) (Uuk)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleoside binding Source: InterPro
    2. nucleotide binding Source: UniProtKB-KW
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiUukuniemi virus (strain S23) (Uuk)
    Taxonomic identifieri487099 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Ixodes ricinus (Common tick) [TaxID: 34613]
    ProteomesiUP000008595: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21032103RNA-directed RNA polymerase LPRO_0000222028Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini978 – 1175198RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the phlebovirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000826. L_PhleboV. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33453-1 [UniParc]FASTAAdd to Basket

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    MLLAICSRTI RQQGLNCPPA VTFTSSHMRP PIPSFLLWTE GSDVLMDFDL     50
    DTIPAGSVTG SSIGPKFKIK TQAASSFVHD FTFAHWCDAS DMPLRDHFPL 100
    VNDTFDHWTP DFISQRLDGS KVVVEFTTNR SDQEQSLISA FNTKVGKYEV 150
    ALHNRSTTSS ILFGVVVVSE TTVVTNLNLN QQEVDELCFR FLVARAVHLE 200
    MTTKMIIPEY DDEDEDKRSR EVKAAFHSVQ PDWNVTEANF APFSRRMFSN 250
    FAQMEPDKEY LAHIILDSLK QAQADLDGNH YLNESLTEQA RLDRNREESL 300
    NMVKDFERDF NNAAQRSAWS HKSTVPFPGV IPKVSGDTTS LSRLVELPVI 350
    TGGSDATIRA WRSAYGSVSN GTVERCDEDV ERERRAALCS LTVEELEESK 400
    ALRMKYHRCK IDNGMMDKLD LAMQGVEAKE FKNHPSIIKK RSKSKKTFPL 450
    TADTRDIDLF LHHDDLMFNN EHSQTPPAAM IEAVKAGADA QSLHGLDKSA 500
    NPWYASALWF LGLPIGLWLF MCTCIGVELS ISLKQHCGRQ KFIIKKLRFF 550
    DIFLLIKPTN SGSHVFYSIA FPESAILGKL HRSQCFKGLQ FEDGWFWTEF 600
    SSFKMSKLTN VVKCLSTGFN LFWFWRDYYE VPFWAGNEKD FQTGKQRANK 650
    MFKFCLLMLL EDKARTEEIA TLSRYVMMEG FVSPPCIPKP QKMIEKLPNL 700
    ARTKFQVWLI SRMLQTIIRV SDYPFKITAG HKSANWTGMF NWVTGEPIES 750
    TQKLISLFYL GYLKNKEESP ERNASIGMYK KILEYEDKHP GRYTYLGLGD 800
    PPSDDTRFHE YSISLLKHLC IHAEHDLRRN WGESFKAMIS RDIVDAIASL 850
    DLERLATLKA SSNFNEEWYQ KRGDGKTYHR SKVLEKVSKY VKKSSSHVHH 900
    IMEECLRKVE SQGCMHVCLF KKPQHGGLRE IYVLGFEERV VQLVIETIAR 950
    QICKRFKSET LTNPKQKLAI PETHGLRAVK TCGIHHETVA TSDDAAKWNQ 1000
    CHHVTKFALM LCHFTDPLFH GFIIRGCSMF MKKRIMIDQS LIDIIDSHTT 1050
    LETSDAYLQK IHRGYHGSLD DQPRWISRGG AFVQTETGMM QGILHYTSSL 1100
    LHTLLQEWLR TFSQRFIRTR VSVDQRPDVL VDVLQSSDDS GMMISFPSTD 1150
    KGATGKYRYL SALIFKYKKV IGKYLGIYSS VKSTNNTLHL LEFNSEFFFH 1200
    INHNRPLLRW ITACDTISEQ ESLASRQEEM YNNLTSVLEG GGSFSLVSFC 1250
    QFGQLLLHYT LLGMTVSPLF LEYIKLVSEI KDPSLGYFLM DHPFGSGLSG 1300
    FKYNVWVAVQ NSILGSRYRS LLEAIQNSDS AAPKKTLDTT TSGTFVQSTI 1350
    IRFGDRKKWQ RLVDRLNLPE DWLDVIDKNP EIVYRRPRDG FEVSLRIAEK 1400
    VHSPGVSNSL SKGNCIIRVI SSSVYILSRS ILSDGLAWLY DEEEEVKRPL 1450
    LYKVMNQPEL DLHSRLTPAQ LSTLFPMMAE FEKLQTHLRS YMKIEGEFIS 1500
    KKKVITQTRV NILETERFLR ARPEDLIADK WFGFTRTRMT PRTFKEEWEN 1550
    LTSVFPWLTG NPSETLELSP FQHHVQLRNF FSRLDLKGRD IRIIGAPIKK 1600
    SSGVSNVSTA IRDNFFPRFV LTHIPDEAAM ERIEAAGILK HALFLTVTGP 1650
    YTDQSKLDMC RDFITSSEPI TLKPNHGKTR TNVLSLFQDY FSKRGPDIIF 1700
    NRIQMANCGV IGGFTSPQKP KEVDGKIVYT GDGVWRGIVD GFQIQLVITY 1750
    MPKQKSNELK SITVNSDRCI SALSSFCQSW CKEMGVFNTE DFSKTQRFSK 1800
    ASFFMHKFKI SGSKQTLGAP IFIVSEKIFR PICWDPSKLE FRVRGNTLNL 1850
    TYKEVNPGAG QRMFNILSYT VKDTDVSDEN AFKLMSLSPR HKFHGREPST 1900
    SWICMRALPI STIDKLLERI LNRERISGSI DNERLAECFK NVMESTLRRK 1950
    GVFLSEFSRA TQKMLDGLSR DMLDFFAEAG LNDDLLLEEE PWLSGLDTFM 2000
    LDDEAYLEEY NLGPFGVFSV EQEMNTKYYH HLLLDSLVED VIQKLSLDGL 2050
    RKLFQEEEAP LEYKKEVIRL LNILQRDASQ IKWKSRDLLS ENMGLDVDDD 2100
    MFG 2103
    Length:2,103
    Mass (Da):241,041
    Last modified:February 1, 1994 - v1
    Checksum:iB0EA708451B0B6BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10759 Genomic RNA. Translation: BAA01590.1.
    PIRiJQ1621.
    RefSeqiNP_941973.1. NC_005214.1.

    Genome annotation databases

    GeneIDi2943071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10759 Genomic RNA. Translation: BAA01590.1 .
    PIRi JQ1621.
    RefSeqi NP_941973.1. NC_005214.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943071.

    Family and domain databases

    InterProi IPR022531. DUF3770.
    IPR007099. RNA-dir_pol_NSvirus.
    IPR014385. RNA-dir_pol_phlebovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    PF12603. DUF3770. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000826. L_PhleboV. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and coding strategy of the Uukuniemi virus L RNA segment."
      Elliott R.M., Dunn E., Simons J.F., Pettersson R.F.
      J. Gen. Virol. 73:1745-1752(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_UUKS
    AccessioniPrimary (citable) accession number: P33453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3