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P33453 (L_UUKS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismUukuniemi virus (strain S23) (Uuk) [Reference proteome]
Taxonomic identifier487099 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Ixodes ricinus (Common tick) [TaxID: 34613]

Protein attributes

Sequence length2103 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the phlebovirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21032103RNA-directed RNA polymerase L
PRO_0000222028

Regions

Domain978 – 1175198RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P33453 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: B0EA708451B0B6BD

FASTA2,103241,041
        10         20         30         40         50         60 
MLLAICSRTI RQQGLNCPPA VTFTSSHMRP PIPSFLLWTE GSDVLMDFDL DTIPAGSVTG 

        70         80         90        100        110        120 
SSIGPKFKIK TQAASSFVHD FTFAHWCDAS DMPLRDHFPL VNDTFDHWTP DFISQRLDGS 

       130        140        150        160        170        180 
KVVVEFTTNR SDQEQSLISA FNTKVGKYEV ALHNRSTTSS ILFGVVVVSE TTVVTNLNLN 

       190        200        210        220        230        240 
QQEVDELCFR FLVARAVHLE MTTKMIIPEY DDEDEDKRSR EVKAAFHSVQ PDWNVTEANF 

       250        260        270        280        290        300 
APFSRRMFSN FAQMEPDKEY LAHIILDSLK QAQADLDGNH YLNESLTEQA RLDRNREESL 

       310        320        330        340        350        360 
NMVKDFERDF NNAAQRSAWS HKSTVPFPGV IPKVSGDTTS LSRLVELPVI TGGSDATIRA 

       370        380        390        400        410        420 
WRSAYGSVSN GTVERCDEDV ERERRAALCS LTVEELEESK ALRMKYHRCK IDNGMMDKLD 

       430        440        450        460        470        480 
LAMQGVEAKE FKNHPSIIKK RSKSKKTFPL TADTRDIDLF LHHDDLMFNN EHSQTPPAAM 

       490        500        510        520        530        540 
IEAVKAGADA QSLHGLDKSA NPWYASALWF LGLPIGLWLF MCTCIGVELS ISLKQHCGRQ 

       550        560        570        580        590        600 
KFIIKKLRFF DIFLLIKPTN SGSHVFYSIA FPESAILGKL HRSQCFKGLQ FEDGWFWTEF 

       610        620        630        640        650        660 
SSFKMSKLTN VVKCLSTGFN LFWFWRDYYE VPFWAGNEKD FQTGKQRANK MFKFCLLMLL 

       670        680        690        700        710        720 
EDKARTEEIA TLSRYVMMEG FVSPPCIPKP QKMIEKLPNL ARTKFQVWLI SRMLQTIIRV 

       730        740        750        760        770        780 
SDYPFKITAG HKSANWTGMF NWVTGEPIES TQKLISLFYL GYLKNKEESP ERNASIGMYK 

       790        800        810        820        830        840 
KILEYEDKHP GRYTYLGLGD PPSDDTRFHE YSISLLKHLC IHAEHDLRRN WGESFKAMIS 

       850        860        870        880        890        900 
RDIVDAIASL DLERLATLKA SSNFNEEWYQ KRGDGKTYHR SKVLEKVSKY VKKSSSHVHH 

       910        920        930        940        950        960 
IMEECLRKVE SQGCMHVCLF KKPQHGGLRE IYVLGFEERV VQLVIETIAR QICKRFKSET 

       970        980        990       1000       1010       1020 
LTNPKQKLAI PETHGLRAVK TCGIHHETVA TSDDAAKWNQ CHHVTKFALM LCHFTDPLFH 

      1030       1040       1050       1060       1070       1080 
GFIIRGCSMF MKKRIMIDQS LIDIIDSHTT LETSDAYLQK IHRGYHGSLD DQPRWISRGG 

      1090       1100       1110       1120       1130       1140 
AFVQTETGMM QGILHYTSSL LHTLLQEWLR TFSQRFIRTR VSVDQRPDVL VDVLQSSDDS 

      1150       1160       1170       1180       1190       1200 
GMMISFPSTD KGATGKYRYL SALIFKYKKV IGKYLGIYSS VKSTNNTLHL LEFNSEFFFH 

      1210       1220       1230       1240       1250       1260 
INHNRPLLRW ITACDTISEQ ESLASRQEEM YNNLTSVLEG GGSFSLVSFC QFGQLLLHYT 

      1270       1280       1290       1300       1310       1320 
LLGMTVSPLF LEYIKLVSEI KDPSLGYFLM DHPFGSGLSG FKYNVWVAVQ NSILGSRYRS 

      1330       1340       1350       1360       1370       1380 
LLEAIQNSDS AAPKKTLDTT TSGTFVQSTI IRFGDRKKWQ RLVDRLNLPE DWLDVIDKNP 

      1390       1400       1410       1420       1430       1440 
EIVYRRPRDG FEVSLRIAEK VHSPGVSNSL SKGNCIIRVI SSSVYILSRS ILSDGLAWLY 

      1450       1460       1470       1480       1490       1500 
DEEEEVKRPL LYKVMNQPEL DLHSRLTPAQ LSTLFPMMAE FEKLQTHLRS YMKIEGEFIS 

      1510       1520       1530       1540       1550       1560 
KKKVITQTRV NILETERFLR ARPEDLIADK WFGFTRTRMT PRTFKEEWEN LTSVFPWLTG 

      1570       1580       1590       1600       1610       1620 
NPSETLELSP FQHHVQLRNF FSRLDLKGRD IRIIGAPIKK SSGVSNVSTA IRDNFFPRFV 

      1630       1640       1650       1660       1670       1680 
LTHIPDEAAM ERIEAAGILK HALFLTVTGP YTDQSKLDMC RDFITSSEPI TLKPNHGKTR 

      1690       1700       1710       1720       1730       1740 
TNVLSLFQDY FSKRGPDIIF NRIQMANCGV IGGFTSPQKP KEVDGKIVYT GDGVWRGIVD 

      1750       1760       1770       1780       1790       1800 
GFQIQLVITY MPKQKSNELK SITVNSDRCI SALSSFCQSW CKEMGVFNTE DFSKTQRFSK 

      1810       1820       1830       1840       1850       1860 
ASFFMHKFKI SGSKQTLGAP IFIVSEKIFR PICWDPSKLE FRVRGNTLNL TYKEVNPGAG 

      1870       1880       1890       1900       1910       1920 
QRMFNILSYT VKDTDVSDEN AFKLMSLSPR HKFHGREPST SWICMRALPI STIDKLLERI 

      1930       1940       1950       1960       1970       1980 
LNRERISGSI DNERLAECFK NVMESTLRRK GVFLSEFSRA TQKMLDGLSR DMLDFFAEAG 

      1990       2000       2010       2020       2030       2040 
LNDDLLLEEE PWLSGLDTFM LDDEAYLEEY NLGPFGVFSV EQEMNTKYYH HLLLDSLVED 

      2050       2060       2070       2080       2090       2100 
VIQKLSLDGL RKLFQEEEAP LEYKKEVIRL LNILQRDASQ IKWKSRDLLS ENMGLDVDDD 


MFG 

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References

[1]"Nucleotide sequence and coding strategy of the Uukuniemi virus L RNA segment."
Elliott R.M., Dunn E., Simons J.F., Pettersson R.F.
J. Gen. Virol. 73:1745-1752(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10759 Genomic RNA. Translation: BAA01590.1.
PIRJQ1621.
RefSeqNP_941973.1. NC_005214.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943071.

Family and domain databases

InterProIPR022531. DUF3770.
IPR007099. RNA-dir_pol_NSvirus.
IPR014385. RNA-dir_pol_phlebovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
PF12603. DUF3770. 1 hit.
[Graphical view]
PIRSFPIRSF000826. L_PhleboV. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_UUKS
AccessionPrimary (citable) accession number: P33453
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families