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Protein

Tyrosine aminotransferase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).By similarity

Catalytic activityi

L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: L-phenylalanine degradation

This protein is involved in step 2 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Tyrosine aminotransferase
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.5. 6524.
SABIO-RKP33447.
UniPathwayiUPA00139; UER00338.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine aminotransferase (EC:2.6.1.5)
Short name:
TAT
Alternative name(s):
L-tyrosine:2-oxoglutarate aminotransferase
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Tyrosine aminotransferasePRO_0000123890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531N6-(pyridoxal phosphate)lysine

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP33447.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi353153.XP_821468.1.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 134Combined sources
Helixi18 – 247Combined sources
Turni43 – 464Combined sources
Helixi53 – 6412Combined sources
Beta strandi68 – 703Combined sources
Helixi78 – 9215Combined sources
Turni96 – 983Combined sources
Helixi99 – 1013Combined sources
Helixi104 – 1063Combined sources
Beta strandi107 – 1115Combined sources
Helixi112 – 12413Combined sources
Beta strandi130 – 1367Combined sources
Helixi140 – 1478Combined sources
Beta strandi151 – 1577Combined sources
Helixi159 – 1613Combined sources
Helixi167 – 1737Combined sources
Beta strandi178 – 1869Combined sources
Turni188 – 1903Combined sources
Helixi196 – 20914Combined sources
Beta strandi213 – 2164Combined sources
Turni218 – 2214Combined sources
Beta strandi245 – 2517Combined sources
Turni252 – 2554Combined sources
Helixi258 – 2603Combined sources
Beta strandi263 – 2686Combined sources
Helixi275 – 28814Combined sources
Helixi293 – 30412Combined sources
Helixi308 – 32922Combined sources
Beta strandi335 – 3373Combined sources
Beta strandi345 – 3506Combined sources
Helixi352 – 3543Combined sources
Beta strandi355 – 3573Combined sources
Helixi361 – 37212Combined sources
Helixi379 – 3824Combined sources
Beta strandi387 – 3915Combined sources
Helixi396 – 41318Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BW0X-ray2.50A/B1-416[»]
ProteinModelPortaliP33447.
SMRiP33447. Positions 4-416.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33447.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWDVSMSN HAGLVFNPIR TVSDNAKPSP SPKPIIKLSV GDPTLDKNLL
60 70 80 90 100
TSAAQIKKLK EAIDSQECNG YFPTVGSPEA REAVATWWRN SFVHKEELKS
110 120 130 140 150
TIVKDNVVLC SGGSHGILMA ITAICDAGDY ALVPQPGFPH YETVCKAYGI
160 170 180 190 200
GMHFYNCRPE NDWEADLDEI RRLKDDKTKL LIVTNPSNPC GSNFSRKHVE
210 220 230 240 250
DIVRLAEELR LPLFSDEIYA GMVFKGKDPN ATFTSVADFE TTVPRVILGG
260 270 280 290 300
TAKNLVVPGW RLGWLLYVDP HGNGPSFLEG LKRVGMLVCG PCTVVQAALG
310 320 330 340 350
EALLNTPQEH LDQIVAKIEE SAMYLYNHIG ECIGLAPTMP RGAMYLMSRI
360 370 380 390 400
DLEKYRDIKT DVEFFEKLLE EENVQVLPGT IFHAPGFTRL TTTRPVEVYR
410
EAVERIKAFC QRHAAV
Length:416
Mass (Da):46,167
Last modified:November 1, 1995 - v2
Checksum:i1D31564359C463C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531H → D AA sequence (PubMed:8100416).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00673 Unassigned DNA. Translation: AAA02975.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00673 Unassigned DNA. Translation: AAA02975.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BW0X-ray2.50A/B1-416[»]
ProteinModelPortaliP33447.
SMRiP33447. Positions 4-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_821468.1.

Proteomic databases

PaxDbiP33447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00338.
BRENDAi2.6.1.5. 6524.
SABIO-RKP33447.

Miscellaneous databases

EvolutionaryTraceiP33447.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATTY_TRYCR
AccessioniPrimary (citable) accession number: P33447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Was originally thought to have three internal disulfide bonds.1 Publication

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.