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Protein

Tyrosine aminotransferase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).By similarity

Catalytic activityi

L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: L-phenylalanine degradation

This protein is involved in step 2 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Tyrosine aminotransferase
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.5. 6524.
SABIO-RKP33447.
UniPathwayiUPA00139; UER00338.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine aminotransferase (EC:2.6.1.5)
Short name:
TAT
Alternative name(s):
L-tyrosine:2-oxoglutarate aminotransferase
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238901 – 416Tyrosine aminotransferaseAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253N6-(pyridoxal phosphate)lysine1

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP33447.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi353153.XP_821468.1.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 13Combined sources4
Helixi18 – 24Combined sources7
Turni43 – 46Combined sources4
Helixi53 – 64Combined sources12
Beta strandi68 – 70Combined sources3
Helixi78 – 92Combined sources15
Turni96 – 98Combined sources3
Helixi99 – 101Combined sources3
Helixi104 – 106Combined sources3
Beta strandi107 – 111Combined sources5
Helixi112 – 124Combined sources13
Beta strandi130 – 136Combined sources7
Helixi140 – 147Combined sources8
Beta strandi151 – 157Combined sources7
Helixi159 – 161Combined sources3
Helixi167 – 173Combined sources7
Beta strandi178 – 186Combined sources9
Turni188 – 190Combined sources3
Helixi196 – 209Combined sources14
Beta strandi213 – 216Combined sources4
Turni218 – 221Combined sources4
Beta strandi245 – 251Combined sources7
Turni252 – 255Combined sources4
Helixi258 – 260Combined sources3
Beta strandi263 – 268Combined sources6
Helixi275 – 288Combined sources14
Helixi293 – 304Combined sources12
Helixi308 – 329Combined sources22
Beta strandi335 – 337Combined sources3
Beta strandi345 – 350Combined sources6
Helixi352 – 354Combined sources3
Beta strandi355 – 357Combined sources3
Helixi361 – 372Combined sources12
Helixi379 – 382Combined sources4
Beta strandi387 – 391Combined sources5
Helixi396 – 413Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BW0X-ray2.50A/B1-416[»]
ProteinModelPortaliP33447.
SMRiP33447.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33447.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWDVSMSN HAGLVFNPIR TVSDNAKPSP SPKPIIKLSV GDPTLDKNLL
60 70 80 90 100
TSAAQIKKLK EAIDSQECNG YFPTVGSPEA REAVATWWRN SFVHKEELKS
110 120 130 140 150
TIVKDNVVLC SGGSHGILMA ITAICDAGDY ALVPQPGFPH YETVCKAYGI
160 170 180 190 200
GMHFYNCRPE NDWEADLDEI RRLKDDKTKL LIVTNPSNPC GSNFSRKHVE
210 220 230 240 250
DIVRLAEELR LPLFSDEIYA GMVFKGKDPN ATFTSVADFE TTVPRVILGG
260 270 280 290 300
TAKNLVVPGW RLGWLLYVDP HGNGPSFLEG LKRVGMLVCG PCTVVQAALG
310 320 330 340 350
EALLNTPQEH LDQIVAKIEE SAMYLYNHIG ECIGLAPTMP RGAMYLMSRI
360 370 380 390 400
DLEKYRDIKT DVEFFEKLLE EENVQVLPGT IFHAPGFTRL TTTRPVEVYR
410
EAVERIKAFC QRHAAV
Length:416
Mass (Da):46,167
Last modified:November 1, 1995 - v2
Checksum:i1D31564359C463C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153H → D AA sequence (PubMed:8100416).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00673 Unassigned DNA. Translation: AAA02975.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00673 Unassigned DNA. Translation: AAA02975.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BW0X-ray2.50A/B1-416[»]
ProteinModelPortaliP33447.
SMRiP33447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_821468.1.

Proteomic databases

PaxDbiP33447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0259. Eukaryota.
COG0436. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00338.
BRENDAi2.6.1.5. 6524.
SABIO-RKP33447.

Miscellaneous databases

EvolutionaryTraceiP33447.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR005958. TyrNic_aminoTrfase.
IPR005957. Tyrosine_aminoTrfase.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000517. Tyr_transaminase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01264. tyr_amTase_E. 1 hit.
TIGR01265. tyr_nico_aTase. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATTY_TRYCR
AccessioniPrimary (citable) accession number: P33447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Was originally thought to have three internal disulfide bonds.1 Publication

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.